1EKR


Conserved Protein Domain Family
MoaC_PE
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cd01420: MoaC_PE 
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MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.
Links
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Statistics
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PSSM-Id: 238708
Aligned: 42 rows
Threshold Bit Score: 185.058
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activedimer interfacetrimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:active site residues are involved in 3 different active sites within the hexamer
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             #               #      # ##               
1EKR_A       15 MVDVSAKAETVREARAEAFVTMrsETLAMIIdgr--hhKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAEp 92  Escherichia coli
Q20624      430 QVDVSQKDTSTRTAVARGTIILtaEISRQISent--ikKGDVLTVAKIASILGAKQVANLIPLCHPIRLDFVDTVFNHDi 507 nematode
CAE01534     81 MVDVSSKHDSTRVAIATCRVLLgqEAFDLVAsnk--iaKGDVLTVAKIAGITGAKQTSNLIPLCHNLNLSHVRVDLTLNe 158 Japanese rice
Q39056      127 MVDVSSKDNSKRTALACCKVILgkRVFDLVLanq--mgKGDVLGVAKIAGINGAKQTSSLIPLCHNIALTHVRVDLRLNp 204 thale cress
XP_316123   491 MVDVDDKLSTKRIAKAQATVYVgpTIAALIEnne--lkKGDVLSISQMAAIVAAKKTSNLIPLCHNIPLSSIKVETNLNs 568 Anopheles gambia...
ZP_00299461  14 MVDVSGKQPTLRTATAAATVAMkpETLADLLagr--ttKGDVLGVARLAGIAAAKKTPELIPLSHPLAIHHAAVDFETEp 91  Geobacter metall...
NP_788494   412 MVDVGAKPSTTRLARAEATVQVgeKLTQLIAdnq--vaKGDVLTVAQIAGIMGAKRTAELIPLCHNISLSSVKVQATLLk 489 fruit fly
Q9NZB8      493 MVDVGRKPDTERVAVASAVVLLgpVAFKLVQqnq--lkKGDALVVAQLAGVQAAKVTSQLIPLCHHVALSHIQVQLELDs 570 human
Q55370       13 MVDISQKVAGDRRAVAQCIVQLpkAIKDYLTgqeiflkKGPVIQTAIIAGTMAVKKTADLIPFCHTLPIHGCKFDINIVy 92  Synechocystis sp...
NP_682152    23 MVDISEKAVSDRRAVAEALIELppVFQAYVQggdlflkKGPVVQTAIIAGTMAVKRTAEVIPFCHPLPITSCRFETDIEs 102 Thermosynechococ...

Feature 1                          #  ###  #          #  #                       
1EKR_A       93 eh---nrVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGD 154 Escherichia coli
Q20624      508 en---skLHCISTARCSGNTGVEMEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTTY 569 nematode
CAE01534    159 ed---ssVMIEGEASTSGKTGVEMEAMTAVAIAGLTVYDMCKAASKNICITDICLQHKSGGKSGS 220 Japanese rice
Q39056      205 ed---fsVDIEGEASCTGKTGVEMEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGS 266 thale cress
XP_316123   569 st---heVHILAKVKCDGKTGVEMEALTAVSIAALTVYDMCKAVSHEILIKNIMLVEKTGGKSEF 630 Anopheles gambiae str. PEST
ZP_00299461  92 et---gtITVKATVRAFERTGVEMEAMTSAAVAALTIYDMCKGADKGITIGDICLLFKEGGKSGT 153 Geobacter metallireducens GS-15
NP_788494   490 te---qsVRLEATVRCSGQTGVEMEALTAVSVAALTVYDMCKAVSHDICITNVRLLSKSGGKRDF 551 fruit fly
Q9NZB8      571 tr---haVKIQASCRARGPTGVEMEALTSAAVAALTLYDMCKAVSRDIVLEEIKLISKTGGQRGD 632 human
Q55370       93 qkrdyleIFLQCAVNTNYKTGVEMEALCGVSVAALTIYDMCKSISSEIIIKNTKLIEKTGGKADV 157 Synechocystis sp. PCC 6803
NP_682152   103 qes-glrIRLRCEVKTCDRTGVEMESLHGVAIAALTIYDMAKALSPHIVIREVRLLAKSGGKKTL 166 Thermosynechococcus elongatus BP-1

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