Conserved Protein Domain Family
NAPRTase_A
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cd01570: NAPRTase_A 
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Links
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Statistics
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PSSM-Id: 238804
Aligned: 29 rows
Threshold Bit Score: 396.944
Created: 29-Jun-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
ZP_00182048   7 ALHTDLYLPRWMYIYWkegrhnERAVFDVYYRSNPfeg----gyVVFAGLENIIEYVQtlrfteEDITYLQKMIDfp--- 79  Exiguobacterium ...
ZP_00044338  12 ALLTDLYQLTMLQSYWkeg-maQSAIYDFGMRSLPgcr----nyLVMAGLESVLELLEslhftaQDLAYLSTLGLfg--- 83  Magnetococcus sp...
NP_624507     4 VTTTDLYEVTMALSYLled-msRPATFSLFVRDLPser----gfLVSAGIEPALDYLSafrvtpSDVEDFASALHrp--- 75  Streptomyces coe...
NP_285595     6 PLLTDLYQLTMMQGYFlsdlhrQQATFDLYFRRLPfeg----gyAVWAGLEPMLDWLQglhfaeADLDYLASLGQfr--- 78  Deinococcus radi...
NP_695491    19 ALMTDMYEYTMLDAALkdgtadRKCVFEVFTRHLPegr----ryGVVAGTGRILDALEhfhldeADLKFLADRHVvs--- 91  Bifidobacterium ...
NP_335010     9 ALFTDLYEVTMAQAYWaer-msGTAVFEIFFRKLPpgr----syIMAAGLADVVEFLEafrfdeQDLRYLRGLGQfs--- 80  Mycobacterium tu...
YP_004227     6 ILYTDLYQLTMGQVYFrmglheKEALFEAFYRRNPdygahqagyTVFAGLDPLLSWMEearfgeEEIAALRSLKSrsgkp 85  Thermus thermoph...
ZP_00092420  13 ALLTDLYQLTMLQGYVerd-mlDGAVFEFFARKPPacr----nfYLAAGLEQVLDYLEqlhftqGELDWLSGLGLfr--- 84  Azotobacter vine...
NP_486522    23 SLLTDLYQLTMAACYTgegveqRRASFELFVRRSPegf----gyLIAMGLAQALEYLEklrfspEQIAALQATGIfaha- 97  Nostoc sp. PCC 7120
NP_213718     5 GLCTDLYELTMAQSYLyeg-ktGTAVFSLFVRKLPekr----nfLISAGLETLVERIKnfkfgdEEIKYLKSLGIfk--- 76  Aquifex aeolicus...

Feature 1                                                                                       
ZP_00182048  80 ---deFKDELRNFk--fSGSISSVkEGEIVFPNEPLVRIEARIFEAKLLQTAILNiANHESLIATKYARIRQSApg--ak 152 Exiguobacterium ...
ZP_00044338  84 ---ddFLSWLQDFr--fTGTVHALaEGTLFFPPAPMLLIEAPLPQAQLVETAVMNqLHFQTLVASKAARVTQACqg--kp 156 Magnetococcus sp...
NP_624507    76 ---yaDLSPLCGMt--fTGEVRAVpEGRVVFAGEPLLEVTAPLAEAQLVETFLLNqVSHQTAVASKAVRSVLAAag--rp 148 Streptomyces coe...
NP_285595    79 ---peFLAALREWr--fSCEVTAFpEGSVVFPHEPLLTVRGPLWEAQLVETALLNtLNFQTLVATKAARCVLAAqagggt 153 Deinococcus radi...
NP_695491    92 ---peTIKWLENFh--fSGTIRGYrEGEMFFPNSPILQVEGTFGECTLLETLILSvLNYDSAVASAASRMASAAkd--rp 164 Bifidobacterium ...
NP_335010    81 ---deFLRWLAGVr--fTGDVWAApEGTVIFPNEPAVQLIAPIIEAQLVETFVLNqIHLQSVLASKAARVVAAArg--rp 153 Mycobacterium tu...
YP_004227    86 lfaedYLRYLKAMggfsGLTLRALpEGRVAHPQVPLVSVEGPLLQAQLLETALLNrLNYETLIATKASRVREAAge--av 163 Thermus thermoph...
ZP_00092420  85 ---paFLDYLAGLr--fSGEVQAMaEGTPFFADEPILRVVAPLPEAQLVESRLINlLHFQTLIASKAARLTLAAsg--rr 157 Azotobacter vine...
NP_486522    98 --gegFWSLLAEGr--fTGDVWAVpEGTAVFANEPLLRVEAPLWQAQLVETYLLNtLNYQTLVATRAARLRDIAgeq-at 172 Nostoc sp. PCC 7120
NP_213718    77 ---ddFLDYLKDFe--fSGNVYAIpEGRIVFQNEPLVQVEAPIPEAQLLETLVINtIQFETMIASKAVRSYLVAkg--kk 149 Aquifex aeolicus...

Feature 1            ###                     ##                                                 
ZP_00182048 153 FLEAGARRAQGidaAYFGTRaSYLAGFDVTSLaSAGRDFGIPCGGTMEHADIqfhdd----eltafRTFAAyypdqatlL 228 Exiguobacterium ...
ZP_00044338 157 FMEFALRRTHGmdaGLKASRsAYLAGASLTSNvEAGRRWQIPVSGTMAHAFVqahgd----elsafRAYAAlype-galL 231 Magnetococcus sp...
NP_624507   149 VVDFSLRRTHGtsaGMQAARtAALTGFAGTSNvAAAVRWGLPASGTMAHSYVeafpd----eeaafRAFARahpgpvtfL 224 Streptomyces coe...
NP_285595   154 VLEFGARRAQGpngAVSAARaAFVGGAVGTSNlEAGRQFGIPVSGTHAHAWVesfpt----eldafRAYAEfypdsttlL 229 Deinococcus radi...
NP_695491   165 CMDMGGRRTNEw-aAVAAARaAVVGGFKGTANlLAAQLYGLKAIGTAAHCFTlvhds----erdafESQIEalgknttlL 239 Bifidobacterium ...
NP_335010   154 VVDFGARRAHGtdaACKVARtSYLAGAAGTSNlLAARQYGIPTFGTMAHSFVqafds----evaafEAFARlypa-tmlL 228 Mycobacterium tu...
YP_004227   164 VLEFGLRRAPAk-gGESATRaSLIGGANRSSAvSLSHLLGLPASGTHAHSLVqafmalgyseedafRAFAEvfpddtilL 242 Thermus thermoph...
ZP_00092420 158 LVDFGLRRAHGaeaGLLAARaSYLAGFQASATvLAGAQFGIPLAGTMAHSFVqahld----eaeafEHFARslpqsvllL 233 Azotobacter vine...
NP_486522   173 LLEFGTRRAFSpqaSLWAARaALAGGLDATSNvLAALQLGQQPSGTMAHALVmalsamegseeqafSAFHRyfpg-aplL 251 Nostoc sp. PCC 7120
NP_213718   150 LVDFGFRRAHGleaGILAARaSYIAGFDGTSNvEAGREFGIPVVGTMAHSYVmifdk----eedafRAFAKlypknaifL 225 Aquifex aeolicus...

Feature 1                                        #                           ##                 
ZP_00182048 229 VDTYDTlksGLPNAITVAKeleakghklRGIRIDSGDLSYLSKRARTMLDeagfpdvDIVLSGDldeYVIQDLRIQga-- 306 Exiguobacterium ...
ZP_00044338 232 VDTYDTl-qGVRHVIALAKelgt-afriRAIRLDSGDLVALAKSARQMLDeagllqmKIYVSGGldeHSVAQLEASga-- 307 Magnetococcus sp...
NP_624507   225 VDTYDSv-rGVRTAARVLRdlgr--gpgCAVRLDSGDLGDLARRARAELDrsglpgvRVVASGGldeYGVDTLVRSga-- 299 Streptomyces coe...
NP_285595   230 LDTVDTlgsGLPNALTVAAelrakghelGGVRVDSGDLAYLSRVIRERLDaagfpdvKIVVSNDlseSVISGVIAEgg-- 307 Deinococcus radi...
NP_695491   240 VDTYNIe-eAVKTAVEVAGpe------lGGVRIDSGDLAAMAQRVRNQLDalgatntTITVTNDldeYALAALQTAp--- 309 Bifidobacterium ...
NP_335010   229 VDTYDTl-rGVDHVIELAKrlgn-rfdvRAVRLDSGDLDELSKATRARLDtagleqvEIFASSGldeNRIAALLAArc-- 304 Mycobacterium tu...
YP_004227   243 LDTVDTlhsGLPHAIRVFEelrrkghrpVGVRIDSGDLAHLAIQVARELDkagfpevLIVLSGDldeLVIWQIKSQvlee 322 Thermus thermoph...
ZP_00092420 234 IDTYDTe-aAARKVVELAPrlaaagirvQGVRLDSGDLGEHARRVRAILDrgglgdaTVFASGNldeYEVRRLLAEga-- 310 Azotobacter vine...
NP_486522   252 IDTYDTi--AAAQHLAEKVntgk--melSGVRLDSGDLVSLSKQVRSLLPd-----vSIFASGDldeWEIAKLQAAga-- 320 Nostoc sp. PCC 7120
NP_213718   226 IDTYDTi-eAAKKVVDLAKegv----pvVGVRIDSGDIVKLSKEVRKILDenglknvRIIVSGGvdeYKIKEWFDRga-- 298 Aquifex aeolicus...

Feature 1                        # ##  #                 
ZP_00182048 307 ------------qANTFLVGTRGIta--yeQPALGMVYKLV 333 Exiguobacterium sp. 255-15
ZP_00044338 308 ------------pIDAYAVGTSLWvs--edLPATSCVYKCA 334 Magnetococcus sp. MC-1
NP_624507   300 ------------pIDVYAVGTRVGts--adAPYLDSAYKLV 326 Streptomyces coelicolor A3(2)
NP_285595   308 ------------rVDVYGVGTQLAtaggpgGGALGGVYKLA 336 Deinococcus radiodurans R1
NP_695491   310 -------------VDSYGVGTMLVtg--sgAPTCAMVYKLT 335 Bifidobacterium longum NCC2705
NP_335010   305 ------------pIDGFGVGTQLVva--qdAPALDMAYKLV 331 Mycobacterium tuberculosis CDC1551
YP_004227   323 aprygvdpdrllkRLVYGVGTRMVvs--wgAPALGGVYKLV 361 Thermus thermophilus HB27
ZP_00092420 311 ------------pIDGFGVGTRLDts--sdAPYLDCVYKLQ 337 Azotobacter vinelandii
NP_486522   321 ------------eIDGYGLGTKLVt-----GSPVNGVYKLV 344 Nostoc sp. PCC 7120
NP_213718   299 ------------pIDAFGVGTKFIts--adAPYFDIAYKLV 325 Aquifex aeolicus VF5

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