1TDJ,1V71,1VE5,2GN0


Conserved Protein Domain Family
Thr-dehyd

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cd01562: Thr-dehyd 
Click on image for an interactive view with Cn3D
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Statistics
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PSSM-Id: 107205
View PSSM: cd01562
Aligned: 74 rows
Threshold Bit Score: 277.446
Threshold Setting Gi: 27376524
Created: 1-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1TDJ_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                     #                               
1TDJ_A     17 LRAVLRAPVYea--aqVTPLQKMEKLssrl-dnvILVKREDRQPvHSFKLRGAYAMMAGLTeeq---kahGVITASAGNH 90  Escherichia coli K12
NP_249542   5 LAALQQAAAIvhqslpPTPQIRWPLLceal-gceVWMKHENHLPvGAFKLRGGLVYFHHLAhqge--rpaAVISATRGNH 81  Pseudomonas aerugi...
NP_493968  41 FGDISMAHHRiqngivRTDCRKSRCLsklf-dmnIYLKMEVNQDtGSFKERGARYALQNLPeek---kkaGVYAASAGNH 116 nematode
NP_519069  16 LRRLRAAAAVvnavipPTPQYCWPLLsqal-gaaVWVKHENHTEvGAFKVRGGLNYLHALRrrdp--elrGVIAATRGNH 92  Ralstonia solanace...
NP_600205   4 LNDVITAQQRtaphvrRTPLFEADPIdg----tqIWIKAEFLQKcGVFKTRGAFNRQLAASenglldptvGIVAASGGNA 79  Corynebacterium gl...
NP_631347   4 ITEIEAAAERiaghvvRTPTVPSPGLsall-gvpVTAKLELLQRtGSFKARGATAKLLSLTeae---raaGVVAVSGGNH 79  Streptomyces coeli...
NP_649886  61 FHDVTSAAFLirggveRTPCPKSTSSdly--gmeLYLKKDFLQYtGSFKERGARYALLSLTeeq---krtGVISASLGNH 135 fruit fly
BAC53614   12 LSAIAGLRARlkqwvrTTPVFDKTDFepvp-gtaVNFKLELLQAsGTFKARGAFSNLLALDddq---raaGVTCVSAGNH 87  Ralstonia pickettii
NP_768053  21 RERIAATEVVirphirRTPLVMADLAdfglpaapITFKLEMLQHsGSFKARGAFANLLLRPvp-----eaGVVAASGGNH 95  Bradyrhizobium jap...
CAG10171  126 FEDISAAAFRiqtgiqKTPCTYSRLSkqy--gmeIYLKKEQLHYtGSVKERGVLYLLTCLTqeq---qrkGVIVSTDCNF 200 Tetraodon nigrovir...
Feature 1                                                                                     
1TDJ_A     91 AQGVAFSSArlGVKALIVMPtatadIKVDAVRGFGGEVLLHganfdeAKAKAIELSQqqgFTWVPpfdhPMVIAGQGTLA 170 Escherichia coli K12
NP_249542  82 GQSVAFSASryGIQPIIVVPhgnsrEKNAAMRSLGAELIEHgedfqaSREYAAERARr-eGLHLIpafhPWLVAGVASYS 160 Pseudomonas aerugi...
NP_493968 117 ALALSLHGKqlGVEVNVVMPkiaplMKINRCQDLGANILVQgediaeSREIALRMAHdsnGTYINgydhYDILAGAGTTG 196 nematode
NP_519069  93 GQSIALAARkqGMSATIVVPhgnsvEKNAAMRALGAELVEAgedfqaSREAAARQAAe-rGLHLVpafhEDLVAGVASYW 171 Ralstonia solanace...
NP_600205  80 GLANAFAAAslSVPATVLVPetapqVKVDRLKQYGATVQQIgseyaeAFEAAQTFESetgALFCHaydqPDIAAGAGVIG 159 Corynebacterium gl...
NP_631347  80 GIAVAVMAAalDVKATVVMPrtapaRSVEIAEEAGALVRLTdgm-dsAFALVTRLREe-gLTLVHpfddPVVVAGQGTVG 157 Streptomyces coeli...
NP_649886 136 AQALCYHGWklNIPVTVVMPkaapiMKIQKCRNYKARVIVDgndmgeAKSLAMRMSReegLLYVNgydhPHIMAGQGTIG 215 fruit fly
BAC53614   88 AVGVAYAAMrlGIPAKVVMIktaspARVALCRQYGAEVVLAeng-qtAFDTVHRIESeegRFFVHpfngYRTVLGTATLG 166 Ralstonia pickettii
NP_768053  96 GAAVAYAAQrlGIPATIFVPditspAKAERIKGNGAKLVIAgsryadALAASEAHVArtgAMAVHaydqAETLLGQGSVA 175 Bradyrhizobium jap...
CAG10171  201 SMAVAHHAVelKIPVFAIMPsscssPRLRIYRDYGAMVISYgstghdSRNHARHLAKengYLYLEedesEAYLAGLGTVG 280 Tetraodon nigrovir...
Feature 1                                                                                     
1TDJ_A    171 LELLQQDah-lDRVFVPVGGGGLAAGVAVLIKQlmpQIKVIAVEAeDSACLKAALDAGHPVDlprv---glfAEGVAVKR 246 Escherichia coli K12
NP_249542 161 LELFAALad-lDEVYVPIGMGSGICGLIAARDAlglKTRIVGVVSaHAPAYALSFEAGTAIShpvd---trlADGMACST 236 Pseudomonas aerugi...
NP_493968 197 IEILEQIqm-pDAILVPVGGGGLVAGVATAVKAlspTTEVIGVVSeTCQAIVKSLQAGHPVYtptr---ptlADGLAVPN 272 nematode
NP_519069 172 LEFFEEAap-lDVVYVPIGMGSGICAAAAARDAfrlSTRIIGVVSaHARCYDYSFNCGAPISapvs---tqlADGLACRT 247 Ralstonia solanace...
NP_600205 160 LEIVEDLpd-vDTIVVAVGGGGLYAGIAAVVAAh--DIKVVAVEPsKIPTLHNSLIAGQPVDvnvs---giaADSLGARQ 233 Corynebacterium gl...
NP_631347 158 LEFAEDAsd-lTDVLVSIGGGGLIAGVAAALRAlrpGVRVWGVETeGAEAMSRALAAGGPLTvpl----ssvVTTLSAPS 232 Streptomyces coeli...
NP_649886 216 LEILEQVpe-pDAVVVPVGGGGLIAGIATAVKAlspKTKIIGVESeKCASFTRAMENDGPIHtpik---ntlADGLAVPK 291 fruit fly
BAC53614  167 HEWLEQAga-lDAVIVPIGGGGLMAGVSTAVKLlapQCQVIGVEPeGADAMHRSFETGGPVKmgsm---qsiADSLMAPH 242 Ralstonia pickettii
NP_768053 176 LELEQDApg-iDTLLVAVGGGGLIGGIAAWYAG---RTRVVAIEPeQSPTLHAAIAAGAPVDapag---glaADSLAPRR 248 Bradyrhizobium jap...
CAG10171  281 MEIFEQVpkvdAVVLPAAGQYGLLAGTAAAIKHlnsQITVIGVEPeGFPLLLQSLKTDSPVKdvhsnpnkqlYGDLMERS 360 Tetraodon nigrovir...
Feature 1                                                                               
1TDJ_A    247 IGDETFRLCqeyldDIITVDsDAICAAMKDLFEDvRAVAEPSGALALAGMKKYIalhnirgeRLAHILSGANVN 320 Escherichia coli K12
NP_249542 237 PDPSALEMIlagadRLVRVSdREIGAAMRLCFTStHNVAEGAGVAALAAAWQERerl--kglKVGLILSGANVD 308 Pseudomonas aeruginosa PAO1
NP_493968 273 AGVNAFASMigkvdRVISVPeNDIAVAILRLIENeKVVCEGAGAIGIGAILSGKlnhl-kgkTVVSILSGGNID 345 nematode
NP_519069 248 PDATALEVIragvdEIVTVTdDEVAEAIRLYFSTtHNIAEGAAAAALAAAWQQRdql--aglRVGLPLTGGNID 319 Ralstonia solanacearum G...
NP_600205 234 IGREAFDIAtahppIGVLVDdEAIIAARRHLWDNyRIPAEHGAAAALASLTSGAykpa-adeKVAVIVCGANTD 306 Corynebacterium glutamic...
NP_631347 233 VSRLTYDHVaelvtEVLVVPdREAVRGSLALAEHaKVWTEPAAGCLLPAARRVVervg-dgaRIGLVVCGGNAT 305 Streptomyces coelicolor ...
NP_649886 292 VGYNAYATAmplidRMVVVKeEWIAVAILRLVEEeKCVVEGAGGAGLAAILAGHldel-kgkKVVVLLCGGNID 364 fruit fly
BAC53614  243 TEQYSYELCrrnvdRLVKVSdDELRAAMRLLFDQlKLATEPACATATAALVGGLkael-agkRVGVLLCGTNTD 315 Ralstonia pickettii
NP_768053 249 VGELMFPIAqahveRVVLVSdEAIRQAQAALWSSlRLVAEPGGAAAFAALLSGRyrps-pgeRVAVLLCGANTT 321 Bradyrhizobium japonicum...
CAG10171  361 LGVNVFQLTkklvdKVISVSeEDSLVAMLRFQEFeRSTVDTEGAMGLAAILAGQlpel-kgrKVVVVVSSANME 433 Tetraodon nigroviridis

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