1ET0


Conserved Protein Domain Family
ADCL_like
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cd01559: ADCL_like 
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ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Links
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Statistics
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PSSM-Id: 238800
Aligned: 15 rows
Threshold Bit Score: 219.488
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Citation:PMID 7748903
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1ET0_A       16 DRATQFGDGCFTTArvidGKVS-LLSAHIQRLQDACQRLmis--cdfWPQLEQEMKTLAAEQq-----NGVLKVVISRGS 87  Escherichia coli
Q56693       16 DRSFQYGDGCFSTIktkkGQLE-HWQAHVERMEACLTTLqip--fpdWRTVLDWAMSATLKDe-----SAGIKIHISRGC 87  Vibrio harveyi
Q9KQI0       16 DRSFQYGDGCFTTIltkeGQVQ-QWSSHKARLQACLDILhip--epnWDRVWQGLQSMILPQe-----KAGLKIHISRGL 87  Vibrio cholerae
ZP_00129535  39 DHLAHRGDGVFESMkf-eGRRLyQLDAHLERMERSARGIyltp-pctQSVLRDIVLQVARAAdt---pDGCIRILLGRGP 113 Desulfovibrio de...
NP_215327    21 DLAAVRGDGVFETLlvrdGRAC-LVEAHLQRLTQSARLMdlp--epdLPRWRRAVEVATQRWvastadEGALRLIYSRGR 97  Mycobacterium tu...
ZP_00066492  21 NRGMAFGDGVFETMrltqGHIP-LLDLHKARLHVGIKTLglnyseaaLNKHLAQLFSIINDSni---aSGRVKLIVARGQ 96  Microbulbifer de...
BAB17203     22 DHMVHRGHGVFDTAmildGHLY-ELDPHLDRFLRSAAKArigt-pfpRDTLRSILVQMTAASnc---rRGSIRYWLSAGG 96  Japanese rice
P28821       20 DHGFLYGIGVFETFrlyeGCPF-LLDWHIERLERALKDLqiey-tvsKHEILEMLDKLLKLNdik-dgNARVRLNISAGI 96  Bacillus subtilis
NP_279464    21 DRGFQYGDAAFETMraygGQTF-AWTAHYRRLQATCDSLgidh-glsEAALRGRVHETLAANdl---aDAYVRLSITRGV 95  Halobacterium sp...
NP_625824    21 DHGLTVGDGIFETVkavdGRPF-ALTRHLDRLTRSARGLglp--apdHDEVRRACAAVLEANpm---pLGRLRVTYTGGH 94  Streptomyces coe...

Feature 1                                                                               #       
1ET0_A       88 GGRgys----------tlNSGPATRILSVtaypahy--drlrneGITLALSpvrlg--------rnphLAGIKHLNRLEQ 147 Escherichia coli
Q56693       88 GGRgys----------psGVEGPVVTISNfsfpahy--lawqerGVQLGVCetrlg--------iqplLAGHKHNNRIEQ 147 Vibrio harveyi
Q9KQI0       88 GGRgysptqvsesivtisAFAFPAHYQAWrd------------kGLAVGICqqrmg--------lnplLAGHKHNNRLEQ 147 Vibrio cholerae
ZP_00129535 114 GGFgid----------paECPVPSLYVVAysltpkp--eewyekGVTAFRTsipa---------kqgyLATIKNANYIPN 172 Desulfovibrio de...
NP_215327    98 EGGsapt-------ayvmVSPVPARVIGArr------------dGVSAITLdrglpadg--gdampwlIASAKTLSYAVN 156 Mycobacterium tu...
ZP_00066492  97 GGQggqgg-----qggqgVNPSPDAGVDVsillyasqlaawvqpAVALKTSrvqlp--------hnvnLAGIKHLNRLDY 163 Microbulbifer de...
BAB17203     97 GDFlls----------saGCAGPAFYAVViptdy-----sqcrhGVRAVTTsvpm---------kpplFATMKNVNYLPN 152 Japanese rice
P28821       97 SDKgfv----------aqTYDKPTVLCFVnqlkpe---slplqkEGKVLSIrrnt----------pegSFRLKSHHYLNN 153 Bacillus subtilis
NP_279464    96 QDGrlt----------prDTTDPTVVVVVdalpr------ggvdGDPVWSMpatvetttvtqhrdttiPSTAKTHNYLPG 159 Halobacterium sp...
NP_625824    95 GPLgs-----------drGEHGPTLVVALgetg-------rrpdSTAVITVpwtrn--------ergaLTGLKTTSYAEN 148 Streptomyces coe...

Feature 1                                                                                       
1ET0_A      148 VLIRSHLeqtnaDEALVLDSEGWVTECCAANLFWRKG-------NVVYTPRLDqagVNGIMR-------QFCIRLLAQss 213 Escherichia coli
Q56693      148 VLAKAEIdgtefADAVTLNVQNHVIETTMANLFWVKD-------EKVFTPGLClsgVAGVMR-------RKVLEYLQSeg 213 Vibrio harveyi
Q9KQI0      148 ILLKREMdnagwDDGVCLDINGKVIETTAANIFWCRD-------GTMFTPCLRhagVAGVAR-------RQILELAQQqe 213 Vibrio cholerae
ZP_00129535 173 VLMKLEArsrgcDIPVSFDENDFIAEGPTENLCLVDAd------GTLVVPEFTn-aLSGTTI-------MRVIDLVRDe- 237 Desulfovibrio de...
NP_215327   157 MAVLRHAarqgaGDVIFVSTDGYVLEGPRSTVVIATDgdqgggnPCLLTPPPWypiLRGTTQ-------QALFEVARAkg 229 Mycobacterium tu...
ZP_00066492 164 VLAAQAAmpaenEQVLLLDVANNLIETVHHNVFFIRG-------SEVITPSLArcgVNGVFKq------WLVNSVIPKag 230 Microbulbifer de...
BAB17203    153 VLSIMDAedrgaFASVWVDGEGNVAEGPMVNVAFVTAa------GELVLPAFDk-iLAGCTAkrllalaPRLVESGLLk- 224 Japanese rice
P28821      154 MYAKREIgndprVEGIFLTEDGAVAEGIISNVFWRKG-------RCIYTPSLDtgiLDGVTR-------RFIIENAKDig 219 Bacillus subtilis
NP_279464   160 VLARRDIaa-daDEALFVTPDGHLTEGAASNLFFVAD-------GTLYTPSGDldvLPGITR-------WAVAELAAEhg 224 Halobacterium sp...
NP_625824   149 VVALARArergaTEALFGNTVGRLCEGTGSNVFVVLD-------GEIHTPPVAsgcLAGITR-------ALAAEWTGAr- 213 Streptomyces coe...

Feature 1                                                                    
1ET0_A      214 ---yQLVEVQASLEESlqa--deMVICNALmpVMPVCACgd----vSFSSATLYEYLAPLC 265 Escherichia coli
Q56693      214 ---ySVQVADFTLTDLlda--deVWMCNSLlgVAPVSGIsapenkiDFPIGKLTRRLQGNL 269 Vibrio harveyi
Q9KQI0      214 ---iPIVIDEFTLEDLlsa--eeVFITNALleVAPVTQIgq----qRLTIGSMTRRFQESS 265 Vibrio cholerae
ZP_00129535 238 ---mNVAFRKVREDELyra-aevMVLGTTTe-CVSVVSFegq-pvgGGRPGPVARRFRELL 292 Desulfovibrio desulfuricans G20
NP_215327   230 ---yDCDYRALRVADLfds--qgIWLVSSMtlAARVHTLdg----rRLPRTPIAEVFAELV 281 Mycobacterium tuberculosis H37Rv
ZP_00066492 231 ---lQLVEREISRVDAeac--daCFITNAYsgLTPVTAIng----hLFNSCEKLNAITGEI 282 Microbulbifer degradans 2-40
BAB17203    225 ----AVTTRHIAADEAkrcsaemAFVGSGLp-VLPIVEWddq-ligDGKVGKTMMALSDLL 279 Japanese rice
P28821      220 --leLKTGRYELEALLta---deAWMTNSVleIIPFTKIeev--nyGSQSGEATSALQLLY 273 Bacillus subtilis
NP_279464   225 ltvhTGAYTPSRLYDAd-----eAFLTNTTweVRPIARVdd----aTYDTCRIGAALASAY 276 Halobacterium sp. NRC-1
NP_625824   214 ----ETDLPLDVLGRAd-----eVFLTSTLrdVQAVHRIddr--elPGAPGPVTAKAMRIF 263 Streptomyces coelicolor A3(2)

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