1L9X


Conserved Protein Domain Family
GATase1_Glutamyl_Hydrolase

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cd01747: GATase1_Glutamyl_Hydrolase 
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Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase
Type 1 glutamine amidotransferase (GATase1) domain found in gamma-Glutamyl Hydrolase. gamma-Glutamyl Hydrolase catalyzes the cleavage of the gamma-glutamyl chain of folylpoly-gamma-glutamyl substrates and is a central enzyme in folyl and antifolyl poly-gamma-glutamate metabolism. GATase activity involves the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate. gamma-Glutamyl hydrolases belong to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site.
Statistics
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PSSM-Id: 153218
View PSSM: cd01747
Aligned: 12 rows
Threshold Bit Score: 404.78
Threshold Setting Gi: 6016129
Created: 27-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic triadactive sitesubstrate
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1L9X_D     33 IGILMqkcrnkv----mknygrYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGsvdlr-------- 100 human
NP_730119  28 IGVLTqevyvdglisrhfdnktSYIAASYVKYLEGAGARVVPIWIGRNRSYYDDLMRKINGVLLPGGatwfnq------- 100 fruit fly
NP_730120  23 IDIATqlqqnf------sgayhSYLAASYVKFLEASGAHVVPIWIGRERAYYALMMSQLNGILLPGGavfideadrqanp 96  fruit fly
XP_475718  52 IGIVShpgdgagg-rvsngtaaSYIAASYVKFVESAGARVVPLIYNEPEERLLEKLSLVNGVLFTGGsvks--------- 121 Japanese rice
XP_419226 437 VGILSqechfde----fhkfgsSYIAASYVKFLESAGARIVPIRLNLSDEEYDRIFHSINGVLFPGGgvdlk-------- 504 chicken
O65355     56 IGILShpgdgasg-rlsnatdaSSIAASYVKLAESGGARVIPLIFNEPEEILFQKLELVNGVILTGGwake--------- 125 thale cress
P93164     56 IGILThpgdgasg-rlsnatgvSYIAASYVKFVESGGARVIPLIYNESPENLNKKLDLVNGVLFTGGwavs--------- 125 soybean
AAH74274   34 IGILAqethfde----lqtfgrSYIAASYVKTIESAGARVIPILLNLAEEEYQKIFNSINGILFPGGavdlv-------- 101 African clawed frog
NP_998487  33 IGVLAqdvfdp------kpdrnSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGgvsle-------- 98  zebrafish
XP_636287  29 IGILTqpfpssi----nikygdNYLMASYVKYVESAGARVVPIFYNQDDESLTTIFKQINGILLPGGdvdfkt------- 97  Dictyostelium disc...
XP_787753   1 MSVLAqgssss-----ikkygsSYIAASYIKYLESAGARVVPILVNQTDEYYGNIFKSVNGILFPGGgadivdd------ 69  purple urchin
EAL30038    3 IGIMCidvaqwle-aeygkkwhSYLAASYVKQLEAAGAHVVPVWIGHNRSYYDSLMNQLNGILLPGGavfideadrq--- 78  Drosophila pseudoo...
Feature 1                                            #                                        
1L9X_D    101 ---------rsdyaKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLIsgecll---tatdtvDVAMPLNFtgg---- 164 human
NP_730119 101 ---------sngyaDAGEHLIHLAIELNDQGVFMPVWGTCLGMELLVYKLanetehr--inceatGMAVPMEFked---- 165 fruit fly
NP_730120  97 dvtsdcvrsaeliyQLAMERNMRAKKLDDRGAYFPVWGTCLGFQLILIHAaeapnvr--iacqpmREAMPVTLtdd---- 170 fruit fly
XP_475718 122 ----------gpyfETIKKVFQYVLDKNDAGIPFPLFAQCLGFELVSMIVskdnnil--esfsatNQASTLQFpny---- 185 Japanese rice
XP_419226 505 ---------tseysRVAKIFYRKALEANDKGDYFPVWGTCLGHELLTYLTsgeill---vntktnGFSLPLNFtsa---- 568 chicken
O65355    126 ----------glyfEIVKKIFNKVLERNDAGEHFPIYAICLGFELLTMIIsqnrdif--ekmdarNSASSLQFven---- 189 thale cress
P93164    126 ----------gpylDTLGNIFKKALERNDAGDHFPVIAFNLGGNLVIRIVseqtdilepftasslPSSLVLWNea----- 190 soybean
AAH74274  102 ---------kseyaRVAKLFYNWALEANDKGDYFPVWGTCLGFEELTYLTsgeill---tlteteDISLPLNFsan---- 165 African clawed frog
NP_998487  99 ---------ssgysKAAGIFYRLALEANSNGDYFPVWGTCLGFELLTLLTsgelll---shtntsGIALPLDFted---- 162 zebrafish
XP_636287  98 ---------eiqyvKTLTLIWDYVLDVNINGDYFPLWGTCLGLEEIVSLQaesfdvl--tdfnaeNYSIPLNFsni---- 162 Dictyostelium disc...
XP_787753  70 -------vsrvgysGAAHILYHLAVQANKQGDFFPLWGICLGFEELMIQTagtdvli--egieahNVSFPIHLepgf--- 137 purple urchin
EAL30038   79 ----srpdltndcvRTADLIYQLAMERNNGAGDPEGYFPLWGTCLGMQLLl-------------iNAAQSTKVrtkcqsm 141 Drosophila pseudoo...
Feature 1                                                                                     
1L9X_D    165 ---qlHSRMFQNFPTELLLSLAVEPLTANFHKWSLsvKNFTMNEKLKKFFNVLTTNTD-GKIEFISTMEGYKYPVYGVQW 240 human
NP_730119 166 ---ykKSRLFASITDDVVDTMVKENVTYHWHQFCYt-EKDFERDLLNETWRVMSLNHDwNGVEFISTVEHIKYPFYGVQF 241 fruit fly
NP_730120 171 ---yqQSQLLGSLPKSVADEMEKHPFACHQHRYCItkESLESYGLAKDWHPLATQKDT-SGLEFITIVEHRRFPIFGCQF 246 fruit fly
XP_475718 186 --sslEGSVFERFDPDLIKKLSTSCLVMQNHKYGIspKTLRENVALSSFFKILTTSPDeNGEVYVSTVQANKYPITCTQW 263 Japanese rice
XP_419226 569 ---akRSRLFKNLPNDLLHAFANEPLTSNFHVWSIsmENFTKNEKLYNFYNILTTNID-NEVEFISTMEAYKYPIYGVQW 644 chicken
O65355    190 --vniQGTIFQRFPPELLKKLGTDCLVMQNHRFGIspQSFEGNIALSNFFKIVTTCVDdNGKVYVSTVQSTKYPVTGFQW 267 thale cress
P93164    191 ---naKGSLFQRFPSDLLTQLKTDCLVLHNHRYAIspRKLQYNTKLSDFFEILATSGDrDGKTFVSTARGRKYPVTVNLW 267 soybean
AAH74274  166 ---alNSKLFKHISKELYTALSSKPITANFHYWSLsmQNFTKNEKLSKFYNVLTTNAD-GSVEFISTFEAYDYPIYGVQW 241 African clawed frog
NP_998487 163 ---vkGSRLFKEFPEELMKSLATEPLTENSHQWSIttENFTANKKLKKFYRVLSTNTD-GYNKFVSTMEAYDFPIYATQW 238 zebrafish
XP_636287 163 ---alESKIMKNCPTNIINSLANDPITMNNHHFGIspNTFDNNSLLNQFFNVLATNNDkSGNEFISLIESKDYPIYAIIW 239 Dictyostelium disc...
XP_787753 138 --edsRLLNKKTTPPSIIHTLTTVNSTLNSHSMGVtpANFTKFPALSSFFRVLSTNHDlNGVKFISTVEAYDFPFYGTQW 215 purple urchin
EAL30038  142 rqalpVCLTEDYRQSKLFMELPEECFASHQHGYCItrESLQEYGLTADWQPLALQKDP-AGCEFVSLIEHRRFPIFGCQF 220 Drosophila pseudoo...
Feature 1     # #                                                                
1L9X_D    241 HPEKAPYEWknld----gisHAPNAVktAFYLAEFFVNEARKNNHHFKSESEEEKaLIYQFSPIYTG 303 human
NP_730119 242 HPEKPLYEFtkt-----sipHTAAAVlsGQFFADFFVSEARESNQSFSNATEQARtLIYNYKPEYTS 303 fruit fly
NP_730120 247 HPERAAFEQlfnspdkcymaHSRMGIdlSQIFGSRFVDFCRRNNNQFESDKLKTRhLIWNWQPVFSG 313 fruit fly
XP_475718 264 HPEKAIFEFgkq-----mipHSEEAVqvTQNFANYFISQARKSQNRPPADKVLDN-LIYNYSPTFIG 324 Japanese rice
XP_419226 645 HPEKNSFEWknss----gipHSSSAIraAHYIADFFINEARKSLHRFPSEGEETKeLIYNYTPTYTG 707 chicken
O65355    268 HPEKNAFEWgss-----kipHSEDAIqvTQHAANHLVSEARKSLNRPESKKVLSN-LIYNYKPTYCG 328 thale cress
P93164    268 QPEKNAFEWatsl----kapHTEDAIrvTQSTANFFISEARKSTNTPDAQKVRDS-LIYNYKPTFGG 329 soybean
AAH74274  242 HPEKNPFEWkkas----nisHSSEAVraAFYMAEFFVNEARKSSHHFTEEEDETKaLIYNYFPKNTG 304 African clawed frog
NP_998487 239 HPEKNAFEWtrp-----yipHTPSAIktTFYMANFFVNEARKNLHSFASTEEEEKaLIYNYKPEYTG 300 zebrafish
XP_636287 240 HPEKSPYSWyskd----atdHSFNAIlaCQYMSNFFVNETRKSNHKFNDEEVLFKsLIYNYNPTYTF 302 Dictyostelium discoideum
XP_787753 216 HPEKNAFEWkvn------scHSKECVelMQFLANFFVEEARKNQHQFSSAEEMAKfLIYNYQPIDLS 276 purple urchin
EAL30038  221 HPERAAFEQlyacedtssqaHSREGIelSERLAGRFVDACRRNRNRFASAEAKSRhLIWNWQPEFCG 287 Drosophila pseudoobscura

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