Conserved Protein Domain Family
AcnA_IRP

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cd01586: AcnA_IRP 
Aconitase A catalytic domain
Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.
Statistics
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PSSM-Id: 153136
View PSSM: cd01586
Aligned: 22 rows
Threshold Bit Score: 682.878
Threshold Setting Gi: 18976573
Created: 16-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand bindingsubstrate
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:Binds the Fe-S cluster required for activity.
  • Comment:Based on related sequences with known structures.
  • Citation:PMID 3972791

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
P48200     84 RVLLQDFTGIPAMVDFAAmreavktlggdpekvhpACPTDLTVdhslqidfskcaiqnapnpgggdlqkagklsplkvqp 163  human
NP_577930  68 RIIMQDYTGVPAIVDLAAmrdyikekgkdpsrvnpKIPVELVVdhslivlyhgtkys----------------------- 124  Pyrococcus furios...
CAD56499   81 RVVMQDYTGVPAVVDLATmreiaaksgrdpsvvnpRVPVDLIIdhsvqvdhwaspqa----------------------- 137  Thermoproteus tenax
P25516     85 RVLMQDFTGVPAVVDLAAmreavkrlggdtakvnpLSPVDLVIdhsvtvdrfgddea----------------------- 141  Escherichia coli
NP_376736  78 RVIMQDYTGVPLLVDLAAmrdemrrkgkdpkivnpVVPADLIIdhsiqvdyygtsya----------------------- 134  Sulfolobus tokoda...
NP_148060  55 RVVMQDFTGVPAVVDLAAmrdamkqfggdpskvnpLIPVDLIIdhsiqvdyygtaea----------------------- 111  Aeropyrum pernix K1
NP_295443  86 RVILQDFTGVPAVVDLAAmrsamvklggdpskinpLIPVDLVIdhsvqvdefgtefa----------------------- 142  Deinococcus radio...
NP_864749  85 RVVLQDFTGVPAVVDLAAmrsameriggdpnkinpLIPVDLVIdhsvqvdffgsega----------------------- 141  Pirellula sp. 1
NP_393590  69 RVVMQDFTGVPAVVDLASmrdtvknlgkdpelinpQVRVDLVIdhsvqvdyygetfa----------------------- 125  Thermoplasma acid...
NP_883444  87 RVILPDSSGLPVLQDLAAlrdavqagggdparvdtRVPVDLIVdhslqvdawstada----------------------- 143  Bordetella parape...
Feature 1                                                                                     
P48200    164 kklpcrgqttcrgscdsgelgrnsgtfssqientpilcpfhlqpvpepetvlknqevefgrnrERLQFFKWSSRVlknvA 243  human
NP_577930 125 --------------------------------------------------lyenmkeelkanrERYSLLKWASKAfenlK 154  Pyrococcus furios...
CAD56499  138 --------------------------------------------------lslnirleiernrERYVFLKWAQSAfknlR 167  Thermoproteus tenax
P25516    142 --------------------------------------------------feenvrlemernhERYVFLKWGKQAfsrfS 171  Escherichia coli
NP_376736 135 --------------------------------------------------lswnmkkeferneERYKFLKWAQLSfrnlR 164  Sulfolobus tokoda...
NP_148060 112 --------------------------------------------------frlnlkreyernrERYQLLKWAQKAfsnfR 141  Aeropyrum pernix K1
NP_295443 143 --------------------------------------------------lannmalefernrERYEFLRWGQQAfdnfG 172  Deinococcus radio...
NP_864749 142 --------------------------------------------------lvqnverefernkERYEFLRWGQQAfdnfG 171  Pirellula sp. 1
NP_393590 126 --------------------------------------------------lekneelefdrnmERYRFLKWAQKAfknfK 155  Thermoplasma acid...
NP_883444 144 -------------------------------------------------vrrnldaefarneqRYRFLKWAQQAFdg-lR 173  Bordetella parape...
Feature 1                                               #                                     
P48200    244 VIPPGTGMAHQINLEylsrvvf----eekdllFPDSVVGTDSHITmvnglGILGWGVGGIETEAVmlglpVSLTLPEVVG 319  human
NP_577930 155 IIPPGKGIIHQINVEhlarivf----leegiaYPDTVLGTDSHTPmvngiGVLGWGVGGIEAEAAllglpYFMKVPEVVG 230  Pyrococcus furios...
CAD56499  168 VFPPGTGIIHQVNLEylarvvw----tegdtaFFETLVGMDSHTTminglGVVGWGVGGVEAEAAmlgepITIRVPRVVG 243  Thermoproteus tenax
P25516    172 VVPPGTGICHQVNLEylgkavwselqdgewiaYPDTLVGTDSHTTminglGVLGWGVGGIEAEAAmlgqpVSMLIPDVVG 251  Escherichia coli
NP_376736 165 VIPPGNGIIHQINLEylskvvdvrevkgvqtaFPEIVIGTDSHTTmangiSVLSWGVGGLEAEAVllgepYTMTVPEVIG 244  Sulfolobus tokoda...
NP_148060 142 VVPPGKGIIHQVNLEylarvvwlsrrngtlyaHPDSLLGTDSHTTminglGVFGWGVGGIEAEAVilgqpYYMLLPEVVG 221  Aeropyrum pernix K1
NP_295443 173 VVPPASGIVHQVNLEylakgvqsraeddgevvYPDSLVGTDSHTTminglGIVGWGVGGIEAEAVmlgqpIYMLMPEVIG 252  Deinococcus radio...
NP_864749 172 VVPPNVGIVHQVNLEylarvvamgkdeqgpvaMPDTLVGTDSHTTminglGVLGWGVGGIEAEANmlgqpLYMLMPEVIG 251  Pirellula sp. 1
NP_393590 156 VIPPGTGIIHQVNLEylaevvfegkkdgkdyaYFDSLVGTDSHTTmingiGVLGWGVGGIEAEAAllgqpITISLPEVIG 235  Thermoplasma acid...
NP_883444 174 VFAPGTGIIHQVNLEklatvvstsehggqqwaCPDFVIGGDSHTPmvnglGVLGWGVGGIDAESAllgraYTFPIPEVVG 253  Bordetella parape...
Feature 1                                                                                     
P48200    320 CELTGSsnpfvTSIDVVLGITKhlrqvGVAGKFVEFFGsgvsqLSIVDRTTIANMCPEYGAILSFFPVDnvtlkhlehtg 399  human
NP_577930 231 VVLEGEpspeiTPTDIVLTITEklrkvGVVGKFLEYTGnv-eaLSAFDRTVIANMTPENGATVGYFPIDeetikfirltr 309  Pyrococcus furios...
CAD56499  244 VRLYGEprpgvTATDIVLAVTEalrkvNVVDAFVEFFGegvrkLSVPDRATIANMAPEYGSTVGLFPVDgntldylsatg 323  Thermoproteus tenax
P25516    252 FKLTGKlregiTATDLVLTVTQmlrkhGVVGKFVEFYGdgldsLPLADRATIANMSPEYGATCGFFPIDavtldymrlsg 331  Escherichia coli
NP_376736 245 VKLVGEinegvTPTDIVLYITEvlrkkGVVGKFVEFFGpslskLSVPDRATIANMAPEYGATVGYFPIDsqtlkylagtg 324  Sulfolobus tokoda...
NP_148060 222 VRLVGElregvTTTDLVLYITEklrkkNVVGKFVEYFGegvkkLSVPDRATIANMAPEYGATMGFFPVDeatleylrgtg 301  Aeropyrum pernix K1
NP_295443 253 FKITGAmpegaTATDLALRVTQmlrekGVVGKFVEFYGaglsnMTLPDRATIANMAPEYGATMGFFPVDdealrylrrtg 332  Deinococcus radio...
NP_864749 252 FELTGElpsgaTATDMVLRVVEilraeGVVGKFVEFFGtgmnaMSVADRATIANMAPEYGATMGFFPVDdltlhymrqtg 331  Pirellula sp. 1
NP_393590 236 VRIKGKmqpgvTATDVVLTVTEmlrkvNVVDKFVEFFGpsvkyLSVPERATISNMCPEFGATCALFPIDdqtlqylettg 315  Thermoplasma acid...
NP_883444 254 VELKGAfrspvTTTDAALLVTQrlraeGVTGCMVEFFGealpgLSVADRATIANMAPEYGATCGFFPVDaqtldylrltg 333  Bordetella parape...
Feature 1                                                                                     
P48200    400 fskaklesmetylkavklfrndqnssgepeySQVIQINLns--ivPSVSGPKRPQDRVAVtdmksdfqaclnekvgfkgf 477  human
NP_577930 310 geskakl------vekyaklnmlyreetpefDKTVKIDLsk--vePSVAGPFHPEDRIRLkdlknsfkvekkt------- 374  Pyrococcus furios...
CAD56499  324 rpeelial----vkkyyeeqgvfrgvedaeySQVVDFDLsa--vePSAAGPTLPWQRRSLqdvpksfveflaqrkkrd-- 395  Thermoproteus tenax
P25516    332 rsedqvelv---ekyakaqgmwrnpgdepifTSTLELDMnd--veASLAGPKRPQDRVALpdvpkafaasnelevnath- 405  Escherichia coli
NP_376736 325 rdyriv--------etyaksqglfydevpiyTEVVEIDLsk--iePSVAGPRNPDERVPLremkkrnekn---------- 384  Sulfolobus tokoda...
NP_148060 302 rpewlvqlv--erytketglwysledpeprySDVVEIDLsd--vePSISGPSHPEDRIPLreakervrkiimeylekkg- 376  Aeropyrum pernix K1
NP_295443 333 rledeigl----veayykaqgmfrtdetpdpVFTDTIELdlativPSLAGPKRPQDRVNLsdmhsvfnealtapvknrgf 408  Deinococcus radio...
NP_864749 332 rskenvel----veryckeqglfrlddgpalNYTKTVSLdlstvePSMAGPKRPQDRVPLasmkkafnesltapvgasgf 407  Pirellula sp. 1
NP_393590 316 rpkdhidl----ikkyleaqglfgegaepkyTRVIELDLst--vkPSVAGPKLPQQRLDLdqvpasflstleqnggdrl- 388  Thermoplasma acid...
NP_883444 334 rtaehielvr-aycqanglwradpaasavryARVVRIDLaq--aePCMSGPRRPQDRLPIgqlaedfrqrlprpaaegg- 409  Bordetella parape...
Feature 1                                       #                                             
P48200    478 qiaaekqkdivsihyegseyklsHGSVVIAAVISCTNNCNPSVMLAAGLLAkkaveaglrvkpyIRTSLSPGSgMVTHYL 557  human
NP_577930 375 -----------kiringgeveieDGIIGLAAIASCTNTSNPYNILAAALVAkkavelglrtkpwVKTTFTPGSrVVVKYL 443  Pyrococcus furios...
CAD56499  396 ------krkaveieiggrrtefgDGDVAIAAITSCTNTSNPYLLVAAGLVAkkaveaglsvppyVKTSFAPGS-RAVEEI 468  Thermoproteus tenax
P25516    406 -----kdrqpvdyvmnghqyqlpDGAVVIAAITSCTNTSNPSVLMAAGLLAkkavtlglkrqpwVKASLAPGSkVVSDYL 480  Escherichia coli
NP_376736 385 --------------ekksgsivsDNDVVLAAITSCTNTSNPTVMIGAGLLAkkaierglrvkpyVKTSTAPGSpVVVEYL 450  Sulfolobus tokoda...
NP_148060 377 -----rgpaivelklgdeevhltDGSVVYAALTSCTNTSNPSVMIAAALLArnavkkglrtrpwVKTSNAPGSrVVPEYW 451  Aeropyrum pernix K1
NP_295443 409 e--lgsdkldaqgtiggtdikigHGAVTLASITSCTNTSNPSVLIAAGLVAkkavekglktkpwVKTSLAPGSrVVTEYL 486  Deinococcus radio...
NP_864749 408 glapealsrtghvsnngastditHGAVVIAAITSCTNTSNPSVMVGAGLLAkkaaergltvpshVKTSLAPGSrVVTDYL 487  Pirellula sp. 1
NP_393590 389 -----vtlrkvplkmkgqnlelsDGDIVIAAITSCTNTSNPYVMIAAGLLAkkaveaglkvnpkVKTSLAPGSrVVTDYL 463  Thermoplasma acid...
NP_883444 410 -----fgpdaaalarapgsaglrHGSIVVAALTSCTNTSNPSVMLTAALVAraarqrgiappawVKRSLAPGSrTVTDYL 484  Bordetella parape...
Feature 1                          #  ##                           #                          
P48200    558 Ss-SGVLPYLSKLGFEIVgYGCSTCVGntaplsdavlnavkqgdlvTCGILSGNKNFEGRLCdcvranyLASPPLVVAYA 636  human
NP_577930 444 Ek-LGLLSYLEALGFHVNgYACASCIGnsgplkrev-eevidkgikVAAVISGNRNFRRRVNskidytyLASPPLVVVFA 521  Pyrococcus furios...
CAD56499  469 LrrAGLMPYLEKLGFHVVaYGCTTCIGnsgplpqpvskaikeydimAAAVLSGNRNFEGRVHpeiraayLASPPLVVAYA 548  Thermoproteus tenax
P25516    481 Ak-AKLTPYLDELGFNLVgYGCTTCIGnsgplpdpietaikkgdltVGAVLSGNRNFEGRIHplvktnwLASPPLVVAYA 559  Escherichia coli
NP_376736 451 Ke-SGLLPYLEALGFHIVgFGCTTCIGnagplpkvveedvkkygleVYGVISGNRNFEGRVNpllkgvyLASPILVVAYA 529  Sulfolobus tokoda...
NP_148060 452 Nr-LGLMPYLEALGFHITgYGCTVCIGnsgplrpeieeairehdlwVATVLSGNRNFSGRIHplargnfLASPPLVVAYA 530  Aeropyrum pernix K1
NP_295443 487 Et-AGLQQYLDQIGFNTVgYGCMTCIGnsgplpepvveaiqegdlvVASVLSGNRNFEGRVNphikanyLASPPLVVAYA 565  Deinococcus radio...
NP_864749 488 Nk-AGLSESLDKLGFNTVgYGCTTCIGnsgplpepvaaaiqegdliASAVLSGNRNFEGRVNpltkanyLASPPLVVAYA 566  Pirellula sp. 1
NP_393590 464 Te-SGLLSYLEKLGFYIVgYGCTTCIGnsgpldqdlgnaivnnnlsVVSVLSGNRNFEARIHkdvkanyLMSPPLVVAYA 542  Thermoplasma acid...
NP_883444 485 Aa-TGLLQDLEALGFGVIgYGCTTCGGksgplapevaqdiadnqwvVCTVLSDNRNFEGRIHklaranyIGSPPLVVAYA 563  Bordetella parape...
Feature 1          
P48200    637 IAGTV 641  human
NP_577930 522 IAGKI 526  Pyrococcus furiosus DSM 3638
CAD56499  549 LAGSV 553  Thermoproteus tenax
P25516    560 LAGNM 564  Escherichia coli
NP_376736 530 LAGRI 534  Sulfolobus tokodaii str. 7
NP_148060 531 LAGRV 535  Aeropyrum pernix K1
NP_295443 566 LAGTV 570  Deinococcus radiodurans R1
NP_864749 567 LAGTT 571  Pirellula sp. 1
NP_393590 543 LAGNI 547  Thermoplasma acidophilum DSM 1728
NP_883444 564 LAGRI 568  Bordetella parapertussis 12822

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