Conserved Protein Domain Family
GATase1_2

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cd01745: GATase1_2 
Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain
This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Statistics
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PSSM-Id: 153216
View PSSM: cd01745
Aligned: 63 rows
Threshold Bit Score: 155.426
Threshold Setting Gi: 34558455
Created: 27-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalytic triad
Feature 1:catalytic triad [active site]
Evidence:
  • Comment:catalytic triad based on similar proteins with structures
  • Comment:Conserved trio of residues critical for catalytic function

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00144555   6 IGISAsmiyeekdqlflgdkyscvaysyidAVYKSWGIPITLPilkdvsa-ireqvklLDGLILSGGrdvdphfyge-ep 83  Fusobacterium nu...
AAN66352      4 VGMTMlrqfnaerqew----rdaldqrwveFLDQCGLTPLYLPndprvsm-alvqslrPQGLLLTGGgscqa-------- 70  Pseudomonas puti...
NP_745734    18 VLMTMgsqerkghdy-----qvmthkyitpLVEFSDCVPVLVPtccgted-letyldmADGVYLTGAgsnidpalygqen 91  Pseudomonas puti...
AAP78034      4 IGITQrllentsyyevr--ealsvewgeffKEHLQGFLPLPLSyvipfstyaqslggnLGGVILSGGndlnsl------- 74  Helicobacter hep...
AAQ59695     15 IGLLPfhavgd--------------kyiaaAAGGAGGLPVLIPslgdeql-lratlatLDGVLLPGSpsnveprhyggpn 79  Chromobacterium ...
ZP_00245523  10 IGLHPfhvag---------------qkyidAVRLAGCLPLVVPsaqahei--delldlADGVFLTGSpsnvhprhfdevv 72  Rubrivivax gelat...
ZP_00578583   7 LGIIAcnrtigveta-----qavmnryataAMRHADCAALIIPslpdlmr-adevvgrLDGVLLTGTpsnveparyg-da 79  Sphingopyxis ala...
ZP_00694299  22 VLMSMgaqerhghpy-----qvmtvkyirpLIEHAGCVPVLAPtcfgtqd-ieqylsmVDGVYLTGAgtnidpalygqpn 95  Rhodoferax ferri...
YP_326629     4 LGVTQrvevveeyger----rdcldqawteLLESWEFRPFPLPntvenve-tyldslnLDGIVLTSGndlsnlk------ 72  Natronomonas pha...
AAS20058     15 VLMSMgaqerkghdy-----qvmthkyiqpLVEFSGCVPVLVPtccgtdd-leqyldmADGVYLTGAgsnidpalydqen 88  Arthrobacter aur...
Feature 1                                       #                                               
ZP_00144555  84 lekleaifPERDVHEMALIKAAIDLkkPILAICRGMQILNVTYGGTLYQDIsyapgehikhyqigspyqath---sikid 160 Fusobacterium nu...
AAN66352     71 ---lsgtaDTRDVTERVLLDLAENLrlPVLGVCRGMQVMLTRAGGTLERLAghvgehmi--------------------- 126 Pseudomonas puti...
NP_745734    92 qtpgkgqdQNRDLFDIPLVKAAIKRglPIFGICRGMQEINVALGGDIYQKVyaepgfndhrenpedpvevqyaqvhgvki 171 Pseudomonas puti...
AAP78034     75 --npnplsSMRDEYEAQILTHCLRYnlPLLGICRGAQMIAEYFGAKLELLEghignhqvv-------------------- 132 Helicobacter hep...
AAQ59695     80 sragtlhdPRRDATTLPLIRLALEEgvPLLGICRGFQEINVALGGELHQHVqeepglrdhreaegddiaamyapahrvgf 159 Chromobacterium ...
ZP_00245523  73 hdpslpldPVRDDWTLPLIPRALERgiPLFAICRGFQETNVALGGTLHQAVqerpglmdhrsddaqavdvqygpahavsv 152 Rubrivivax gelat...
ZP_00578583  80 atgegpfdPDRDRMMIELVAAVIAAqrPLFGICRGFQEINVALGGTLRRDTaandellrhhapegvsfdamfdhrhrvdl 159 Sphingopyxis ala...
ZP_00694299  96 ltpekaqdKDRDLFDLPTIRMALAMglPLLGVCRGMQEMNVAFGGDIHQQLytipklkdhredpaapvseqyaashkvrl 175 Rhodoferax ferri...
YP_326629    73 --npddpaPERDRFERAALEWAIDHkvPVCGVCRGLELLNDHFDGSLSPVSghvavdhgvsfgyeai------------- 137 Natronomonas pha...
AAS20058     89 etpnkgqdRDRDLFDLPLIRAAIARglPIFGICRGMQEINVALGGDIYQKVyaepgfndhrenpddpvevqyapshsvrp 168 Arthrobacter aur...
Feature 1                                                                      # #              
ZP_00144555 161 knsilfkmadkseieRVNSFHHQALkqv--akgLKVVATAPDGIIEAVEAededgtfVMGVQFHPEmmfdk----stfiR 234 Fusobacterium nu...
AAN66352    127 --------nmqeqrrRVNSYHEYGFrea--pdgYRVLALADDGVIEAVYDdh---rrHTGIMWHPErelpa---dpldiQ 190 Pseudomonas puti...
NP_745734   172 qpgswlhdtlgtdeiRVNSLHGQGLhkl--gagIEAIARAEDGLVEAIHApsi-spfLFAVQWHPEwqaak----npdsI 244 Pseudomonas puti...
AAP78034    133 -------dissgekfEVNSFHNYGIral--gdcLEPLVRAEDRSIEAFKHkh---kpIFAMMWHIErapk------mgeN 194 Helicobacter hep...
AAQ59695    160 veggllaewsgareaMVNSLHQQGIkrl--apsLIAEAHAEDGLVEAYRVrns-kgfAFAVQWHPEwlywd----nplsM 232 Chromobacterium ...
ZP_00245523 153 vpgglldtllggadfKVNSLHGQGVnrl--apgLRAEATAPDGIIEAFSLpsa-pafNLGVQWHPEwqard----npvsM 225 Rubrivivax gelat...
ZP_00578583 160 vaggllasayempslEVNSVHFQGIgal--adgLTVEARAPDGLVEAYSArpn-gapLLAVQWHPEwatda----dtrsQ 232 Sphingopyxis ala...
ZP_00694299 176 vpgtwfaglmqqdeiAVNSLHGQCIktl--ghgLQALAHAEDGVIEAIHLpef-aqfTLGVQWHPEwmaaq----nphsI 248 Rhodoferax ferri...
YP_326629   138 dfsedadtvqlpseiKTNSYHDYGIdpsgvadpLSVLGTAADGTVEALHHpe---lpVLGIMWHPErdpdrpessraldR 214 Natronomonas pha...
AAS20058    169 vagswfaelmgkgeiQVNSLHGQAIrnl--gkgLEVLATAEDGLIEAIHApsl-spfLFAVQWHPEwqaal----npdsV 241 Arthrobacter aur...
Feature 1              
ZP_00144555 235 GMFKRFI 241 Fusobacterium nucleatum subsp. vincentii ATCC 49256
AAN66352    191 RVRHAFG 197 Pseudomonas putida KT2440
NP_745734   245 KIFQAFG 251 Pseudomonas putida KT2440
AAP78034    195 ILFNQWK 201 Helicobacter hepaticus ATCC 51449
AAQ59695    233 AIFHAFG 239 Chromobacterium violaceum ATCC 12472
ZP_00245523 226 KLLRAFG 232 Rubrivivax gelatinosus PM1
ZP_00578583 233 TYFHLLG 239 Sphingopyxis alaskensis RB2256
ZP_00694299 249 RLFEAFG 255 Rhodoferax ferrireducens DSM 15236
YP_326629   215 KLFDALF 221 Natronomonas pharaonis DSM 2160
AAS20058    242 KIFQAFG 248 Arthrobacter aurescens

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