1OX4,1K9V,1KA9


Conserved Protein Domain Family
GATase1_IGP_Synthase
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cd01748: GATase1_IGP_Synthase 
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Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS)
Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS). IGPS incorporates ammonia derived from glutamine into N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (PRFAR) to form 5'-(5-aminoimidazole-4-carboxamide) ribonucleotide (AICAR) and imidazole glycerol phosphate (IGP). The glutamine amidotransferase domain generates the ammonia nucleophile which is channeled from the glutaminase active site to the PRFAR active site. IGPS belong to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site.
Links
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Statistics
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PSSM-Id: 153219
Aligned: 89 rows
Threshold Bit Score: -1
Created: 27-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:
  • Comment:Conserved trio of residues critical for the catalytic hydrolysis of glutamine and the production of ammonia.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1OX4_A        7 VHVIDVESGNLQSLTNAIEHLg-----YEVQLVKspkdfnisgTSRLILPGVGNYghfvdnLFNRGFEKPIREYIesgkP 81  baker's yeast
EAM93913      2 IAIIDINTGNLSNINRIVRGK------VTSDPYEie------kSVKIIFPGVGSFqy--vsQIIEPIKDLLVEKIksgiP 67  Ferroplasma acid...
Q8ZY40        3 VGVVDYTVGNIGSVLTALKRAg-----AVPVVVKgvee--agrVDAVVLPGVGTYe----aAYALARQFKEVVLEk---P 68  Pyrobaculum aero...
1K9V_F        3 IGIISVGPGNIMNLYRGVKRAsenfedVSIELVEspr---ndlYDLLFIPGVGHFgegmrrLRENDLIDFVRKHVederY 79  Thermotoga maritima
Q8TV83        3 VAIVEYGVGNLNSVYRAVKHLgh---ePVVTDDPsel----hdADAVILPGVGNFraaaekLEETGLCDEIRELLgs-vP 74  Methanopyrus kan...
Q57929        2 IGIIDYNAGNLRSIQKAVELY------DKVIITNnsee--llaCDKIILPGVGNFgs--amENLAPLKETIYKIVddrvP 71  Methanocaldococc...
P58789        4 IAIVDLGIGNLANVKKALKGY------ITSDPYEie------kADKIVLPGVGNFga--vvDKLAPIKDIIIEGInegkP 69  Pyrococcus furiosus
P61780        2 IAILDYGMGNIHSCLKAVSLY------TKDFVFTkdhs-tienSKALILPGDGHFdkamenLNSTGLRKTIDKHVtsgkP 74  Leptospira inter...
AAU27281      2 IAVIDVSGNNLTSLTNALIRLg-----GHFALTHdaee--iqkASHVILPGVGTArsgmtaLQQNGLIDVLRTLTq---P 71  Legionella pneum...
ZP_00540288   2 IAIVDYGVGNIANIERALKELg-----EAVIVTSdlel--lgqAEALVLPGVGAYapamarLEETGLIEFLQEQAtk-kP 73  Exiguobacterium ...
EAM93913      2 IAIIDINTGNLSNINRIVRGK------VTSDPYEie------kSVKIIFPGVGSFqy--vsQIIEPIKDLLVEKIksgiP 67  Ferroplasma acid...
Q8ZY40        3 VGVVDYTVGNIGSVLTALKRAg-----AVPVVVKgvee--agrVDAVVLPGVGTYe----aAYALARQFKEVVLEk---P 68  Pyrobaculum aero...
1K9V_F        3 IGIISVGPGNIMNLYRGVKRAsenfedVSIELVEspr---ndlYDLLFIPGVGHFgegmrrLRENDLIDFVRKHVederY 79  Thermotoga maritima
Q8TV83        3 VAIVEYGVGNLNSVYRAVKHLgh---ePVVTDDPsel----hdADAVILPGVGNFraaaekLEETGLCDEIRELLgs-vP 74  Methanopyrus kan...
Q57929        2 IGIIDYNAGNLRSIQKAVELY------DKVIITNnsee--llaCDKIILPGVGNFgs--amENLAPLKETIYKIVddrvP 71  Methanocaldococc...
P58789        4 IAIVDLGIGNLANVKKALKGY------ITSDPYEie------kADKIVLPGVGNFga--vvDKLAPIKDIIIEGInegkP 69  Pyrococcus furiosus
P61780        2 IAILDYGMGNIHSCLKAVSLY------TKDFVFTkdhs-tienSKALILPGDGHFdkamenLNSTGLRKTIDKHVtsgkP 74  Leptospira inter...
AAU27281      2 IAVIDVSGNNLTSLTNALIRLg-----GHFALTHdaee--iqkASHVILPGVGTArsgmtaLQQNGLIDVLRTLTq---P 71  Legionella pneum...
ZP_00540288   2 IAIVDYGVGNIANIERALKELg-----EAVIVTSdlel--lgqAEALVLPGVGAYapamarLEETGLIEFLQEQAtk-kP 73  Exiguobacterium ...

Feature 1           #                                                                           
1OX4_A       82 IMGICVGLQALFAGSVEspk------stGLNYIDFKLSRFdds-ekPVPEIGWNScipsenlf----fgldpykRYYFVH 150 baker's yeast
EAM93913     68 YLGICLGLEILFENSEEgp-------gnGLGVFNGTVKKFng---vKTPHMGWNTvnvkspski--megigndsFFYFMH 135 Ferroplasma acid...
Q8ZY40       69 TLAICLGMQLLFESSEEgg-------gqGLGVFKGRVERIka---rKVPNIGWRYthvvkns------eiiaegYYYYLH 132 Pyrobaculum aero...
1K9V_F       80 VVGVCLGMQLLFEESEEapg------vkGLSLIEGNVVKLrs---rRLPHMGWNEvifkd---------tfpngYYYFVH 141 Thermotoga maritima
Q8TV83       75 LLGICLGMQLLMESSEEspe------srGLGVFRGTCVALpn--dvKTPHMGWNTvefrtee-----frefdgeMFYFVH 141 Methanopyrus kan...
Q57929       72 FLGICLGMQILFEESEEkrg------ikGLGIIKGNVIKFkd--veKLPHMGWNSvkivkdcpl--fegiknnsYFYFVH 141 Methanocaldococc...
P58789       70 FLGICLGMQLLFEESEEspg------keGLGIFKGKVVKLkn---vRTPHIGWNQvwikkeckl--feglkngsYFYFVH 138 Pyrococcus furiosus
P61780       75 LFGICIGFQILFESSEEiaqgskkeqieGLGYIKGKIKKFhgk-dfKVPHIGWNRlqirrkdksvllkgigdqsFFYFIH 153 Leptospira inter...
AAU27281     72 LLGICLGMQLLLEYSEEdd-------ipCLGLIPGVAELLkaernhPVPHMGWNNlhwqktssl--qqglnnsdYVYFVH 142 Legionella pneum...
ZP_00540288  74 FLGICLGMQLLFESSDEdgq------teGLGILPGTVEKLps--dvRLPHMGWHQlkn-------------hgeAVYFVH 132 Exiguobacterium ...
EAM93913     68 YLGICLGLEILFENSEEgp-------gnGLGVFNGTVKKFng---vKTPHMGWNTvnvkspski--megigndsFFYFMH 135 Ferroplasma acid...
Q8ZY40       69 TLAICLGMQLLFESSEEgg-------gqGLGVFKGRVERIka---rKVPNIGWRYthvvkns------eiiaegYYYYLH 132 Pyrobaculum aero...
1K9V_F       80 VVGVCLGMQLLFEESEEapg------vkGLSLIEGNVVKLrs---rRLPHMGWNEvifkd---------tfpngYYYFVH 141 Thermotoga maritima
Q8TV83       75 LLGICLGMQLLMESSEEspe------srGLGVFRGTCVALpn--dvKTPHMGWNTvefrtee-----frefdgeMFYFVH 141 Methanopyrus kan...
Q57929       72 FLGICLGMQILFEESEEkrg------ikGLGIIKGNVIKFkd--veKLPHMGWNSvkivkdcpl--fegiknnsYFYFVH 141 Methanocaldococc...
P58789       70 FLGICLGMQLLFEESEEspg------keGLGIFKGKVVKLkn---vRTPHIGWNQvwikkeckl--feglkngsYFYFVH 138 Pyrococcus furiosus
P61780       75 LFGICIGFQILFESSEEiaqgskkeqieGLGYIKGKIKKFhgk-dfKVPHIGWNRlqirrkdksvllkgigdqsFFYFIH 153 Leptospira inter...
AAU27281     72 LLGICLGMQLLLEYSEEdd-------ipCLGLIPGVAELLkaernhPVPHMGWNNlhwqktssl--qqglnnsdYVYFVH 142 Legionella pneum...
ZP_00540288  74 FLGICLGMQLLFESSDEdgq------teGLGILPGTVEKLps--dvRLPHMGWHQlkn-------------hgeAVYFVH 132 Exiguobacterium ...

Feature 1                                                      # #              
1OX4_A      151 SFAAilnsekkknlendgwkiAKAKYGse--eFIAAVNKNNIFATQFHPEKSgkaGLNVIENFL 212 baker's yeast
EAM93913    136 SYYApenq----------ytvMETEYGn---kFASGIEMGNIYGVQFHPEKSgndGIRVLKNFG 186 Ferroplasma acidarmanus Fer1
Q8ZY40      133 SYGVrwg-----------eneAYTAYIkleekYVAAVERGHIIGVQFHPERSgrtGLELIKRFL 185 Pyrobaculum aerophilum
1K9V_F      142 TYRAvcee---------ehvlGTTEYDge--iFPSAVRKGRILGFQFHPEKSskiGRKLLEKVI 194 Thermotoga maritima
Q8TV83      142 SYRVaped---------dvvlGETEYGer-fpSVIGDRGRLIYGMQFHPEKSgpvGLKLLGEVL 195 Methanopyrus kandleri
Q57929      142 SYHVnpde---------dcivGKTEYGr---eFPSVINKDNVFATQFHPEKSgkiGLKIIENFV 193 Methanocaldococcus jannaschii
P58789      139 SYHAvpqdp--------diiaTTTDYEna--eFVSSVCFENIFGVQFHPEKSsknGLILLRNFR 192 Pyrococcus furiosus
P61780      154 SYRPtdaeg--------naitGLCDYYqe--kFPAVVEKNNIFGTQFHPEKShthGLKLLENFI 207 Leptospira interrogans serovar C...
AAU27281    143 SYALkadn----------yalARCQYHe---eFTAVVKKGNFYGMQFHPEKSanvGMVLLNNFL 193 Legionella pneumophila subsp. pn...
ZP_00540288 133 SYGAvcdp---------dwivDSVEYGr---lVPAIVQKDLVTGMQFHPEKSgevGLKLLKEWR 184 Exiguobacterium sp. 255-15
EAM93913    136 SYYApenq----------ytvMETEYGn---kFASGIEMGNIYGVQFHPEKSgndGIRVLKNFG 186 Ferroplasma acidarmanus Fer1
Q8ZY40      133 SYGVrwg-----------eneAYTAYIkleekYVAAVERGHIIGVQFHPERSgrtGLELIKRFL 185 Pyrobaculum aerophilum
1K9V_F      142 TYRAvcee---------ehvlGTTEYDge--iFPSAVRKGRILGFQFHPEKSskiGRKLLEKVI 194 Thermotoga maritima
Q8TV83      142 SYRVaped---------dvvlGETEYGer-fpSVIGDRGRLIYGMQFHPEKSgpvGLKLLGEVL 195 Methanopyrus kandleri
Q57929      142 SYHVnpde---------dcivGKTEYGr---eFPSVINKDNVFATQFHPEKSgkiGLKIIENFV 193 Methanocaldococcus jannaschii
P58789      139 SYHAvpqdp--------diiaTTTDYEna--eFVSSVCFENIFGVQFHPEKSsknGLILLRNFR 192 Pyrococcus furiosus
P61780      154 SYRPtdaeg--------naitGLCDYYqe--kFPAVVEKNNIFGTQFHPEKShthGLKLLENFI 207 Leptospira interrogans serovar C...
AAU27281    143 SYALkadn----------yalARCQYHe---eFTAVVKKGNFYGMQFHPEKSanvGMVLLNNFL 193 Legionella pneumophila subsp. pn...
ZP_00540288 133 SYGAvcdp---------dwivDSVEYGr---lVPAIVQKDLVTGMQFHPEKSgevGLKLLKEWR 184 Exiguobacterium sp. 255-15

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