1L5J


Conserved Protein Domain Family
AcnB

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cd01581: AcnB 
Click on image for an interactive view with Cn3D
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle
Aconitase B catalytic domain. Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle. Aconitase has an active (4FE-4S) and an inactive (3FE-4S) form. The active cluster is part of the catalytic site that interconverts citrate, cis-aconitase and isocitrate. The domain architecture of aconitase B is different from other aconitases in that the catalytic domain is normally found at C-terminus for other aconitases, but it is at N-terminus for B family. It also has a HEAT domain before domain 4 which plays a role in protein-protein interaction. This alignment is the core domain including domains 1,2 and 3.
Statistics
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PSSM-Id: 153131
View PSSM: cd01581
Aligned: 8 rows
Threshold Bit Score: 639.93
Threshold Setting Gi: 15890258
Created: 16-Jul-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingsubstrate
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1L5J_A      384 LAQKMVGRa---cGVKGIRp-GAYCEPKmtSVGSQDTTGPMTRDELKDlaclg--fsadLVMQSFCHTAAYPkpvdvNTH 457  Escherichia coli
ZP_00054840 382 LAQKMVGRacglpEGKGMRp-GTYCEPKmtTVGSQDTTGPMTRDELKDlaclg--fsadMVMQSFCHTAAYPklvdvKTH 458  Magnetospirillu...
AAD32176    382 LAQKMVGRacglpEGQGVRp-GTYCEPRmtTVGSQDTTGPMTRDELKDlaclg--fsadMVMQSFCHTAAYPkpvdvKTH 458  Neisseria menin...
P56418      375 LAQKIVGHa---cGVKGILp-GTYCEPKvtTVGSQDTTGAMTRDEVKElaslk--fdapFVLQSFCHTAAYPkpsdvSLH 448  Helicobacter py...
NP_661443   375 LAQKIVGKa---cGLPGVRp-GMYVEAEtlTVGSQDTTGPMTRDEIKElaals--fsadLFMQSFCHTAAYPkpsdvQLH 448  Chlorobium tepi...
P74582      374 LAQKMVGKa---cGVQGIRp-GTSCEPImtTVGSQDTTGPMTRDELKElaclg--fnadLTLQTFCHTAAYPkpvdiKTH 447  Synechocystis s...
ZP_00147947 373 LAQKIVGQa---cSVDGVLp-GTACEPImtTVGSQDTTGPMTTDELTElaclk--fqapMFMQSFCHTAAYPkltdvKMH 446  Methanococcoide...
NP_355930   446 AVEKIFNRnavgvTPGKVLhaGSDVRVKvnIVGSQDTTGLMTAQELEAmaatvisplvdGAYQSGCHTASVWdkkaqANT 525  Agrobacterium t...
Feature 1                                                        #                              
1L5J_A      458 HTLPDFIMNrg-------gVSLRPGDGVIHSWLNRml-lPDTVGTGGDSHTRfpIGISFPAGSGLVAFAaatgvMPLDMP 529  Escherichia coli
ZP_00054840 459 RELPGFISTrg-------gVALRPGDGVIHSWLNRll-lPDTVGTGGDSHTRfpIGISFPAGSGLVAFAaatgvMPLDMP 530  Magnetospirillu...
AAD32176    459 KELPAFISTrg-------gVSLRPGDGVIHSWLNRll-lPDTVGTGGDSHTRfpIGISFPAGSGLVAFAaatgvMPLDMP 530  Neisseria menin...
P56418      449 ATLPGFITQrg-------gVALHPGDGVIHTWLNRmg-lPDTLGTGGDSHTRfpLGISFPAGSGLVAFAavtgtMPLNMP 520  Helicobacter py...
NP_661443   449 RSLPYFIMSrg-------gVALKPGDGVIHTWLNRmv-lPDTLGTGGDSHTRfpIGCSFPAGSGLVAFAgvtgtMPLNMP 520  Chlorobium tepi...
P74582      448 KDLPDFFSTrg-------gVALRPGDGIIHSWLNRml-lPDTVGTGGDSHTRfpLGISFPAGSGLVAFAaalgvMPLDMP 519  Synechocystis s...
ZP_00147947 447 RTLPDFVSDrg-------gVSLNPGDGIIHSWLNRll-vPDTVGTGGDSHTRfpIGISFPAGSGLVAFAgalgfMPLDMP 518  Methanococcoide...
NP_355930   526 PKLMSFMHNfgvitgrdpkGVYHSMTDVIHKVLNDitvdDRAIIIGGDSHTRmsKGVAFGADSGTVALAlatgeATMPIP 605  Agrobacterium t...
Feature 1                                                                                       
1L5J_A      530 ESVLVRFKGKmqpgiTLRDLVHAIPLyaikqglltvekkgkknIFSGRILEIEGlpdLKVEQAFELTDASAERSAAGCTI 609  Escherichia coli
ZP_00054840 531 ESVLVRFKGKmqpgvTLRDLVNAIPLyairaglltvekkgkknVFSGRILEIEGlpdLKVEQAFELSDAAAERSAAACSV 610  Magnetospirillu...
AAD32176    531 ESVLVRFSGKlqpgvTLRDLVNAIPLyaikqglltvakagkknIFSGRILEIEGlpdLKVEQAFELTDASAERSAAGCTV 610  Neisseria menin...
P56418      521 ESVLVRFKGEmnpgiTLRDLVNAIPYyaikkglltvekkgkinVFNGRILEIEGlpdIKMEQAFELSDASAERSAAACVV 600  Helicobacter py...
NP_661443   521 ESVLVRFTGElqpgiTLRDLVNAIPYvaikrglltvekkgkknIFAGKVLEIEGlpqLKVEQAFELSDASAERSAAACTV 600  Chlorobium tepi...
P74582      520 ESVLVKFTGElqpgvTLRDIVNAIPWvamqqgkltvgkgdkvnVFNGRIMEMEGlpdLKVEQAFELTDATAERSCSGSTI 599  Synechocystis s...
ZP_00147947 519 ESVLVRFSGKlnsgiTLRDVVNSIPYyaiqqglmtvpkknkinIFNGRILEIEGlpdLTAEQAFELTDSAAERSAAAGCI 598  Methanococcoide...
NP_355930   606 QSVKVTFKGTmqpymDFRDVVHATQAqmlqq--------hgdnVFQGRIIEVHIg-tLLADQAFTFTDWTAEMKAKASIC 676  Agrobacterium t...
Feature 1                                                                                       
1L5J_A      610 KLNKEPIIEYLNSNIVLLKWMIAEGYGDRRTLERRIQGMEKWl------aNPELLEADaDAEYAAVIDIDLadikePILC 683  Escherichia coli
ZP_00054840 611 RLDKAPIIEYMTSNITLMKWMIANGYEDPRTLGRRIKAMEAWi------kKPDLLAPDaDAEYAAVIEIDLadvkePIVA 684  Magnetospirillu...
AAD32176    611 KLNKEPIIEYMKSNVVLMKNMIANGYQDPRTLERRIKAMEKWl------aNPELLEADkDAEYAAVIEINMddikePIIA 684  Neisseria menin...
P56418      601 RLNKEPMIEYLKSNIKLIDEMIASGYEDKETLKKRRDAMQAWv------dNPVLLEPDsNAQYAAVIEIDVaeitePILA 674  Helicobacter py...
NP_661443   601 RLDKEPVIEYLQSNVKLLAQMIEEGYGDANTIKRRIGKMEEWl------aNPQLLEPDaDAEYAAVIEINMseitePILA 674  Chlorobium tepi...
P74582      600 KLSEETVAEYLRSNVVLMKNMIARGYQDARTLLRRIAKMEEWl------aNPSLMSGDaDAEYADVIEVNLdeikePIVA 673  Synechocystis s...
ZP_00147947 599 QLDEKPVATYLRSNVALMKKMIGNGYSDAQTLQKRIEAVEEWl------eDPKLLKADpNADYAAVIGIDLadikePILA 672  Methanococcoide...
NP_355930   677 ISEDETLIESLEIAKSRIQIMIDKGMDNAAQTLKGLIDKADQriaeirsgETPALKPDaNAKYFAEVVVDLdiinePMIA 756  Agrobacterium t...
Feature 1                                            #                                          
1L5J_A      684 APNDPDDARPLsavqg-----------ekideVFIGSCMTnigHFRAAGKLLdahk------gqlpTRLWVAPPTr---- 742  Escherichia coli
ZP_00054840 685 CPNDPDDVKLLsevag-----------akideVFIGSCMTnigHFRAAGKVLegks-------dipTRLWIAPPT----- 741  Magnetospirillu...
AAD32176    685 CPNDPDDVCFMsersg-----------tkideVFIGSCMTnigHFRAASKLLegks-------dipVRLWVAPPTk---- 742  Neisseria menin...
P56418      675 CPNDPDDVATLsevladttg----krphaideVFIGSCMTnigHFRAFGEIVknap-------psqARLWVVPPSk---- 739  Helicobacter py...
NP_661443   675 CPNDPDDVATLseiladek------rpknideVFVGSCMTnigHFRALGEVLrgkg-------qakTRLWVVPPTk---- 737  Chlorobium tepi...
P74582      674 APNDPDNVKLMsecag-----------dviheVFIGSCMTnigHYRAAAKILegag-------tvkGRLWICPPTr---- 731  Synechocystis s...
ZP_00147947 673 CPNDPDDVKLLsevag-----------tpiqdVFIGSCMTnigHFRAAAEIWrdqk------fnsdVRTWICPPTr---- 731  Methanococcoide...
NP_355930   757 DPDVNNNDVSRrythdtirpvsyygatkkvdlGFVGSCMVhkgDVKIVAQMLrnmektegkvefkaPLVVAAPTYniide 836  Agrobacterium t...
Feature 1                                                #  ##                #                 
1L5J_A      743 ----MDAAQLTe-----------EGYYSVFGKSGARIEIPGCSLCMGnqarvadgATVVSTSTRNFPNRLGtga-----n 802  Escherichia coli
ZP_00054840 742 ----KMDALILn----------eEGYYSILGKSGARMEMPGCSLCMGnqaqirkgSTAMSTSTRNFPNRLGidt-----n 802  Magnetospirillu...
AAD32176    743 ----MDAKELSd-----------EGHYGVLGRAGARMEMPGCSLCMGnqaqvhegATVMSTSTRNFPNRLGknt-----f 802  Neisseria menin...
P56418      740 ----MDEQELIn-----------EGYYAIFGAAGARTEVPGCSLCMGnqarvrdnAVVFSTSTRNFDNRMGrga-----k 799  Helicobacter py...
NP_661443   738 ----MDMKKLIe-----------EGYYSIFGTAGARTEVPGCSLCMGnqarvadnAVVFSTSTRNFDDRMGkga-----k 797  Chlorobium tepi...
P74582      732 ----MDEQQLRe-----------EGIYGIFAAAGARTEMPGCSLCMGnqarvedgVTVFSTSTRNFNNRMGkga-----q 791  Synechocystis s...
ZP_00147947 732 ----MDQAKLRe-----------ESVFSVYGQVGARIEIAGCSLCMGnqarvpdeSTVFSTSTRNFDNRVGdga-----q 791  Methanococcoide...
NP_355930   837 lkaeGDWEILQkysgfefddvnpKTSNRTEYDNILYLERPGCNLCMGnqekaakgDTVLATSTRLFQGRVVedsaekkge 916  Agrobacterium t...
Feature 1                         
1L5J_A      803 vfLASAELAAVAALIGKL 820  Escherichia coli
ZP_00054840 803 vyLGSAELAAVCALMGKI 820  Magnetospirillum magnetotacticum
AAD32176    803 vyLGSAELAAICSKLGKI 820  Neisseria meningitidis
P56418      800 vyLGSAELGAACALLGRI 817  Helicobacter pylori
NP_661443   798 vyLGSAELAAVCALLGHL 815  Chlorobium tepidum TLS
P74582      792 vyLGSAELAAVCALLGKI 809  Synechocystis sp. PCC 6803
ZP_00147947 792 vyLGSAELGAVISNLGRI 809  Methanococcoides burtonii DSM 6242
NP_355930   917 slLASTPVVVLSAILGRT 934  Agrobacterium tumefaciens str. C58

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