1JEY,1JEQ,1JEY


Conserved Protein Domain Family
vWA_ku
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cd01458: vWA_ku 
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Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or non-homologues end joining and facilitate repair by the non-homologous end-joining pathway (NHEJ). The Ku heterodimer is required for accurate process that tends to preserve the sequence at the junction. Ku78 is found in all three kingdoms of life. However, only the eukaryotic proteins have a vWA domain fused to them at their N-termini. The vWA domain is not involved in DNA binding but may very likey mediate Ku78's interactions with other proteins. Members of this subgroup lack the conserved MIDAS motif.
Links
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Statistics
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PSSM-Id: 238735
Aligned: 20 rows
Threshold Bit Score: 149.051
Created: 1-Nov-2000
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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interface
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:interface residues
Evidence:
  • Comment:VWA domain makes very few contacts at the interface
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                      #  # #         
1JEY_A     35 RDSLIFLVDASKAMF------ESQSEde------------------lTPFDMSIQCIQSVYISK-IISSDRDLLAVVFYG 89  human
1JEY_B      7 KAAVVLCMDVGFTMS------NSIPGi-------------------eSPFEQAKKVITMFVQRQ-VFAENKDEIALVLFG 60  human
CAC86194   47 FDVVLCLVDFQQRMFqgvvahDCKNPfaggaeqvydditevkvketpTVFEKAICCVQQLYKDK-GISDSNDMVALVLYN 125 Trypanosoma brucei
XP_312232  40 RSGLILTVDCASYMF------EREGGes------------------eSRFVEVLHIIEAMMRNK-VVTNETDLVGVVFYN 94  Anopheles gambiae ...
BAA76954    6 KSAVVLCMDVGLAMS------HSNQGk-------------------eSPFEQAKKVMMLFLQRQ-VFAESKDEIAVVLYG 59  African clawed frog
AAG44852   28 KEFVVYLIDASPKMFc----sTCPSEeed---------------kqeSHFHIAVSCIAQSLKAH-IINRSNDEIAICFFN 87  thale cress
CAC05245    4 KECTVFVLDLGKDMG------TCHHGrs------------------hSDLEWTLSYFHDELSHKfLANRKTDVVGIVGYK 59  fission yeast
EAA27151    4 KEATVYVIDLGESMA------DCHNGrn------------------eSDLEFGMRYIWDKITTTvAASRKTWNVGVVGLN 59  Neurospora crassa
Q23976      6 PENDVDLLSGSEDEEd-----VSMKRdyhgreailfvvdanlqtagvERLLEALNIIRTAFISG-LLVNDKDLIGLIFAN 79  fruit fly
NP_499438  18 KKYTFFIIDGNPAMFe-----TSKAGe-------------------pPEFKLALKLILDEIVRVcCSRSLNNHIGVIVTS 73  Caenorhabditis ele...

Feature 1                                    # #                                              
1JEY_A     90 TEKDKns----------vnFKNIYVLQELDNPGAK--RILELDQFkgqqgqkrf-------qdmmghgsdYSLSEVLWVC 150 human
1JEY_B     61 TDGTDnpls------ggdqYQNITVHRHLMLPDFD--LLEDIESKiqpg------------------sqqADFLDALIVS 114 human
CAC86194  126 TRECThp-----------dYPGVYVFHTFCSAEIQ--SVLDLEELvaagrvpsagyenivtkighsteakSHLGDALRAA 192 Trypanosoma brucei
XP_312232  95 TKHNPapeteeelqpglvaPRQCAIYLPLGATSVE--MIRKVRGMresddlfgf-------dakyghaqgTSMSNVLWLC 165 Anopheles gambiae ...
BAA76954   60 TDTTDnala------redqYENISVHRHLMLPDFD--LLEQIENVvepg------------------svqADFLDALIVS 113 African clawed frog
AAG44852   88 TREKKnl----------qdLNGVYVFNVPERDSIDrpTARLIKEFdlieesfdkeig--sqtgivsdsreNSLYSALWVA 155 thale cress
CAC05245   60 CDDTKndla------eqeaYWNISVLYPIQTALFS--KLQSVSQTlkps-----------------ntmqGDLISAIVVS 114 fission yeast
EAA27151   60 TDETNnnenr----eeyqgYENISVLQELGPMTMA--SLRALKSKieps-----------------stssADAISAIVVA 116 Neurospora crassa
Q23976     80 TKHSPppleasa-ldnivmPDNCAVFLPLRQLTKP--IVEHYLEFmggvetqfad-----vyglaepdgrGRFDLMIRLC 151 fruit fly
NP_499438  74 TKNSEte-----------gLENSTLLVPMGVLGQE--EVNKIKEIaeeenllsav------nnyggdhhkSDLSNVLNYC 134 Caenorhabditis ele...

Feature 1                                                                                     
1JEY_A    151 ANLFsd--vqFKMSHKRIMLFTNEdnphg--------ndsakASRARTKAGDLRdt-gIFLDLMHLKkpgg--------- 210 human
1JEY_B    115 MDVIqhetigKKFEKRHIEIFTDLssr-------------fsKSQLDIIIHSLKkc-dISLQFFLPFslgkedgsgdrgd 180 human
CAC86194  193 RHLFsq--lpSEVKHRRIFLFTNDvnphr--------gdeelLQKCAIQIESLSsg-gVGLVCYDMSptalpspaastqs 261 Trypanosoma brucei
XP_312232 166 SRMFsh--cgYKLAQSTIVLFTSNdqphd--------sssseYQQALVKARDLQqk-eIFVELVPMSgsf---------- 224 Anopheles gambiae ...
BAA76954  114 MDLLqketlgKKYTRLHIAVFSDLssp-------------fsVNQLEVIIANLKka-eITLQFFLPFsvdeeefggssnn 179 African clawed frog
AAG44852  156 QALLrk--gsLKTADKRMFLFTNEddpfgsmrisvkedmtrtTLQRAKDAQDLG----ISIELLPLSqpdk--------- 220 thale cress
CAC05245  115 FDLMarh-ckKNKWKKKMIVLTAArgi-------------idFSDYIGIAEQLLqh-dVFLGVYGVDfd----------- 168 fission yeast
EAA27151  117 LRMIqtf-tkKLKYKRKIIVVTNGesp-------------idDDQSEEVANMLNdv-gIELIVLGVDfddaeygfke--- 178 Neurospora crassa
Q23976    152 IEMLek--cgKKLNNAKIAYVTDVrephp--------snsnhFQAALQKASDLEgk-eFEFHVIPMVddf---------- 210 fruit fly
NP_499438 135 KRVFas---cSNTRHQSVIYLTNNrnpferddflesshfkrtKAAVTKIIGEGHrktlGEFSVIMLPedgykpqdkdekr 211 Caenorhabditis ele...

Feature 1                                                                                     
1JEY_A    211 --------------------------------------------fdiSLFYRDIIsiaed-------edlrvHFEESsk- 238 human
1JEY_B    181 gpfrlg-----------------------ghgpsfplkgiteqqkegLEIVKMVMisleg-------edgldEIYSFs-- 228 human
CAC86194  262 ge------------------------------aaamserwatqfggvDEFWSALTgavpkatn--ssrvgtiDIVHLnsd 309 Trypanosoma brucei
XP_312232 225 ---------------------------------------------ecGKFYKEFLctvle--------eeldEFECPvye 251 Anopheles gambiae ...
BAA76954  180 rgnags-----------------------sdrgcgpgkglsdqqkegIEMVRKIMfsldg-------eeglsEVFTFr-- 227 African clawed frog
AAG44852  221 -------------------------------------------qfniTLFYKDLIgln------------sdELTEFmps 245 thale cress
CAC05245  169 ---------------------------------------------qeDINYSEPLkesqkke----nevriqEFVESchg 199 fission yeast
EAA27151  179 -------------------------------------edkprhkeqnEKILKTLVdhc-----------esgAFGTMaqa 210 Neurospora crassa
Q23976    211 ---------------------------------------------dyEPFYKEFItlsra--------ieldAFQVPda- 236 fruit fly
NP_499438 212 kepwydldtevfstecdaaarirqkitaqrshatltvnvgpgvtfdvSVFSMVMEakpldhsqkytrdteekIVKTSgyv 291 Caenorhabditis ele...

Feature 1                  ## ###
1JEY_A    239 --------leDLLRKVRAK 249 human
1JEY_B    229 ----------ESLRKLCVF 237 human
CAC86194  310 --------dsVMLGALSTA 320 Trypanosoma brucei
XP_312232 252 q------skeRLLHRLFVR 264 Anopheles gambiae str. PEST
BAA76954  228 ----------DSLERLSIF 236 African clawed frog
AAG44852  246 vg----qkleDMKDQLKKR 260 thale cress
CAC05245  200 qyctfqqiynNIGKPWVRK 218 fission yeast
EAA27151  211 vee-latpriKSVRPFKAY 228 Neurospora crassa
Q23976    237 ---------qMLREILSDR 246 fruit fly
NP_499438 292 --------kkESKMELEST 302 Caenorhabditis elegans

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