2H31


Conserved Protein Domain Family
SAICAR_synt_Ade5

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cd01416: SAICAR_synt_Ade5 
Click on image for an interactive view with Cn3D
Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Eukaryotic group of SAICAR synthetases represented by the Drosophila melanogaster, N-terminal, SAICAR synthetase domain of bifunctional Ade5. The Ade5 gene product (CAIR-SAICARs) catalyzes the sixth and seventh steps of the de novo biosynthesis of purine nucleotides (also reported as seventh and eighth steps). SAICAR synthetase converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Statistics
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PSSM-Id: 133471
View PSSM: cd01416
Aligned: 20 rows
Threshold Bit Score: 330.409
Threshold Setting Gi: 189313912
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               # #### #           #           #                                 #       
2H31_A         7 LNIGKKLYEGKTKEVYELLDSp--gKVLLQSKDQITAGNAARKNhlEGKAAISNKITSCIFQLLQEAGIKTAFTRKc--G 82   human
A9WK38         1 MELGYVLTEGKTKIVYAHPTDp--dLAILYHKDGITAGDGARRSviEGKGELAGQTTANVFRLLNRAGIATHFVDAp--E 76   Chloroflexus s...
A7NKB4         1 MNLGEKLTEGKTKIVYAHPNDp--tLAIIIHKDGISAGDGARRHiiPGKGALSGRTTANVFTMLNHAGVATHFVAAp--E 76   Roseiflexus ca...
YP_001547593   1 MQYGTKLAEGKTKIIYAHPEDq--sLAYMVQKDSISAGDGARRNeiDGKGAISGRTSANVFALLNRSGVRTHYQSDp--E 76   Herpetosiphon ...
XP_001622041   1 MKIGEKIIEGKTKIVYALPDSpdgnHVLLKSKDKITAFDATRKDemSGKAAQSTATTCAIFEMLKACGLKTHFVKRcesD 80   starlet sea an...
XP_002155272   6 YGANDLIIEGKTKAIYALPEYldgqYVIMKSHDQITCGDGARKDilIGKGALSNATNAAIFEYLNNAGVRTHFHRSv--S 83   green hydra
XP_001749986   2 EMLGKTIVEGKTKVVHQHARNf--dQVILVSKDRITAGDGARAHeiSGKAKVANDTTCTIFEFLNSVGIPSHFVAR---S 76   Monosiga brevi...
XP_002113072  13 IKIGRKIIEGKTKVVFAIDDPtscnLVVLRSKDAITAFDGQRAHemSFKGKYSTATTCGVFDLLQYCDVPTHYRYHy--D 90   Trichoplax adh...
XP_002123527  50 FTLGKMFCEGKTKVVYEINTKtp-gRCLIVSKDIITAGDGAKRNvmEGKAELSSATNAAVMQMLNDFGLKTAFIKGv--N 126  Ciona intestin...
XP_638800     16 LKDKTFLASGKTKTIYQLNKEd--qYVLIESNSAITAGDGAKKDilPNKDIYSTTTTVNNFKVLQLSGINTHFVKQv--E 91   Dictyostelium ...
Feature 1             #### #   # # #   ###                        # #     #                      
2H31_A        83 ETAFIAPQCEXIPIEWVCRRIATGSFLKrn---pgVKEGYKFyPPKVELFFKDDaNNDPQWSEEQLIAAKFcfa---gll 156  human
A9WK38        77 PRLTVVRRCRMIPLEVVMRRLPAGSYLRrh----pEAAGQRFdPPLVEFFLKDDaRHDPQIAPQEIIAQGI--------- 143  Chloroflexus s...
A7NKB4        77 PTVMIVRRCVMIPLEVVNRRIATGSYIRrh---pdVAEGTRFdPPLLEFFLKDDaRHDPQISPEEIVAQGI--------- 144  Roseiflexus ca...
YP_001547593  77 PGVMLVERCEMLPLEVVMRRLATGSYCRrh---peTPEGTRFsPPLVEFFYKDDaNHDPQIYLEGIVEKGL--------- 144  Herpetosiphon ...
XP_001622041  81 PEAFIGIACEMIPLEVVCRRIATGSFLKry---pgVKEGYRFtPPKQEFFLKDDaQHDPFWTYEQCVEAAFeig---gkk 154  starlet sea an...
XP_002155272  84 ETECIVERCQMIPLEIVSRRLATGSYLKrn---pgVNEGFRFsTPKMEYFFKDDaNHDPQWSSDQILENKLmig---glt 157  green hydra
XP_001749986  77 GDMMVAKKVHMIPIECVARRVAYGSYLRrfktpfpVTEAYRFpTPCLEFFYKDDaNHDPQVTKEQLLSNPLlldeakqlr 156  Monosiga brevi...
XP_002113072  91 ENSFVAIFCNMIPLEVVVRRIATGSFLKrh---qgVKEGYRFsPLKLEFFYKDDaQHDPLVSIEQILHMKLtag---kvv 164  Trichoplax adh...
XP_002123527 127 KKSFLAWKCDMIPIEWVARRVATGSFIRrh---vgVKEGYRFsPPKLETFYKDDeNHDPQWSREVLEEAKLkcg---kiv 200  Ciona intestin...
XP_638800     92 PNAFIAKKCSMIPLEVIVRRLATGSYLKrn---thVTEGTKFnPPLIEFTFKDDvQHDPLVTEQDILEMNLkig---gvp 165  Dictyostelium ...
Feature 1                                        ### #             #    ####                     
2H31_A       157 IGQTEVDIXSHATQAIFEILEKSWLPQNCTLVDXKIEFGVDvttkEIVLADVIdNDSWRLWPSGDRSQQKDKQSYRDLKE 236  human
A9WK38       144 ATPAEVEQMTDTGRKVFVTLEAAWQQLDVTLVDLKIEFGRTaq-gDLLVADVIdNDSWRIWPSGDPAQMLDKQVYRNAQV 222  Chloroflexus s...
A7NKB4       145 ASADEVEQLASESRRVFLLIEEAWAAQDIVLCDLKIEFGRDas-gALVVADVIdNDSWRIWPGGMKERMLDKQVYRNMPV 223  Roseiflexus ca...
YP_001547593 145 ATAEEVSFIEQEGTRVFELLEQTWAERGVQLVDLKIEFGRTad-gSLIVADMIdNDSWRLWPDGDKSKMLDKQIYRNLQT 223  Herpetosiphon ...
XP_001622041 155 IGKHELDIMSESAIAIFEIIERAWATVDVALVDMKIEFGVNrktgELMLADVVdNDSWRIWPSGDKRLMRDKQVYRNLPE 234  starlet sea an...
XP_002155272 158 IGQFELDEITLVAKTCFEILEKAWASRNCVLVDMKVEFGVTiknkEIVLADVIdNDSWRIWPAGDKRLMKDKQVYRNLSV 237  green hydra
XP_001749986 157 LTPKYVEQMELWTRAVFETLERAWAVQGCTLVDMKIEFGIDmq-gRLILADVIdNDAWRVWPQGDRRLMKDKQFYRELKT 235  Monosiga brevi...
XP_002113072 165 IGKDEIDIMSKVALATFEILERAWSTLNCNLIDLKVEFGVSas-gTLLLADVIdNDSWRLWPSGDKRLQKDKQAYRDLKQ 243  Trichoplax adh...
XP_002123527 201 VTPDLIDIMEKMTITIFEVLEKAWKSKNVSLIDMKIEFGVRqdtnEIVLADVIdNDSWRIWPSGDKRLMKDKQVYRNLKE 280  Ciona intestin...
XP_638800    166 ITSKLLSQTRHIATLSFEALERAWQSLDVTLVDFKVEFGITsq-gELILADVIdNDSWRIWPKGDKTLMKDKQVYRNLPS 244  Dictyostelium ...
Feature 1                                                 
2H31_A       237 VTP-------------------EGLQXVKKNFEWVAERVEL 258  human
A9WK38       223 VDE-------------------ALLADVRARYALVAELTGR 244  Chloroflexus sp. Y-400-fl
A7NKB4       224 VTD-------------------DGLEQVRRLYEEVAHRTDA 245  Roseiflexus castenholzii DSM 13941
YP_001547593 224 VTE-------------------EALQNLKAKYEEVRDITES 245  Herpetosiphon aurantiacus ATCC 23779
XP_001622041 235 VTP-------------------EALEQVKKNYAWVAGESQK 256  starlet sea anemone
XP_002155272 238 VTT-------------------EAMSEIRKNYTWVSNEVKL 259  green hydra
XP_001749986 236 VTD-------------------ADLTEVLKKYEWVADAVRG 257  Monosiga brevicollis MX1
XP_002113072 244 VTD-------------------QAMEEIRGNYAWVAKKIDQ 265  Trichoplax adhaerens
XP_002123527 281 VTN-------------------GDMQNLKENYTWVSNQLTA 302  Ciona intestinalis
XP_638800    245 ALNtpgatpttqsgpllntlsdQQLKMIEDNYAWVATSTEK 285  Dictyostelium discoideum AX4

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