Conserved Protein Domain Family
Apg7
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cd01486: Apg7 
Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an important step in autophagy. Autophagy is a dynamic membrane phenomenon for bulk protein degradation in the lysosome/vacuole.
Links
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Statistics
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PSSM-Id: 238763
Aligned: 11 rows
Threshold Bit Score: 476.865
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative ATP
Feature 1:putative ATP binding site [chemical binding site]
Evidence:
  • Comment:binding site is based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          # # #                   # #        #               #                       
P38862    326 KVLLLGAGTLGCYVSRALIAWGVRKITFVDNGTVSYSNPVRQALYNFED---CGKPKAELAAASLKRIFPLMDATGVKLS 402 baker's yeast
NP_611350 341 KCLLFGAGTLGCAVARNLLSWGFKHITLLDSGKVGFSNPVRQNLYTHADavaGNRMKATTAAQRLKEINPSAETAGYVLE 420 fruit fly
NP_596084 337 KCLLLGAGTLGCGVARNLLSWGVRHVTFVDYSTVSYSNPVRQSLFTFEDc-kRKLPKAECAAQRLKEIYPNMFSTGYNIS 415 fission yeast
NP_502064 326 KVLILGAGTLGCNIARCLIGWGVRHISFLDNSTVSYNNPVRQSLSEFEDa-rLGRGKAETAQAAIQRIFPSIQATAHRLT 404 nematode
EAK87707  252 KFLIVGSGTLGCSVARNLIGWGIRNFKFIDHSKVSLNNPMRQCLFTLEDv-kNKKNKAIAAVERLRYVCPDIHAEGIDFE 330 Cryptosporidium pa...
AAO39077  363 SCLLLGSGTLGCNVARSLMSWGVRNITFVDSSKVSYSNPVRQSLFTFADcspKAKEKSIAAADALKKIFPAINANAHVFS 442 Dictyostelium disc...
CAD70899  365 KCLLLGAGTLGSYVSRNLLGWGVRKITFIDYGSVSYSNPVRQPLFKFEDchnGGKPKAIQAAEALKEIYPGVDVEGYALS 444 Neurospora crassa
NP_917670 465 RCLLLGAGTLGCDVARILMDCGVRKLTVVDSGRVVVSNLARQSLYTSDD---RDSPKASAILGRLKERCPSVDAKGIKME 541 Japanese rice
NP_568652 359 KCLLLGAGTLGCQVARTLMGWGIRNITFVDYGKVAMSNPVRQSLYNFEDclgRGEFKAVAAVKSLKQIFPAMETSGVVMA 438 thale cress
T34556    179 KCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDclgGGKPKALAAADRLQKIFPGVNARGFNMS 258 human
EAK86180  406 RCLLLGAGTLGCYVARSLLGWGIRQITLVDSAKVSFSNPVRQPLFDFEDcleGGQPKAECAARRLKRIYPGIDAQGISLS 485 Ustilago maydis 521

Feature 1                                             #  #                                    
P38862    403 IPMIGHKLVNEea----qhKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNi--------ENKTVINAALGFDSYLVM 470 baker's yeast
NP_611350 421 IPMPGHTIGESlla--qtkEHLKVIEKLVQDHDVIFLLTDSRESRWLPTLLGAa--------KEKIVINAALGFDSYLVM 490 fruit fly
NP_596084 416 IPMLGHPIYEAgie--ktmHDYETLENLISTHDAIFLLTDTRESRWLPTVISTa--------MDKLLINSALGFDSWLVM 485 fission yeast
NP_502064 405 VPMPGHSIDEKdvp--eleKDIAKLEQLVKDHDVVFLALDSREARWLPTVLASr--------HKKIAISVAIGFDTYVII 474 nematode
EAK87707  331 IPILGDSTLSLeq----flKSVNETKDNIIDSDVVMLLTDNKESRWLPTVLIGlinryynrrRPILCITVGLGFDSFIVV 406 Cryptosporidium pa...
AAO39077  443 IPMPGHSVPQSeyq--sirNTIELLENLIKQHDVIYLLTDSRESRWLPTMLSRa--------HGKLCINAALGFDSYLVI 512 Dictyostelium disc...
CAD70899  445 VPMLDHAIHNEak----tkADFDKLKELIDSHDAIFLLMDTRESRWLPTLMGKa--------ANKIVMNAALGFDTYVVM 512 Neurospora crassa
NP_917670 542 IPMPGHPVSPNeav--svlEDCKRLQELVSSHDAVFLLTDTRESRWLPTLLCAn--------ENKIAITAALGYDSYLVM 611 Japanese rice
NP_568652 439 IPMPGHPISSQeed--svlGDCKRLSELIESHDAVFLLTDTRESRWLPSLLCAn--------ANKIAINAALGFDSYMVM 508 thale cress
T34556    259 IPMPGHPVNFSsvtleqarRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAAs--------KRKLVINAALGFDTFVVM 330 human
EAK86180  486 IPMPGHPVAPIaep--qvrEDVGRLEKLVDEHDVIYLLMDSRESRWLPTLLGAa--------KSKLVINAALGFDSYLVM 555 Ustilago maydis 521

Feature 1                                                                                     
P38862    471 RHGNrdeq---------------------------sskQLGCYFCHD-VVAPTDSLTDRTLDQMCTVTRPGVAMMASSLA 522 baker's yeast
NP_611350 491 RHGTtrkeagddgqe-------------ieglkcingdQLGCYFCND-VTAPGNSLKDRTLDQQCTVTRPGVSNIAASYA 556 fruit fly
NP_596084 486 RHGSvlq----------------------------kenRLGCYFCND-IFAPSNSLVDRTLDQTCTVTRSGCANIATAIA 536 fission yeast
NP_502064 475 RHGIgsrsesvsdv---------------sssdsvpysQLSCYFCSD-VTAPGNSTFDRTLDQQCTVARPGTSMIASGIA 538 nematode
EAK87707  407 RNTFtet----------------------------dysSSGCYFCGDfSINSKNNTLDIPVDQQCSVVRMGASYFASSIA 458 Cryptosporidium pa...
AAO39077  513 RHGIkdqcqnelnps-------------issklgyqgsDLGCYFCND-VIAPTDTLKDRTLDQMCTVTRPGLSMMASSIA 578 Dictyostelium disc...
CAD70899  513 RHGAapnd--------------------------gseeTLGCYFCND-VVVAADSMKDQTLDQQCTVTRPGVAAIASALL 565 Neurospora crassa
NP_917670 612 RHGAgpgtncgspdvvaa-------adtlsaedvlgrqRLGCYFCND-VVAPVDSVSNRTLDQQCTVTRPGLSSITSGCA 683 Japanese rice
NP_568652 509 RHGAgptslsddmq--------------nldinktntqRLGCYFCND-VVAPQDSMTDRTLDQQCTVTRPGLAPIAGALA 573 thale cress
T34556    331 RHGLkkpkqqgagdlcpnhpvasadllgsslfanipgyKLGCYFCND-VVAPGDSTRDRTLDQQCTVSRPGLAVIAGALA 409 human
EAK86180  556 RHGAppqsaesvtgvapda----skaskgkdakqswhgRLGCYFCND-VVAPSDSLTDRTLDQMCTVTRPGLAAIAGASA 630 Ustilago maydis 521

Feature 1                                                                                     
P38862    523 VELMTSLLQTKysgs---------------------ettVLGDIPHQIRGFLHNFSilkletpaYEHCPACSPKVIEAFT 581 baker's yeast
NP_611350 557 VELLVALLQHPrkelapayyaqsgr-grseeteekvpegLLGILPHSIRGMLCNYEnilpatqkFAQCIACSAAVLNEYK 635 fruit fly
NP_596084 537 VELFVSLLQHPnghaapv---------------lnedqtVLGELPHQIRGFLHNFSlmkisgmaYPQCSACSECIINEWN 601 fission yeast
NP_502064 539 VELLSSVLQYPdplktpa--------------shddnttVLGAAPHQIRGFLGRFQqilpsvkrFDQCVACGDAIAAQFQ 604 nematode
EAK87707  459 VELIMNLSQHPltwnaphlsn--------esnksdenksLLGTTPQCIRGFLADFSfctdpiqrNKCCIACSDKLIDKIH 530 Cryptosporidium pa...
AAO39077  579 VELLISTIHHPyggrakgete---------tdvyvqgstPLGIIPHQLRGFISHYQtlplfsnpYKHCTACSDYIIDEYN 649 Dictyostelium disc...
CAD70899  566 VELLTSILQHPlkqhapapvstgt--gsavsyerdppdhPLGLVPHQVRGFLSNFQnmvirgksYPQCSACSKPILDAYK 643 Neurospora crassa
NP_917670 684 ADLFTRMLHHPdgihapge------------iagtssegPLGLLPHQIRGSLSQYNlltllgysSSNCTACSNAVLSEYH 751 Japanese rice
NP_568652 574 VELLVGVLQHPlginakgdnss-------lsntgnnddsPLGILPHQIRGSVSQFSqitllgqaSNSCTACSETVISEYR 646 thale cress
T34556    410 VELMVSVLQHPeggyaiasss---------ddrmnepptSLGLVPHQIRGFLSRFDnvlpvslaFDKCTACSSKVLDQYE 480 human
EAK86180  631 VELMVSVLQHElglhapatageslrqgiedaqaiadattVLGIVPHQLRGFLAQFNtlrvvgqaYDRCTGCSAAVVDAYR 710 Ustilago maydis 521

Feature 1                             
P38862    582 DLGWEFVKKALEHPl-YLEEISGL 604 baker's yeast
NP_611350 636 KEGHAFLFKTFETAk-FLEDLTGI 658 fruit fly
NP_596084 602 REKWMFVLRAINEPd-YVEELCGL 624 fission yeast
NP_502064 605 QNGWKFVRDVMNSPg-RLEEVTGL 627 nematode
EAK87707  531 KDEVNTLSEIFINPr-KVESISGL 553 Cryptosporidium parvum
AAO39077  650 SKGFDFIINVMNDSs-CLTKICGI 672 Dictyostelium discoideum
CAD70899  644 EGGWEFVKTALASRd-YVAELSGL 666 Neurospora crassa
NP_917670 752 RRGMDFVMQVINEPt-YLEDLTGL 774 Japanese rice
NP_568652 647 ERGNSFILEAINHPt-YLEDLTGL 669 thale cress
T34556    481 REGFNFLAKVFNSShsFLEDLTGL 504 human
EAK86180  711 TEGFEMILRAMNEDk-YLEHLTGL 733 Ustilago maydis 521

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