2TRX,1MEK,1A8L,1A8Y,1A8Y,1A8Y,1B9Y,1BYE,1DSB,1E6B,1EEJ,1EEM,1F2E,1FO5,1FOH,1FOV,1G6Y,1G7E,1G7O,1GP1,1GSE,1H75,1HYU,1HYU,1IYI,1J9B,1JFU,1K0N,1KNG,1KTE,1LU4,1M2A,1NHY,1NM3,1O73,1OC3,1ON4,1OYJ,1PRX,1PSQ,1QGV,1QMV,1R4W,1RW1,1SEN,1T1V,1T4Z,1UC7,1V2A,1WIK,1WOU,1XVW,1XW5,1YY7,1Z9H,2BJX,3LJR,3PGT


Conserved Protein Domain Family
TRX_superfamily
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cd01659: TRX_superfamily 
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Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of target proteins via the reversible oxidation of their active site dithiol. The PDO members of this superfamily include TRX, protein disulfide isomerase (PDI), tlpA-like, glutaredoxin, NrdH redoxin, and the bacterial Dsb (DsbA, DsbC, DsbG, DsbE, DsbDgamma) protein families. Members of the superfamily that do not function as PDOs but contain a TRX-fold domain include phosducins, peroxiredoxins and glutathione (GSH) peroxidases, SCO proteins, GSH transferases (GST, N-terminal domain), arsenic reductases, TRX-like ferredoxins and calsequestrin, among others.
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Statistics
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PSSM-Id: 238829
Aligned: 133 rows
Threshold Bit Score: 28.4334
Created: 12-Dec-2003
Updated: 9-Sep-2024
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2TRX_A     24 LVDFWAewc-------gpCKMiapildeia--deyqgkltVAKLNIdqnpgtap-------kygirgiPTLLLFkng--- 84  Escherichia coli
1B9Y_C    137 VVNIYEdgv-------rgCDAlnsslecl---aaeypmvkFCKIRAsntgagd--------rfssdvlPTLLVYkgg--- 195 Norway rat
1UC7_A     32 MLDLYAdwc-------vaCKEfekytfsdpqvqkaladtvLLQANVtandaqdval---lkhlnvlglPTILFFdgqgqe 101 Escherichia coli
1WOU_A     28 FAYFTGskdaggkswcpdCVQaepvvregl--khisegcvFIYCQVgekpywkdpnndfrknlkvtavPTLLKYgt---- 101 human
CAA71103  205 VLDVGLkhc-------gpCVKvyptvikls--kqmadtvvFARMNGdendscmqf----lkdmdvievPTFLFIrdg--- 268 potato
NP_006399  73 MIIHHLdec-------phSQAlkkvfaenk--eiqklaeqFVLLNLvyettdkh------lspdgqyvPRIMFVdpsltv 137 human
BAB68388   30 VVDAHQkwc-------gpCTAivgmlkrik-nelgddllrFATAQVdvidtle--------qyrgkcePNFLFYggg--- 90  Ciona intestinalis
P92979    377 IVVLYApwc-------pfCQAmeasydela-dklagsgikVAKFRAdgdqkefak-----qelqlgsfPTILVFpkns-- 441 thale cress
Q9H2J4    116 ILHLYKqgi-------plCALinqhlsgl---arkfpdvkFIKAISttcipn----------ypdrnlPTIFVYleg--- 172 human
CAI12977  163 LIKITSdwc-------fsCIHiepvwkevi-qeleelgvgIGVVHAgyerrlah-------hlgahstPSILGIin---- 223 human

2TRX_A     85 evaAT--------KV 91  Escherichia coli
1B9Y_C    196 eliSN--------FI 202 Norway rat
1UC7_A    102 hpqAR--------VT 108 Escherichia coli
1WOU_A    102 --pQK--------LV 106 human
CAA71103  269 eicGR--------YV 275 potato
NP_006399 138 radITgrysnrlyAY 152 human
BAB68388   91 elvAA--------VR 97  Ciona intestinalis
P92979    442 srpIK--------YP 448 thale cress
Q9H2J4    173 dikAQ--------FI 179 human
CAI12977  224 -gkIS--------FF 229 human
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