1G8M


Conserved Protein Domain Family
IMPCH

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cd01421: IMPCH 
Click on image for an interactive view with Cn3D
Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-ribonucleotide. The IMPCH domain then converts the formyl-5-aminoimidazole-4-carboxamide-ribonucleotide to inosine monophosphate. This is the final step in de novo purine production.
Statistics
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PSSM-Id: 238709
Aligned: 41 rows
Threshold Bit Score: 160.457
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:purine monophosphate binding site [chemical binding site]
Evidence:
  • Structure:1G8M binds guanosine-5'-monophosphate

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # #                   #  #                            ##                 
1G8M_A        6 QLALLSVSEKAGLVEFARSLNALGLGLIASGGTATALRDaGLPVRDVSDLTGFPEXLgGRVKTLHPAVHAGILarniped 85  chicken
NP_878830     8 RQALISVFDKSNLLHFSKSLSHLGIKLLSTEGTALILTNaGLTVNKISDYTNFPEIMnGQVKTLHHKICAGILsrknlde 87  Candidatus Bloch...
ZP_00000562   1 MRILISVYDKTGLVNFLSSIKDHIDEIYGTEGTVKYLKDnNIAANNSSNLTGFDDLLgGRVKTLHPAIFSGILskrdses 80  Ferroplasma acid...
Q8D244        9 RCALISVSDKTGIFSLAKNLIKHKVKLITTSGTYKYLLEkGIFSTSVSEYINHPEIInGRVKTLHPKIHGGILsnnknin 88  Wigglesworthia g...
NP_393539     1 MNFLISVYDKTGLAEFLKKVRGHIDVVYATSGTYRSLKDlGLNLHETSEITGFDDLLgGRVKTLHPVLYAGLLyrdrn-- 78  Thermoplasma aci...
ZP_00118813   7 KSALISVFYKDNLDSLVKKLHANGVTIYSTGGTQSFIEGlNVPVVPVEDLTGYPSILgGRVKTLHPNVFGGILnrrents 86  Cytophaga hutchi...
Q8A155        8 KTALVSVYHKEGLDEIITKLYEEGVEFLSTGGTRQFIESlGYPCKAVEDLTTYPSILgGRVKTLHPKIFGGILcrrdleq 87  Bacteroides thet...
Q89B23        8 KNVLISVSDTSNIIEFSKSLISKNIKLFATKGTANFLKKnNIYATDITNYTNFPEIMnGRIKTLHHKIYASILaqpkhdk 87  Buchnera aphidic...
Q8KA70        8 KNALVSLSDKTDLLKISKILAEKKINLFCTGGTADVLKKnKIPVLEISDYTNFPEIMnGRLKTLHPKIIGGILgrrekdq 87  Buchnera aphidic...
NP_110535     1 MNFLISVYNKEGLTDFLARVKANIDYIYATGGTAKFLEKnGYTVRDTSEITGFSDLLgGRVKTLHPKIYAALLyrekn-- 78  Thermoplasma vol...
Feature 1                         #                      #                                      
1G8M_A       86 na-dxnkqdfsLVRVVVCNLYPFvktvsspgvtvpeaveKIDIGGVALLRAAAKNharVTVVCDPADYSSVAKexaaskd 164 chicken
NP_878830    88 s--iihkygiqPIDMVIVNFYPFhlilqnkqhdsekileYIDIGGPNMVRAAAKNyknTVIIVDNNDYDNILNeintlh- 164 Candidatus Bloch...
ZP_00000562  81 nm-qlekyhykDFDMVICNLYPFveasktd--dlekmieNIDIGGLSLIRAAAKNyknVAVLSHPDDYSMVKDvlqkn-- 155 Ferroplasma acid...
Q8D244       89 e---nknlnikKIDMVITNFYPFkkkvkkenikieniidNIDIGGVALARSAAKNykyVTVVVNINQYSKLSSemdkns- 164 Wigglesworthia g...
NP_393539    79 ------egnqvKFDVVISNLYPFsvdmkt----edemieNIDIGGVSLTRAAAKNyrnILVLTSPEDYATAADvinsg-- 146 Thermoplasma aci...
ZP_00118813  87 dqseiaqynipEIDLVIVDLYPFeetvasga-ekqaiieKIDIGGVSLIRAAAKNhkdVVILASKEQYRVLESildakg- 164 Cytophaga hutchi...
Q8A155       88 diqqiekyeipEIDLVIVDLYPFeatvasga-seadiieKIDIGGISLIRAAAKNyndVIIVASQAQYKPLLDmlmehg- 165 Bacteroides thet...
Q89B23       88 k--tiekyniiLMDIVVINFYPFeeasnntnlhlndiieHIDIGGPAIVRAAAKNyknVLVVTQPNLYQSIVNemnlnn- 164 Buchnera aphidic...
Q8KA70       88 k--imklhnliPIDIVIVNFYPFekiqnrkeftieeiidNIDIGGPTLVRAAAKNykdVIVIVDLSDFTSCIQlintn-- 163 Buchnera aphidic...
NP_110535    79 ------easdlHFDVLVSNLYPFtgntgn----enemieNIDIGGVSLTRAAAKNyknVLVLSSPDDYTEAAEiissg-- 146 Thermoplasma vol...
Feature 1                                     
1G8M_A      165 kdtsvETRRHLALKAfthtaqYDAAISDYF 194 chicken
NP_878830   165 gsislNTRLNLAAKAfkyikqYDTMISDYF 194 Candidatus Blochmannia floridanus
ZP_00000562 156 gkidmKTREILGLRAfsrsadYDIQIYNKL 185 Ferroplasma acidarmanus
Q8D244      165 gsvsfKTRFYFSTLAfqysysYDKEIFNYF 194 Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis
NP_393539   147 -nipeDYRKRMAMKAfirmaeYDARINEGL 175 Thermoplasma acidophilum
ZP_00118813 165 gatdiEDRFRFAGEAfditshYDTAIYRWF 194 Cytophaga hutchinsonii
Q8A155      166 atsslEERRWMAKEAfavsshYDSAIFNYF 195 Bacteroides thetaiotaomicron
Q89B23      165 niiseTTKLKFATIAfkhtmnYDNNIYQYL 194 Buchnera aphidicola (Baizongia pistaciae)
Q8KA70      164 -tvslETRFDLATKAfkytalYEEIISKYF 192 Buchnera aphidicola (Schizaphis graminum)
NP_110535   147 -kndaEYRKRMALKAfarmaeYDAIIYNGL 175 Thermoplasma volcanium

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