1JSW,1GK2,1GK2,1GKM,1W27,1T6P,1DOF,1K7W,1C3U,1I0A,1XWO,1HY0,1TJ7,1AOS,1Q5N,1YIS,1RE5,1FUO,1J3U,1YFE,1FUQ,1YFM,1VDK


Conserved Protein Domain Family
Lyase_I_like

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cd01594: Lyase_I_like 
Click on image for an interactive view with Cn3D
Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions
Lyase class I_like superfamily of enzymes that catalyze beta-elimination reactions and are active as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. This superfamily contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase. The lyase class I family comprises proteins similar to class II fumarase, aspartase, adenylosuccinate lyase, argininosuccinate lyase, and 3-carboxy-cis, cis-muconate lactonizing enzyme which, for the most part catalyze similar beta-elimination reactions in which a C-N or C-O bond is cleaved with the release of fumarate as one of the products. Histidine or phenylalanine ammonia-lyase catalyze a beta-elimination of ammonia from histidine and phenylalanine, respectively.
Statistics
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PSSM-Id: 176466
View PSSM: cd01594
Aligned: 412 rows
Threshold Bit Score: 40.6696
Threshold Setting Gi: 78063864
Created: 28-Jun-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Structure:1DOF_A; Pyrobaculum aerophilum adenylosuccinate lyase homotetramer, subunit contacts at 3.5 A
    View structure with Cn3D
  • Structure:1JSW_A, Escherichia coli, L-aspartate ammonia lyase homotetramer, subunit contacts at 3.5 A
    View structure with Cn3D
  • Citation:PMID 9230045
  • Structure:1GK2_A, Pseudomonas putida, histidine ammonia-lyase (Hal) mutant F329g homotetramer, subunit contacts at 3.5 A.
    View structure with Cn3D
  • Structure:1K7W_A; duck delta 2 crystallin mutant homotetramer, contacts at 3.5 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1JSW_A       48 VRGMVMVKKAAAMANkelqtipksvanaiiaacdevlnn--------gkcmdqfpvdvyqggagtsvnmnTNEVLanigl 119 Escherichia coli
1DOF_A       25 INAYLEVERALVCALeelgvaergccekvnkasv------------------sadevyrleretghdilsLVLLLeqksg 86  Pyrobaculum aero...
NP_787919    33 IRERIRVEIGWVFFLwrkavfglaeptkederflssiv---------hdahkniprvkkieeriqhdvkaVEIFLrerft 103 Tropheryma whipp...
CAC22697     58 FKYRVQVEVLYFQALckevpvitqlrgvtdaqleklratt-----fenftvddarmikdieavtnhdikaVEYYLkdkms 132 Leishmania major
ZP_00308064  40 IHYRVKIEIEYFIALcekpvpqlkdfdksiypalraiyl--------efsledaqrikdiekvtnhdvkaVEYFIkeklk 111 Cytophaga hutchi...
NP_696947    39 NRERMRVEVEWMILLangfegngnqpivdgvkpftaeeqaflraipedfgaegikqhaaheaithhdvkaVEYYIddqid 118 Bifidobacterium ...
EAN76778     47 FRYRVLVEVEYFTALckdvptivplrsvtdeqlqklrkit-----ldcfsvssaeeikrlervtnhdikaVEYFIkermd 121 Trypanosoma brucei
XP_636767    39 IKYRVQVEIEYFIELsklselkplnavnkeddhkklrdiy------lqfkesdaqkikqiekttnhdikaVEYFIkekmh 112 Dictyostelium di...
ZP_00766150  36 FRYRVRVEVEYLIFLsrargihfvppltppqqaalraly-------rqfgdddalaiaawdrrvnhdvkaVEYWLrerlt 108 Chloroflexus aur...
YP_063223    33 NRARVQVEVEWLLYLtnhrmfgssplsaeqagqlralad--------gfgqaeidrlaeleattkhdvkaVEYLVrerlh 104 Leifsonia xyli s...
Feature 1                                                                                       
1JSW_A      120 elmghqkgeyqylnpndhvnkcqstndayptGFRIAVYSSLi-kLVDAINQLREGFERKAvefqdilkmgrt-qlqdavp 197 Escherichia coli
1DOF_A       87 cryvhy---------------gatsndiidtAWALLIRRALa-aVKEKARAVGDQLASMArkyktlemvgrt-hgqwaep 149 Pyrobaculum aero...
NP_787919   104 qqglgnive--------llhfactsedinnlAYALNMKAALsevILPSIDELIGHLEKMSqkyagdamlart-hgqpatp 174 Tropheryma whipp...
CAC22697    133 acgleaeke--------fihfgltsqdinntSIPMLLRDALhhhYIPTLDQLIAHLKSKLpewdvpmlarth--gqpasp 202 Leishmania major
ZP_00308064 112 kydlgnyle--------fihfgltsqdinntSIPLLLKDVLnncIYPELSASIKQIEALAkswetipmlakt-hgqpasp 182 Cytophaga hutchi...
NP_696947   119 kapaeltninde--lktlvhfactsedinnlSIARCVKNAMenvWTPEFKRIIDHLAGKAeefkdmpllslt-hgqpatp 195 Bifidobacterium ...
EAN76778    122 tcglshvte--------fvhfgltsqdinntAIPMMIRDAIvtlYLPALDGIIGSLTSKLvdwdvpmlarth--gqpasp 191 Trypanosoma brucei
XP_636767   113 telqysevvt------efihfgltsqdinntAIPLSIVESVekvLIPQLKQSILEPLRQFaqqwksipmlarthgqpatp 186 Dictyostelium di...
ZP_00766150 109 tlgltghle--------avhfaltsedvnnlAYALMVKEARemvLLPALESLLERIRQLAdeeaatpmlart-hgqpatp 179 Chloroflexus aur...
YP_063223   105 tlgldhiae--------lthfaatsedinnlSYALTVSAAVnevWLPNYRAVIAELRAQAaqhrdaamlart-hgqpatp 175 Leifsonia xyli s...
Feature 1               #      #  ##  #                                                         
1JSW_A      198 mtlgqEFRAFSILLKEEVKNIQRTaelllevnlgataigtglntpkeysplavkklaevtgfpcvpaedlieatsdcgAY 277 Escherichia coli
1DOF_A      150 itlgfKFANYYYELYIACRQLALAeefirakiggavgtmaswgelgle------vrrrvaerlglphhvittqvapreSF 223 Pyrobaculum aero...
NP_787919   175 ttlgkELLVFVYRLKRQRKNLEDVqflgkfsgatgtfsahcvaapnypwq---ewakefvnsfgliynpittqiephdWQ 251 Tropheryma whipp...
CAC22697    203 tnlakEFMVWIERLEEQRTMLLSIpntgkfggatgnfnahlcaypgvnwl--efgelflskylglrrqryttqiehydNL 280 Leishmania major
ZP_00308064 183 trlgkEFMVFVERLINQINLLHQIpysakfggatgnfnahnvaypeinwi--efgndfvnttlglsrnqyttqiehydNL 260 Cytophaga hutchi...
NP_696947   196 ttlgkELAVYVYRLNRQLKHIENQeylgkingatgtfgahlaacpdvdwi--avsrefvtnrmgltwnplttqieshdWQ 273 Bifidobacterium ...
EAN76778    192 tnlakEFVVWIERLREQRRQLCEVpttgkfggatgnfnahlvaypsvnwr--afadmflakylglkrqqattqienydHL 269 Trypanosoma brucei
XP_636767   187 ttvgkELMVFIERLENQINHLEQSvphtckfggatgnlnahkvsypaidwvvfsekfvkvlhpslkrmrfttqiehydNV 266 Dictyostelium di...
ZP_00766150 180 ttfgkEMNVFFMRLRRAINDMMAIkitgklngasgvfaahhvalpqidwl---kfsrafvrsldlepillttqiephdTL 256 Chloroflexus aur...
YP_063223   176 ttmgkELAVFAHRLERIRKQVEQTeylgkfsgatgtfaahliadpsadwl---aiseefvrslgldwnplttqieshdWQ 252 Leifsonia xyli s...
Feature 1        #         ##  #  ##                                 #  #  #  ##                
1JSW_A      278 VMVHGALKRLAVKMSKICNDLRLlssgpraglneinlpelqagssimpakvnpVVPEVVNQVCFKVigndttvtmaaeag 357 Escherichia coli
1DOF_A      224 AVLASALALMAAVFERLAVEIRElsrpeigevvegg-----ggssamphkanpTASERIVSLARYVralthvafenvalw 298 Pyrobaculum aero...
NP_787919   252 CELLERVGHICRILHNLATDMWSyisfgyfqqgfise---svgsstmphkvnpIRFENAEANLEMAcgiiscivaslsts 328 Tropheryma whipp...
CAC22697    281 AAICDACARLHTILMDLAKDVWQyislgyfdqkvkag---evgssamphkvnpIDFENAEGNLGMSnavlgflsaklpis 357 Leishmania major
ZP_00308064 261 AALFDTLKRISTILIDFDRDVWQyvsmnyfkqkvkkd---evgssamphkvnpIDFENSEGNLGVAialfehfstklpis 337 Cytophaga hutchi...
NP_696947   274 AELYSTVSHANRIMHNLCVDVWMyisrgvfaqvpvkg---atgsstmphkvnpIRFENAEANFEIScslldtlsatlves 350 Bifidobacterium ...
EAN76778    270 AALCDACARLHVILIDMCRDVWQyismgffkqkvkeg---evgsstmphkvnpIDFENAEGNLALSnallnffasklpis 346 Trypanosoma brucei
XP_636767   267 ASLLDAFKRINTILIDLCRDIWTyismeyfnqklvkg---evgsstmphkvnpIDFENAEGNMGVAnalyehlsaklpis 343 Dictyostelium di...
ZP_00766150 257 AALCDALKRIGAILTDLSQDCWRyisdgylvqaarag---evgsstmphkvnpIDFENAEGNLALAgallelfsrklpvs 333 Chloroflexus aur...
YP_063223   253 AELYGRISHANRVLHNLCTDIWTyislgyfrqtpepg---atgsstmphkvnpIHFENAEANLELSsaildslaanlvts 329 Leifsonia xyli s...
Feature 1                                      
1JSW_A      358 -qlqlnvmepvigqAMFESVHILTNACYNLL 387 Escherichia coli
1DOF_A      299 -herdltnsanervWIPEALLALDEILTSAL 328 Pyrobaculum aerophilum
NP_787919   329 rlqrdlsdssvqrnIGVALGHSLVAIDNLKR 359 Tropheryma whipplei str. Twist
CAC22697    358 rlqrdltdstvlrnLGVPLSHALIAFASLQR 388 Leishmania major
ZP_00308064 338 rlqrdltdstvlrnIGVPLGHFLIALKSLQK 368 Cytophaga hutchinsonii
NP_696947   351 rwqrdltdsttqrnIGSALGYSLLALTNLMG 381 Bifidobacterium longum NCC2705
EAN76778    347 rlqrdltdstvlrnLGVPIGHACVAFASISQ 377 Trypanosoma brucei
XP_636767   344 rlqrdltdstvlrsIGVPFSHSILSFKSIQR 374 Dictyostelium discoideum AX4
ZP_00766150 334 rlqrdlsdstvlrnLGLAFGYCLLAYQRLLR 364 Chloroflexus aurantiacus J-10-fl
YP_063223   330 rlqrdltdssaqrnIGVGIGHSVLALDNIQR 360 Leifsonia xyli subsp. xyli str. CTCB07

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