Conserved Protein Domain Family
HMT_MBD
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cd01395: HMT_MBD 
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Links
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Statistics
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PSSM-Id: 238689
Aligned: 9 rows
Threshold Bit Score: 69.7159
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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DNA binding
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # # #         # #          #  #   #                    
Q96T68     164 PLQLPiKCHFQRRHAKTNsh----sSALHVSYKTPCG--RSLRNVEEVFRYLletecnfLFTDNFSF 224  human
AAN61106   183 PLQLPiSCDFQRCHLKINsp----dDLSHILYKAPCG--RSLRDYDEVHSYLtetgchfLAVDNFSF 243  African clawed frog
CAF97873   621 PLLMPlLYEFRRMTGRRKvn---rkMSFHVIYKAPCG--LCLRNMSEIQHYLfqtncdfIYLEMFCL 682  Tetraodon nigroviridis
Q15047     599 PLLVPlLYDFRRMTARRRvn---rkMGFHVIYKTPCG--LCLRTMQEIERYLfetgcdfLFLEMFCL 660  human
AAN71064   446 PLAKPlLSGWERLVMRQK-------TKKSVVYKGPCG--KSLRSLAEVHRYLrat-envLNVDNFDF 502  fruit fly
P34544     829 PIHTPlLCGWRRIMYTMStgkkrgaVKKNIIYFSPCG--AALHQISDVSEYIhvt-rslLTIDCFSF 892  nematode
CAE71274   782 PLHTPlLCGWKRLKYTMHsgkkrasVKKVIIYRAPCG--KPLEKTSEIADYLrst-rsqLTIDCFSF 845  Caenorhabditis briggsae
XP_317488  318 LLARPlITGWERHKTAARg-----qKKSVVLYRAPCG--RRLRNMAELHQYLrvt-dspLNVEHFDF 376  Anopheles gambiae str. PEST
NP_996941  151 PLRAPlLCHFQRVCDDAGv------VYKAPCGRSLSCmqEVLHFLLQTQSVCv------LQTDRFSF 205  zebrafish

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