Conserved Protein Domain Family
vWA_ywmD_type

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cd01456: vWA_ywmD_type 
VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the members of this subgroup. All members of this subgroup however have a conserved MIDAS motif.
Statistics
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PSSM-Id: 238733
Aligned: 11 rows
Threshold Bit Score: 172.229
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
metal
Feature 1:metal ion-dependent adhesion site (MIDAS)
Evidence:
  • Comment:divalent cations are bound by the MIDAS motif

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           # # #                                       
P70960       15 FGLTSPAFAAekte---------teaKAPANVAVLLDASGSMA--------KRIDGVSKFNSAKKEISKFASSLpEGTQV 77  Bacillus subtilis
NP_246767   247 VTEKTPAPPEkvcsi-------stkpGENPQMVIVFDNSRSMLyslleskqSLADFEYRWVRYLTSAEETAHIRrSPNRL 319 Pasteurella mult...
ZP_00091112 341 QQLIVNAKNLcpde---------rpkELAPELAIVFDASGSMDis----llATKQEIDRAVMVQGMTDIAARVL-LGGNP 406 Azotobacter vine...
BAB98414     18 AFIVALAFSLspva---------kaqANETPTMIVLDNSGSMTa-------QDAGGQTRIDAAKQASTQLINDIsDRTDV 81  Corynebacterium ...
NP_302380   524 GDDGMRATLVee------------miQPSSGVAATIMLDQSMP--------TDEGGKTRLANVVAALDDKINAMpPTSVM 583 Mycobacterium le...
ZP_00058477 422 SANVLNAMLEnwa-----------elRKPANVLLVIDTSGSMQe------sVPGTGSTRLELAKEAAITSLDEFsDSDRV 484 Thermobifida fusca
NP_828167   389 QPYEEPAPEPasektlqeslgtwtitVQSARITTVVDISASMSe------aVPGSSRSRMDVTKASLLQTLTTFtPDDEI 462 Streptomyces ave...
ZP_00058698 312 APGEQAAKSLiqaw---------nqlKLGTRLLTVIDISGSMAe------lVPGTGLTRMQVTTMAATQGLTLFpGNAEV 376 Thermobifida fusca
CAD52984    356 PPSGPVADALlavl---------rnpVLPRRATVLLDVSESMR--------TTEGGATRLQNTVRALSEQFRRVpDATEL 418 Rhodococcus fasc...
P70961       15 VSIASPSFAAe--------------kQADTNVAVLFDGSGSMV--------QKTGGERKIDIAKKSVKSFAELLpKDTNL 72  Bacillus subtilis
NP_630326    20 AGMAFPAGASage----------ptgEDAPKVDLVLDVSGSMRt-------RDIDGGTRMAAAKQAFNEVLDATpEEVRL 82  Streptomyces coe...
Feature 1                                                                                       
P70960       78 KMSVFGs------------------eGNNKNSGKVqs----cEAIRNVYGFqs--fNEQSFLNSLNTIg-------PTGW 126 Bacillus subtilis
NP_246767   320 EVAKQSsasi-------------insIAKTVDIGLvel--kgCPTANNHGYys-paKRKQLRAKINAMqpapdsdeNSGG 383 Pasteurella mult...
ZP_00091112 407 GIDTTGhlyrepkritaakqattavvQRLPSDVSAglvlierCPASRSMGFft-pvQRGGLLARLNSIq-------PVEG 478 Azotobacter vine...
BAB98414     82 GLTYYGgn-----------------tGETEADVEMg------CQDVTILGGps-rgNADTLIDTINSLq-------PRGF 130 Corynebacterium ...
NP_302380   584 GLWTFDg-------------------HKGQTEVTTg------QLADPVNGQprsaaLTAALDKQYSSNg------gAVSF 632 Mycobacterium le...
ZP_00058477 485 GLWMFStd-----------------lEDNGQDWRElvp--lgPLGASVNGTp---rREELAERISNLPpgg---gtGLYD 539 Thermobifida fusca
NP_828167   463 GLWNFSa------------------kLDGDKDYRVlv---ptGRLGDRGGRd---tQRDRLSAAFSALepvrggatGLYD 518 Streptomyces ave...
ZP_00058698 377 GLWEFSv------------------dLDEGRDYRElvp--irPLDTDVNGAt----QHETLTAALAQLapkpdgdtGLYD 432 Thermobifida fusca
CAD52984    419 GLWSFSe------------------dLNNSLPFRVdvp--tgPMTVPVGTTp----RRSALDATAEALtpa--tgsFTYA 472 Rhodococcus fasc...
P70961       73 MLRVFGh------------------aGNNKLSGKAls----cSTTETIYGLhp--yEGSLFDNSLSELk-------PTGW 121 Bacillus subtilis
NP_630326    83 GIRTLG--------------------ADYPGDDRKtgc-kdtAQLYPVGPL-----DRTEAKTAVATLs-------PTGW 129 Streptomyces coe...
Feature 1       #                             #                                                 
P70960      127 TPIAKALNEAKSSFdqldaKGE-KVVYLLTDGEETCgg-----npIKTAKELQkd---------nITVNVIGFDyke--g 189 Bacillus subtilis
NP_246767   384 TPLYSGLKQAAAMVd---gKKRdGFILLISDGEDSCetg----dvCALAQQIAkrq-------prLKINVVDIGga---- 445 Pasteurella mult...
ZP_00091112 479 TPLADGVAKAGQMLdg--vNRE-SVMVVVSDGEESChq-----dpCAVARDLArrk-------phLKINVVDIAg----- 538 Azotobacter vine...
BAB98414    131 TPIGKALTDTAAEL-----PEG-GNIVLVSDGIANCtpp----dvCEVAQELAqsgin--lvintIGLNVDPAA------ 192 Corynebacterium ...
NP_302380   633 TTLRMIYQEMLANYh----VGQtNSVLVITAGPHTDq-------tLDGARLQDfirtsa-dpakpIAVNVIDFGtd---p 697 Mycobacterium le...
ZP_00058477 540 TALAAHTLVAEHSR-----PDAiNAVVFLTDGKNEDlng----isLEKLLDSItpep----gqqgVRIFTISYGed---a 603 Thermobifida fusca
NP_828167   519 TTLAAYKAATASYV-----KGKfNALVILTDGVNEDpgsisrstlLTQLRKLAdpr-------hpVPLIMIAVGpe---a 583 Streptomyces ave...
ZP_00058698 433 TILAAYQELTETYA-----PDRvNTLLVLTDGNNDDy-------dSITLEELLkelgeayqpdrpVSIIAISFGpd---v 497 Thermobifida fusca
CAD52984    473 SVLVAYLDAVAGYV-----PGRvNSVVLITDGPDDS---------PLSADELLteltsasdparpVAVNVVRIGdg---s 535 Rhodococcus fasc...
P70961      122 TPIAKALADTRKEFeafdaDGK-NVVYLITDGEETCg--------GDPAAEIEklra----snvdTIVNIIGFNfd---v 185 Bacillus subtilis
NP_630326   130 TPIGPALLKAADDLdg--gDGS-KRIVLISDGEDTCapl----dpCEVAREIAak---------gIGLTIDTLGlvpntk 193 Streptomyces coe...
Feature 1                                   
P70960      190 yKGQLNAIAKVGGGEyfpaYTQKDVEKI 217 Bacillus subtilis
NP_246767   446 kAANCVAKATKGKVFt--aNSQKQLVNM 471 Pasteurella multocida
ZP_00091112 539 -TGAGNCLAQATGGRvfnaRNAGELAAM 565 Azotobacter vinelandii
BAB98414    193 -REELECIAGVGGGTy---ADASDAQSL 216 Corynebacterium glutamicum ATCC 13032
NP_302380   698 dQATWKAVAQISGGSy---QNLSTSASL 722 Mycobacterium leprae
ZP_00058477 604 dLKTMTQIAEATNAAa---YDASDPQSI 628 Thermobifida fusca
NP_828167   584 hRQEAERIAGATGGS----GHQVDSPAQ 607 Streptomyces avermitilis MA-4680
ZP_00058698 498 dPEPLERIAEVTRGAa---YTTEDPTEI 522 Thermobifida fusca
CAD52984    536 pAPVFTDIAARTGGTvd-tVPTSDSPDL 562 Rhodococcus fascians
P70961      186 kGNEEMKQAAVAGGGeyisANSADEFEQ 213 Bacillus subtilis
NP_630326   194 mRQQLSCIAEATGGTytsvEHTDELTDK 221 Streptomyces coelicolor A3(2)

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