Conserved Protein Domain Family
SGNH_hydrolase_like_6
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cd01844: SGNH_hydrolase_like_6 
SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Links
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Statistics
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PSSM-Id: 238881
Aligned: 13 rows
Threshold Bit Score: 213.723
Created: 21-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                #                           #           
CAB61298    173 VWLHHGSSISHGSDAaSPTTTWPALAAslggveLINLGLGGSALldpf-tarAMRDTPADLISVKIGINVVnadv----m 247 Streptomyces coe...
CAD74160    219 PIVFYGTSITHGACAsRPGMVHTAILGrrfdqpVVNLGFSGNGKmdae-vgeFLVQVDAAVYVIDCLPNMNaam------ 291 Rhodopirellula b...
ZP_00519673 185 PIVFYGTSITHGIGAsRAGMTHVAMLGrtfhreVFNLGFSGNGRmepe-vlkFVGELDPAVFVLDCLPNMGaql------ 257 Solibacter usita...
NP_601589   160 VWINYGSSISHGSVAtAPTKIWPAIVAqsknynLRNFGFGGSAMldpf-marLIRDTPADLITLEIGINIVngdv----m 234 Corynebacterium ...
AAO78698    178 PIVFYGTSILQGGCAnRPGMAHTNIISrrlnreIVNLGFSGNALldye-iaeVMSSVDAGVYVLDFVPNASsdq------ 250 Bacteroides thet...
YP_099471   187 PLVIYGTSIAQGACAsRPGMAWGNILNrklghpVINLGFSGNGKleea-lfdLLSEIDARLYIIDCMPNLAgkeas--av 263 Bacteroides frag...
AAK83171    158 RWVHYGASESQGRGAlSPTRNWTATVAtelgldLTSLAIGAGCYlqpl-fatLLRDLPADLITCMVGMNIYgaralnqft 236 Streptomyces vir...
ZP_01092696 198 PLVFYGTSIMHGACAsRPGMSITGIVGrrmnrpVINLGFSGNGRleae-vgeFLCELDPAVFIIDCLPNVDgpv------ 270 Blastopirellula ...
CAI78039    174 RWVHHGSSISHCIEAdGPTGTWPVVAAaladteVINLSQAGNALldpy-varTIRDMPADLISLKVGINIValsa----f 248 Streptomyces amb...
ZP_01354384 184 KLIFYGTSITQGGCAsRPGMAYTNYLArklnlaHCNFGFSGNGLgeyevakmLSEIEQPLLYIIDYEANSGtngr----- 258 Clostridium phyt...
ZP_00569083 143 RWLAYGDSIVEGWVAsSAGSSWPARLGrrlgldVCNLGYAGAARgeip-saeHLASVPAALISISYGTNCWstiphtael 221 Frankia sp. EAN1pec
ZP_01256650  85 PVIFYGTSITQGGCAsRPGMAHTNIMSrqldidVYNFGFSGNCRmeqp-iaeLISSVEPSLYIIECMPNMIkpel----- 158 Psychroflexus to...
ZP_01105746 178 PIVVYGTSIAQGACAsRPGMAWTNILSrrfkepVINLGFSGNGRleqe-iieLMTEIHASVYVLDCLPNLSpnekrtkse 256 Flavobacteriales...

Feature 1                                                                                       
CAB61298    248 rlrAFGPAVHGFLDTVreghptAPLLVVSPllcpvqedtpgplapdfsglaegrlrfvatgdpaerasgkltlnvirdeL 327 Streptomyces coe...
CAD74160    292 vseKCVPLVKQIRKAKp----nTPIVLVEDrrntnswilpar--------------------------dahhtanhqalQ 341 Rhodopirellula b...
ZP_00519673 258 vteRTAPGVKLLREAHp----nTPILLVEDrniqtgflvear--------------------------rkaneanhaalR 307 Solibacter usita...
NP_601589   235 rrrGLEAAVDGFINTIrdghptTPIKIVSPfycpihektpgpgafdtssfgsgq--irfiatgepdehgrltlemvrevL 312 Corynebacterium ...
AAO78698    251 iyeKMETFYRILRDKHp----rTPIIFIEDpvfthalfdkki--------------------------aieinkknkavN 300 Bacteroides thet...
YP_099471   264 vyqRTLEGVKKLREKSr-----APILLVEHdgysnefssesa--------------------------eesyrvanaelR 312 Bacteroides frag...
AAK83171    237 yrpNLVGLVRIIRERHp----sTPLVIASHhyspwhdplegd-------------------------gylsltevreqtR 287 Streptomyces vir...
ZP_01092696 271 vaeKTGPLVLQLRKAHp----eTPILLVEDrtytfapfrqss--------------------------rerhagsraafK 320 Blastopirellula ...
CAI78039    249 rlrTFGPALHGFLDTIrdghpdTPLLLISPvscpaleqvpgpaatgpdgria------algdpadvaggaltltvvraeL 322 Streptomyces amb...
ZP_01354384 259 mvkSLDDFVHCLRESHk----eVPILVVSRvphmmdfleest--------------------------tslrnslrefqR 308 Clostridium phyt...
ZP_00569083 222 lraGLDVFLTVVRQGHp----dTPIVVTTPirrpdaettpnr--------------------------vgatlddlrvaM 271 Frankia sp. EAN1pec
ZP_01256650 159 iteRTIPLVKTIRKKNp----dTPIIFVELfkspitllnnki--------------------------rnenkamddalK 208 Psychroflexus to...
ZP_01105746 257 iqkRITNSVNLLRKEHp----kTPILLVQHagysdglvdisr--------------------------qkvyttlntwmT 306 Flavobacteriales...

Feature 1                                             #  #                 
CAB61298    328 SRIVSERAADhe-nLYYLDGRELYGqada---adlPLPDDIHPDAATHRLIGERFAKLA 382 Streptomyces coelicolor A3(2)
CAD74160    342 EAYKTLLADGvt-gLHYIAGDELYGtd------gdGATDGSHASDLGFMRQADVFDPVL 393 Rhodopirellula baltica SH 1
ZP_00519673 308 EAFAALQAEKvp-hIYYLEGANLLGdd------geGTVDGSHPTDLGFMRQAAEFERVL 359 Solibacter usitatus Ellin6076
NP_601589   313 EGFVEKQKDPh---LTYVDGASLYQas------daPLLDNLHPDEASHALIAQRLLKQL 362 Corynebacterium glutamicum ATCC 13032
AAO78698    301 SVFKSLKTKGek-nIYIISSEKMLGed------geATVDGIHFTDLGMMRYADLVCPVI 352 Bacteroides thetaiotaomicron VPI-5482
YP_099471   313 KAYETLQKEQvp-tVYYLTKEEIGMpm-------dAMVDGVHSTDLGMQQYADSYRKKI 363 Bacteroides fragilis YCH46
AAK83171    288 EVVDLLRADGde-nVHYVHGPSLAGpetahlyvepRYTDPLHFNQEGHDLLAAAFQRKL 345 Streptomyces viridochromogenes
ZP_01092696 321 TAFENLQTAGvk-nLHYLPGDDLLGsd------geAATDGSHPNDLGMMRYADAYVPAL 372 Blastopirellula marina DSM 3645
CAI78039    323 ARIAAARQASdp-hLHHLDGRTLLGphe-----adDLGDGLHPTAAAYRRMGRRFAAYA 375 Streptomyces ambofaciens ATCC 23877
ZP_01354384 309 ETVEKFRTLGdn-aIYFLDGYTLWGddf-----deYTVDFIHPTDLGFYFMGKGLEPII 361 Clostridium phytofermentans ISDg
ZP_00569083 272 ASLVQARIDGgdpsLTLVHGETLLDe--------sLLADGVHPGDDGHAVMADRLEPVL 322 Frankia sp. EAN1pec
ZP_01256650 209 AEYNKMIENDfk-nIFFIETPELADsd------heGTVDAIHFTDLGFQRYADFLVEKL 260 Psychroflexus torquis ATCC 700755
ZP_01105746 307 ESYERLLEENvt-gLYMLSKDNIRLsn-------dAFVDGTHPTDLGMQQYADAYEKVL 357 Flavobacteriales bacterium HTCC2170

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