Conserved Protein Domain Family
vWA_VGCC_like

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cd01463: vWA_VGCC_like 
VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at its N-terminus the VWA and cache domains, The alpha 2 delta gene family has orthologues in D. melanogaster and C. elegans but none have been detected in aither A. thaliana or yeast. The exact biochemical function of the VWA domain is not known but the alpha 2 delta complex has been shown to regulate various functional properties of the channel complex.
Statistics
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PSSM-Id: 238740
Aligned: 8 rows
Threshold Bit Score: 250.389
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
metal
Feature 1:metal ion-dependent adhesion site (MIDAS)
Evidence:
  • Comment:divalent cations are bound by the MIDAS motif

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          # # #                                                       
P13806     241 RRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDV-SCFQHLVQANVR---- 315  rabbit
NP_033915  242 RNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVePCLNGTLVQADRt--- 318  house mouse
T18770     301 RFRPWFVNAESVPKDIVFLLDYSGSVKGPTMHLIKITMMYILSTLSPNDYFFGVYFNNHFNPIiSCANRTFMPATTs--- 377  Caenorhabditis e...
NP_610902  253 RLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVvPCFEDTLIQANLg--- 329  fruit fly
NP_609762  141 RTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPvPCFKDRMVRATPd--- 217  fruit fly
NP_723955  222 RKRSWYIETATCSKDIVILLDHSGSMTGFRHHVAKFTIRSILDTFSNNDFFTILRYSSEVNDIiPCFNGALVQATPeni- 300  fruit fly
P34374     236 RNTEWYINSATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTFSKNTFLLdGCNGTNGLLQATm--- 312  Caenorhabditis e...
XP_318596  207 RKRSWYIETATCSKDIVILLDNSGSMTGYRNYIAQLTVKSILDTFSNNDFINIYKYSNDVEPLvPCFKVGLKILDEkcne 286  Anopheles gambia...
Feature 1                           #                                                          
P13806     316 ----NKKVLKDavnniTAKGITDYKKGFSFAFEQLL-------------------------------------------- 347  rabbit
NP_033915  319 ----NKEHFREhldklFAKGIGMLDIALNEAFNILSd------------------------------------------- 351  house mouse
T18770     378 ----NKKVFFEelgmlEEKDQAHFATPLKFSLDVLRgnld---------------------------------------- 413  Caenorhabditis e...
NP_610902  330 ----NIRELKEgielfRPKSIANYTAALTKAFELLEe------------------------------------------- 362  fruit fly
NP_609762  218 ----NIQEIKSavkaiKLQDTANFTAGLEYAFSLLHk------------------------------------------- 250  fruit fly
NP_723955  301 -evfNQQIEQLd----DPEGYANLTLAYETAFQLLRkyy----------------------------------------- 334  fruit fly
P34374     313 ---rNKKALRRkmdtyQSEGKAEYEKALPLAFSVLLdlkgsyalytkeemsmmsanatneyqfhlelpehvlaatkqyid 389  Caenorhabditis e...
XP_318596  287 rvrfNNTSLLQd---mLVQATPENMRFFNEYVRELLpegyanvkkafva------------------------afellqk 339  Anopheles gambia...
Feature 1                            #                                                         
P13806     348 -----NYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKk--------VRVFTFSVGQHNydRGPIQWMACENKGYYYE 414  rabbit
NP_033915  352 ----fNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDr-------kVRIFTYLIGREAafADNLKWMACANKGFFTQ 420  house mouse
T18770     414 -snqsLFADYRSEGHKLLIIFTDGVDEWPHQILDEEFQTRnse---lirIFGFSMGYGTSL--LPLQQYMACKSHGGYSE 487  Caenorhabditis e...
NP_610902  363 ----tKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDppy----kpVRVFTYLIGKEVanWDDIRWMACENQGYYVH 434  fruit fly
NP_609762  251 ----yNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHm-------pVRIFTYLIGSDSgsRSNLHDMACSNKGFFVQ 319  fruit fly
NP_723955  335 ---dsRHCVTNSTCNQAIMLVTDGVAGNTTEVFQKYNWGNgengtsqmdTRVFTYLLGKEVtkVREIQWMACLNRGYYSH 411  fruit fly
P34374     390 sinngGGDNNRGACENVIMLITDGAPNAYKKIFDMYNADKk--------VRVFTFLVGDEAidFNEVREMACNNRGYMVH 461  Caenorhabditis e...
XP_318596  340 yreirRCNESVSGCNQAIMLITDGVPSNITEVFEAYNWFEngt---kipVRVFTYLLGREVtkVREIQWMACLNRGYYSH 416  Anopheles gambia...
Feature 1           
P13806     415 IPSIG 419  rabbit
NP_033915  421 ISTLA 425  house mouse
T18770     488 IDSIM 492  Caenorhabditis elegans
NP_610902  435 LSDTA 439  fruit fly
NP_609762  320 INDYD 324  fruit fly
NP_723955  412 VQTLD 416  fruit fly
P34374     462 VANMA 466  Caenorhabditis elegans
XP_318596  417 IQSLD 421  Anopheles gambiae str. PEST

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