1CWS


Conserved Protein Domain Family
Cdc25_Acr2p
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cd01443: Cdc25_Acr2p 
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Cdc25 enzymes are members of the Rhodanese Homology Domain (RHOD) superfamily. Also included in this CD are eukaryotic arsenate resistance proteins such as Saccharomyces cerevisiae Acr2p and similar proteins. Cdc25 phosphatases activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to activate their Cdk/cyclin substrates. The Cdc25 and Acr2p RHOD domains have the signature motif (H/YCxxxxxR).
Links
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Statistics
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PSSM-Id: 238720
Aligned: 7 rows
Threshold Bit Score: 139.078
Created: 22-Jun-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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oxyanionactive site
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:oxyanion binding site
Evidence:
  • Comment:this is the catalytic pocket
  • Structure:1C25 binds tungstate
  • Comment:both sulfate and tungstate anions are shown to bind in the catalytic site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1CWS_A     43 LKYISPETMVALLtgkfs---nivdkFVIVDCRYpyEYEg-GHIKTAVNLPLer-dAESFLlkspiap---csldkrVIL 114 human
Q06597      2 VSFITSRQLKGLIenq-------rkdFQVVDLRRe-DFAr-DHITNAWHVPVtaqiTEKQLnqlikglsdtfsssqfVKV 72  baker's yeast
EAA58746   19 PASLPRPMLLQWLqpgsnr--tpgadFLLVDLRRt-DFEg-GTIKGSLNLPAq--sLYPTLptlfnl----vrsagvKDV 88  Aspergillus nidula...
XP_327483  26 LMNISRAEVLEMLkgstge--tagkdFVLVDLRRd-DCKg-GTIRGSINLPAq--sMYQTLptiydm----fkaagvKKA 95  Neurospora crassa
XP_380932  25 CTRTDPAIISKLIevnaalgknakrdFLLVDVRRt-DWEg-GTISTSINLPAh--tFYQTRpqvyql----vkqagiKRI 96  Gibberella zeae PH-1
EAA42885    3 FKRIQPQELDALTsts--------nrFVVIDVRDd-DYDtgGHYKGSVNIPVg--dILDGRkdvme------mldryDLI 65  Giardia lamblia AT...
AAS73185    4 YTYIKPEELVELLdnpd-----slvkAAVIDCRDs-DRDc-GFIVNSINMPTi--sCTEEMyeklakt---lfeekkELA 71  Leishmania major

Feature 1        #######                                      
1CWS_A    115 IFHCEFSSERGPRMCRFIRerdravndypslyyPEMYILKGGYKEFFP 162 human
Q06597     73 IFHCTGSKNRGPKVAAKFEtylqee---ditskFESCILVGGFYAWET 117 baker's yeast
EAA58746   89 IFYCGSSQGRGTRAAGWFAdylrqq--gveeseTKSWKLEGGIKGWVR 134 Aspergillus nidulans FGSC A4
XP_327483  96 IFYCGTSRGRGSRAARWLSdylvk----igddsIQSFALFEGIKGWAN 139 Neurospora crassa
XP_380932  97 IFYCGSSNGRGPRCARWMQdylde----vgetdIKAEILTGGIKGWQK 140 Gibberella zeae PH-1
EAA42885   66 VCYCMLSQQRGPAAARSLCsaf---------pqKKIYVVTGGFTAMLE 104 Giardia lamblia ATCC 50803
AAS73185   72 VFHCAQSLVRAPKGANRFAlaqkk----lgyvlPAVYVLRGGWEAFYH 115 Leishmania major

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