Conserved Protein Domain Family
vWA_collagen
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cd01472: vWA_collagen 
von Willebrand factor (vWF) type A domain; equivalent to the I-domain of integrins. This domain has a variety of functions including: intermolecular adhesion, cell migration, signalling, transcription, and DNA repair. In integrins these domains form heterodimers while in vWF it forms homodimers and multimers. There are different interaction surfaces of this domain as seen by its complexes with collagen with either integrin or human vWFA. In integrins collagen binding occurs via the metal ion-dependent adhesion site (MIDAS) and involves three surface loops located on the upper surface of the molecule. In human vWFA, collagen binding is thought to occur on the bottom of the molecule and does not involve the vestigial MIDAS motif.
Links
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Statistics
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PSSM-Id: 238749
Aligned: 39 rows
Threshold Bit Score: 140.826
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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integrin-coll..metalputative
Feature 1:integrin-collagen binding site
Evidence:
  • Comment:three loops on the upper surface of integrin that coordinate the metal through MIDAS residues also engage collagen
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ### #                                                                  
Q02388      37 ADIVFLLDGSSSIGr------sNFREVRSFLEGLVLPFsg-----------aASAQGVRFATVQYS--DDPRTEFGLDa- 96   human
Q02788     624 LDVVFVIDSSESIGy------tNFTLEKNFVINVVNRLgaia-------kdpKSETGTRVGVVQYS--HEGTFEAIRLdd 688  house mouse
P12110     614 LDVVFVIDSSESIGy------tNFTLEKNFVINVVNRLgaia-------kdpKSETGTRVGVVQYS--HEGTFEAIQLdd 678  human
P20785     823 ADIMLLVDSSTSVGs------kNFDTTKNFVKRLAERFlea---------skPAEDSVRVSVVQYSgrNQQKVEVPFQ-- 885  chicken
P12109      36 VDLFFVLDTSESVAlrlkpygaLVDKVKSFTKRFIDNLrdry-------yrcDRNLVWNAGALHYS--DEVEIIQGLTrm 106  human
P12109     828 ADITILLDGSASVGs------hNFDTTKRFAKRLAERFlta--------grtDPAHDVRVAVVQYSgtGQQRPERASLqf 893  human
Q04857     825 ADITILLDSSASVGs------hNFETTKVFAKRLAERFlsa--------graDPSQDVRVAVVQYS--GQGQQQPGRAal 888  house mouse
AAH47255    64 VDIFFVLDTSESVAl-------RVKPFKTLVTQVKEFTkkfidkltsryyrcDRNLVWNAGALHYS--DEVILINSLT-- 132  African clawed frog
Q04857      35 VDLFFVLDTSESVAl-------RLKPYGALVDKVKSFTkrfidnlrdryyrcDRNLVWNAGALHYS--DEVEIIRGLTrm 105  house mouse
AAH47255   848 ADITMLVDSSTRVGn------qHFQTSKSFVKLLAERFlka---------kpPPSGSARVSVVQYSgqNQQIVEAQFL-- 910  African clawed frog

Feature 1                            #                                                         
Q02388      97 --lGSGGDVIRAIRELSYKGGNTRTGAAILHVADHVFlpqlARPGVPKVCILITDG------KSQDLVDTAAQRLKg--- 165  human
Q02788     689 ervNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIke-sRRQKTRVFAVVITDGrh---dPRDDDLNLRALCDRdvtv 764  house mouse
P12110     679 ehiDSLSSFKEAVKNLEWIAGGTWTPSALKFAYDRLIke-sRRQKTRVFAVVITDGrh---dPRDDDLNLRALCDRdvtv 754  human
P20785     886 ---RNYTVIAKAVDNMEFMNEATDVNAALQYIMGLYQr--sSRSGAKKKVLVFSDGns---qGITARAIERTVQEVq--- 954  chicken
P12109     107 --pGGRDALKSSVDAVKYFGKGTYTDCAIKKGLEQLLvg-gSHLKENKYLIVVTDGhplegyKEPCGGLEDAVNEAk--- 180  human
P12109     894 --lQNYTALASAVDAMDFINDATDVNDALGYVTRFYRe--aSSGAAKKRLLLFSDGns---qGATPAAIEKAVQEAq--- 963  human
Q04857     889 qflQNYTVLASSVDSMDFINDATDVNDALSYVTRFYRe--aSSGATKKRVLLFSDGns---qGATAEAIEKAVQEAq--- 960  house mouse
AAH47255   133 ---RDMKTLRDNVETVEYIGKGTHTDCAIKRGIEEVLig-gSHQKENKYLIVVTDGhplegyKEPCGGLEDAANEAk--- 205  African clawed frog
Q04857     106 --pSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLig-gSHLKENKYLIVVTDGhplegyKEPCGGLEDAVNEAk--- 179  house mouse
AAH47255   911 ---TNYTVLEVPVDNMQFINGATNVVSALRAVTELYRe--dSLAGVNKKLLVFSDGn-----TQEEKGLLKVVQDAq--- 977  African clawed frog

Feature 1                                               
Q02388     166 --QGVKLFAVGIKna-dPEELKRVAsqpt--sdfFFFVNDF 201  human
Q02788     765 taIGIGDMFHETHe---SENLYSIAcdkpqqvrnMTLFSDL 802  house mouse
P12110     755 taIGIGDMFHEKHe---SENLYSIAcdkpqqvrnMTLFSDL 792  human
P20785     955 -qAGIEVYVLAVGsq-vNEPNVRVLvtgk-stnyDVAYGER 992  chicken
P12109     181 -hLGVKVFSVAITpdhlEPRLSIIAtdh----tyRRNFTAA 216  human
P12109     964 -rAGIEIFVVVVGrq-vNEPHIRVLvtgk-taeyDVPYGES 1001 human
Q04857     961 -rAGIEIFVVVVGpq-vNEPHIRVLvtgk-taeyDVAFGER 998  house mouse
AAH47255   206 -hLGIKVFSVAISpnhlEPRLSVIAsda----shRRNFTAT 241  African clawed frog
Q04857     180 -hLGIKVFSVAITpdhlEPRLSIIAtdh----tyRRNFTAA 215  house mouse
AAH47255   978 -sAGIEIYVLAVGsr-lNYPNLQVMltgs-aadiAGPFPEE 1015 African clawed frog

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