Conserved Protein Domain Family
GATase1_CobQ

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cd01750: GATase1_CobQ 
Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ)
Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ). CobQ plays a role in cobalamin biosythesis. CobQ catalyses amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide in the biosynthesis of cobalamin. CobQ belongs to the triad family of amidotransferases. Two of the three residues of the catalytic triad that are involved in glutamine binding, hydrolysis and transfer of the resulting ammonia to the acceptor substrate in other triad aminodotransferases are conserved in CobQ.
Statistics
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PSSM-Id: 153221
View PSSM: cd01750
Aligned: 82 rows
Threshold Bit Score: 115.806
Threshold Setting Gi: 2622614
Created: 29-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic triad
Feature 1:catalytic triad [active site]
Evidence:
  • Citation:PMID 8208731
  • Comment:catalytic triad based similar proteins with structures
  • Comment:Conserved trio of residues critical for the catalytic function.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00046865  14 DLMNTYGDSGDVKVIRYLLDKqgYQTKVDNislddkfdandyDFLFFGGGQDFEQTVVakd-------lpRHKETIenyi 86  Lactobacillus ga...
NP_218230    10 DVMGTYGDGGNAVVLRQRLLLrgIAAEIVEitladp-vpdslDLYTLGGAEDYAQRLAtrhl----rrypGLQRAAgr-- 82  Mycobacterium tu...
NP_695630    13 KDMNIYGDSGNVLTIRRRLELygYEPVVHQynqgdd-wpdqvDLILGGGGQDTGQKKIiddfyhradllrSLAADGt--- 88  Bifidobacterium ...
NP_765131    12 DKLNLYSDIGNIMALKQRAKKrnIKINVKEinetegvtfddcDIFFIGGGSDREQALAtkels---kiktSLKNAIed-- 86  Staphylococcus e...
NP_787625     9 HQLSIRGDRGNVTALKARAHFagHKLEIYDlhpgnv-lptgvSGVVIGSGPDYVLADLlgd-------mrRLACDLkalr 80  Tropheryma whipp...
BAC74835     14 DLLSTYGDQGNALVVERRARQrgLDVARLDvrsdqp-iptsgDIYLIGGGEDRPQRLAaerl----rrdgGLHRAVgn-- 86  Streptomyces ave...
YP_056347    14 SLLGIYGDHGNAVVLTKRLQWrgIDAELLIvepgqp-vptdgAVYLLGGGEDTAQITAvqel----eadgGLFTALdd-- 86  Propionibacteriu...
ZP_00549388  15 ELLGTYGDGGNAIVLSQRLRWrgLPVEVVNvpagsa-vpescDIYLLGGGEDAPQVLAadgi----rqnrAIRRAVss-- 87  Frankia sp. CcI3
YP_290769    16 DLLSTYGDRGNVLILRRRAELrgIPTEVVRvhssdp-vpeegDVYLLGGGEDRPQILAaqrl----radgGLKRAAer-- 88  Thermobifida fus...
ZP_00413971  14 RDMNIYGDWGNALVLQQRLRWhgYTPELLEynvgde-fpagvDLIVGGGGQDSGQLVIqddllsrestlkELAEAGt--- 89  Arthrobacter sp....
Feature 1                #                                                                     #
ZP_00046865  87 nagnPMLCICGGYQLM---GDYYKTNSGit-ikGLGILPLHTi----------fKADKRMIgdtrym-tewgeVKAFENH 151 Lactobacillus ga...
NP_218230    83 --gaPVLAICAAIQVL---GHWYETSSGdr-vdGVGLLDVTTspq-------daRTIGELVskplla-gltqpLTGFENH 148 Mycobacterium tu...
NP_695630    89 ----PMLMICGLYQLF---GEYFETVDGtr-ldGIGVIGAYTv----------gQNVRMIGnlvehs-dqfgdVIGYENH 149 Bifidobacterium ...
NP_765131    87 --gmPGLTICGGYQFL---GHKYITPDGte-leGLGVLDFYTe----------sKKERLTGdiiies-dtfgtIVGFENH 149 Staphylococcus e...
NP_787625    81 ddnvPFLAISNGLRLLsekFVSHDDVEHt----AAGVYPISC------------HRIRRRVgesivk-cdfgeLVGFENH 143 Tropheryma whipp...
BAC74835     87 --gaIVFSVCAGYQIL---GHEFINDLGqr-epGLGLLDVVStrgeg--ercvgDVLGDIDprlg-----lpqLTGFENH 153 Streptomyces ave...
YP_056347    87 --gaMLFAVCAGYQIC---GKSFTIGARdeaikGLGLLDAETrrg-------peRAVGEVLhiwtqpdgntypITGFENH 154 Propionibacteriu...
ZP_00549388  88 --gaAVLAVCAGYQVI---GATFPSGGEih--eGLNLVDVETrrsfgpsdappaRAVGDIVvepdar-lglptLYGYENH 159 Frankia sp. CcI3
YP_290769    89 --gaVVFAVCAGYQII---GETYGDDQNnp-lpGVGILDVRSgrg-------dtRAVGEIVadvdpa-lgvgrITGFENH 154 Thermobifida fus...
ZP_00413971  90 ----PMLLICGMYQLF---GKFFKTRTGsv-ipGIGVLDVEThgt-------deRLIGNVTvssp----efgdVLGYENH 150 Arthrobacter sp....
Feature 1        #                                                                        
ZP_00046865 152 SGQTyfdntnmlhpfgemiegygnnpqdKVEGLRYk-----------nFIGSYSHGPLLRn-----TNVANAIV 209 Lactobacillus gasseri
NP_218230   149 RGGTvlgpgtsplga--vvkgagnragdGFDGAVAg-----------sVVATYMHGPCLAr----nPELADLLL 205 Mycobacterium tubercul...
NP_695630   150 SGQTflregvqplgtv-nqdgrgnngedHTEGARVh-----------nVIGTYMHGSLLPk----nPAISDFLI 207 Bifidobacterium longum...
NP_765131   150 GGRTyhpyg---------------tlgrVTYGYGNndndrkegihyknLLGSYLHGPILPk----nHEITDYLL 204 Staphylococcus epiderm...
NP_787625   144 DIEItdnehplgy------gldsrgtfsRPHGFFLg-----------nLMACFLHGAFLPl----nPIVADWFL 196 Tropheryma whipplei st...
BAC74835    154 QGVThlgpsarplaq--vrlgkgngtgdGTEGAYNd-----------tVFGTYMHGPVLArnpliaDLLLKLAL 214 Streptomyces avermitil...
YP_056347   155 GGWTelgsdakplaa---vesgwgngnrRDEGAVQg-----------rVIGTYPHGPVLVrnpqlaDHVLEMAL 214 Propionibacterium acne...
ZP_00549388 160 AGRTrrlpgasgiplg-tvrlgigdgdgGTDGIVDg-----------rVIGTYLHGPVLAq----nPALADLLL 217 Frankia sp. CcI3
YP_290769   155 QGRTaigpaarpls----ttvrgvgndgTTEGAYQg-----------tVIGTYLHGPALPr----nPALADLLL 209 Thermobifida fusca YX
ZP_00413971 151 SGQTtlgpgvrplgs--tpkgignnskdGQEGARYr-----------nIVASYLHGSLLPk----nPAIADFLI 207 Arthrobacter sp. FB24

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