1CE8,1A9X,1BXR


Conserved Protein Domain Family
MGS_CPS_II

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cd01424: MGS_CPS_II 
Click on image for an interactive view with Cn3D
Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways responsible for the synthesis of pyrimidine nucleotides or arginine. The MGS-like domain is the C-terminal domain of CarB and appears to play a regulatory role in CPS function by binding allosteric effector molecules, including UMP and ornithine.
Statistics
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PSSM-Id: 238712
Aligned: 73 rows
Threshold Bit Score: 118.736
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:IMP binding site
Evidence:
  • Structure:1CE8_A binds inosine monophosphate (IMP)
  • Comment:Binding of allosteric ligands IMP, UMP, and ornithine is believed to regulate enzyme function.
  • Citation:PMID 7577987

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #     #                   # ##               #                         ### 
1CE8_A       943 GRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGeaGINPRLVNKVh---EGRPHIQ-DRIKNGEYTYIINTTs 1018 Escherichia coli
Q97FT3       939 GNLYVSIKDVDKQESVPIIKKYTEFGYKIYASLGTGKFLQkqGIDCEVLRTD----DLMKAIG-DGKINLIINSPTRGNt 1013 Clostridium ac...
ZP_00061435  945 GNVLLSIADRDKTECIEIAQALSDLGFNLVASEGTYTNLSgvGIEVDMVTDD----EMIEMIKkDKISLVINTPTRGKIp 1020 Clostridium th...
P58941       936 GQIVFTIADDSKAEALSLARRFKAIGYQIMATQGTAAYFAeqGLSACLVGKIg---DAANDIP-TLVRHGHVQAIVNTVg 1011 Streptococcus ...
Q8RBK0       936 GKILLSIAERDFQEAVSLVEKLQSLGYEIYATYRTGKYFSlmGIHANIMSLD----HAIKLLK-NGYFDAVVNTPTKGKk 1010 Thermoanaeroba...
ZP_00045887  936 GNVLLTIEDRDKDKILPIAKRFARIGYRIFATKGTAEFLKsnGLHVDLVTKVhegeNKDDNIL-NELRDGKIDLVINTMg 1014 Lactobacillus ...
ZP_00099038  942 GSLLVTLADRDKAEGIPLVKKFADLGFRILATEGTAKTLReeGIQVAPVAKLh---QGSTEIT-DAIRQGVIQCVLNTTt 1017 Desulfitobacte...
NP_735523    936 GNIVFTVDDTDKEEALELAKVYQSIGYRIYATQGTAIYFDanGLETVLVGKLg--eNDRNHIP-DLIKNGKIQAVINTVg 1012 Streptococcus ...
AAN87360     937 GTLLVSVAERDKEEVAGLIRDYADLGFKIVATKQTASALKraGITVTTVNTAd---HSLQLLL-DQIKDGAIQLVINTPt 1012 Heliobacillus ...
P77886       936 GNVLLTVRDEDKPETVALAKRFHALGYQLLATRGTATALTthGLPVTTVDKId---SGERDLL-HRMEAGEIQVVINTVs 1011 Lactobacillus ...
Feature 1                                           
1CE8_A      1019 grr-aieDSRVIRRSALqykvhYDTTLNGGFATAM 1052 Escherichia coli
Q97FT3      1014 v----gtRGFSIRRKAAeykvgAFTCIDTAKAFLT 1044 Clostridium acetobutylicum
ZP_00061435 1021 e-----rHGFILRRTAIeynipCITSLDTARSMIS 1050 Clostridium thermocellum ATCC 27405
P58941      1012 ikrtadkDGQMIRSSAIeqgvpLFTALDTAKAMLT 1046 Streptococcus pyogenes MGAS8232
Q8RBK0      1011 p----dnAGFKLRRTAVeyripLFTSIDTIKAALN 1041 Thermoanaerobacter tengcongensis
ZP_00045887 1015 hdieknsDGFIIRRMAIqqnvpLLTALDTADALLT 1049 Lactobacillus gasseri
ZP_00099038 1018 hnkkqesDGFAIRRTAVeqgipCFTSLDTASAWVH 1052 Desulfitobacterium hafniense
NP_735523   1013 qnnidnhDALIIRRSAIeqgvpLFTSLDTAHAMFK 1047 Streptococcus agalactiae NEM316
AAN87360    1013 rgkvagrPGFRIRRAASeyrvpCLTSLDTAGALLE 1047 Heliobacillus mobilis
P77886      1012 deeqaenDGTLIRNTSImhgipLFTALDTVAAILQ 1046 Lactobacillus plantarum

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