Conserved Protein Domain Family
RhoBTB

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cd01873: RhoBTB 
RhoBTB protein is an atypical member of the Rho family of small GTPases
Members of the RhoBTB subfamily of Rho GTPases are present in vertebrates, Drosophila, and Dictyostelium. RhoBTB proteins are characterized by a modular organization, consisting of a GTPase domain, a proline rich region, a tandem of two BTB (Broad-Complex, Tramtrack, and Bric a brac) domains, and a C-terminal region of unknown function. RhoBTB proteins may act as docking points for multiple components participating in signal transduction cascades. RhoBTB genes appeared upregulated in some cancer cell lines, suggesting a participation of RhoBTB proteins in the pathogenesis of particular tumors. Note that the Dictyostelium RacA GTPase domain is more closely related to Rac proteins than to RhoBTB proteins, where RacA actually belongs. Thus, the Dictyostelium RacA is not included here. Most Rho proteins contain a lipid modification site at the C-terminus; however, RhoBTB is one of few Rho subfamilies that lack this feature.
Statistics
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PSSM-Id: 133275
View PSSM: cd01873
Aligned: 4 rows
Threshold Bit Score: 286.864
Threshold Setting Gi: 42601322
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Comment:Rho molecules assume an active conformation when bound to GTP and inactive when GTP is hydrolyzed to GDP
  • Comment:Mg2+ ion plays a key role in bringing together the functional regions of the phosphate-binding, switches I and II
  • Citation:PMID 9545299

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ######                                                       ## #    
Q9BYZ6     13 ETIKCVVVGDNAVGKTRLICARACNatl-tqyQLLATHVPTVWAIDQYRVCQevlersrdvvddvSVSLRLWDTFGDHHK 91  human
AAF44065   12 ELVKCVLVGDTAVGKTRLICARACNkhv-slsQLLSTHVPTVWAIDQYRIYKdvlerswevvdgvNVSLRLWDTFGDHDK 90  fruit fly
AAS21349    3 LDFKIVVVGDVNVGKTRLICSRAYRktacldkIRTPAHASSVWAIDQRLSEL-------------WNSHRLWDTFGAHDR 69  Oikopleura dioica
AAH73188   13 ETIKCVVVGDNAVGKTRLICARACNttl-tqyQLLATHVPTVWAIDQYRVCQevlersrdvvdevSVSLRLWDTFGDHHK 91  African clawed frog
Feature 1                                                             # #                     
Q9BYZ6     92 DRRFAYGrSDVVVLCFSIANPNSLHHVK-------TMWYPEIKHFCPRAPVILVGCQLDLRyadleavnrarrp----la 160 human
AAF44065   91 DRRFAYGrSDVVLLCFSIASPISLRNCK-------MMWYPEIRRFCPDVPVILVGCKNDLRymyrdenylsyfgekgtfv 163 fruit fly
AAS21349   70 DRRFAFGhADVVLLCFSIASENSLRNIKaplkkltNFWIHETRQHLKSVPQFVVGCKADLRhcnldef------------ 137 Oikopleura dioica
AAH73188   92 DRRFAYGrSDVVVLCFSIANPNSLNHVK-------TMWAQEIKHFCPRTPVILVGCQLDLRyadleavnrarrp----la 160 African clawed frog
Feature 1                                    ##                
Q9BYZ6    161 rpikpneilpPEKGREVAKELGI--PYYETSVVAQFGIKDVFDNAIRAA 207 human
AAF44065  164 raalksdlvmPDEARAVAKELGV--AYYETSVFTYFGVNEVFENAIRSA 210 fruit fly
AAS21349  138 ----narcgqLATKVAFKSELSLslPYYETSVVTGDGVEDLFTNAIRAA 182 Oikopleura dioica
AAH73188  161 rpikrgdilpPERGREVAKELGI--PYYETSVFDQFGIKDVFDNAIRAA 207 African clawed frog

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