Conserved Protein Domain Family
vWA_transcription_factor_IIH_type
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cd01453: vWA_transcription_factor_IIH_type 
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.
Links
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Statistics
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PSSM-Id: 238730
Aligned: 10 rows
Threshold Bit Score: 247.629
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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partial metal
Feature 1:partial metal ion-dependent adhesion site (MIDAS)
Evidence:
  • Comment:divalent cations are bound by the MIDAS motif
  • Comment:the midas motif in general has the signature DxSxS-X(60-64).T-X(24-34)D
  • Comment:the midas motif in this group has the signature DxS-X(60-64).S-X(24-34)D
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #                                                                   
Q04673    121 GIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNpq---dHIDALk 197 baker's yeast
Q9JIB4     56 GMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNpr---kHITSLk 132 house mouse
AAH45397   56 GMMRHLFVIIDSSRSMEDQDLKPNRLTSTLKLMEHFVEEYFDQNPISQIGIITTKNKRAEKLTDLAGNpk---kHITALr 132 zebrafish
NP_649427  59 GMMRHMFVVLDCSESMSVPDLKPTRLRCTVKLLELFIEEFFDQNPISQLGLIALKAKRAEKVTELTGTsr---vHLKALe 135 fruit fly
AAO51083   94 GMQRHLCLILDLSKTLSNQDLKPSRYQVLLQNVELFIKEFFDQNPISQLSIIITKNSKAEKISELSGNrl---rHIQAMk 170 Dictyostelium disc...
P34567     60 GIMRHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNirvlkeSLNTLt 139 Caenorhabditis ele...
NP_705057  81 GIFRHIIILFDMSSSMKERDLKPDRINVALECVESFLKNFFFKNPVGHVGVVALKNSSAKLIQPFTSNvddilnSILKEr 160 Plasmodium falcipa...
AAC97995   79 GLIRYLYIVIDFSRAAAEMDFRPSRMAIMAKHVEAFIREFFDQNPLSQIGLVSIKNGVAHTLTDLGGSpe---tHIKALm 155 thale cress
O74995     84 GIIRHMVLVLDLSNSMEERDFHHKRFDLQIKYASEFVLEFFEQNPISQLSIIGVMDGIAHRITDLHGNpq---sHIQKLk 160 fission yeast
NP_584711  40 GIVRHLHIIIDVSEAIDKSDFLPTFRANVTKVLEGFIPSFYSENPLSTLSFLSIRDVCVKYTSSMDIDi-----HAFLGq 114 Encephalitozoon cu...

Feature 1                #                                 #                                  
Q04673    198 sirkqepKGNPSLQNALEMARGLllpVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELC 277 baker's yeast
Q9JIB4    133 kavdmtcHGEPSLYNSLSMAMQTlkhMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLA 212 house mouse
AAH45397  133 kavdstcVGEPSLYNSLNMALQTlkhMPAHTSREVLVIFSSLTTCDPGNIYELIKTLNGLKIRVSVIGLSAEVRVCTILT 212 zebrafish
NP_649427 136 slanvslTSEPSLQNGLDLALKSlkvVPSHASREIVIIMGSLTTCDPVDINLTIDELKKEGIRCSVISLSAEIHVARYLT 215 fruit fly
AAO51083  171 da--iamEGEPSIQNSLEVALSSlcyVPKYGSREVLFIFSSLTTCDPSSLQKTIQSLKNESIRVSFIHMAAELYICKAIA 248 Dictyostelium disc...
P34567    140 ea---fcGGDFSLQNALQLACANlkgMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMA 216 Caenorhabditis ele...
NP_705057 161 ta---glQGSPSLEEGLQIAHDLlidMPLYGTKEVLIMYGSIRTCDKKNILNVLELLVKSNIYVNCISIAPEMHILKHIC 237 Plasmodium falcipa...
AAC97995  156 gk--leaLGDSSLQNALELVHEHlnqVPSYGHREVLILYSALCTCDPGDIMETIQKCKKSKLRCSVIGLSAEMFICKHLC 233 thale cress
O74995    161 sl--rdcSGNFSLQNALEMARASlshIASHGTREVLIIFGSILSSDPGDIFKTIDALVHDSIRVRIVGLAAEVAICKEIC 238 fission yeast
NP_584711 115 t-----gSKWFSLLNGLEGSIEVm--KNTMHVKEILVIVASTSTRDPHGYAEVLAKLRAYNIKVHFISLCGEITLYKSIS 187 Encephalitozoon cu...

Feature 1                                      
Q04673    278 KATNYgdesfYKILLDETHLKELFNe-AVTPLP 309 baker's yeast
Q9JIB4    213 RETGGt----YHVILDETHYKELLAh-HVSPPP 240 house mouse
AAH45397  213 RETGGs----YNVILDESHFKELLLl-HVKPPP 240 zebrafish
NP_649427 216 QQTMGt----FGAVLDDAHFRDQLMs-QVDPPP 243 fruit fly
AAO51083  249 EQTNGt----SKVILNEEHFNESLMl-KCQPPP 276 Dictyostelium discoideum
P34567    217 KATKGe----YSVALDPDHLQLLFSk-HTLPPS 244 Caenorhabditis elegans
NP_705057 238 EKSNGf----YKICSSKNSLMNEINnnAETPLW 266 Plasmodium falciparum 3D7
AAC97995  234 QETGGl----YSVAVDEVHLKDLLLe-HAPPPP 261 thale cress
O74995    239 NKTNSstknaYGVVISEQHFRELLLe-STIPPA 270 fission yeast
NP_584711 188 KATEGr----FYVPVDAGHLSAIMRe-LSHPTD 215 Encephalitozoon cuniculi

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