1PUJ,1U0L,3H2Y


Conserved Protein Domain Family
YlqF_related_GTPase
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cd01849: YlqF_related_GTPase 
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Circularly permuted YlqF-related GTPases
These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.
Links
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Statistics
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PSSM-Id: 206746
Aligned: 14 rows
Threshold Bit Score: 106.7
Created: 6-Jan-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1PUJ_A: B. subtilis Ylqf Gtpase binds GTP/Mg2+, defined using 3.5 A contacts
  • Structure:1U0L_C: T. maritima Yjeq GTPase binds GDP, defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          ## ##                         ##           
1PUJ_A     25 DIVYELVDARIPmssrnpmi----edilknkpRIMLLNKADKADaavtqqwk--ehfenqgIRSLSINSVNGQglnqivp 98  Bacillus subtilis
1U0L_C     86 DQVILVVTVKMPetstyiidkflvlaekneleTVMVINKMDLYDeddlrkvreleeiysglYPIVKTSAKTGMgieelke 165 Thermotoga maritima
Q13823    218 DVVVQVLDARDPmgtrsphietylkkekpwkhLIFVLNKCDLVPtwatkrwv-avlsqdypTLAFHASLTNPFgkgafiq 296 human
Q58859     25 DVILLVLDARDPemtrnrele--kkikakgkkLIYVLNKADLVPkdilek-----wkevfgENTVFVSAKRRLgtkilre 97  Methanocaldococcus...
NP_569915 176 DVVVQIVDARNPllfrsadleryvkevepskmNMILVNKSDLLTeeqrrhwa--eyfdsegIRTAFYSATLVEeelkrea 253 fruit fly
NP_597162 172 DVVIEVIDARDPdssrnseae--kivsehgkkLIMVLNYTQYVPrevvdew----kvhlkrDGNDCIEVTEEDmrqig-- 243 Encephalitozoon cu...
CAD51649  187 DVVFYVIDIRNPliyldkdii--nfinsckkqIIIILNKCDLLDngiieqwv--vffrtyfITIPFISFMNKSiqpsylc 262 Plasmodium falcipa...
XP_678291 168 DIIFYLVDVRNPliyldkdii--dfikmckkeIIIVLNKCDLVDkeitkqwl-iyfrnyyiTIPFICHIKNNPqylqkqn 244 Plasmodium berghei
AAW42371  148 DVICEVVDARDVlggrsgyie--rlvkeaegrIILIINKIDLVPrevlqsw----vsqldiPTFLFKSALPVPptpsssr 221 Cryptococcus neofo...
XP_757519 141 KTIVLALDARDPqsfrcpwlea-eisntkskkLAFALGRADMVPletvaawt-aylsttagVATFPISSPPDQlaentga 218 Ustilago maydis 521

Feature 1                                                                                     
1PUJ_A     99 askeilqek--------------------------------------------------------------fdrmrakgv 116 Bacillus subtilis
1U0L_C        --------------------------------------------------------------------------------     Thermotoga maritima
Q13823    297 llrqf----------------------------------------------------------------------gklht 306 human
Q58859     98 mikq-----------------------------------------------------------------------slkem 106 Methanocaldococcus...
NP_569915 254 eecldsfpevqqlrraveeikqsldsvedalnvieqkyktipetqndelprlpgdknsprllsrlelieflrniytgprh 333 fruit fly
NP_597162     --------------------------------------------------------------------------------     Encephalitozoon cu...
CAD51649  263 tknksnernykinnnnynnit--------------------------------------mnhkmsntkscpikniienls 304 Plasmodium falcipa...
XP_678291 245 nqtkhinsnqqneqrnnlidinnnq-----------------------------tnisaenfyqnntnyyikqvlknivn 295 Plasmodium berghei
AAW42371  222 npgpsfflepsvilgre---------------------------------------------qliaaakkwsaekkksrk 256 Cryptococcus neofo...
XP_757519 219 ealvq----------------------------------------------------------------------qldlk 228 Ustilago maydis 521

Feature 1                 #######                                                       # 
1PUJ_A    117 kprairALIIGIPNVGKSTLINRLAKkniak--------------tgdrPGITTSQQWVKVg---kELELLDTPGI 175 Bacillus subtilis
1U0L_C    166 ylkgkiSTMAGLSGVGKSSLLNAINPglklrvse-------vseklqrgRHTTTTAQLLKFd---fGGYVVDTPGF 231 Thermotoga maritima
Q13823    307 dkkqisVGFIGYPNVGKSSVINTLRSkkvcn--------------vapiAGETKVWQYITLm---rRIFLIDCPGV 365 human
Q58859    107 gkkegkVGIVGYPNVGKSSIINALTGkrkal--------------tgsvAGLTKGEQWVRLt---kNIKLMDTPGV 165 Methanocaldococcus jan...
NP_569915 334 teqhvtVGMVGYPNVGKSSTINSLMTvkkvs--------------vsatPGKTKRFQTLFLd---kDILLCDCPGL 392 fruit fly
NP_597162 244 --ketrIGIFGNPGSGKNFVLRGISRileek--------------pnsvVVSVPLSKVTLSs---iLRGCHGLMGI 300 Encephalitozoon cunicu...
CAD51649  305 knnpitYGVIGHIYTGRNSFINTLLKefn------------------yiNNLKNEQIDIKLt---hNINLYVKPGL 359 Plasmodium falciparum 3D7
XP_678291 296 snikitYGVVGYIYTGRRSFMKTILNef-------------------nfVNSNNKQVDVNVd---nNINIYTKCGL 349 Plasmodium berghei
AAW42371  257 sdeplvLALMGLPSVGKTSILNSLLPstanksrhvvaplipsgqsakslQPTTKSPVEVEIdvdglKIKVIDTPGW 332 Cryptococcus neoforman...
XP_757519 229 gvgkgdIAVVGLAHSGRSTVADAILNaiglped----------edvedeDNETTDWPAVLD-----TSALIPVKSS 289 Ustilago maydis 521

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