Conserved Protein Domain Family
PncB_like

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cd01401: PncB_like 
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Statistics
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PSSM-Id: 238695
Aligned: 21 rows
Threshold Bit Score: 520.652
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
Q9HW26     12 QNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRNqed-----lrLYLPAIREQLEYLAGLAISDEQLafle---ripfLA 83  Pseudomonas aerugi...
P39683      7 KSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSsqlt---fnkEAINWLKEQFSYLGNLRFTEEEIeylkqeipylpSA 83  baker's yeast
Q9UTK3      7 VSILDTDLYKLTMLQAVLEHYPDAQVSYKYTNRSpkma---lnqEAYNWLREQIRGLRNLHLLPEEEqwlrk--ncpyLK 81  fission yeast
Q8TMW6      3 KSILDNDLYKFTMQMAVLELFPKAEAEYRFTNRGshhfseefveKLRRVIDEDISALMLTEDEYQWLgen-----csfLK 77  Methanosarcina ace...
NP_810826   4 RTLLDTDLYKFTTSYAYIKLFPYAMGTFSFNDRNete----yteEFLEALKSEFNKLSRLRLTEEELeymtr--ncrfLP 77  Bacteroides thetai...
EAK96194   11 KSFLDTDLYKLFMHAAVNKQFPDVPVKYRYTNRTpqlk---lnsQAISWLKKQIEYLGDLRFSAEEIlylhr--vlpqLP 85  Candida albicans S...
EAK85718   22 RSILDTDLYKLTMQQAVLRHYPHTRVAYKFTNRSaatm--kftrQAMDRIRNHIDNLVHLSLSAQERawler--scpyLG 97  Ustilago maydis 521
NP_904408   5 RSILDTDLYKFTTGYAYAKLFPRAYGEFRFIDRNrqg----fteEFAELVRGEIRAMAALSLTRDEKeflqr--elpyLP 78  Porphyromonas ging...
Q8DA38     12 QSVLDLDVYKINMMQAAYRFYPQTQVRYELIVRSddn-----lsDLVEEVREEINRLAELRFDAAQLaylae--kapyLT 84  Vibrio vulnificus
EAA61949   12 FSLLDTDLYKLTMQCAILKYFPDVQVTYGFTNRTphmk---ltrGAYKWMLAQMDKLANIRVTEDEIaflkr--rcpyFN 86  Aspergillus nidula...
Feature 1                                                                                     
Q9HW26     84 PDFIRFLGLFRFNPRYVQtgie-----------ndefFLRLKGPWLHVILFEVPLLAMISEVRNRARYPAATVEQARERL 152 Pseudomonas aerugi...
P39683     84 YIKYISSSNYKLHPEEQIsftseeie---gkpthyklKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQA 160 baker's yeast
Q9UTK3     82 ESFYEFMHEFEFDPENSIslnyds--------etkdlSIFIHGLWKNTIFYEIPLLALVSESYFKFVDKDWSPEGQFEKA 153 fission yeast
Q8TMW6     78 PMYLEYLKNFRFKPGEVEvclte----------ekelDIRIKGPWHSTILWEIVLMAAVSELYFTTIEKEWNGKEWDGNI 147 Methanosarcina ace...
NP_810826  78 RVYWEWLSSFRFDPDKIDihldt----------tgrlHIEVSDFLYKVTLYEVPLLAIVSEIKNKFFGNVPDMSEILCKL 147 Bacteroides thetai...
EAK96194   86 SDYLEYLADFKLVPSSQIkyldn---------degdfELEIVGKWNDTILYEIPLLALVSEAYFKFVDTDWNYEGQYALA 156 Candida albicans S...
EAK85718   98 KDYLDYLEAFRFQPKQQVqlrflptg----edgwghlDLNVSGVWSDVIFYEVPLMAIVSEVYFSTIDTDWSLQDQYQQA 173 Ustilago maydis 521
NP_904408  79 PIYIDFLDGFRFDPEEVTvsida----------qghlDIRAQGLLYRVTLWETPILAVISELYYRFIGAEPDWKQVEEVT 148 Porphyromonas ging...
Q8DA38     85 AEFLSYLETFRFHPQQQVsvgifrt-----aqgdcqlRVTINGIWHETILYETLVMSIISELRNRRYWAQIPQSQLHKVL 159 Vibrio vulnificus
EAA61949   87 TAYLDFLTNFRLKPSEQIdinftpvndtgsdsdfgdiDYIVKGAWVDTILYEIPLLALTSQAYFMFSDKDWNYECQEGKA 166 Aspergillus nidula...
Feature 1                                      ###                                ##          
Q9HW26    153 QEKFDwlrreasa--------eelagfkMADFGTRRRFSYRVHEAVVSGLKEdf--------pGCFVGTSNVHLARKLDL 216 Pseudomonas aerugi...
P39683    161 EKKAEtlfd---------------ngirFSEFGTRRRRSLKAQDLIMQGIMKavngn-pdrnkSLLLGTSNILFAKKYGV 224 baker's yeast
Q9UTK3    154 YEKGKrlir---------------agcaFTDFGTRRRRDPHTQEIVLQGLMKaqed---fkgpGSFLGTSNVYFAAKYNL 215 fission yeast
Q8TMW6    148 SATSEsiltaygekileigkileengclFAEFGTRRRRSFELHDQVMKTLLQi----------ETLTGTSNVFFAKKYGL 217 Methanosarcina ace...
NP_810826 148 SEKVElsnq---------------hqlrFSEFGTRRRFSIDVQETVIKRLNDt---------aKYCTGTSNCYFAMKYGM 203 Bacteroides thetai...
EAK96194  157 QKKAKqlis---------------necnFSEFGTRRRRSYESQEIVIKAIKDvqid----tqsKYIAGTSNVYFAMKYDL 217 Candida albicans S...
EAK85718  174 FDKACrlts---------------ngirYSEFGTRRRRSYQTHRIVLQGLMAgdlsassgcssGKLLGTSNVHFAQQFDL 238 Ustilago maydis 521
NP_904408 149 RSKGElmre---------------hratFSIFGMRRRFSLEVEDRVTDILKQya--------gESLFGTSNVHLAHKHGL 205 Porphyromonas ging...
Q8DA38    160 EDKLDfldselkr--------rnitnfrFSEMGTRRRFSFAAQKTMLDVLRArv--------pELLLGTSNYHLAQEFNL 223 Vibrio vulnificus
EAA61949  167 YRKGYvlle---------------ngctFSEFGTRRRRSYHTQDLVMQGLCRaaregkakglpGVFTGSSNVHFAMKYDV 231 Aspergillus nidula...
Feature 1                                                                                     
Q9HW26    217 KPLGTMAHEWLMAHQQLgprlidsqsAALDCWVReyr----------glLGIALTDCITT----DAFLRDFDLYFAk--- 279 Pseudomonas aerugi...
P39683    225 KPIGTVAHEWVMGVASIsedylhankNAMDCWINtfg---------aknAGLALTDTFGT----DDFLKSFRPPYSd--- 288 baker's yeast
Q9UTK3    216 NVSGTVAHEWYMGIAAItqnykqanrIASLKWVQtfg----------tsLLIALTDTFST----DVFLKSFTANSAddl- 280 fission yeast
Q8TMW6    218 KPIGTVGHEWIMGTSALiglr-yanrFAFENWVEvyk----------gdLGIALTDTFGS----EAFFKDMDLKLSk--- 279 Methanosarcina ace...
NP_810826 204 KMMGTHPHEWFMFHGAQfgyk-hanyMALENWVNvyd----------gdLGIALSDTYTS----GIFLSNLSRKQAk--- 265 Bacteroides thetai...
EAK96194  218 PPIGTVAHEWYMGIASItqdyvhankLAMDYWIDtfg---------akyAGLALTDTFGT----DNYLTMFVAPYVn--- 281 Candida albicans S...
EAK85718  239 VPIGTVAHEWTMAIAALqgya-hsnlKALQLWDAvysapdfvansathdLTIALTDTFST----NVFWNDLLDNPSgiei 313 Ustilago maydis 521
NP_904408 206 RVSGTHPHEWIQFHGAIygyk-manyVAMEDWINvyd----------gdLGTVLTDTYTT----DVFMRNFSKKHAm--- 267 Porphyromonas ging...
Q8DA38    224 TPIGTVAHEWTMAHQALvaiq-hsqrVALDKWLEafn----------gsLGIALTDTIGI----DAFLSDFDLDKAt--- 285 Vibrio vulnificus
EAA61949  232 DPVGTVAHEWYMTIAAItddyenaneMALKYWLGcfg---------egvLGIALTDTFGTpaflDAFRKPIPDYTSagtg 302 Aspergillus nidula...
Feature 1                                                         #                           
Q9HW26    280 ---------------------------------------------lFDGLRHDSGDPLLWAEKTIAHYLklgi-dplTKT 313 Pseudomonas aerugi...
P39683    289 ---------------------------------------------aYVGVRQDSGDPVEYTKKISHHYHdvlklpkfSKI 323 baker's yeast
Q9UTK3    281 -------------------------------------------anvFHGVRQDSGCAEEYIEKVVKHYKsigv-dpsTKV 316 fission yeast
Q8TMW6    280 ---------------------------------------------iYDGFRHDSGDPFTFVDRVIDHYRkmgi-dpmKKV 313 Methanosarcina ace...
NP_810826 266 ---------------------------------------------lFDGVRCDSGNEFDFIDKLVARYKelgi-datTKT 299 Bacteroides thetai...
EAK96194  282 ---------------------------------------------eYSGVRQDSGDPELYAEKIARHYEkmgi-aknTKI 315 Candida albicans S...
EAK85718  314 -------------------------------------------arrWRGLRQDSGDSKAFAQKALDAYRsigv-dpkSKV 349 Ustilago maydis 521
NP_904408 268 ---------------------------------------------lFTSLRHDSGDPEIFIEKAVRRYEelrv-dpkIKY 301 Porphyromonas ging...
Q8DA38    286 ---------------------------------------------aYAGVRHDSGSPFVWGDKIIAHYEslgi-dptTKT 319 Vibrio vulnificus
EAA61949  303 avsttasgpsttaesniqseaetkapitaplspdhpppavktyaqvYAGVRQDSGDPSYFVKMARDFYDreg--itgTKT 380 Aspergillus nidula...
Feature 1        ##                       # ##  #                                             
Q9HW26    314 LVFSDGLDlPRALKIYRALqg-riNVSFGIGTHFTCDlp--------gvEPMNIVVKMSACN------GHPVAKISDTPG 378 Pseudomonas aerugi...
P39683    324 ICYSDSLNvEKAITYSHAAkengmLATFGIGTNFTNDfrkkse-pqvksEPLNIVIKLLEVN------GNHAIKISDNLG 396 baker's yeast
Q9UTK3    317 IVHSDALNvDRCIELYKYCekcgiKSAFGIGTNLTSDfqkvsn-psevsKPMNIVIKLFSAE------GTKAVKISDDIM 389 fission yeast
Q8TMW6    314 IVFSDALNaEAAIRLKKYCqd-kiNCSFGIGTSLTNNseff-----resPPLNMVIKLHSVN------GIPVVKLSDSPE 381 Methanosarcina ace...
NP_810826 300 IVFSNALDfTKALEIQEYCkd-kiRCSFGIGTNLTNDtg---------fAPSNIVMKLTQCKmnvnqeWRECIKLSDDEG 369 Bacteroides thetai...
EAK96194  316 ICFSDSLNvEKCLKYKNTAdklglISTFGIGTFFTNDfnkls--ngeksQPMNIVIKIKEAN------GKPAIKISDNIG 387 Candida albicans S...
EAK85718  350 VIYSDGLDvDRCLELAAYSnhigiGAAFGIGTSFTNDfiqls--taqksKPLNIVIKLDSVE------HRRVVKISDDLT 421 Ustilago maydis 521
NP_904408 302 IIFSDSLTpQRAIEIQKLCag-riKASFGIGTNLTNDvgg-------gvEPLNIVMKLWKCKmtakddWHYCVKLSDVDG 373 Porphyromonas ging...
Q8DA38    320 LIFTDGLDfARALDICEYFag-raQISFGIGTFLANDmgnwtndkgtryQPISMVVKMAECN------GSPVAKISDEPE 392 Vibrio vulnificus
EAA61949  381 VVFSDSLDiEHCLEYKVLAeeagfKPVFGVGTFFTNDfintt--tneksQPLNIVIKISSAN------GRAAVKLSDNMG 452 Aspergillus nidula...
Feature 1        
Q9HW26    379 KAQ 381 Pseudomonas aeruginosa
P39683    397 KNM 399 baker's yeast
Q9UTK3    390 KNT 392 fission yeast
Q8TMW6    382 KET 384 Methanosarcina acetivorans
NP_810826 370 KHT 372 Bacteroides thetaiotaomicron VPI-5482
EAK96194  388 KNM 390 Candida albicans SC5314
EAK85718  422 KNT 424 Ustilago maydis 521
NP_904408 374 KHT 376 Porphyromonas gingivalis W83
Q8DA38    393 KAM 395 Vibrio vulnificus
EAA61949  453 KNT 455 Aspergillus nidulans FGSC A4

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