1R9G,1Q7R


Conserved Protein Domain Family
GATase1_PB

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cd01749: GATase1_PB 
Click on image for an interactive view with Cn3D
Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis
Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis. Glutamine amidotransferase (GATase) activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate. This group contains proteins like Bacillus subtilus YaaE and Plasmodium falciparum Pdx2 which are members of the triad glutamine aminotransferase family and function in a pathway for the biosynthesis of vitamin B6.
Statistics
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PSSM-Id: 153220
View PSSM: cd01749
Aligned: 54 rows
Threshold Bit Score: 223.556
Threshold Setting Gi: 50255460
Created: 21-Sep-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic triadpredicted
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1R9G_B       24 IGVLGLQGAVREHi-----hAIEACGAAGLVVKrpeq-----lneVDGLILPGGESTTXRRLIDTYQFXEPLREFAaqgk 93  Bacillus subtilis
NP_228282     3 IGVLGVQGDVREHv-----eALHKLGVETLIVKlpeq-----ldmVDGLILPGGESTTMIRILKEMDMDEKLVERInngl 72  Thermotoga marit...
YP_023282     3 IGVLGIQGDVYEHyta-irpLKNKYKVEAYIIRspee-----ineMDGIIIPGGESTTITRFLSRYINIINENVRNg--m 74  Picrophilus torr...
YP_007237     3 IGILALQGDFFKHq-----eMLHSLGIETIQVKtrne-----ldfCDALIIPGGESTVMMRQLETTNLKELLVHFAih-k 71  Parachlamydia sp...
NP_789434     3 VGVLSLQGSFYEHl-----sILSRLNTDHIQVKtsed-----lsrVTRLIIPGGESTAMLALTQKSGLFDLVRDRImsgm 72  Tropheryma whipp...
NP_393487     3 IGVLGFQGDVQEHm-----dMLKKLSRKNRDLTlthvkrvidlehVDALIIPGGESTTIYKLTLEYGLYDAIVKRSaegm 77  Thermoplasma aci...
NP_110576     3 VGIIGFQGDVEEHiaivkkiSRRRKGINVLRIRrked-----ldrSDSLIIPGGESTTIYKLISEYGIYDEIIRRAkegm 77  Thermoplasma vol...
ZP_00378208   3 VGVLSLQGAFREHl-----gVLDSLGVNSCKVTrpeh-----ledIDSLIVPGGESSAIVRIAAGTGLFPTLSDKIragl 72  Brevibacterium l...
ZP_00524947   4 VGVLSLQGDFAAHg-----aALERAGAQPVFVRereq-----lnqIEGLILPGGESTTMLKLLRYEDLFDDVAEFGrt-k 72  Solibacter usita...
Q5NHE5        5 VGVLAIQGGYQKHa-----dMFKSLGVEVKLVKfnnd-----fdsIDRLVIPGGESTTLLNLLNKHQIFDKLYNFCss-k 73  Francisella tula...
Feature 1            #                                                                          
1R9G_B       94 PXFGTCAGLIILAKeiags---dnphLGLLNVVVERNSFGRQVDSFEADLTIKgld------epFTGVFIRAPHIleage 164 Bacillus subtilis
NP_228282    73 PVFATCAGVILLAKrikny---sqekLGVLDITVERNAYGRQVESFETFVEIPavg-----kdpFRAIFIRAPRIvetgk 144 Thermotoga marit...
YP_023282    75 KIMGTCAGAIILSKdtgdp---rvhgTGIMDIKIQRNAYGRQIDSFIDAVNIKni-------gtFNAVFIRAPVIddpg- 143 Picrophilus torr...
YP_007237    72 PVFGTCAGLILMSShvqns---ammpLGLLHIAVERNAFGRQVDSFQVDVSVYlkpg---deicFPAFFIRAPRIrtset 145 Parachlamydia sp...
NP_789434    73 PVYGTCAGMIMLSTfvedf--pnqktLSCLDIAVRRNAFGRQINSFESEVSFLns--------kITVPFIRAPKItqige 142 Tropheryma whipp...
NP_393487    78 PIMATCAGLILVSKntnde---rvrgMGLLDVTIRRNAYGRQVMSFETDIEINgi-------gmFPAVFIRAPVIedsg- 146 Thermoplasma aci...
NP_110576    78 PVMATCAGLILISKdtndd---rvpgMNLLDVTIMRNAYGRQVNSFETDIDIKgi-------gtFHAVFIRAPRIkeyg- 146 Thermoplasma vol...
ZP_00378208  73 PVFGTCAGLILLADrltddsldgfdrLGGLDITVARNAYGRQRESFSTPVHVSgfa------edFEATFIRAPQImehgd 146 Brevibacterium l...
ZP_00524947  73 PVFGTCAGAILMAKgvtnp---aqesFGLVDIEVERNAYGRQTDSRIAQVRPFpdfenrtapgeLKAVFIRAPIIrried 149 Solibacter usita...
Q5NHE5       74 PVFGTCAGSIILSKge--------gyLNLLDLEVQRNAYGRQVDSFVADISFNdk--------nITGVFIRAPKFivvgn 137 Francisella tula...
Feature 1                                 # #            
1R9G_B      165 -nvevLSEHNGRIVAAKQGQFLGCSFHPELTeDHRVTQLFV 204 Bacillus subtilis
NP_228282   145 -nveiLATYDYDPVLVKEGNILACTFHPELTdDLRLHRYFL 184 Thermotoga maritima MSB8
YP_023282   144 -ktsvLGEYNGKPVIVENENAIAMTFHPELTgDLRVHEYFL 183 Picrophilus torridus DSM 9790
YP_007237   146 -pvqiLASYEGEPILVRQGHHLGASFHPELTvNPSIHLYFL 185 Parachlamydia sp. UWE25
NP_789434   143 gvdvlSRLESGDIVAVRQGNVMATAFHPELTgGAAVHEYFL 183 Tropheryma whipplei TW08/27
NP_393487   147 -ktevLGTLDGKPVIVKQGNVIGMTFHPELTgDTRLHEYFI 186 Thermoplasma acidophilum DSM 1728
NP_110576   147 -nvdvMASLDGYPVMVRSGNILGMTFHPELTgDVSIHEYFL 186 Thermoplasma volcanium GSS1
ZP_00378208 147 -dvevLAEHDGSPVLVRQGNIWGGSFHPELGaDTRIHREFL 186 Brevibacterium linens BL2
ZP_00524947 150 -gvrvLASYQGDPVLIEQGRFLVATFHPELTdDARVHSLFL 189 Solibacter usitatus Ellin6076
Q5NHE5      138 -qvdiLSKYQNSPVLLRQANILVSSFHPELTqDPTIHEYFL 177 Francisella tularensis subsp. tularensis

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