1JBQ,1D6S,1O58,1OAS,1VE1,1WKV,2BHS,2EGU,2ISQ,2Q3B,3BM5


Conserved Protein Domain Family
CBS_like

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cd01561: CBS_like 
Click on image for an interactive view with Cn3D
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Statistics
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PSSM-Id: 107204
View PSSM: cd01561
Aligned: 90 rows
Threshold Bit Score: 231.249
Threshold Setting Gi: 71041836
Created: 1-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1JBQ_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #                                          
1JBQ_A    107 GDTPMVRInkigkk---fglkceLLAKCEFFNAgGSVKDRISLRMIEDAERDgtlk-pgdtIIEPTsGNTGIGLALAAAv 182 human
CAD31609    4 DRTPLPFSqysaaya--lpriirCGSNLYLAQF-AFMKLLPAKYIIGQAVARgtlt-hdtiVLETSsGTFALGLAVVCRe 79  Mesorhizobium loti
NP_625288   1 MIHPHIADalkvp------dlvrLNDDLVLIRF-ESMKIYSALAAVRHLLERgtir-pgqtLIDSSsGIYAYALALACHr 72  Streptomyces coeli...
CAD30138   12 GNTPLVQLqldss------argnVFAKLEMLNP-FGMKDRAAKKVILEAKKNgvlk-dgapIIESSsGTMALGLAMVGTy 83  Bacillus thuringie...
NP_738028  43 GNTPLVRLdrltr-----drdftLWAKLEYFNPgGSAKDRTAQAMVTAGTLKpg-----dmVVESSsGNLGIALAREAVl 112 Corynebacterium ef...
NP_792757   9 GYQSLGDIvhdqtflevtgvgpdFFLKMESLNPaGSIKLKTAVGLVNDVQARgllg-pqttLIESSsGNLGVALAMICAe 87  Pseudomonas syring...
NP_824825  14 GNTPLVELerllp-----dfgsrVFGKIERFNPgGSIKDRSALGMLLAGIRSgevqpgrtvIIESSsGNLAVGLAQICRy 88  Streptomyces averm...
NP_828338  10 FNEEELYVdlrsi------fghsLFLKCEGFNFaGSIKLKAATEMVEAAERDgvlt-pesiLVESSsGNLGVALSMIAAs 82  Streptomyces averm...
NP_866067  24 GGTPLVRLnrfld-----rpdieLIVKWEAANPgGSAKDRPAAKMLSEALKRgeig-pettIVESTsGNMGIGLAQVCRy 97  Pirellula sp. 1
AAP92492    5 PVTPVRTVrteia-----giprtITLKLEGHSPwRSVKGRTALSLIRSVAGDltap--datVVESTsGNLGLALSAICRd 77  Streptomyces vinaceus
Feature 1                                                                                     
1JBQ_A    183 rGYRCIIVMPEkmSSEKVDVLRALGAEIVRTptnarf--dspesHVGVAWRLKNeipnSHILDQYRNASNPLAHYdTTAD 260 human
CAD31609   80 yGFSLEIFTDPvmDKGLENRLRSLGAEVFIItekakeggyqrsrLDAMHARMRQlgesHFWPRQYETPDNPAAYR-CFAD 158 Mesorhizobium loti
NP_625288  73 yGMRCHVVASTtvDTTTRAQLEILGATVEQVrpsrnl-kldqelRVRRVREILAdhpdWHWMRQYHDDVHYLGYQ-EVAD 150 Streptomyces coeli...
CAD30138   84 lGHPVHIVTDKrtDQMTLAKLKSLGCKLEIVtemthl--gwqsaRLDRLEEILKenkeAFCPRQYENSDNPNAYE-SLAD 160 Bacillus thuringie...
NP_738028 113 gDWTFHCVVDPraNRSTVKHMQALGAVVHQItepdeetgdwlvaRRKRVAQLLQeipeAICLDQYSNTEAFRAHQeGTMA 192 Corynebacterium ef...
NP_792757  88 rGIPFTCVVDPnsSSHNIRMMRSYGAQVIQVeipdan-ggflgtRIALIREKVAsdprYVWLNQYENAANPRAHArTTAH 166 Pseudomonas syring...
NP_824825  89 fGLRFICVVDGktTEQNLAILSAFRAEVEVVterdeltgeflpvRLRRVRELVAatpdAYWPNQYASLLNPKAHE-TTMR 167 Streptomyces averm...
NP_828338  83 kGYRFLCVTDSrgNLSTRMMMEALGSEVHMIagqean-ggflgaRIAYVRALCAsddrYVWLSQYTNPSNWKAHYrKTAP 161 Streptomyces averm...
NP_866067  98 hGLKFICVVDPraQKQNLSIIEALGGTIELVtqplkg--dflaaRIAKVCELIEttpnSYWPNQYANTDNPRSHFkGTIR 175 Pirellula sp. 1
AAP92492   78 lGLRFIAVVDHrqSPVIQQAIEANGGELDWVrtpdda-tthlqdRLARVRELERdlphAVWPNQYENDANWRIHEtWTAP 156 Streptomyces vinaceus
Feature 1                                                                                     
1JBQ_A    261 EILQQCdgkLDMLVASVGTGGTITGIARKLKEkcpgCRIIGVDPegsilaepeelnqteqtTYEVEGIGydfIPTVLDrt 340 human
CAD31609  159 QISELLg-aDVTLVGSVGSGGSTCGTIERLRQkalgARLIGVDTfnsvif------gqldgERKLRGLGnslVPKNVKhe 231 Mesorhizobium loti
NP_625288 151 RITTAFpstPLTVVGGVGSGASTGGLVERLRAtdpsVRLVGVQPfgsvtfg---sqahhdpEAIIAGIGssiVFDNVRhh 227 Streptomyces coeli...
CAD30138  161 EALEELg-hIDILVASVGSGGSLCGTARALKKanpdLRVVAVDAvgsvif-----nqpdipGRLQGGHGnsvIPKNVDfs 234 Bacillus thuringie...
NP_738028 193 EIVQQLghaPDHLLVAVSTTGTIGGCLRHIEAhhlpTQVTAVDAmgsvlf------dgnpgPRHLPGFGagmVPELSRqi 266 Corynebacterium ef...
NP_792757 167 SISRHFg-hVDYLFVGAGTTGTLMGCLQHFQRhhptTKIIAVDSvgsvtf------gtpasRRFIPGLGtsqRPPIFNgd 239 Pseudomonas syring...
NP_824825 168 EIEESLdgaVDFLFCSVSTFGTLRGCRDHIRArgldTTIVAVDAlgsaif------glestQRLIPGHGasvVPPLMDas 241 Streptomyces averm...
NP_828338 162 EIARQFp-rLDVLFVGAGTTGTLMGCARYFREwhrpVRIVAVDSvgsvsf------ggppgRRMIPGLGmsmRPPLLDes 234 Streptomyces averm...
NP_866067 176 EIDETLngeFDVLFVATSSTGTAQGCRDFLKSrgrdVQVVAVDSvgsvlf------ggssgPRKIPGLGagkEPRLAAgq 249 Pirellula sp. 1
AAP92492  157 EFDAQVthrAQALFAGVSTGGTLAGLSRHFRRtrpgLRIVAVDVrgstvf------ggvprPRTLTGIGagrRSAFLTra 230 Streptomyces vinaceus
Feature 1                                                                       
1JBQ_A    341 vvDKWFKSNDEEAFTFARMLIAQeGLLCGGSAGSTVAVAVKAAqelq-egqRCVVILPDSVRNYMT 405 human
CAD31609  232 lyDEVHFTSASLAFAATQALHERhAIFAGPTSGASYIVGRWRArqh--peeTVVVICPDEGHRYAE 295 Mesorhizobium loti
NP_625288 228 lyDAVHWLDFTHAMSGTIALLRErAVFAGLSTGAGYLAATYEArrh--pdrLHLVIGADTGHRYVE 291 Streptomyces coelicolor A3(2)
CAD30138  235 iiDEVHWLNDEECYAANLELAKCeKLFAGNSSAASYAVSRFLSsrcs-eetNILTIFPDRGDRYYK 299 Bacillus thuringiensis serovar i...
NP_738028 267 tpHRVLRVADRESVEGARTLVRKeTILPGASGGAVIAAVDKLKdvfe-sgsDVVVILHDSGTRYMD 331 Corynebacterium efficiens YS-314
NP_792757 240 giHALEMVPEANAVAMCRILARSkGMLVGGSTATVIAAVHAWRerie-pgsVVVALSPDWGERYLD 304 Pseudomonas syringae pv. tomato ...
NP_824825 242 aaDEVVHISDLECVVACRRLIGReAVLAGGSSGATVAALWKIRhrip-egsNCVLIFPDGGDRYLD 306 Streptomyces avermitilis MA-4680
NP_828338 235 yvDEVIRVEEADTIRTCHRLARR-GFLFGGSTGTVVSGATDWLaghdarelTAVAVGPDLGERYLD 299 Streptomyces avermitilis MA-4680
NP_866067 250 sfDHLVRVSDLECVVGCRRAAQReAMLIGGSAGGVLMSVGRMQeqf--agkRCVAVLHDSGTRYLE 313 Pirellula sp. 1
AAP92492  231 stDDVLLVDERQAVACCHTLRADtGTAVGGSSGAVLAGCLEYLyrhp-evrHALCLCPDLGDHYGP 295 Streptomyces vinaceus

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