Conserved Protein Domain Family
SIR2-like

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cd01406: SIR2-like 
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Statistics
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PSSM-Id: 238697
Aligned: 21 rows
Threshold Bit Score: 179.905
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAC16793      19 GYAAVFAGAGLSVa--SGYVDWKTLVTPLAQELnlnie-----------------------------eendlTKVAQYYr 67   Pediococcus pe...
NP_946172     67 KGAAVFFGAGLSIp--CGIPGWSQLLQNFKIERalleda---------------------------dlrddpLTMAELAs 117  Rhodopseudomon...
NP_052709     23 GNLIIFVGAGISMl--LGLPSWKGYAQEILEDAiekgvidsely-----------------eklkeedpkkiLTICKMLf 83   anthrax bacterium
NP_832692     30 GKLVLFVGAGVSMkgkSNLPNFDDLVDEIAKTLyvekre---------------------------itephdYYLGKIAk 82   Bacillus cereu...
NP_762610     22 GRVVFFCGAGVSRa-kAGFADFFGLASSVTSELgvetsspalklieaa---------keitastgvegvvsaDRIFGLLe 91   Vibrio vulnifi...
CAE15078      21 GHVVFFCGAGISLa-kAKLPNFFQLAQKVIDLLgttndsqarqlydflnkglkdkegnevalpsyastlistDRIFSLLe 99   Photorhabdus l...
P55383        21 GNVVFLCGAGVSA---PQLPNFRDLVLNVYNRLgeertpaed----------------------hafqasryEEVLGALs 75   Rhizobium sp. ...
NP_794029    182 GRFSLTLGAGVSSs--AGLPDWNTLLNSLLVSMlsqenfggph-------------------gdpakvseivARLMEVDg 240  Pseudomonas sy...
NP_970413    135 KRVVPFVGAGLTVs--CGMPTWTSFLNDQATENel------------------------------------dLEMFKSLi 176  Bdellovibrio b...
ZP_00200395   20 GRLVIFAGAGVSKgspSNFPDFEGLADEVMSRSaqil-------------------------------trgkAEPVDHFf 68   Moorella therm...
CAC16793      68 nefksrgdinq----timeafskekePNENIDILTRLPiy-------------------------tYWTTNYDKLLEEGF 118  Pediococcus pe...
NP_946172    118 kqvghenlqe-----tlrilsnqatkFSVNHALLAALScp-------------------------iYITTNYDVLFEKAF 167  Rhodopseudomon...
NP_052709     84 dekeiipksa-----neifkfekneeYKAIYEKLYSMNa--------------------------iYITTNYDECLDVLT 132  anthrax bacterium
NP_832692     83 tkdvhqvar--------dlvhiekskPNPLHYAIPRLFpldt---------------------dirIVTTNFDQHFTTAI 133  Bacillus cereu...
NP_762610     92 refltrdiyks----vakaltpegevDLSAHQTMLKLAttnd--------------------givrLVTTNFDRLFDLCK 147  Vibrio vulnifi...
CAE15078     100 qefetnliekt----vaqvlkpsdtvDTSAHKLLLDLAttse--------------------grvqLITTNFDRLFNDCS 155  Photorhabdus l...
P55383        76 rrlvrsedvid---aaaaelqvpanpDTAHHDVILRLSrdqv--------------------grpiIVTTNFDTLFERSL 132  Rhizobium sp. ...
NP_794029    241 pstlmlaryirkglavgspveqqgfvDAITHQLYSLRDkkfpveselissiaklctptrtganvrsILTYNFDDFIERAL 320  Pseudomonas sy...
NP_970413    177 skghyencadl----lleqmtgprfnERYKHSFTLRQSvvgpikyl-------------ptiftngVITTNFDEVLEKTY 239  Bdellovibrio b...
ZP_00200395   69 grlkkkgvhvhr--ivreiltrpdakPTKLHKELLSLFrnpq---------------------evrVVTTNFDRHFSTAA 125  Moorella therm...
CAC16793     119 Knnnrkvdvkcret--------------------rlstqkydrdaiLYKMHGDVDDPAEa---------VLTKQDYEIYN 169  Pediococcus pe...
NP_946172    168 Keihrggkipvvvndad-------------mqtnevqdalankdpvLFKIHGCAERTKEh--------lILTRRDYRIHY 226  Rhodopseudomon...
NP_052709    133 TpqsdnekvsnsmdlseenklteqssetkvfidhtelleaelkngnVIHIHGSVKKEESm---------LVTVQDYLERY 203  anthrax bacterium
NP_832692    134 Keinrdinvyya-----------------------palptgrafkgLAYIHGNVEQEKEa--------lILTDGDFGRAY 182  Bacillus cereu...
NP_762610    148 Pdintfmpprlp------------------------dlnhpidfngTVYLHGKVNEDGTgaas---ngfVLSSSEFGDAY 200  Vibrio vulnifi...
CAE15078     156 Lteipcflppnl-----------------------pdlsknelidgLVYLHGRSNSDYIgaeg---ngfVLSGSEFGRAY 209  Photorhabdus l...
P55383       133 Mvshsaafatqesaa-----------------gqdipapgsarftgVVHTHGRLTDDELnlsq---telVLTSAQYGEAY 192  Rhizobium sp. ...
NP_794029    321 Lsrslvhksvfe-----------------------efetpsaeelpVYHVHGFLPEDRQrysnldrctlVFSEEGYHQIY 377  Pseudomonas sy...
NP_970413    240 Alksrpldaitdd----------------------wmthvkkgnnfIYKIHGTIEGTANr---------VLTKNEYDSKY 288  Bdellovibrio b...
ZP_00200395  126 Sklfgdnkipvyw---------------------apalplghrfngIVYLHGCVDQEAEe--------fILTDSDFGRAY 176  Moorella therm...
CAC16793     170 Qrn-----plFTSILQGDLi----sKTFLFIGFSFEDPNLTNVLAatrni-----ldeniSNNYWLEKRVTkpsdieest 235  Pediococcus pe...
NP_946172    227 Rfn-----vkFFTKIKSLMe----dHCVLFAGFSHKDPEVSRLVEdiiydyenhqsgkpaPRFFSLQFQMLsht------ 291  Rhodopseudomon...
NP_052709    204 GtiskqshpeVSVFLDQVFns---nYVVLFMGYGLEEFEILEYMLsktkn-----pshtiSHYMLFSENEEnpqmtnl-- 273  anthrax bacterium
NP_832692    183 Lte-----gwARRFLVDLFs----nYTVLFVGYSHNDPVMKYLATglp---------pstRRFAFVAQGENtyh------ 238  Bacillus cereu...
NP_762610    201 Lan-----gwATSFVKGILe----kYVVVFVGYSADDPPIQYLLEalnks------sshlNDIYAFQSGDEsyass---- 261  Vibrio vulnifi...
CAE15078     210 Lsd-----gwATNFIREIFs----kYTVVFIGYSANDPPMQYLLEglnkn------likaKNVYAFQSGTIeeark---- 270  Photorhabdus l...
P55383       193 Lra-----gwAARFLFDLMr----cRTLVLVGYTANDAPVRYILNvlegdr---erftdlRRVYALSSSNGdpqaaaapw 260  Rhizobium sp. ...
NP_794029    378 Rday---hwsNLVQLNSFKe-----SSCLMIGLSLTDPNLRRLLEiasks------ieepKHFAFMRRLTSkkfmeg--- 440  Pseudomonas sy...
NP_970413    289 Geng---svnLERVLPKFLractesFSLMFVGCSLTSDRTFQTLKkinsd-----fgmttTHFAILQKPEDrakrnqr-- 358  Bdellovibrio b...
ZP_00200395  177 Lte-----gwATSFLKSLFg----kYAVLFVGYSHNDQIMEYLGRslp---------pesLRFALVPEDIGeeerekw-- 236  Moorella therm...
CAC16793     236 eakvryevdrtkqelkihELQRYGI 260  Pediococcus pentosaceus
NP_946172    292 ----------------peIFAARGI 300  Rhodopseudomonas palustris CGA009
NP_052709    274 -----------ykkyysnFGVELIP 287  anthrax bacterium
NP_832692    239 ---------------wehLGIRPIV 248  Bacillus cereus ATCC 14579
NP_762610    262 --------------kwhhKGVKAIA 272  Vibrio vulnificus CMCP6
CAE15078     271 --------------lwehKGVQAIA 281  Photorhabdus luminescens subsp. laumondii TTO1
P55383       261 qal---avepllfdpeggNPYGPLW 282  Rhizobium sp. NGR234
NP_794029    441 ------------asgkplKISNAVV 453  Pseudomonas syringae pv. tomato str. DC3000
NP_970413    359 -----------ekelveaNIFPIWF 372  Bdellovibrio bacteriovorus HD100
ZP_00200395  237 -----------klrgiepIFYPHTK 250  Moorella thermoacetica ATCC 39073
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