Conserved Protein Domain Family
IPMI_Swivel
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cd01577: IPMI_Swivel 
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Links
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Statistics
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PSSM-Id: 238809
Aligned: 36 rows
Threshold Bit Score: 97.6592
Created: 16-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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substrate
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Comment:These residues participate in the active site of the catalytic domain.
  • Comment:Based on related sequences with known structures.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                               ###   
NP_661513  11 VLGKNIDTDQIIPAEHLvyslsdpeevkmygkyalsgvpidqaglpegnipfveegeftsPYSIIIagpNFGCGSSREHA 90  Chlorobium tepidum...
Q8YX03     15 LVGNDIDTDRIIPARYLkaitfdglregafiddr----------talkgahpfdqpqyqdANILIVn-rNFGCGSSREHA 83  Nostoc sp. PCC 7120
Q8ZRI9     14 MLEPNIDTDVIMPKQFLkgidrqgldkgvffdrrfm------aggqpnpdfilnmpgwqsATFLLVg-pNFGCGSSREHA 86  Salmonella typhimu...
Q9PLW2     14 LEYANIDTDQIIPKQFLlavskqgfgkhlfhdlryld----dkesvlnmdfnlnkkeyqnSSILVSf-eNFGSGSSREHA 88  Campylobacter jejuni
NP_810772  16 LPLENVDTDQIIPARFLkattreekffgdnlfrdwr-----ynadgslnkdfvlndptysGQILVAg-kNFGSGSSREHA 89  Bacteroides thetai...
CAE00174   18 IRGNDIDTDQIIPARFMkvvtfdglgefaffdqry-------dendepkdhplnepqfqdASIMVVn-aNFGCGSSREHA 89  Haloferax volcanii
NP_880107  14 MNQDHVDTDAIIPQRWLvtverdgladgfmgawryd------ehgqprpecvlnqpayqgAAIVLAr-eNYGCGSSREHA 86  Bordetella pertuss...
Q02144     14 VMNDNIDTDQIIPKQFLkaidkkgfgknlfyewryl------kdydenpdfilnapkykkASLLISg-dNFGSGSSREHA 86  Lactococcus lactis...
O53236     14 LRRSNVDTDQIIPAVFLkrvtrtgfedglfagw------------rsdpafvlnlspfdrGSVLVAg-pDFGTGSSREHA 80  Mycobacterium bovis
Q9ZND4     15 LRGEDIDTDRILPARFMkvltfeglgqylfyderf-------dekgnpkphplndpryrgATILLVe-sGFGSGSSREHA 86  Thermus thermophilus

Feature 1                                                                       
NP_661513  91 PfALKVAGAkAIIAESYARIFYRNCVDGgfvipfetaQPLNKsim------------tgdELSLDM 144 Chlorobium tepidum TLS
Q8YX03     84 PqALSKWGIqAVIGESFAEIFFGNCVAIg-------vPCVTAdeaivkqlqelvaanpqaNVSINL 142 Nostoc sp. PCC 7120
Q8ZRI9     87 VwGLKQLGVrGLIGSTFAGIFDDNCQRNg-------iLTVSLdepalarlaqlaasadtnSITVSL 145 Salmonella typhimurium
Q9PLW2     89 PwALVDYGIrAIIAPSFADIFKNNALGNg-------lLTIELakdevleivdelkksqdkNIEISL 147 Campylobacter jejuni
NP_810772  90 AwAIAGYGFrVVVSSFFADIHKNNELNNf-------vLPVVVtegflqelfdsifadpkmEVEVNL 148 Bacteroides thetaiotaomicron VPI...
CAE00174   90 PqALMRWGIdAIVGESFAEIFAGNCLALg-------iPTVTAdhetvtelqdwvdehpdgDIDVDV 148 Haloferax volcanii
NP_880107  87 VwAHQGYGIrAIVAASYGPIFHENCLKNg-------lLPVTLpaadvatlmaqaladpgcACEVDL 145 Bordetella pertussis Tohama I
Q02144     87 AwALSDYGFrAIIAGSYSDIFYNNALKNg-------lLPIKQprevlnql---tklssqeEITIDL 142 Lactococcus lactis subsp. lactis
O53236     81 VwALMDYGFrVVISSRFGDIFRGNAGKAg-------lLAAEVaqddvellwklieqspglEITANL 139 Mycobacterium bovis
Q9ZND4     87 PqAIKRAGFkAIIGESFAEIFFGNATAIg-------lPCVSLapedlgvlfrsveenpelEVEIDL 145 Thermus thermophilus

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