1E5X,1V7C,2D1F


Conserved Protein Domain Family
Thr-synth_1

?
cd01563: Thr-synth_1 
Click on image for an interactive view with Cn3D
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Statistics
?
PSSM-Id: 107206
View PSSM: cd01563
Aligned: 39 rows
Threshold Bit Score: 302.59
Threshold Setting Gi: 29829733
Created: 1-Aug-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:2D1F_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #                       
1E5X_A      108 WSKKEWVLPeid-ddDIVSAFEGNSNLFWAerfgkqflgxnDLWVKHCGISHTGSFKDLGXTVLVSQVNRLrkxkrpvVG 186 thale cress
2D1F_A       16 IAAYRDRLPvgd-dwTPVTLLEGGTPLIAAtnlsk--qtgcTIHLKVEGLNPTGSFKDRGMTMAVTDALAHg-----qRA 87  Mycobacterium tu...
NP_109409    61 LWRFAHMLPct--eaEAVSLGEGLTPLLAApriga-flgvpNLAIKDEGRNPTWSHKDRFSTIAVSVARARg-----aKI 132 Mesorhizobium lo...
NP_279584    59 LWRYAELLPft--rgSAVSMDEGATALVPCpglad-elgvgELYIKDEGRNPTGTFRDRGQTVAMTAAAQHg-----aSE 130 Halobacterium sp...
NP_280770    49 LWAFSEFLPva--adDAVSLGEGWTPLVSAse--------wDAEFKLDYVCPSGSYKDRGAAVLMTRAAALg-----vDR 113 Halobacterium sp...
NP_578909    43 WERFSEFFPle--ldPELSLGEGDTPLTRAkklsk--elgiELYLKNETINPTWSFKDRGTYLGIHRAIQLd-----fRR 113 Pyrococcus furio...
NP_771417   125 MWRYRELLPvrk-ckDIVSLGEVTTPLIRLpklgk-klgggEIIVKDEGRLPTGSFKARGLVMAVSMGKALg-----iKH 197 Bradyrhizobium j...
NP_781250    52 LERYQDFFPfde-inNELSLNEGFTSLVSSprmak-rigikNIYFKNESQNPTWSFKDRGTLFGIHHAYSMg-----yKK 124 Clostridium teta...
NP_824367    53 LWRYAECLPla---aPTTSLGEGRTPLVSLt---------dGVAAKLDFLMPTLSFKDRGAVLLAELALQLr-----pRQ 115 Streptomyces ave...
ZP_00135386  48 LFRYRKFIAlqdeswRDISLGEGMTPIVRFd---------eNVLLKMDYFMPTLSFKDRGAAVLISHCKSIg-----vDS 113 Actinobacillus p...
Feature 1                                                                                       
1E5X_A      187 VGCAStGDTSAALSAYCASAgIPSIVFLPankisxAQLVQPIANGAFVLSIDTDFDgCXKLIREITAEl---pIYLAns- 262 thale cress
2D1F_A       88 VLCAStGNTSASAAAYAARAgITCAVLIPqgkiamGKLAQAVMHGAKIIQIDGNFDdCLELARKMAADfp--tISLVns- 164 Mycobacterium tu...
NP_109409   133 VATASsGNAGASLAAYAARAgLKCVVTTFags-agAMLAQIRKYGATVLPLVSKMDrWSLLEQAAARYd---wFIASpyh 208 Mesorhizobium lo...
NP_279584   131 VALAStGNAGQSAGAYAGRAgLDAHVFLPsrs-gfTTKAMVNVHGGDMNVVQGRIGdANAAFEDAMDEhgeawYSLQaf- 208 Halobacterium sp...
NP_280770   114 VVEDSsGNAGAAVAQYAARAgIDAEIYVPada-paAKLDAMEAAGATTVPVAGGRRaVTEACVSEAVGsd--aWYASha- 189 Halobacterium sp...
NP_578909   114 IGTVStGNMAASVAAYGAHSeLEVYILVSsti-peEKIKALAPYGAKIVKVHGDYGeLYYRALEIGQKk---gIYFIns- 188 Pyrococcus furio...
NP_771417   198 MAMPTnGNAGAALAAYATSCgIKTTIFCPadt-peVNVSEIELQGATVYRVNGYIDdCGKIVGEGNAKvg--wFDTStl- 273 Bradyrhizobium j...
NP_781250   125 VGAVStGNMAVSVAAYGQRAgFETFIFVGeni-peEKLNPVAIYGANLIKVEGDYGkLYYESLEIGKDq---gIYFIns- 199 Clostridium teta...
NP_824367   116 VVADSsGNAGTAIAAYCARAaLPCTVYVPegt-saKKLEQIEAHGARLRVVEGDREaTAHAAREAADEag--vFYAShv- 191 Streptomyces ave...
ZP_00135386 114 VVQDSgGNAGNSVAAYCAKAgIQCEIFVPegt-spKKINMIEAHGAKANVIKGSRDhCADVCRAKVENeg--vYYANhv- 189 Actinobacillus p...
Feature 1                                                                                       
1E5X_A      263 -----lnSLRLEGQKTAAIEILQQFdwqVPDWVIVPGGNLGNIYAFYKGFKXCQELGLVDr-IPRXVCAQAANANPLylh 336 thale cress
2D1F_A      165 -----vnPVRIEGQKTAAFEIVDVLg-tAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDk-LPRMLGTQAAGAAPLvlg 237 Mycobacterium tu...
NP_109409   209 gpvvgshPLGIEGYKTIAYEIVEQSdgtAPDWCVLPVCYGDALSGVWAGFCELFAQGSITr-LPRLVAAEVHGSLADala 287 Mesorhizobium lo...
NP_279584   209 -----atPYRHEGKKTLLYETVEQLdweTPDHVVYPTGDGGGLVGMWKAATELRELGITAd-VPAMYAAQAEGCAPIvra 282 Halobacterium sp...
NP_280770   190 -----wsPSFYAGTATVAYEIAAQRgwrAPDAVVVPVGHGTLLLGAYRGFRALAAGGWIEs-MPRLLGVQAAGVEPVaaa 263 Halobacterium sp...
NP_578909   189 -----ddPFRVEGYKSISFEISEEI---TPDYVIVPTSSGGLFRGIVKGFLEAKNSGLIEk-LPRFFVVQAEGCSPIcka 259 Pyrococcus furio...
NP_771417   274 -----kePYRIEGKKTMGLELAEQLgwdVPDVIFYPTGGGTGLIGMWKAFDELEKIGFIGskRPRMVAVQASGCAPMvra 348 Bradyrhizobium j...
NP_781250   200 -----dvTYRVEGYKTAAFEMCEQLnfnVPDYVVVPTSAGGNIRGILKGFKEFKEAGIIDr-VPKMICAQASGCSPIcns 273 Clostridium teta...
NP_824367   192 -----fnPYFLHGTKTYVHELWEDLggrLPDALVVPVGNGTLLLGAALAVAELHAAGLIDr-RPALYAVQAAAVAPLaha 265 Streptomyces ave...
ZP_00135386 190 -----ynPFFYEGTKTYIYETFEQLg-rIPKHIVVPVGNGTLFIGVIKGLEHLLESGVIDe-MPTIIALQSEYCDPLlqa 262 Actinobacillus p...
Feature 1                                                                                       
1E5X_A      337 yksg-wkdfkpXTASTTFASAIQIGDPVSIDRAVYALKKCnGIVEEATEEELXDAXAQADST-GXFICPHTGVALTALFK 414 thale cress
2D1F_A      238 ---------epVSHPETIATAIRIGSPASWTSAVEAQQQSkGRFLAASDEEILAAYHLVARVeGVFVEPASAASIAGLLK 308 Mycobacterium tu...
NP_109409   288 sg----adavsERQMLFDSLAVSIGTPRSTFQALKALRESgGHAVPVSNHGLIAMQERLARDeGIFAELASVTPLIAISK 363 Mesorhizobium lo...
NP_279584   283 fqeg-rdahepWDTPDTICGGIEIPDPAGSRLVLEALRESnGGAVAASDEEILEAGTAVASRaGPEMGATCAAAAAGAWE 361 Halobacterium sp...
NP_280770   264 vn----gsasdEDAVNEAADGIQIRSPARLDQVAAAVAATdGDVVACDESATTDALASLHEA-GLYVEPTSAVAVAGLAA 338 Halobacterium sp...
NP_578909   260 fnag-kekierFENPHTIAHAIENPYPPSGNAVLRLLKKLnGICTTVTDEEILEAQKILGRE-GIFVQLASATGIAAVKK 337 Pyrococcus furio...
NP_771417   349 fdag-tehatrWEDAHTIASGIRVPQAIGDFLILRAVRESkGFAIAVDDDKISAALNEVAREeGLLLCPEGAATYAAYKE 427 Bradyrhizobium j...
NP_781250   274 fkeg-kdeierIMDPCTIAHGIENPFPPSGNDTLRKIRENgGTCVAVTDEEIIKAQKEMAKE-GIFVQPESCVPLASVKK 351 Clostridium teta...
NP_824367   266 weqgaddlvgvTPAAPTFAEGIAIPRPPRARQILRAVRESgGAFLTVTEDQIRHAQSDLASR-GLYVESTGVACWAAVRA 344 Streptomyces ave...
ZP_00135386 263 vkkg-qkfaeqVEIKPTIAEGIAIGQPMRASEILAYAEKYaIRFVHAPEDKILAARNALAKK-GIYCEHTTAANYAAYLH 340 Actinobacillus p...
Feature 1                                   
1E5X_A      415 LRnqgv----iaptDRTVVVSTAHGLKF 438 thale cress
2D1F_A      309 AIddgw----vargSTVVCTVTGNGLKD 332 Mycobacterium tuberculosis
NP_109409   364 LRdqgi----iatpDRVVAVVTASGLKD 387 Mesorhizobium loti MAFF303099
NP_279584   362 LAdrda----fgedDTVVVVSTGTANKA 385 Halobacterium sp. NRC-1
NP_280770   339 YRargv----vgdsDDVVVALTGSGLKK 362 Halobacterium sp. NRC-1
NP_578909   338 LRrkgi----ikegAIVVSILTGSGLKT 361 Pyrococcus furiosus DSM 3638
NP_771417   428 SLadgr----vsktDRVMLFNCATGLKY 451 Bradyrhizobium japonicum USDA 110
NP_781250   352 LKiegy----ldenDSVACVLTGSGLKY 375 Clostridium tetani E88
NP_824367   345 GAlpqprprpgegmPAAVVPLCGAGLKT 372 Streptomyces avermitilis MA-4680
ZP_00135386 341 YCely------gavEDCLITICGAGLKS 362 Actinobacillus pleuropneumoniae serovar 1 str. 4074

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap