1NI9


Conserved Protein Domain Family
FBPase_glpX

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cd01516: FBPase_glpX 
Click on image for an interactive view with Cn3D
Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core structure around the active site is well preserved. In E. coli, FBPase II is part of the glp regulon, which mediates growth on glycerol or sn-glycerol 3-phosphate as the sole carbon source.
Statistics
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PSSM-Id: 238774
Aligned: 23 rows
Threshold Bit Score: 373.861
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:by similarity to inositol monophosphatase
  • Citation:PMID 1332026

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #                       ##                       
1NI9_A        4 RRELAIEFSRVTESAALAGYKWLGRGDKNTADGAAVNAMRIMLNQVNIDGTI-VIGEGEIDEAp-mLYIGEKVGTGRg-- 79  Escherichia coli
CAB39821     23 DRNLAMELVRVTEAGAMAAGRWVGRGNKEGGDGAAVDTIRELVNTVSMRGVV-VIGEGEKDHAp-mLYNGEEVGNGDg-- 98  Mycobacterium le...
ZP_00019436   2 ERNLGMDLVRATEAAALRSGRWMGRGDKNSADQAAVDAMRMALNSVPMNGIV-VIGEGEKDEAp-mLYIGERVGNGEg-- 77  Chloroflexus aur...
ZP_00053394   6 KTVGAYELRRATEAAARAAYAWIGRGDKALADDAAVAAMQTELDGLDLNGLM-LIGEGPKDEIg-mLYHGQRFGAATae- 82  Magnetospirillum...
ZP_00055376  12 DRNLALEVVRVTEASALAAARQTGRGDERAADEAACSAMRHALNGLSMDGVI-VNGEGDDSTQp--LHTGEKVGNGKg-- 86  Magnetospirillum...
NP_698276    13 DRILTLELVRVAERAAVAAARLRGRGDEMAADQAAVDAMRQELNRLPITGTV-VIGEGERDEAp-mLYIGEEVGTKQg-- 88  Brucella suis 1330
NP_966451     2 MEDLAYKLVKVTEAAALAAYKLAGFGDEKKADQVAVDAMRTVLNSMEINGTI-VIGEGERDEAp-mLYIGEKVGTGNg-- 77  Wolbachia endosy...
ZP_00186344   2 VGAGALEYAAVTERVALRVARLEGSGDAGKAYALAAKTFREELRGMPVAGRVaLLREHHVDEQgrsRPLKEEAGTLRagd 81  Rubrobacter xyla...
ZP_00191650  15 DRNLGLDLMRATEAAAMAAGQWAGRGEKNSGDAAAVDAMREVLAGVSMRGRI-VIGEGEKDEAp-mLHNGELVGDGSg-- 90  Kineococcus radi...
ZP_00270023   6 DRNLALDVARVTEAAAIAAARYMGRGDERAADLAATAAMREALTTVPMAGTI-TLGALADPDDg-lFRLGEGVGNGTg-- 81  Rhodospirillum r...
Feature 1                    #####                                                              
1NI9_A       80 ------dAVDIAVDPIEGTRMTAMGQANALAVLAVGDKGCFLNAPD-MYMEKLIVGPG-AKGTIDLNLPLADNLRNVAAA 151 Escherichia coli
CAB39821     99 ------pDCDFAVDPIDGTTLMSKGMPNAISVLAVADRGAMFDPSAvFYMNKITVGPD-AAHVLDITAPIGENIRAVAKV 171 Mycobacterium le...
ZP_00019436  78 ------eEIDVAVDPVEGTTLLAEGMPGAIAIVAVAERHSFYNWRGiPYMDKLAVGER-AKGVIDINAPVAYNIRAVART 150 Chloroflexus aur...
ZP_00053394  83 ------pAWDLVVDPLEGTSFLAKGMTNAMAVVAMAPHGTLFDPAPaRYMEKLAAPPA-AKGKIDPKAPVAERLAQLSAA 155 Magnetospirillum...
ZP_00055376  87 ------pKVDIVLTALEGRSICARGAHNALSVVAMTEEGSFLKVPQhSYMEKIVVGAGmPSSIIDLDSTPEENLSRIAKA 160 Magnetospirillum...
NP_698276    89 ------pAVDIALDPLEGTTICAKNLPNSLAVIAIAEKGNLLYAPD-VYMEKIAVGPGyPKGVVDLDATPTDNIMSIAKA 161 Brucella suis 1330
NP_966451    78 ------pEIDIAVDPLEGTTICAHYKSGAMSVLAATKKGNFLHAPD-VYMEKIAVGKNlPEGVVSLKNSIEKNLDNLAKA 150 Wolbachia endosy...
ZP_00186344  82 vvgsgrvRVDLAVEPVEGLSLLVKGQEGAISAIAAAPEGTMLRMPD-MYMSKLIVGPR-ARGHIDIDAPAAENVEAIAAA 159 Rubrobacter xyla...
ZP_00191650  91 ------pQIDIAVDPVDGTTLLASGMPNAIAVIAASDRGSMYDPRDvFYMHKLVVGPA-AAGRVDIDAPVADTIATVAKA 163 Kineococcus radi...
ZP_00270023  82 ------lLIDVGVTPLEGATICAMGAPNATACMALARKGELLAVPP-VYMEKIAVGPGvPEGCLSLDADPAENIRALAKV 154 Rhodospirillum r...
Feature 1                                             #                         #               
1NI9_A      152 LGKPLSELTVTILAKPRHDAVIAEMQQLGVRVFAIPDGDVAASILTCMp-dSEVDVLYGIGGAPEGVVSAAVIRALDGDM 230 Escherichia coli
CAB39821    172 KDLSVRDMTVCILDRPRHAQLIDDVRATGARIRLITDGDVAGAISACRp-qSGTDMLAGIGGTPEGIIAAAAIRCMGGAI 250 Mycobacterium le...
ZP_00019436 151 LNKQVEDVTVVVLDRPRHKDLIRQIREIGARIKLIPHGDVSAGIMTSIe-nPPADILMGIGGAPEAVLTAAALKCLGGEI 229 Chloroflexus aur...
ZP_00053394 156 LNKPIEDITVYVIEKPRHKALVNAIHNAGARVALYPAGDVAGALMAAIp-gSGIDALMGTGGTPEGLLSAMAIRAMGGEF 234 Magnetospirillum...
ZP_00055376 161 KGVTLSELTVSVLDRPRHGELIERLYAAGVRVMLFDDGDVSGALAAGLp-dSGVDVYMGSGGAAQGVLAAAGLKCLGAQM 239 Magnetospirillum...
NP_698276   162 KGVKPNEITACIMDRPRHARLIEEVRATGAAIRLIGDGDVAGVMHTTDpdeTGIDIYIGIGGAPEGVLAAAALRCIGGQM 241 Brucella suis 1330
NP_966451   151 KKCKVNDLVVTVLKRERHNELIEKIRKLGAKIKLIDDGDVAAVVSLIN---GNHDMYIGIGGAPEGVLAAAALSSIGGQM 227 Wolbachia endosy...
ZP_00186344 160 LGRRASEITVVVLDRDRHRELIEEIRRTGARIHMRPEGDLTPSIAVGLr-dSDVHAVIGIGGAPEGVLAAAVVKCLGGEI 238 Rubrobacter xyla...
ZP_00191650 164 KAVGGADITVAILDRPRHAGLISAVRQAGARIKLFSDGDVAASIAAASp-gSSIDILLGIGGTPEGIITACAMKAMGGQI 242 Kineococcus radi...
ZP_00270023 155 RGVPAEALLICVLDRPRNEALVDRVRSTGARITLISDGDVSGAVAVGLp-eTGVDMYMGSGGAAEGVLAAAGLRCLGGVL 233 Rhodospirillum r...
Feature 1                                                                                       
1NI9_A      231 NGRLLARHDVkgdneenrrigeqELARCKAMGI-EAGKVLRLGDMARSDnVIFSATGITKGDLLEGISRkg-niATTETL 308 Escherichia coli
CAB39821    251 QAQLAPRDDV-------------ERRKALDAGY-NLDRILTTEDLVSGEnVFFCATGVTDGDLLKGVRYya-ggCTTQSI 315 Mycobacterium le...
ZP_00019436 230 QCKVWPRNDE-------------ERARLAELGL-DPKQVLTTRDLVRGEnVVVAATGITSGEFLRGVEYfg-ggARTHSV 294 Chloroflexus aur...
ZP_00053394 235 LGRIDPQLAT-------------EAAAVEEAGM-DLNHWYQLDEMVRSDkVVFCATGITTGLLLDGVERtr-dqEKTQTL 299 Magnetospirillum...
ZP_00055376 240 QCRLLCRSDQ-------------DHAAARRVGIaDTRRKWNIEDMVRGE-VMFAATGITDGHVLKGARLapnnrAESHSL 305 Magnetospirillum...
NP_698276   242 QGRLQLNTEE-------------KVARAAKMGIsDPKKIYTLEEMAKGD-VLFAATGVTDGNMLSGVKFar-dyIQTHTI 306 Brucella suis 1330
NP_966451   228 EGRLIFDTDQ-------------LKERAKNLNIhDPEKIYTVKDMARGE-SVFIATGVTSGELVDGVDNi----CSTSSL 289 Wolbachia endosy...
ZP_00186344 239 QARMWPVNRS-------------QVERLREYGLaDPERKLTTDDLISGDdVVFAATGLTSGETLAGVRYfr-ggARTHTV 304 Rubrobacter xyla...
ZP_00191650 243 QARLHAGDDD-------------ARRRALEAGH-DLHRILHTDDLVAGDnTFFVATGITDGDLLAGVHYvp-ggARTRSL 307 Kineococcus radi...
ZP_00270023 234 QGRLMVRGDS-------------EKAAVRAAGItDPDRILTMADMVPGE-TMFAATGVTDGALLRGVRLha-gsARSSTL 298 Rhodospirillum r...
Feature 1                        
1NI9_A      309 LIRGk-sRTIRRIQSIH 324 Escherichia coli
CAB39821    316 VMRSk-sGTVRMIEAYH 331 Mycobacterium leprae
ZP_00019436 295 VMRSr-sGTVRYIEATH 310 Chloroflexus aurantiacus
ZP_00053394 300 MIGGa-aGPRQMLTSWH 315 Magnetospirillum magnetotacticum
ZP_00055376 306 VMRSv-tGTIRYLSVQH 321 Magnetospirillum magnetotacticum
NP_698276   307 VMRSs-sQTVREIKARH 322 Brucella suis 1330
NP_966451   290 IILPnklIKLQTMQNLC 306 Wolbachia endosymbiont of Drosophila melanogaster
ZP_00186344 305 VMSTr-pRMIRFIDTIH 320 Rubrobacter xylanophilus DSM 9941
ZP_00191650 308 VMRSr-sGTVRSVTSDH 323 Kineococcus radiotolerans SRS30216
ZP_00270023 299 VMRSr-tGTLRFIDTRH 314 Rhodospirillum rubrum

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