1O1Y


Conserved Protein Domain Family
GATase1_1

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cd01741: GATase1_1 
Click on image for an interactive view with Cn3D
Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain
This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Statistics
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PSSM-Id: 153212
View PSSM: cd01741
Aligned: 151 rows
Threshold Bit Score: 110.413
Threshold Setting Gi: 65304609
Created: 27-Aug-2004
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic triad
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:
  • Comment:Conserved trio of residues critical for catalytic function.
  • Comment:By similarity to Class I glutamine amidotransferases

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1O1Y_A       15 VLAIRhveied---------------------------------------------lgxxedIFREKn------------ 37  Thermotoga maritima
EAA78707      7 RVAILanfilddtgg--------------------------------------rpmidkitqLIRQSkp----------- 37  Gibberella zeae ...
CAE26846      3 RVLVAegnsndgrrqiie--------------------------------sagrsmaegyaeTLRAIdptlai------- 43  Rhodopseudomonas...
AAN62239      5 RILICdgntaadrasfkk--------------------------------fvgyapskhfelMLKRCss----------- 41  Pseudomonas aeru...
AAW46822     38 RLPLItlslqhngthgesrppplrhprespprvppprlhpahtaqnddvvresgnyhaiyskWLTDSlatypdpav---- 113 Cryptococcus neo...
ZP_00423421  68 HLAVVegntaetrqlqla--------------------------------aggsaysasyadVLQNLr------------ 103 Burkholderia vie...
AAV96281      3 EILIVessspgi--------------------------------------------asarreLGRAApqnfsrv------ 32  Silicibacter pom...
EAN34400      9 KILIFvpcd--------------------------------------------------ndlFKERHgklvrqwlvyvse 38  Theileria parva
CAI72934      9 KILIFvpcdndl-------------------------------------------fkdrhgkLVKQWlvyvsey------ 39  Theileria annulata
ZP_00857064   3 RLLVLegnsl-----------------------------------------------agrrrWAEIAghtpsesy----- 30  Bradyrhizobium s...
Feature 1                                                                                       
1O1Y_A       38 ----------WSFDYLDtpkgekl----erpleeYSLVVLLGGyxgayeeekYPFLKYEFQLIEEILKKe----IPFLGI 99  Thermotoga maritima
EAA78707     38 ---------dAEINVYAaiegdt-----lpdpetKDLIILTGGpfnllkderPKWVVDTLEYLKTVTAGps--kPKILGI 101 Gibberella zeae ...
CAE26846     44 ----nlfspaDEADRLPapl------------ssYDGVVVTGSslhv--yrtEPAVTRQIDFLREVFDAg----VPVFGS 101 Rhodopseudomonas...
AAN62239     42 ---------qIQTDIAYpadpdpl---rvlplgaYDGILFTGSnshi--ykqDPGVLRQIEFAKAAFESg----TPMFGV 103 Pseudomonas aeru...
AAW46822    114 --arstrlivDPYDVVHkkayppperlqhaapdaYDCVMLTGSkhta-ydtsNPFIPPLVHFIRSLASSpayqhLKLIGI 190 Cryptococcus neo...
ZP_00423421 104 ---------dVKVDIIYptdegelp--svdalgnLDGVVLTGSwlni--yngGEAIDRQVELMRRVFQSg----TPFFGS 166 Burkholderia vie...
AAV96281     33 ---faaaipdIKIRVVEpylkelt----cadfdgVDGVVMTGAgddw--aadDDLATPIRAACDLALETg----RPVLGV 99  Silicibacter pom...
EAN34400     39 yynkkinfnfTEINIIHqkippl------ndvlkYNGLLITGGfasi--ghkDPWLGELRHLIRLLFVHk----FPMFGI 106 Theileria parva
CAI72934     40 ----ynkkvtFNFTEFNiisqkip---plnqvlqYNGLLITGGfasi--grkDAWLDELRHLIRQLFLHk----FPMFGI 106 Theileria annulata
ZP_00857064  31 ---advlralAPEAVVDiatpadadaqlpqpidaYQGIVITGSalni--yqrEPEALRQIELVRKIFAQg----VPMFGS 101 Bradyrhizobium s...
Feature 1       #                                                                               
1O1Y_A      100 XLGSQXLAKVLGASVYRGkng--------------------------------------eeiGWYFVEKVSdnkffre-- 139 Thermotoga maritima
EAA78707    102 CWGQQAIALALGGALGKSdkg--------------------------------------qivGIADIPLTPegtkf---- 139 Gibberella zeae ...
CAE26846    102 CWGLQLGVVAAGGTVIPNpkrr-------------------------------------evpFARSVTLTAagkthqmh- 143 Rhodopseudomonas...
AAN62239    104 CWGLQLATVAAGGEVLPSraadc----------------------------------vceapFASGVQLTEhgcshpmh- 148 Pseudomonas aeru...
AAW46822    191 CFGHQILSIALGGECVPGhng--------------------------------------weiGVYGCQLTDqgrywwtgd 232 Cryptococcus neo...
ZP_00423421 167 CWGLQVATVAAGGTVRRNprgrevgv----------------------------aeplrkteAGQDHPLLRgkpd----- 213 Burkholderia vie...
AAV96281    100 CYGLQIATVCLGGKIAASpkgk-------------------------------------etgLALKVELTEqgarhpmm- 141 Silicibacter pom...
EAN34400    107 CFGFQVISQALGSSYLLApygfnffaldyklepkasaffkpffnyyhryeynnklngnktnnGVIDLNKENyns------ 180 Theileria parva
CAI72934    107 CFGFQIISQALGSSYLIApyg--------------------------------------fnfFVLDYKLESkasaf---- 144 Theileria annulata
ZP_00857064 102 CWGLQLATVAAGGEVSLNpagr-------------------------------------evgFARKIALTEagrahrlh- 143 Bradyrhizobium s...
Feature 1                                                                                       
1O1Y_A      140 -----fpdrlrVFQWHGDTFd---lPRRATRVfts------------------------ekYENQGFVyg---------- 177 Thermotoga maritima
EAA78707    140 -------fespSLTIHKNHEil-vtDIGPHLLpl--------------------------aLNNEVLMskd--------- 176 Gibberella zeae ...
CAE26846    144 ---qsrpaafdALAIHLDVVsv--lPPDSVVTafn------------------------dmAAVQAVEfrsg-------r 187 Rhodopseudomonas...
AAN62239    149 ---qsrpaefdVFSFHSDEVir--lPYGAIVTar-------------------------nrNFIQAVEiryg-------k 191 Pseudomonas aeru...
AAW46822    233 vegqgggdkvyIEQMHKDHVps--lPPGCTLLlst------------------------prYPIHSFLkphplstpsrpl 286 Cryptococcus neo...
ZP_00423421 214 --------pymALTVHLDEVes--vAPGMTVLagn------------------------swSAVQAAEfssg-------d 252 Burkholderia vie...
AAV96281    142 ---qgrrqgfsVACAHRDEVir--mPDGGQRLayn------------------------ahSDVQAMSvqqs-------g 185 Silicibacter pom...
EAN34400    181 ---------iiGLFSHNDVIts--lPDGSNIDygsyedqnrteidealsdlvvtnisssdkFPILGYLagds------kr 243 Theileria parva
CAI72934    145 -------fkpfLNYYHKCEHklngnKNGVTDLkkanfn-----------------siiglfSHNDVITslpdps---nid 197 Theileria annulata
ZP_00857064 144 ---aargsvfdAPAIHSDIVtr--lPPDATVTarn------------------------gmSEVQAAEiryg-------r 187 Bradyrhizobium s...
Feature 1               # #                                                                     
1O1Y_A      178 -kAVGLQFHIEvgartxkrwieaykdelek--------------------------kkidprllletaereekvlKGLLR 230 Thermotoga maritima
EAA78707    177 gqVLTFQGHPEmdsvlsrlfvasdnpvlv-----------------------------gagsdsglkpidsphdgEIIFE 227 Gibberella zeae ...
CAE26846    188 slFWGVQYHPEfelpymasilrrnasslvaeaafssegelve--mvdamdshgndgdrvrhpsllpddvldrhtrTIEIA 265 Rhodopseudomonas...
AAN62239    192 stFWGVQYHPElsgldqagflresagalvadgryeslehvehaaqamsrfqngveiseedmihfetinmnsfefrPLEIL 271 Pseudomonas aeru...
AAW46822    287 ahILTVQGHPEftpsivhhiinaraaagvfddqt------------------aqearrraggkdgtggegfgrigWAVWR 348 Cryptococcus neo...
ZP_00423421 253 svGWAVQYHPEfslrniagfvrrygadliaqgtlkdeasveqkakslelcesaatgasaaetlnlddtvlssasrTRELT 332 Burkholderia vie...
AAV96281    186 vdFWGLQYHPEispsivanairehgslfsntgidied------------llkvetdletaqrlgcsladfelpnrTRELI 253 Silicibacter pom...
EAN34400    244 tfILSLQHHPEfhtspgltyfndvlsl---------------------------------klsqglmssdqfeknIEMIK 290 Theileria parva
CAI72934    198 fgAYEGQNQAEidealsdmvvtkisssdkfpvlg-------------------ilagnsqrtfiislqhhpefhtQQGLK 258 Theileria annulata
ZP_00857064 188 grFWGVQYHPEfsfqdvac-------------------------------------------------visrigqPLVDE 218 Bradyrhizobium s...
Feature 1          
1O1Y_A      231 SLL 233 Thermotoga maritima
EAA78707    228 RIV 230 Gibberella zeae PH-1
CAE26846    266 NWL 268 Rhodopseudomonas palustris CGA009
AAN62239    272 NWL 274 Pseudomonas aeruginosa
AAW46822    349 VLL 351 Cryptococcus neoformans var. neoformans JEC21
ZP_00423421 333 NWF 335 Burkholderia vietnamiensis G4
AAV96281    254 NWI 256 Silicibacter pomeroyi DSS-3
EAN34400    291 MFN 293 Theileria parva
CAI72934    259 YFN 261 Theileria annulata
ZP_00857064 219 GFF 221 Bradyrhizobium sp. BTAi1

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