Conserved Protein Domain Family
SGNH_hydrolase_like_1

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cd01832: SGNH_hydrolase_like_1 
Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxlic acid. Myxobacterial members of this subfamily have been reported to be involved in adventurous gliding motility.
Statistics
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PSSM-Id: 238870
Aligned: 35 rows
Threshold Bit Score: 105.043
Created: 17-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:by similarity to othe members of this super-family
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                                        
CAB39707      4 SYVAVGDSFTEGVGdpg-----------------pdGAFVGWADRLavlladr------rpegdftYTNLAVRGRLLdq- 59  Streptomyces coe...
ZP_01060221  43 SYLALGDSYTIGESv---------------------CSTCRFPIQLeealatq-------tqgtieTDIIATTGWRTd-- 92  Leeuwenhoekiella...
ZP_01423932  39 RMVAFGDSITQAFLadgnigqigdr-pqyswatgtnATVNSLAERIrsst------------gvitATNVAVSGSSMn-- 103 Herpetosiphon au...
CAB62724     65 SVAAVGDSITRGFDacav---------------lsdCPEVSWATGSsakvdslavrllgkadaaehSWNYAVTGARMa-- 127 Streptomyces coe...
BAB53676     73 GIECFGDSTENGHNgepp--------------ygqvAEIPSARMQLllrdyt--------nnnlitVTNRAIDGTRLtqm 130 Mesorhizobium lo...
ZP_01407255  36 SIEIFGDSIARGPGist----------------pmpATLRALRPAWaiddrs---------asglvLADLIAGYSAPwpg 90  Acidovorax avena...
ZP_01428240  43 GIAALGDSISTGFGsclvvapcernswstgnslrveSHYRRLLDQDsti--------------rgqAFNHARTGARAs-- 106 Salinispora trop...
ZP_01225319 316 KLLALGDSYTIGQSv---------------------CESCSFPMQLktalemey-----serdqidLQIIAQTGWSTs-- 367 marine gamma pro...
ZP_01252163  23 SYLALGDSYSIGEQv---------------------SEEESWPVLLtsflnqq-------gypvekPEVIAVTGWRT--- 71  Psychroflexus to...
ZP_00948974  34 SFLALGDSYTIGQNv---------------------SEDNRWPNQLkealnrd-------glkvrdIKIIAKTGWRTd-- 83  Croceibacter atl...
Feature 1                                                                                       
CAB39707     60 ------iVAEQVPRVVgl----aPDLVSFAAGGNDIIr----pGTDPDEVAERFELAVAALt----aAAGTVLVTTGFDt 121 Streptomyces coe...
ZP_01060221  93 ------dLINAINNENpa---ntYDLVTLLIGVNNQYq-----GRSFSQYETEFPQLLMTAinlaqgDKDRVLVVSIPDy 158 Leeuwenhoekiella...
ZP_01423932 104 ------aLLSQVNTANsa----nAQYATILLGANDICrssesaMTSVATYRAQLISGLNQLts--nePEARIFIASIPDi 171 Herpetosiphon au...
CAB62724    128 ------dLTAQVTRAAqr----ePELVAVMAGANDACrsttsaMTPVADFRAQFEEAMATLrk--klPKAQVYVSSIPDl 195 Streptomyces coe...
BAB53676    131 i---dgtDGSGSTFAAkma-vspSLIITINHGLNDTQna---iPTPPKTYRDYLIQAVKICrs---aPIPKVPIFKTPNp 200 Mesorhizobium lo...
ZP_01407255  91 apadaypRGPQPPFAQvs---rsARVVVLAAGLNDALe-----MRTPAQYGADLREAIRIVr----aEGRLPVLAGIVDl 158 Acidovorax avena...
ZP_01428240 107 ------aLASQAAQATrd----rPDRITVLIGANDIChgevaaMTPVETFRSQVDRGLRVLsa--elPKARLLVVSIPDl 174 Salinispora trop...
ZP_01225319 368 ------nLKEAIFTAApa---adYDLATLLIGVNNQFr-----KIPFSLFETEFEELVNSAisfvggDRSKVIILSIPDy 433 marine gamma pro...
ZP_01252163  72 -------DELQDFIASlhykkesFDLVSLLIGVNNQYq-----KKPFKKFKSEFEDLLKTAielssqHNKGVFIVGIPDy 139 Psychroflexus to...
ZP_00948974  84 ------dLISAINYRLdet--etYDVVSVLIGVNNQYq-----KKSITTYEEDLKVVFEKAikhskkGAKGVFALNIPDy 150 Croceibacter atl...
Feature 1                                                                                       
CAB39707    122 rg-----------------------------vpVLKHLRGki-------------------------------------a 135 Streptomyces coe...
ZP_01060221 159 ---------------------------------AYTPFGQnsgnaet---------------------------iseeid 178 Leeuwenhoekiella...
ZP_01423932 172 f-------------------------------qVWQTFKGnptaraiwnqfnvcqsmfenpestapadverrqrvrqrii 220 Herpetosiphon au...
CAB62724    196 krlwsqgrtnplgkqvwklglcpsmlgdadsldSAATLRRntvr--------------------------------drva 243 Streptomyces coe...
BAB53676    201 --------------------------------iYAVPVLGttdka-------------------------------srln 217 Mesorhizobium lo...
ZP_01407255 159 pva---------------------------dlfTPERVARr--------------------------------------a 173 Acidovorax avena...
ZP_01428240 175 hrlwevghtneravr---awsrgicpallenptSTDPADRsrrdav-----------------------------rerva 222 Salinispora trop...
ZP_01225319 434 ---------------------------------AFTRFGQgsgaat----------------------------itaele 452 marine gamma pro...
ZP_01252163 140 ---------------------------------SLSKFAQdeklkk----------------------------vssrlk 158 Psychroflexus to...
ZP_00948974 151 ---------------------------------GSAPMLHhkaeqv-----------------------------aveid 168 Croceibacter atl...
Feature 1                                               #  #                
CAB39707    136 TYNGHVRAIADRYGCPVLDLWSlrs------vqDRRAWDADRLHLSPEGHTRVALRAGQA 189 Streptomyces coelicolor A3(2)
ZP_01060221 179 AYNAYARAISEQQGIRFVNITDitrr----gvaEPNLVASDGLHPSEDAYAEFVARLLPF 234 Leeuwenhoekiella blandensis MED217
ZP_01423932 221 DFNSQLSEVCNDYLRCRFDQNLlfn-----apiSPTLITADYYHPSIVGQQVLATNLAQA 275 Herpetosiphon aurantiacus ATCC 23779
CAB62724    244 DYNEVLREVCAKDRRCRSDDGAvhef----rfgTDQLSHWDWFHPSVDGQARLAEIAYRA 299 Streptomyces coelicolor A3(2)
BAB53676    218 DYVQIMRDVAEAMGVVLVDVNEmvdalvasgnyRVQDIVPDGVHPSQYAYQMIGQLTARP 277 Mesorhizobium loti MAFF303099
ZP_01407255 174 ELNAVTLALAAELGLQHAGWGEd---------yRGPVDVIDNVHRTQAASDRLAVLLAAA 224 Acidovorax avenae subsp. citrulli AA...
ZP_01428240 223 DYNDQLAAACEAYGSRCRYDNGaahr---lrftLDLVNTFDWFHPNLAGQERLAEITWGA 279 Salinispora tropica CNB-440
ZP_01225319 453 MYNNFAQNYAQENSISFVYITDitdq----gleNPALVASDGLHPSEIAYAEFVERLLPL 508 marine gamma proteobacterium HTCC2207
ZP_01252163 159 RYNRYIEKMSQRYNVVYFPMQQfskp----lhkEKLMLAEDLLHPSGLQYKAWVDSFKDE 214 Psychroflexus torquis ATCC 700755
ZP_00948974 169 EFNTVFKKVASTYKIPVYDINTiskq----aysNESLIASDGLHPSGAQYKLWVEYMLPF 224 Croceibacter atlanticus HTCC2559

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