Conserved Protein Domain Family
RT_pepA17
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cd01644: RT_pepA17 
RT_pepA17: Reverse transcriptase (RTs) in retrotransposons. This subfamily represents the RT domain of a multifunctional enzyme. C-terminal to the RT domain is a domain homologous to aspartic proteinases (corresponding to Merops family A17) encoded by retrotransposons and retroviruses. RT catalyzes DNA replication from an RNA template and is responsible for the replication of retroelements.
Links
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Statistics
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PSSM-Id: 238822
Aligned: 23 rows
Threshold Bit Score: 222.18
Created: 27-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputativeputative NTP
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based primarily on the structure of the stalled complex of HIV-1 RT bound to NTP and DNA primer-template (1RTD).
  • Citation:PMID 9831551
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                          ######        
S33901       792 TWYLPHFAVVNppk-peKLRVVHDAAArt--rGVALNDMLLKGPNLlqsLPGVIMRFRQHNITATADIKEMFIQVKLRPE 868  domestic silkworm
CAJ14165     727 GYYMPHHAVFKqdstttKCRVVFDGSCkt-snGRSLNDILKVGPTIqqdTTDILLRWRRRAIAVVGDVEKMYRQVWVHEE 805  African malari...
AAN87269     784 KYFLPHQAVIRdsslttKLRVVFDASAkt-tnNKSLNDIMWVGPRVqkdIFDIIIKWRKWEFVVSADIEKMYRQIKIDNN 862  fruit fly
NP_508324    960 VHYLSHHPVFKlssvstKLRIVYDASAranknSQSLNDALHTGEKLlpkLNGVLMRIRVPPILVSSDIEKAFLMLELHPQ 1039 nematode
T31617       131 VHYLSHHPVFKpsststKIRIVYDASAkanknSKSLNEMLHAGESLlpkLSEVLLRTRKPEILVSGDIEKAFLMVSLHEN 210  nematode
ZP_00373744  117 VFYMPHHPVLGk-----KLRVVFDGSFqd-ssGQSLNDTLNVGPSIqrnLFDVCVRFRLHKYVFSADIIKMFRQIWINKH 190  Wolbachia endo...
AAB03640     608 CFYLPHHAVIKldslttKCRVVFDGSGkd-ssGVSLNDRLHIGPPIqrdLFGVCLRFRQHQYVLCADVEKMFRGIKVFKP 686  fruit fly
CAD32253     836 SYHLPHHAVVKpestttKLRVVFNASSps-anGISLNDILHAGPVLqsdLTIQVLKWRYFQYVFSADITKMYRQIWVDPK 914  fruit fly
NP_508646    947 EYFMPHRAVIKessnttKLRVVLDASSpi-gkDLSLNDCLHAGTNLltpLYGILLRSRCYRYIIVADIEKAFHQVRLQVK 1025 nematode
T26836      1114 NYNMPHRAVIKessnttKVRVVYDASSha-vgQLSLNDVVHAGANMvipLFGILIRSRFIKLMIVGDLEKAFHQVQVQPE 1192 nematode

Feature 1                                       ##                                      # ##     
S33901       869 DKDALRYLWRKDQRdnkp---peeNRMTSLIFGAssspstAIYVKNLNAQKHeathpe----aaatiqNRHYVDDYLDIF 941  domestic silkworm
CAJ14165     806 DRKFQRILWRSHSSeki-----ktYELNTITYGTa----sAPFLAIRTLNQVlednkeky-plaasriNDFYVDDFISGA 875  African malari...
AAN87269     863 DQKYQYILWRNSPKeki-----ktYKLTTVTYGTa----sAPYLATRVLVDIadkcknq--visaiirNDFYMDDLMTGA 931  fruit fly
NP_508324   1040 DRDCCRFLWQPPGQtqp-----vcYRFLRVPFGVk----sSPFLLNASIKKHlrseqse---lakkiaLNIYVDNVFMGV 1107 nematode
T31617       211 DRDTCRFLWTPPDGskp-----icYRFCRVPFGVk----sSPFLLNATIKTHletyntq---maqeilKNIYVDNKLLGT 278  nematode
ZP_00373744  191 HRNYQRIVWREHPSapl-----lhYQLCTVTYGTa----cAPFLAVRVLEQLardyqhlyptaarillEDFYVDDVLTGA 261  Wolbachia endo...
AAB03640     687 HTNFQRIVWRTTENepl-----lhFRLLTVTYGLa----pSPFLAVRVLKQLaddhgheypaaahallHDAYVDDIPTGA 757  fruit fly
CAD32253     915 HTPFQRILFRNKEGdi------rdFELKTVTFGVn----cAPFLAIRVLQQLaediqvpfpnasriiqQHMYVDDVLAGA 984  fruit fly
NP_508646   1026 HRSVTQFLWLADPSqpanadnvvrYRFTRIPFGVa----sSPFLLGAAIHHFlgrnphr---lnneirDNLYVDNCMLGT 1098 nematode
T26836      1193 FRNLTLFLWLTDLNkpitrdnictKRFVRLPFGMs----cSPNLLASTIVHFlvhnpde---lnndilDNLYVDNILIGT 1265 nematode

Feature 1                                                                                        
S33901       942 kglkdavlvttdfrrkherkptsktfwidseivlrwtrtesrsykpyVAQRLTAIed-------------sSTINERRWL 1008 domestic silkworm
CAJ14165     876 ds-------------------------------------------enEAKQLCEEtkaa---------lamGGFPLRKWA 903  African malari...
AAN87269     932 ds-------------------------------------------veEANKLITLiphe---------lqkVGFNLRKWI 959  fruit fly
NP_508324   1108 anakeg------------------------------------vqfyrESKKIFAK----------------VQMNLTQYE 1135 nematode
T31617       279 pwniqsdilsiniap------------------piatalskrrilqsVASTYDLLgvvapvvvrgklfiqkLWARPAEWD 340  nematode
ZP_00373744  262 dtee---------------------------------------kllqYKQELIQLms-------------cAQLELGKWI 289  Wolbachia endo...
AAB03640     758 ntfe---------------------------------------elmiLKDELIALld-------------kGKFKLRKWS 785  fruit fly
CAD32253     985 ns-------------------------------------------vnEAQSSIRElqaa---------lsaSGFPLRKWT 1012 fruit fly
NP_508646   1099 ddftkv------------------------------------mptamAAKSIFRK----------------MNMNLREFV 1126 nematode
T26836      1266 ndl------------------------------------------alIMNRITRLkqi----------fshMKMNIREFV 1293 nematode

Feature 1                                          ##        
S33901      1009 Ptkhnvaddv------------trhvpmsyqNEHRWFRWTEFLR 1040 domestic silkworm
CAJ14165     904 Sncphilpseteidn---iqrvielksregaVSTLGLVWNPILD 944  African malaria mosquito
AAN87269     960 Snnskilttvedtg-----dnkvlniienecVKTLGLKWEPQKD 998  fruit fly
NP_508324   1136 Snskelnemigi--------iegkaadqkvnLKLLGTSWNTNKD 1171 nematode
T31617       341 Se----------------------------lTESETQEWRQIEK 356  nematode
ZP_00373744  290 Snsnrvvdpetti------tnntsysplettNKVLGIHWQPHTD 327  Wolbachia endosymbiont of Drosophila ananassae
AAB03640     786 SnswrllkslpeedrcfepiqllnksaadspVKVLGIQWNPGKD 829  fruit fly
CAD32253    1013 Snnksvlkdvpaehl---lhsefldidaestAKTLGIRWRAKSD 1053 fruit fly
NP_508646   1127 Tncdgimqhir-----------aedraesrdIKLLGCMWNSNET 1159 nematode
T26836      1294 Vnhdesmekid-----------pkdrvsartIKLLGMKWNSSPD 1326 nematode

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