Conserved Protein Domain Family
MGS_CPS_I_III
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cd01423: MGS_CPS_I_III 
Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
Links
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Statistics
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PSSM-Id: 238711
Aligned: 21 rows
Threshold Bit Score: 110.852
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable
Feature 1:probable substrate binding site [chemical binding site]
Evidence:
  • Comment:Based on related structures in the CPSase-like MGS family.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #      #                    # ##                                           
BAA21088  1307 RGVFISCDv---DAMAEDLCPtlsasdrFPVFTSKQTSRVLAd---------------------------------yGIP 1350 Trypanosoma cruzi
CAA91059  1323 QNIFISIGgyhaKAEMLKSVEall-klgYELYGSKGTADYFQs---------------------------------nKIN 1368 Caenorhabditis e...
Q09794    1395 KNILISIGsykeKAELLPYVKkly-ennYNIFATAGTSDYFMe---------------------------------sGVP 1440 fission yeast
AAD09129  1401 RNILLSIGsykeKMEMLPSIIklr-dvgFELFATSGTADFLKe---------------------------------nGVP 1446 Emericella nidulans
P07259    1361 KNILLSIGsykeKQELLSSVQkly-nmgYKLFATSGTADFLSe---------------------------------hGIA 1406 baker's yeast
P20054    1290 KNVLLSIGsfkeKHEFLPSAHkli-klgYTLFGTQGTADFYSe---------------------------------nGVP 1335 Dictyostelium di...
AAA29522  2237 KSILISIKnlnnKLAFEEPFQllf-lmgFTIYATEGTYDFYSk----------------------------------FLE 2281 malaria parasite...
P27708    1313 KNILLTIGsyknKSELLPTVRlle-slgYSLYASLGTADFYTe---------------------------------hGVK 1358 human
NP_812777  939 KAVMFSSGamksKVDLLDASRmlf-akgYQIYATAGTAAFLNa---------------------------------hGVE 984  Bacteroides thet...
AAL27793  1498 RTILISAGplwsKMELEPYFKill-dlgFTIYATEGTYRFLMnsvvrgqgthlpgnaspasdsglrtpttaesdadaCIR 1576 Toxoplasma gondii

Feature 1                                                             ## #                     
BAA21088  1351 HTVltq---------rhEDSep--------------tfDTAVAvk---eKFDLVIQLRDKrqdfmlRRCTQENATADYWI 1404 Trypanosoma cruzi
CAA91059  1369 VKPvdw---------pfEEGssdekt------asgtrsVVEFLen---kEFHLVINLPIRgsgayrVSAFRTHGYKTRRM 1430 Caenorhabditis e...
Q09794    1441 CKYlad---------lpAEEanne-----------yslSAHLAn----nMIDMYINLPSNnryrrpANYISSGYKSRRLA 1496 fission yeast
AAD09129  1447 VKYlei---------lpGEDediks---------eyslTQHLAn----nLIDLYINLPSSnrfrrpANYMSKGYRTRRMA 1504 Emericella nidulans
P07259    1407 VQYlev---------lnKDDddqks---------eyslTQHLAn----nEIDLYINLPSAnrfrrpASYVSKGYKTRRLA 1464 baker's yeast
P20054    1336 VTQlnw---------deEDLg-----------------ENVIQkkm-teNTIHLINLPSKnkyrrpSSFMSRGYSLRRVA 1388 Dictyostelium di...
AAA29522  2282 SFNvnk---------gsKFHqrlikvhnknaenispntTDLIMn----hKVEMVINITDTlktkvsSNGYKIRRLASDFQ 2348 malaria parasite...
P27708    1359 VTAvdw---------hfEEAvdge----------cppqRSILEqla-ekNFELVINLSMRgaggrrLSSFVTKGYRTRRL 1418 human
NP_812777  985 TTPvy-----------wPDEkp--------------gaENNVMkmiadhKFDLIVNIPKNhskrelTNGYRIRRGAIDHN 1039 Bacteroides thet...
AAL27793  1577 AKYasriirvrkpivgsNEShnggh--------qsphaLSLIEs----gKVEMVINVPDSmnhraaTNGYLMRRTATDCG 1644 Toxoplasma gondii

Feature 1                             
BAA21088  1405 RRlavdynhslLTEPNVVRMFCE 1427 Trypanosoma cruzi
CAA91059  1431 AIdng---iplITDIKCAKTFIQ 1450 Caenorhabditis elegans
Q09794    1497 IDysv----plVTNVKCAKLMIE 1515 fission yeast
AAD09129  1505 VDyqt----plVTNVKNAKILIE 1523 Emericella nidulans
P07259    1465 VDysv----plVTNVKCAKLLIE 1483 baker's yeast
P20054    1389 IDfqv----plITNIKCAKLFVD 1407 Dictyostelium discoideum
AAA29522  2349 VPl--------ITNMKLCSLFID 2363 malaria parasite P. falciparum
P27708    1419 AAdfs---vplIIDIKCTKLFVE 1438 human
NP_812777 1040 IPl--------ITNARLASAFIE 1054 Bacteroides thetaiotaomicron VPI-5482
AAL27793  1645 VPl--------LTNVKVASMFVE 1659 Toxoplasma gondii

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