Conserved Protein Domain Family
IPMI

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cd01583: IPMI 
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
Aconatase-like catalytic domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes.
Statistics
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PSSM-Id: 153133
View PSSM: cd01583
Aligned: 42 rows
Threshold Bit Score: 485.927
Threshold Setting Gi: 22001738
Created: 16-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand bindingsubstrate
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:Binds the Fe-S cluster required for activity.
  • Comment:Based on related sequences with known structures.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
O28316       30 LAMIHDITAPLAIKAFREilgsdakvwdKSKVIMAFDHqvpadsvhaaENHKMLRKFAEEqg-iLNYDV--KGGIAHQIM 106 Archaeoglobus fu...
ZP_00001343  33 RTIIVDMAALHPEFIENPpvk----pfnPEKISLVFDHyvpapgieiaNRVNRLRKLVNRwgitDFYDVg-RGGISHVLG 107 Ferroplasma acid...
ZP_00166256 165 LAMSHDSSGPRRVAPLLEalgt--tvwdPSRYVVVTDHfvpas-dpaaEAILHFTRDWTRs--sGAHLId-GEGICHVVL 238 Ralstonia eutrop...
O67078       31 LAMANDVTAPLAIKILEKygid--kvfdPERIALVLSHfvpakdiksaEQAKIVREFVKKhgikWFFEE--GEGIEHAIL 106 Aquifex aeolicus
Q9WZ24       28 IALANDITAPLAIKKFKEyggk--kvkyPDRVVLVPDHftpnkdiksaMQVKMMREFAREqgieKFFEIg-RMGIEHVLL 104 Thermotoga maritima
Q8RDK2       30 MVLGNDITAPVAIKEFEKigvd--kvfdNTKIALVPDHfvpskdiksaEQVNVMRKFAKKynivNFFEVg-RMGIEHALL 106 Thermoanaerobact...
Q8U2A1       32 FMFGNDVTTPLAIKTFRKigve--kvfdPERIAIVLDHftpnkdikaaEQCKFSREFAREqgikWFFEGg-NVGVEHCLL 108 Pyrococcus furiosus
Q7VH31       31 MVLGNDITTPVAINAFKEakfq--kvfdKDKISLVMDHfapnkdikaaTQSAQCRCFAKDfdisHYYDVg-NMGVEHALL 107 Helicobacter hep...
CAE14162     34 RIYVQDGNSPTIAKLFRQhnlk--rvlrPEKIGFFFDHsvivpdrlmaERVNEAMEFAKSig-vNIFAR--GEGISHLIA 108 Photorhabdus lum...
O59391       22 LVYAHDGTMPLIIEAFNKvfn-----svKARAYVFFDHvypap-tvkvANLQKEIREFARr---HGIPVveGKGISHQLV 92  Pyrococcus horik...
Feature 1                        #                                                              
O28316      107 VEnh-vePGMLIVGADSHTCMYGALGAFATGIGSTDMGFVlamgkLWFKVPESIRFNVHGKlekhvYGKDIVLKLIGmvg 185 Archaeoglobus fu...
ZP_00001343 108 GEkgwfrPGSLIANTDSHTIATGAFNTLGRGLGTPEIMNIiatgkTWFLLGETLKVNLENSmrlgtSAKDVFFYMASvi- 186 Ferroplasma acid...
ZP_00166256 239 PEhghvlPGRLIVGGDSHSPTGGAFGAYMFGVGATEMAGVlatgeIWLRVPQTIRLQWDGAlapgvCAKDMMLFLCAklg 318 Ralstonia eutrop...
O67078      107 PEqglvvPGDLVVGADSHTCTYGALGAFATGVGSTDIAYAmatgeVWLRVPESMKFIFYGKlkpwvMGKDLILYTIGqig 186 Aquifex aeolicus
Q9WZ24      105 PEegivkSGDLVVGADSHTCTYGALGAFATGVGSTDIAGFyligkVWFRVPESIKVTLRGKfkdlvTAKDLVLKLISilg 184 Thermotoga maritima
Q8RDK2      107 PEqglvlPGDVVIGADSHTCTYGALTCFATGVGSTDMAAAmatgkAWFKVPEAIKFVLKGNlgkwvSGKDVILYIIGkig 186 Thermoanaerobact...
Q8U2A1      109 PElglvlPGELIIGADSHTCTYGALGAFATGVGSTDLAVAmatgeAWFRVPETIKFVYEGDlqpwvTSKDLILYTIGdig 188 Pyrococcus furiosus
Q7VH31      108 PEqgivtIGDLIIGADSHTCTYGALGAFSTGVGSTDMAVGmatgqAWFKVPYAIKFNLKGKlrpyvSGKDVILHIIGkig 187 Helicobacter hep...
CAE14162    109 LEeqwfqPGNIVIGADSHTCTGGAVQSLALGMGASDVLAAmltgqTWLKVPETVSLSISGQphpatRTKDVMLALLRhfg 188 Photorhabdus lum...
O59391       93 VEmglaeKSRIVVGGDSHTPTLGALGVFAVGMGATDVAVVlglgkTWLRVPESVAVIFEGKpsrttMAADVMIRLITslr 172 Pyrococcus horik...
Feature 1                                                                                       
O28316      186 aDGANyKACIYSGevvekLGMSDRLTMCNMAIEMGGKAGIVEPDkttleylkamgrp-------yegellksdedaeFQE 258 Archaeoglobus fu...
ZP_00001343 187 gDVPN-KNIEFLGngiysLNIDQRSSISTMCAEVSAEFAVFPEDkvlrqymvergyg-------nyrpaapdrdaeyVNE 258 Ferroplasma acid...
ZP_00166256 319 lGGGRyEAIEYAGsavaaLPMQERMTLANMSAELGAQTGLVAPDvvtldwlaaagvpaqtlaeidlahwrsdtdaplLAN 398 Ralstonia eutrop...
O67078      187 vDGALyRAMEFDGetirnLSMEQRFTIANMAIEAGGKSGIISPDektieyvkqrakr-------pwkvyqsdpdaeyHSV 259 Aquifex aeolicus
Q9WZ24      185 vDGANyKAIEFSGpgvkeISMDGRFTISNMAIEAGGKTGLFPVDeitiayerergie--------veemypdedakyVRE 256 Thermotoga maritima
Q8RDK2      187 vDGALyKSMEFTGni-kaLSIDDRFTIANMAIEAGAKNGIFDFDeiteayvkkrakr-------eykvferdedaeySEV 258 Thermoanaerobact...
Q8U2A1      189 vNGALyKVMEFSGeviekLSVEQRMTMTNMAIEAGAKTGIIEPDkktieyvkgrakr-------eykiyksdedakyYKV 261 Pyrococcus furiosus
Q7VH31      188 vDGALyKSMEFGGeglknLTIDDRLCIANMAIEAGAKNGIFEVDditisyakgrtkr-------dfriykadvdaeyEQV 260 Helicobacter hep...
CAE14162    189 qSPFLyRSVELCGewsqtLSLDSAASFASMGVELGAKCVFMPDGpgrpanmr------------------pinpevvDHH 250 Photorhabdus lum...
O59391      173 nYDMNyKALEFFNv---pFTADERLTLTNFSVEANAKTALIGEEydg---------------------------rnyIKE 222 Pyrococcus horik...
Feature 1                                                 #                                     
O28316      259 VELDVtgmePQVAAPHRV-DNVVGIseveg--trvdqVFIGSCTNgryeDLKIAAEILkgek-----vasnVRLIVIPAS 330 Archaeoglobus fu...
ZP_00001343 259 VNIDMgkiePMVALPDRIiNNVKPVseigk--veidvAVVGSCANgrlsDLRDVAEAVknkk-----indnVRFIVTPAS 331 Ferroplasma acid...
ZP_00166256 399 HVFDAaaltPQVAAPHSP-ANSAPVdqaag--esvqiAYLGACTGakleDLRMAASVLrgrr-----vapgVSLQVAPAS 470 Ralstonia eutrop...
O67078      260 YEWDAsqiePLVAWPYLP-SNVHPVsesth--itidqAFIGSCTNgrieDLRVAAKVFeaalkqgkkvhpyVRCIVIPAS 336 Aquifex aeolicus
Q9WZ24      257 VEMDLselePQVAYPFLP-SNAKDVseaekerikidqAVIGSCTNgrieDLRLAAQILkgrt-----vspdVRCIIIPGS 330 Thermotoga maritima
Q8RDK2      259 IEINLddirPQVAFPHLP-ENTRSIdevgk--vkidqVVIGSCTNgrlsDMEIAYRILkgkk-----vhpdVRLIIFPAT 330 Thermoanaerobact...
Q8U2A1      262 IEYDVskiePQVAFPHLP-ENTVPIskaakmnikidqVVIGSCTNgrleDLRMAAEVLegqk-----vapwVRLIILPCS 335 Pyrococcus furiosus
Q7VH31      261 FDIDLdsinHTVAFPHLP-ENTKEKddwge--ikidqVVIGSCTNgrlsDMAVAAEILkdkt-----iaknTRCIIIPAT 332 Helicobacter hep...
CAE14162    251 LTFLLseltPHISLPHSP-AQSVPLetlsg--qkidyVFIGSCTNsrleDIAEVAAILdkhr-----vhqdVHCIVTPGS 322 Photorhabdus lum...
O59391      223 ISFELsslgPMVAKPFSP-ANGVEVekveg--tkidqVFIGSCTNgrfeHIKRAAEILkge-------evaVRTIIGPAS 292 Pyrococcus horik...
Feature 1                                  #  ##                 #                              
O28316      331 hREYRRALkEGLIEIFVDAGALVEaPCCGPCMGgsfgliasgEVSVSTSNRNFIGRQGspegkiyLVNPAVAAATAIYGE 410 Archaeoglobus fu...
ZP_00001343 332 kEIYEEALkLGYIDTIIKSNAMVTnPTCGACLGghmgvvgngDTVLSSTTRNFKGRMGaggariyLASARSVAISAINGY 411 Ferroplasma acid...
ZP_00166256 471 aRDQQQAQrEGTLAVLADAGADLLpNACGACAGygaarfpagSRAIASTARNFSGRMGdagsavwLASPLTVAASAVTGR 550 Ralstonia eutrop...
O67078      337 kAIYKQALkEGLIDIFMEAGCVVStSTCGPCLGghmgvlaegERCISTSNRNFPGRMGhpksesyLANPAVVAASAIMGR 416 Aquifex aeolicus
Q9WZ24      331 qKVYKQALkEGLIDIFIDAGCAVStPTCGPCLGghmgvlaegEVAISTTNRNFVGRMGhpnskvfLASPAVAAASAIKGY 410 Thermotoga maritima
Q8RDK2      331 qEIYLECVkRGYIEEFIKAGAAVStPTCGPCLGghmgvlakgERALATTNRNFVGRMGhpesevyLASPAVAAASAIAGY 410 Thermoanaerobact...
Q8U2A1      336 pTVYFKAMkEGLLEIFLEAGAVIGpPTCGPCLGghmgilasgERAVSTTNRNFVGRMGhpksevyLASPYVAAASAILGR 415 Pyrococcus furiosus
Q7VH31      333 qNIYLECInRGYLETFIKAGAVVStPTCGPCLGghmgilaanEKCVSTTNRNFVGRMGhitsevyLSSPEVAAASAVRGI 412 Helicobacter hep...
CAE14162    323 kRVYLEAMrRGYIEKIVSAGALVTpPGCGACVGtqgtipakgERVLSTMNRNFQGRMGnaeaeiyLSSPLVAANVALHGR 402 Photorhabdus lum...
O59391      293 vNVYKRMVrEGIVDILLDAGATILpPGCGPCLGrhmgvlgdkEVVLSTTNRNFRGRMGsptaeiyLASPLTAAVSALYGE 372 Pyrococcus horik...
Feature 1        
O28316      411 I 411 Archaeoglobus fulgidus
ZP_00001343 412 I 412 Ferroplasma acidarmanus
ZP_00166256 551 I 551 Ralstonia eutropha JMP134
O67078      417 I 417 Aquifex aeolicus
Q9WZ24      411 I 411 Thermotoga maritima
Q8RDK2      411 I 411 Thermoanaerobacter tengcongensis
Q8U2A1      416 I 416 Pyrococcus furiosus
Q7VH31      413 L 413 Helicobacter hepaticus
CAE14162    403 V 403 Photorhabdus luminescens subsp. laumondii TTO1
O59391      373 I 373 Pyrococcus horikoshii

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