1QMH,1G6S,1UAE


Conserved Protein Domain Family
EPT_RTPC-like

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cd01553: EPT_RTPC-like 
Click on image for an interactive view with Cn3D
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.
Statistics
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PSSM-Id: 238794
Aligned: 4 rows
Threshold Bit Score: 179.398
Created: 6-Jul-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:The putative location of the active sites of RTPC and EPT are in the same pocket
  • Structure:1QMH_B: Escherichia coli Rna 3'-Terminal Phosphate Cyclase charged pocket believed to be the active site of RNA cyclase activity
  • Structure:1G6S_A: Escherichia coli EPSP Synthase contacts with substrates shikimate-3-phosphate and glyphosate
  • Citation:PMID 1939260

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1QMH_B      8 LDGAqge------------------------------------------------------------------------- 14  Escherichia coli
1G6S_A     16 INLPgsksvsnralllaalahgktvltnlldsddvrhmlnaltalgvsytlsadrtrceiignggplhaegalelflgna 95  Escherichia coli
1UAE       16 VTISgaknaalpilfaallaeepveiqnvpklkdvdtsmkllsqlgakverngsvhidardvnvfcapydlvktmrasiw 95  Escherichia coli
Q09870      3 TGQLkrf------------------------------------------------------------------------- 9   fission yeast
Feature 1                                                                                     
1QMH_B        --------------------------------------------------------------------------------     Escherichia coli
1G6S_A     96 gtamrplaaalclgsndivltgeprmkerpighlvdalrlggakityleqenypplrlqggftggnvdvdgsvssqflta 175 Escherichia coli
1UAE       96 algplvarfgqgqvslpggctigarpvdlhi-----------sgleqlgatikleegyvkasvdgrlkgahivmdkvsvg 164 Escherichia coli
Q09870        --------------------------------------------------------------------------------     fission yeast
Feature 1                                                                            #        
1QMH_B     15 -----------------------------------------------------------------gggQILRSALSLSMI 29  Escherichia coli
1G6S_A    176 llmtaplapedtvirikgdlvskpyiditlnlmktfgveienqhyqqfvvkggqsyqspgtylvegdaSSASYFLAAAAI 255 Escherichia coli
1UAE      165 atvtimcaatlaegttiienaarepeivdtanflitlgakisgqgtdriviegverlgggvyrvlpdrIETGTFLVAAAI 244 Escherichia coli
Q09870     10 -----------------------------------------------------------------kgcEYLTHRLVLATL 24  fission yeast
Feature 1                                                                                 #   
1QMH_B     30 TgqPFTITSIragrakpgllrqhltAVKAATEIcGATVEgaelgsqRLLFRPgt--vrGGDYRFAigsagsctLVLQTVL 107 Escherichia coli
1G6S_A    256 KggTVKVTGIgrnsm-----qgdirFADVLEKM-GATICwg---ddYISCTRge--lnAIDMDMNhi-----pDAAMTIA 319 Escherichia coli
1UAE      245 SrgKIICRNAqpdt--------ldaVLAKLRDA-GADIEvg---edWISLDMhgkrpkAVNVRTAphpa-fptDMQAQFT 311 Escherichia coli
Q09870     25 SgtPIRVEGIypdeadpgvkdyqvsFLRLLEKLtNGSVIeisytgtSFIYRPgn--iiGGRVVHDcpttkgigYFLEPIL 102 fission yeast
Feature 1                                                                                     
1QMH_B    108 PALWFadgpSRVEvsggtdnpsappadfirRVLEPLLAKIGIHQQTTLlrhgfypagggvvATEVSPvasFNTLQLgerg 187 Escherichia coli
1G6S_A    320 TAALFakgtTTLRniynwrv----ketdrlFAMATELRKVGAEVEEGHd------------YIRITPpekLNFAEIaty- 382 Escherichia coli
1UAE      312 LLNLVaegtGFITetvf----------enrFMHVPELSRMGAHAEIESn------------TVICHGvekLSGAQVmat- 368 Escherichia coli
Q09870    103 ILCLFaktpTSLTltgvtssnedigvdvlrTSVLPSLQKRFQVGDELElrilkrgsapgggGEVNFLcpvIKESLPpirl 182 fission yeast
Feature 1                                                                                     
1QMH_B    188 nivqmrgevllagvprhvaereiatlagsfslheqnihnlprdqgpgn------------tvsleveseniterffvvge 255 Escherichia coli
1G6S_A        --------------------------------------------------------------------------------     Escherichia coli
1UAE          --------------------------------------------------------------------------------     Escherichia coli
Q09870    183 sefgrvfrirgiasstrvspafanrlvesargvlnpfipdvfiytdvrrgdecgnspgysitlvaetnkgcsyaaehcge 262 fission yeast
Feature 1                                    #                          #              
1QMH_B    256 krvsaevvaaqlvkevkrylastaavgeylaDQLVLPMAla-----gAGEFTVAHPSCHLL--TNIAVV-ERF 320 Escherichia coli
1G6S_A    383 ----------------------------ndhRMAMCFSLvals-dtpVTILDPKCTAKTFP--DYFEQL-ARI 423 Escherichia coli
1UAE      369 -----------------------------dlRASASLVLagciaegtTVVDRIYHIDRGYE--RIEDKL-RAL 409 Escherichia coli
Q09870    263 agetpedvgsfcakklleviesggcvdpytqPSTLTGMLls----seDVNTIVVGQLGITSqlVVFLRDvKAL 331 fission yeast

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