Conserved Protein Domain Family
PolY_Pol_V_umuC

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cd01700: PolY_Pol_V_umuC 
umuC subunit of DNA Polymerase V
umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Statistics
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PSSM-Id: 176454
View PSSM: cd01700
Aligned: 51 rows
Threshold Bit Score: 301.774
Threshold Setting Gi: 46190813
Created: 6-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active siteDNA binding
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ##  ##                                       #  #                            
ZP_01058405   5 GLVDCNNFYASCERVFQPe-lIERPLVVLSNNDGC--------VVARSQEAKDLGi-pMGVPLFKIRNLVRdhg------ 68  Roseobacter sp. ...
CAC42065     16 LCVDVKSFFASVECVKRGldpLQAFLVVMSNADRAgg-----lVLAASPQMKKVFrikTGSRKFEVPEDDPri------- 83  Listeria innocua
NP_863146    13 FLIDMKSFYASVECIERNldpLTTELVVMSRADNTgs----glILASSPEAKKRYgitNVSRPRDLPQPFPktl------ 82  Enterococcus fae...
EAN09835     22 LCIDCKSFYASVECVERGlnpLKAKLVVMSYPSDDpsqrgsglILASSPAAKKAYgisNVSRSRDLPFPYPedl------ 95  Enterococcus fae...
BAA23799     16 FCIDVKSFNASVECVERGldpLKTMLVVMSNSENSgg-----lVLAASPMAKKVLgisNVTRKNEVPDHPNli------- 83  Enterococcus fae...
YP_395772    13 LMIDSKSFYASVESVKRGlnpLKSILVVMSTAKNAgs----glVLAASPRAKQLFgisNVTRATQVPVHDKrl------- 81  Lactobacillus sa...
AAB52385     21 FFEDVKSNYASIECIERGlnpLTTSLCVMSRADNSng-----lTLAASPTFKKVFgmsNVSHSKELPFLVHnrkfnyrlw 95  Lactococcus lactis
NP_979456    16 LCVDLRSFYASVSCIKKGldpRYTKLAVVGDVNRSgs-----iVLAATPPLKALGv-kKMARLYEIPKRPDii------- 82  Bacillus cereus ...
YP_060480    15 AFLDMKSFYASVECVDRGlhpLYTSLCVMSRADNSag-----lILASSPMFKKVFgkaNVGRSYDLPFDINtrkfsyqna 89  Streptococcus py...
ZP_00120955  17 IAIDLKSFYASVECVARGldpLTTHLVVADETRTDkt-----iCLAVSPSLKNYGi-pGRARLFEVKQRLNgvnieravh 90  Bifidobacterium ...
Feature 1                                                                       ##              
ZP_01058405  69 ----------------------------vevRSSNYALYGDLSERVMSILads--aprSEVYSIDECFLDLhhlav---- 114 Roseobacter sp. ...
CAC42065     84 -----------------------------iiAPPRMQLYLKVNELIQKIFlryvsredFHVYSIDEAFLDVthskkl--- 131 Listeria innocua
NP_863146    83 -----------------------------hvVPPRMNLYIKRNMQVNNIFrryvadedLLIYSIDESILKVtrslnlftt 133 Enterococcus fae...
EAN09835     96 -----------------------------viAPPRMALYMRKNMEINNIYkkyadeqnHSVYSIDESFVDVtdslklf-- 144 Enterococcus fae...
BAA23799     84 ------------------------------iVPPRMKLYMKKNQEINNLYnrfvsnedHSVFSVDESFLDVtasltyf-- 131 Enterococcus fae...
YP_395772    82 -----------------------------ivAEPRMNLYIEENLKINRIFqrftaeedIQPYSIDESLLDIttswhl--- 129 Lactobacillus sa...
AAB52385     96 ykkhtdifgqtvepdpkyiseverwarqtyiVPPQMLLYIKKNLEVINILreitsideIHAYSIDESCLDVtesldfffp 175 Lactococcus lactis
NP_979456    83 ------------------------------iVNPIMHTYMKCSTYITSLAlqyvapedFHQYSIDEFFMDMtasihl--- 129 Bacillus cereus ...
YP_060480    90 wkqglevt-------pkyksfiehwakrtliVPPRMDRYIEKNLEIQHIFqdyaapddILPYSIDEGFIDLtsslsyfis 162 Streptococcus py...
ZP_00120955  91 apggrliges---cdacdlerspglkasmviAKPRMAHYLEISGQIYGIYlkyaapehIHVYSIDEVFIDAtpylrs--- 164 Bifidobacterium ...
Feature 1                                                       #                               
ZP_01058405 115 -------psltEWCLDLRQQVRAWtgiPVSIGIGp-TKTLAKLANKLAKSSPRt--gGVLDLvhhpqwr-epalrkvAVG 183 Roseobacter sp. ...
CAC42065    132 ------fgsaeVIAKKIQADILKElklYVTVGIGd-NPLLAKLALDNEAKHQKs---GIAEWrykdvpe--tvwkirPIT 199 Listeria innocua
NP_863146   134 --egtrsqrrkKLAQMIQENIKEElglIATVGVGd-NPLLAKLALDNEAKHNE----GFVAEwtyenvp-ekvwnipEMT 205 Enterococcus fae...
EAN09835    145 -----sakdarELARMIQTDVYRQtgiFTTIGIGd-NPLLAKFALDLESKKNSdm-kAEWRYedvhqk----lwlveNIT 213 Enterococcus fae...
BAA23799    132 -----kcdtayKLAKIIQRVIYNHmglYVTIGIGe-NPLLAKLALDNEAKNAP----GFVAEwryedvp-ekvwpisPLT 200 Enterococcus fae...
YP_395772   130 -----fgqtpyEVARQIQLTVKKEtgiYLTVGIGd-NPLLAKLALDLEAKHNHsl-iAEWHYedvpdk----lwpvtDLA 198 Lactobacillus sa...
AAB52385    176 e-itntyeqmdKLAQMLQRKIYHKtglYVTIGMGd-NPLLAKLAMDNYAKHNTn--mRALIRyedvps---kvwsisDMT 248 Lactococcus lactis
NP_979456   130 -----fasnprEFALKFKREIYERtriESTIGIGp-NLLLSKVAMDVEAKKNRd---GIVQWtyddipe--klwsirPLS 198 Bacillus cereus ...
YP_060480   163 dksmsrkdkldNVSAMIQRDIYSKtgiISTVGMSnsNPLLAKLALDNEAKKTAtm-rANWSYedvetk----vwaipKLT 237 Streptococcus py...
ZP_00120955 165 -----lgmgphAMARTIVREILTKtgiTATAGIGs-NMYLAKVAMDIVAKHMPadkdGVRVAelnemsyrrllwdhrPLT 238 Bifidobacterium ...
Feature 1                                                                                       
ZP_01058405 184 DVWGIGRRWSQMLEAQNIhtahdlsra---------sdgwvrkrmGIVGLRTVHELRGiachdld---tqpdpkQTTCCS 251 Roseobacter sp. ...
CAC42065    200 DFWGIGKRTAFQLERMGIysihglsqm---------lpsylkrrlGVIGEQLYYHAHGidysrls--ekykpieKSYGKS 268 Listeria innocua
NP_863146   206 DFWGIGSRMKKRLNQMGImsirdlanw---------npytiknrlGVIGLQLYFHANGidrtdiai-ppeptkeKSYGNS 275 Enterococcus fae...
EAN09835    214 DVWGIGRRTAIRLKRMGIftmhdlaha---------nyyqlkqnfGVLGTQLYAHSWGvdrsflg--qkykvksKSIGNS 282 Enterococcus fae...
BAA23799    201 EFCGIGNRMAARLKKLGIrsiydlahi---------epymlkerfGIMGLQLYAHSWGidrsflgq-kagrpteKSFGNS 270 Enterococcus fae...
YP_395772   199 RVWSIGQRTATKLNQLQIhsmgdlaht---------npydlkqkmGIIGSQLFAFSWGidraivh--qkytpkeRSYGNS 267 Lactobacillus sa...
AAB52385    249 DFWGINVRTEARLNKLGIhsikelaha---------dpdmlkrelGVIGLQQFFHANGidetrlt--dkykrksVSFSNS 317 Lactococcus lactis
NP_979456   199 KFWGISYKTEMKLNRKGIhtignlaqy---------plrylkqsfGVIGEELHLHSNGidfsria--ekyvpatTSIAKS 267 Bacillus cereus ...
YP_060480   238 DFWGIGSKTEIHLQKLGIhsikelanf---------npdilkkefGKVGVQLWFHANGvdesnvh--epykpksRGLGNS 306 Streptococcus py...
ZP_00120955 239 DFWRVGRGYAKKLEHAGLmtmgdiarcsvgrasdyynedllyrmfGVNAELLIDHAWGwepceiadirsyepgaHSISSG 318 Bifidobacterium ...
Feature 1                                                                                       
ZP_01058405 252 RSFGRVisekqdlrSAVITFAERAAGKvraanqVAGALQVFVSTd----------------------------------- 296 Roseobacter sp. ...
CAC42065    269 QILEKDyhdpnqiaIIIQEMVEEVAMRlrnhhvDTSVIHLSCGYsrys-----------------------------tkn 319 Listeria innocua
NP_863146   276 QVLPRDytrrneieLVVKEMAEQVAIRirqhncKTGCVHLHIGTsile-----------------------------trp 326 Enterococcus fae...
EAN09835    283 QVLNRDytrrneieIVIKEMADQVATRlrrsgaKAEVISLWIGFsmgyvd-------------------------rsgsr 337 Enterococcus fae...
BAA23799    271 QVLPKDyankeqikLVLKELSDQVASRlrmascQTTCVSLFVGYskgqtd-------------------------kygqt 325 Enterococcus fae...
YP_395772   268 QVLPRDyflqteieVVIREIAEQVAARlrahrkQACMISLGIGFsfsene-------------------------sgvhs 322 Lactobacillus sa...
AAB52385    318 QTLPRDytrkseigLIINEMAEQVAVRlrkskkKATNFSLFVGFsmad-----------------------------ykk 368 Lactococcus lactis
NP_979456   268 QILFRDysie-efiVILLEHVEEVCYRlrrekkYAQTIHFSVGYske------------------------------ygg 316 Bacillus cereus ...
YP_060480   307 QVLPRDyrtqreieIVLAEMADQVANRlrsahkKATVVSIHIGYsrte-----------------------------mkk 357 Streptococcus py...
ZP_00120955 319 QVLTGPadya-tarLITKEMADALALDlvdksvLTNRLTLAVGYdigsldsskldscadyamkraaeraaksyqgpvtid 397 Bifidobacterium ...
Feature 1                                                               
ZP_01058405 297 RFNKAAPQygsaatvr--falptsdALHIVCAASRALervwrgGFAYRKAGVLLLD 350 Roseobacter sp. MED193
CAC42065    320 GFSHQKKImsts---------sskeLVPYFLELFWKYq----eNDAVRSVAVSCAG 362 Listeria innocua
NP_863146   327 GFSHQMKIpitd---------ntkeLQNYCLFLFDKYy----eGQEVRHVGITYSK 369 Enterococcus faecium
EAN09835    338 GFHQQMKVpatn---------sskqIANYLLQIFDRHy----kYQDIRNVGVNCSK 380 Enterococcus faecium DO
BAA23799    326 GWRRQMKVepsn---------ntkvLTEHVLRLFEENya---pGVDVRKLGVSYGR 369 Enterococcus faecalis
YP_395772   323 GFGRSLKIeptn---------gnheITTTAIQLFREQw----qHQTIRHISLTCGQ 365 Lactobacillus sakei subsp. sakei 23K
AAB52385    369 SLSVSRKIepts---------stkdLQEIATRLFNEKy----dEGAVRRIGVSANN 411 Lactococcus lactis
NP_979456   317 GIKKANTLnratn--------ltmdIYNVCTYFLYERh----tGEPIRSVSLSLTN 360 Bacillus cereus ATCC 10987
YP_060480   358 SINAQKKIdpan---------lpktMVGHVLELFRKKy----tSGAVRQIGVSYGG 400 Streptococcus pyogenes MGAS10394
ZP_00120955 398 RFGRKVPKsavgsiglgdftsssarIREAMTMLYERIvd---sRLLVRRLTVIADD 450 Bifidobacterium longum DJO10A

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