1RP1,1BU8,1HPL,1HPL,1GPL,1N8S,1ETH


Conserved Protein Domain Family
PLAT_lipase
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cd01755: PLAT_lipase 
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PLAT/ LH2 domain present in connection with a lipase domain. This family contains two major subgroups, the lipoprotein lipase (LPL) and the pancreatic triglyceride lipase. LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs). The central role of triglyceride lipases is in energy production. In general, PLAT/LH2 domain's proposed function is to mediate interaction with lipids or membrane bound proteins.
Links
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Statistics
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PSSM-Id: 238853
Aligned: 27 rows
Threshold Bit Score: 105.07
Created: 14-Sep-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1RP1      332 WRYGVSITLSGkr----atGQAKVALFGSKGNTHQFNIFKgil---kpGSTHSNEFDAKLdVGTIEKVKFLWNNNnpt-- 402 dog
P11602    341 FHYQVKIHFFGktnvtkvdQPFLISLYGTLDESENIPFTLpev---ssNKTFSFLIYTEVdIGDLLMLKLQWEKDtffsw 417 chicken
126314    341 FHYQVKIHFSGtesethtnQAFEISLYGTVAESENIPFTLpev---stNKTYSFLIYTEVdIGELLMLKLKWKSDsyfsw 417 human
1354893   179 FHYQVKVHFFGktqlsytdQPMKISLYGIHGEKENIPYIMptl---ntNSTVSFLLTTDAdIGELLMVKLLWEKDtlisw 255 zebrafish
BAB20997  357 YHYQLKIHFSSkvnrsemePSLTVSLYGTNGEAENLELKLkek--iatNKTHSFLLVTEKdIGDLLMLKFKWEETngwst 434 red sea bream
AAH60756  350 FHYQMKMHIFNyksalesePTFSVTLMGTLNDSVPLPLAVpge--igyNFTNTFLVYTEDnIGDLLKIHLKWDGSkqmwy 427 African clawed frog
NP_956422 351 YHYQMKMHVFDrknaenadPTFYVKLYGSYNDSSNLIVDVteg--iglNLTNTFLVFTEEdIGELLKISLRWEGPsdswt 428 zebrafish
Q9Y5X9    347 YHYQMKIHVFSyknmgeiePTFYVTLYGTNADSQTLPLEIver--ieqNATNTFLVYTEEdLGDLLKIQLTWEGAsqswy 424 human
CAG08599  299 YHYQMKMHVFNrknsdnadPTFYVQLFGAHKDTGDLLVNDdigdllkiRLTWEAEGDSWSsVWKNLKKSFWGWKAkp--- 375 Tetraodon nigrovir...
XP_697356 350 FHYQLKINFVGqinhlemdPAMTISLYGTIGETEDLKLSIqek--itsNKTHSFLVVTEKdIGDLLMLKLKMEDSsssll 427 zebrafish

1RP1      403 ------------------fpkVGAAKITVQKGeektVHSFCSESTVRE-----DVLLTLTPC 441 dog
P11602    418 sd-------------wwtpfaFTIQRVRVKSGetqkKVVFCSRDGSSRlg-kgEEAAIFVKC 465 chicken
126314    418 sd-------------wwsspgFAIQKIRVKAGetqkKVIFCSREKVSHlq-kgKAPAVFVKC 465 human
1354893   256 p--------------wwnsdtFHIRKLRIKSGetqsKIIFSAKESEFSylsrgGEAAVFVKD 303 zebrafish
BAB20997  435 snmlkmv--sswwsgdsdganMEVHKIRIRAGetqqKMVFCVKDPESQk---lTQEVTFVKC 491 red sea bream
AAH60756  428 sfwnsfq--nywakndvidkeLHIRRIRVKSGetqqKFTFCLENPESTll-mpGSELVFVKC 486 African clawed frog
NP_956422 429 saikhlgssffswssaasqkiLEVRRIRVKAGetqkKFTFCAEETEISp----GEEIMFVKC 486 zebrafish
Q9Y5X9    425 nlwkefr--sylsqprnpgreLNIRRIRVKSGetqrKLTFCTEDPENTsi-spGRELWFRKC 483 human
CAG08599  376 --------------------vLQIRRIRVKAGetqkKFTFCAQDPEKTei-ssGESLTFLKC 416 Tetraodon nigroviridis
XP_697356 428 nllss------wwsgdptdsgLRVQKIRIRAGetqkKMVLCLKDPQTPg---lAQDFVFVKC 480 zebrafish
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