Conserved Protein Domain Family
Miro2
?
cd01892: Miro2 
Mitochondrial Rho family 2 (Miro2), C-terminal
Miro2 subfamily. Miro (mitochondrial Rho) proteins have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. Genes encoding Miro-like proteins were found in several eukaryotic organisms. This CD represents the putative GTPase domain in the C terminus of Miro proteins. These atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Most Rho proteins contain a lipid modification site at the C-terminus; however, Miro is one of few Rho subfamilies that lack this feature.
Links
?
Statistics
?
PSSM-Id: 206679
Aligned: 27 rows
Threshold Bit Score: 197.466
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Rho molecules assume an active conformation when bound to GTP and inactive when GTP is hydrolyzed to GDP
  • Comment:Mg2+ ion plays a key role in bringing together the functional regions of the phosphate-binding, switches I and II
  • Citation:PMID 9242920
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ######                                                             
CAD56957     413 QRSVLLCKVVGACGVGKSAFLQAFLGRglg---------------------------------hqDTREQPPGYAIDTVQ 459 human
BAD81741     361 FANLIYVGYPGDFDSAFTTTRKRRVDRkkkqtqrn-----------------------vfqqpsdAPPVNGEQFAANTVE 417 Japanese rice
AAF27037     424 ERKVVQCFVFGPKNAGKSALLNQFIGRsydd------------------------------dsnnNNGSTDEHYAVNMVK 473 thale cress
AAT77915     421 QRNVFQCYVFGPRGAGKTALLQSFLGRqp----------------------------------sdALPMNGERFAANTVE 466 Oryza sativa (j...
NP_198106    426 ERKVFQCFVFGPNNAGKSALLNCFLGRsyt---------------------------------dnQESTTDERYAVNMVD 472 thale cress
CAF90509     426 QRSVFHCNVFGDVGSGKSSFLQAFLGRnlavnahsyhlsgsfedfirhvfvlrvcfcfssqdqkwINEEHKSYYAINTTY 505 Tetraodon nigro...
NP_500620    423 DRKVFQCLVVGAKDAGKTVFMQSLAGRgma--------------------------------dvaQIGRRHSPFVINRVR 470 Caenorhabditis ...
NP_001006208 416 QRNVFRCNVVGMKGCGKSGVLQALLGRnlmr-------------------------------qrqIRAEHKSYYAINTVY 464 chicken
CAD56956     415 QRNVFRCNVIGVKNCGKSGVLQALLGRnlmr-------------------------------qkkIREDHKSYYAINTVY 463 human
NP_651205    443 SRSVYKCHVIGPKGSGKTGMCRGFLVEdmhk-------------------------------ligKEFKTNVVNCINSVQ 491 fruit fly

Feature 1                      ## #                                                            # 
CAD56957     460 Vn----GQEKYLILCEVGTDGLLATSLDa----tCDVACLMFDGSDPKSFAHC----ASVYKHHYMdg-qtPCLFVSSKA 526 human
BAD81741     418 Lp---dGTRKTLVMREISEGDVGPLLSDkeslapCDVAVIVYDSGDEVSWQRArellVQVATRGKNtgyevPCLIVAAKD 494 Japanese rice
AAF27037     474 EpgvisDTDKTLVLKEVRIKDDGFMLSKeal-aaCDVAIFIYDSSDEYSWNRAvdmlAEVATIAKDsgyvfPCLMVAAKT 552 thale cress
AAT77915     467 Ls----GSRKTLVFREIPEDDVRPLLADreslapCDVAVFVYDSCDEFSWQRTrdllVEVATHGENtgyevPCLIVAAKD 542 Oryza sativa (j...
NP_198106    473 Es----GAKKTLIMREIPEDGVQGLFSSkeslaaCDIAVFVYDSSDESSWKRAtqllVEVANYGEAtgyevPCLMVSAKD 548 thale cress
CAF90509     506 Vy----GQEKYLLLHEVFPDFDYLSDVDl----aCDAVCLVYDVSNPYSFEYC----ASVFKQYFLds-ktPCMMIAAKS 572 Tetraodon nigro...
NP_500620    471 Vk----EESKYLLLREVDVLSPQDALGSge--tsADVVAFLYDISNPDSFAFC----ATVYQKYFYrt-ktPCVMIATKV 539 Caenorhabditis ...
NP_001006208 465 Vy----GQEKYLLLHDVSDSEFLTDAETi-----CDVVCLVYDVSNPKSFEYC----VRIFKQHFMds-riPCLVVAAKS 530 chicken
CAD56956     464 Vy----GQEKYLLLHDISESEFLTEAEIi-----CDVVCLVYDVSNPKSFEYC----ARIFKQHFMds-riPCLIVAAKS 529 human
NP_651205    492 Vy----GQEKHLILRDIDVRHALDPLQPqe--vnCDVACLVYDSSNPRSFEYV----ARIYIKYYAes-kiPVMIVGTKC 560 fruit fly

Feature 1        #                            ##                                
CAD56957     527 DLPEGvavSGPSPAEFCRKHrLPAPVPFSCAGPaepSTTIFTQLATMAAFPHlvhAELHPSSF 589 human
BAD81741     495 DLDQSp-lALQDSTRVSHDMgIETPIPISVRLRd--LNNIFCRIVHAAQQPHlsiPETEAGKT 554 Japanese rice
AAF27037     553 DLDPFp-vAIQESTRVTQDIgIDAPIPISSKLGd--VSNLFRKILTAAENPHlniPEIESKKK 612 thale cress
AAT77915     543 DLDQSp-lALQESTRVSQDMgIEMPIPISVRLRd--LNNIFCRIVHAAQQPHlsiPETEAGKT 602 Oryza sativa (japonica cultivar-...
NP_198106    549 DLDSSp-iSIQESTRMTQDMgIEPPVSISSKLGd--FNNLFRKILTAAQHPHlsiPETEAGKS 608 thale cress
CAF90509     573 DLPEVrqmFGCSPLEFCRRYrMPPPQSFTCNTAaapSRSIYTKLTTVAMYPH---ARLRCMCT 632 Tetraodon nigroviridis
NP_500620    540 EREEVdqrWEVPPEEFCRQFeLPKPIKFSTGNIgqsSSPIFEQLAMMAVYPH---LRRVFYLN 599 Caenorhabditis elegans
NP_001006208 531 DLHEVrqeYSISPAEFCKKHkMPPPQAFTCNTVdmpSKDIFVKLTTMAMYPHvtqADLKSSTF 593 chicken
CAD56956     530 DLHEVkqeYSISPTDFCRKHkMPPPQAFTCNTAdapSKDIFVKLTTMAMYPHvtqADPKSSTF 592 human
NP_651205    561 DMDERrqdYLMQPSEFCDKYkLLPPHLFSLKTN---KKELYTKLATMAAFPRfqaAWILFYKH 620 fruit fly

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap