1OBG


Conserved Protein Domain Family
SAICAR_synt_Sc
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cd01414: SAICAR_synt_Sc 
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non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.
Links
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Statistics
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PSSM-Id: 133469
Aligned: 89 rows
Threshold Bit Score: 209.327
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # #### #                         #           #                                
1OBG_A     13 LVARGKVRDIYEVDa------------------gTLLFVATDRISAYDVIMENs-----iPEKGILLTKLSEFWFKFLSn 69  baker's yeast
AAF97181    4 MLYQGKVKQVWSTDdp-----------------dILEFRFTNQISVFDQIIPSl-----iPRKGESLNRTTAHWFKLVEq 61  uncultured marine ...
Q9HLC0      3 IIAKGKVKDVYDDGd-------------------TLVFRFSNRISVFDKIIPTe-----iENKGESLCRTSSFWFRYIGe 58  Thermoplasma acido...
Q9HNU7      9 GMASVKDRRVESPAtdt--------------dlgRGVFEFSDRYSVFDWGEMPdh----vPGKGASLCTMGAYTFEQLAa 70  Halobacterium sp. ...
EDY37097    3 LIRKGKVKEVYALNd------------------kELLFLFTDNISVFDKIIPSk-----iPRKGETLCKSAAFWFEKIGe 59  Aciduliprofundum b...
YP_024131   3 FVSSGKVKDIYNDNg-------------------NLVFKFSNRISVFDKIIPSe-----iPYKGEVLCRTAYYWYRLCEd 58  Picrophilus torrid...
EED32739   20 PVHSGKVRSVYFLRpedsrrliqergypvaphsdLAVMVISDRLSAFDCLWHSesl-agvPGKGAALNAIAAHWFESFGq 98  gamma proteobacter...
YP_843921  10 LLMRGKVKEAYDLGs-------------------ELEFQFTDNISVFDKIIPTr-----iPYKGETLCREGVFWFERAEr 65  Methanosaeta therm...
EED35172   21 PVHSGKVRSAYWLTsndsrrlveargypasadsqLGILIISDRISAFECLWHGegdlrgvPGKGAALNAISAHWFDRFRt 100 gamma proteobacter...
YP_658825   2 TSVKEFLIETEPTTtg----------------ygRGRFVFTDQYSVFDWGAMPdq----iPHKGTSLCTMGAYNFELLEe 61  Haloquadratum wals...

Feature 1                                  #                                                  
1OBG_A     70 ------------------------dVRNHLVdiapgktifdylp-----------------------------------a 90  baker's yeast
AAF97181   62 e----------------------gvCGTHLVelnapdrclv--------------------------------------- 80  uncultured marine ...
Q9HLC0     59 r-----------------------gIKNHFIemidnrtm----------------------------------------- 74  Thermoplasma acido...
Q9HNU7     71 agvpthyqgvrtpdgetvrladapeAPTQMVidltqvptlp--------------------------------------- 111 Halobacterium sp. ...
EDY37097   60 m-----------------------kIKNHYLscedskmr----------------------------------------- 75  Aciduliprofundum b...
YP_024131  59 l-----------------------nIKTDLIglksnnem----------------------------------------- 74  Picrophilus torrid...
EED32739   99 a----------------------qlAPHHLLem----------------------------------------------- 109 gamma proteobacter...
YP_843921  66 m-----------------------gIRNHFVrylppagmi---------------------------------------- 82  Methanosaeta therm...
EED35172  101 e----------------------glARSHILev----------------------------------------------- 111 gamma proteobacter...
YP_658825  62 n-----------------------gISTHYIgvvrpskaetttidnqssdesdhittdpcsldacstaptemaikltqvp 118 Haloquadratum wals...

Feature 1                      #### #   # # #   ###                                    # #    
1OBG_A     91 klsepkyktqleDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGtv-hgLKQPQGLKE--SQEFPEPIFTPSTKAEqg 167 baker's yeast
AAF97181   81 ---rkvevvkepGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQRGEltaesLGVSQDAEY--GVKLSEPFVEVTTKFEa- 154 uncultured marine ...
Q9HLC0     75 ----rvrkydvpEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGStkpadIGLNHFPDY--GEKLPSPVFEVTTKREk- 147 Thermoplasma acido...
Q9HNU7    112 ---fedgsydydRYHDAGGSNYLVPLEVVFRNAVPVGSSLRTRCAPad-vgIDADEWPQG--PVELPETIVEFSTKYEe- 184 Halobacterium sp. ...
EDY37097   76 -----vgrfriiNKPRIENENYLIPLEFITRYYVAGSLYERLKNGKmdyklLGFESMPEY--GEKLPEPYFEITTKFEa- 147 Aciduliprofundum b...
YP_024131  75 ----vvkrydvvNKGFNFKINYMIPIEFITRYYVAGSLYDRIKSKKidyhdLGFKNEPEY--GEKLPDPFFEMTTKREk- 147 Picrophilus torrid...
EED32739  110 ----------phPMVWIVRQAKPLMIEAIARRYLTGSLWRAYAQGErviggVTLPDGLKQ--YQRFSELLFTPSTKGVvr 177 gamma proteobacter...
YP_843921  83 ---vrkvsivspERITRETKGHLIPLEFICRWYVAGSLFDRIESGEiepeaLGFPRGRKVsfAEQLPEPYIELSTKLEk- 158 Methanosaeta therm...
EED35172  112 ----------phPLVWVVQRAQPIQIEAIARRYITGSMWRAYHAGArdfcgYTLPPGLRA--HERLEELVVTPSTKGIir 179 gamma proteobacter...
YP_658825 119 alpyddgaydyeSYHEAGGQNYLIPLEVVFRNSVPIGSSLRDRKSPqe-ydIDADAWPSN--PVELPKPVIEFSTKYEe- 194 Haloquadratum wals...

Feature 1              #                                                    ### #             
1OBG_A    168 -------eHDENISp---AQAAEl------VGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDek---tnEI 228 baker's yeast
AAF97181  155 --------FDRNIDr---EEALQis----nITDQEFDSIVQAALKVDEIIEREAAKNGLIHVDGKKEFALGpg----rKV 215 uncultured marine ...
Q9HLC0    148 --------TDRLLDi---DEALEis----gLTREEYAEIRETILKIDEMMEQEVGKRGLIHADGKKEVALGke----rEP 208 Thermoplasma acido...
Q9HNU7    185 --------QDRYLSr---SMADEi------AGDADIAELDALARRVNETITDCAADAGFVHDDGKLECVYVd-----gEV 242 Halobacterium sp. ...
EDY37097  148 --------YDRKVSf---EEAREig----gLRQSEIEEIRELILKVDEIITNEVGKRGLLHVDGKKEFAFGeg----rEI 208 Aciduliprofundum b...
YP_024131 148 --------TDRVLNt---DEAMSis----gMEKHEIYEMMELIFKIDRRINESVESRGLIHVDGKKEFALGlk----rEP 208 Picrophilus torrid...
EED32739  178 glrdvpetDDAPLSp---AALRShyqafglQSEAQLDACVTALRSGFECIERSLAQHGELLVDTKFEFGIAptlhggeEL 254 gamma proteobacter...
YP_843921 159 --------TDRLLSr---DEALEla----kLSPQEFEEITEIIIRIDEDIRRCVEPRGLIHVDGKKEFAFDen----rEI 219 Methanosaeta therm...
EED35172  180 gipgvpeaDDVNVSrsilRAHWRaf---dfRASATSIATSSCYAPALTLSAAISPGQGRIFVDTKFEFGYVhsesgtlEM 256 gamma proteobacter...
YP_658825 195 --------QDRYLDr---EEAERi------AGAASIDTLEELAVSVNRIITREAEKRGFVHEDGKIECLYHd-----gEI 252 Haloquadratum wals...

Feature 1        #     ####                                                                   
1OBG_A    229 ILVDEVlTPDSSRFWNgasykvgesqdSYDKQFLRDWLTANKlng------------------------vngVKMPQDIV 284 baker's yeast
AAF97181  216 VLVDTFgTLDEDRWWDaeays-ngeciELSKEFVRTHYINSGhqaelklar------------dsgaidppiPALPESVI 282 uncultured marine ...
Q9HLC0    209 IIVDTFgTADEDRFWEkkeyd-agrivELSKEMVRQYYRSTGyhdrlyear------------srgmpepdiPPLPEDMA 275 Thermoplasma acido...
Q9HNU7    243 RVADVAgTFDENRFRFdg--------rEVSKEAVRQFYKRSDpewvgavkdakraadergvadwkslcepspDPLPPEIL 314 Halobacterium sp. ...
EDY37097  209 YLVDTFgTLDEDRWWDkdaye-rgkivQLSKEFVRQYYRSIGyyeelkmar------------eegkeepeiPPLPKDMV 275 Aciduliprofundum b...
YP_024131 209 VVCDTFgTPDEDRFWDlkeyk-knnimELSKEMVRQYYRETGyherlysar------------enhekepdiPPLNDEMI 275 Picrophilus torrid...
EED32739  255 IYMDEVgTPDSSRIWRqddwq-rgqpkEHSKEQFREALMAWVedrdmlldpar---------mtersafakaNPVPDTFF 324 gamma proteobacter...
YP_843921 220 MVVDVYgTADEDRFWDramye-egeyvDLSKEYVRKYYRQIGykdmlyqar------------sskmpepeiPPLPDEIV 286 Methanosaeta therm...
EED35172  257 IYMDEVgTPDSSRIWEgdayr-qgqvvERSKEAFRQALLDLApdpavlldkqr---------maerlafaatTTLPLELM 326 gamma proteobacter...
YP_658825 253 ILADVVgTFDENRFGYnd--------qEVSKEVIRQQYKQIDpewvsavtdakrqakiqdvadwrghcdrspTPLPQPFI 324 Haloquadratum wals...

Feature 1                     
1OBG_A    285 DRTRAKYIEAYETLTG 300 baker's yeast
AAF97181  283 EETASLYSSMYERLTS 298 uncultured marine group II euryarchaeote 37F11
Q9HLC0    276 RKVSDLYKTMYERITG 291 Thermoplasma acidophilum
Q9HNU7    315 QAAADLYAAGANRYTA 330 Halobacterium sp. NRC-1
EDY37097  276 EKVSKLYVEMYERITG 291 Aciduliprofundum boonei T469
YP_024131 276 KRISNLYIDLYQKITG 291 Picrophilus torridus DSM 9790
EED32739  325 EDLSHTYAAQAERILG 340 gamma proteobacterium NOR5-3
YP_843921 287 QRTSEIYIKLYERITG 302 Methanosaeta thermophila PT
EED35172  327 MDVSQNYLGLGREITG 342 gamma proteobacterium NOR51-B
YP_658825 325 NTISDLYAAGTNAYVD 340 Haloquadratum walsbyi DSM 16790

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