Conserved Protein Domain Family
MoaC_A
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cd01419: MoaC_A 
MoaC family, archaeal. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.
Links
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Statistics
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PSSM-Id: 238707
Aligned: 12 rows
Threshold Bit Score: 204.903
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:active site residues are involved in 3 different active sites within the hexamer
  • Comment:by similarity to structure 1EKR_A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #               #      # ##              
Q58535       12 MVDISKKEDVERICVAEGYIKLKPETIKLIKEq---kIKKGNVLTTAQIAGILAVKKTYELIPMCHPLPITSVNVDFEVF 88  Methanocaldococc...
Q8TXV5       10 MVDVTGKKEEIRIAEASGFLRLTEDGVNAVKSgeshpQGKGDPIEVAKVAAILAVKKTPELVPHCHPIKITGVDVDVEVL 89  Methanopyrus kan...
Q9HQ89       20 MVDVGSKPDTARRAVASGDLHLAESTIDAVRDd---gIGKGNVLATARVGAIQAVKHTWETIPMCHQIPITNVDTTFDVR 96  Halobacterium sp...
Q9YCA4       15 MVDITAKEPVRREAVASGFISLKRETVKAIREg---rVEKGDVISVASVAAVLAVKETPRLIPLTHPIPIEKVEPEVRVR 91  Aeropyrum pernix
ZP_00307082   1 MIDITDKNTVKREAMATGTIKLNKETIKLIREk---qVKKGDVIETAKIAGTIAVKNTSGMIPYCHPVPVMSIDFNFEVE 77  Ferroplasma acid...
Q9UXF7        7 MVDISQKETVLREAEAEGFIKLKNDTIKRIIEn---eIEKGNVITVAKTAGIMAAKKTSELLPLCHLIPLENVDIDIKIE 83  Sulfolobus solfa...
O59475       15 MVEIGYKDVVFRKAVAKGRIKLKPETVKLIKEg---kIEKGNVLATAQIAGILAVKRTPELIPLCHPIPITGVDITFDFG 91  Pyrococcus horik...
O26900       17 MVDVGSKPVVRRTATAEGHILLREDTINLIREk---kIEKGNVLATAQIAAIVAVKRTWEIIPLCHPLPLTGVDVEFDLD 93  Methanothermobac...
Q9HKV1        1 MINISEKAISARTATATGRIHLRRSTIQAIREk---kVKKGDVLEVSRVVGTQHAKNTFLQIPYCHNIPIEGVDVDFNVG 77  Thermoplasma aci...
O28132       13 MVDVSHKDDVDRIAVAEGYIRLRSSTIEAIINk---eVAKGNVIAAANIAGVMAVKKTPELIPMCHPIPITSVKFDFDIE 89  Archaeoglobus fu...
Q8TRK7       18 MVDISEKNNVLRMARAAGEIVLSAETMEKIRTg---tVEKGNVFATARVAAVLAVKKTPETIPMCHQIPITGIDVDLEIG 94  Methanosarcina a...
YP_023839     1 MIDISSKEIIKREASASGRIRLKSETLNAIIEn---nVKKGDVIETARIAGTMAVKNTAGVVPYCHNVPLSSIDFDFKVL 77  Picrophilus torr...

Feature 1                      #  ###  #          #  #                          
Q58535       89 EDKIKAICSVKTTYKTGIEMEALTGVSIALLTIWDMVKSAEKDEDGQYKTAEIFGIRVVEKIKK 152 Methanocaldococcus jannaschii
Q8TXV5       90 EDGVKMSVRVKSEGKTGVEMDALTGLVVGLVTLWDMVKYAEKDEEGQYPHTRIENVRVVEKIIK 153 Methanopyrus kandleri
Q9HQ89       97 DDRVVLEVAVETTGKTGCEMEALEGVTTGLNVVWDMVKAAEKDADGQYPGTAIENVGVDTKEKH 160 Halobacterium sp. NRC-1
Q9YCA4       92 DDGVEVRVRVATTAKTGVEMEALAGVTAALLTVWDMVKSLEKDETGNYPDTVITGVKVEVKRKG 155 Aeropyrum pernix
ZP_00307082  78 DSKIIVTCRVKAIYRTGVEMEAINGVQVALLTIWDMVKYLEKDETGNYPDTSIGNVTVVYKRKG 141 Ferroplasma acidarmanus
Q9UXF7       84 NSGIRVRSKVKAHYKTGVEMEALVATSISLLTIWDMVKKYEKDENGKYPYTMIDDIKVIDKIKE 147 Sulfolobus solfataricus
O59475       92 EDYIEVTCEVRAYYKTGVEMEALTGVTVALLAIWDMVKAVEKDEKGQYPYTRIENVHVVEKVKT 155 Pyrococcus horikoshii
O26900       94 DDRITARVTVRCDGKTGVEMEAVTGVSVALLTIWDMVKSVEKDDDGQYPETAISNIRVIKKEKL 157 Methanothermobacter thermautotro...
Q9HKV1       78 EDYVEVSCTLTTTYKTGIEMEAISCVSGALINIWDMVKYLEKDESGNYPETRIDGIHVVEKRKT 141 Thermoplasma acidophilum
O28132       90 SVGIRVKCTVKSKGKTGVEMEALTGVSVALLTIWDMVKSLEKDERGNYPKTLIEVIRVVEKVKG 153 Archaeoglobus fulgidus
Q8TRK7       95 KDSVSAVVEVRTVGKTGVEMEALTGVSVALLTVWDMVKSAEKDETGNYPHTLIRNIRVLEKLKG 158 Methanosarcina acetivorans
YP_023839    78 NDCIESICTVKAIYRTGVEMEAIHGVMVSLLTIWDMVKYMEKDDNGQYPETLISDVKVLYKVKS 141 Picrophilus torridus DSM 9790

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