1G18,2CVF,1SZP,2REC


Conserved Protein Domain Family
RecA-like
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cd01393: RecA-like 
RecA family
RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.
Links
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Statistics
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PSSM-Id: 410881
Aligned: 16 rows
Threshold Bit Score: 148.655
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ATP bindinghexamer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:contains Walker A and Walker B motifs
  • Structure:1G18; Mycobacterium tuberculosis RecA bound to ATP analog ADP-AlF(4), contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ######                           #                                    
1G18_A        60 GRVIEIYGPeSSGKTTVALHAVANaqa------aggVAAFIDAEHaldpdyak----------------------klgvd 111 Mycobacterium t...
2CVF_A        20 GVLTQVYGPyASGKTTLALQTGLLsg---------kKVAYVDTEGgfsperlvqmae--------------trglnpeea 76  Thermococcus ko...
1SZP_A        99 GSITELFGEfRTGKSQLCHTLAVTcqipldigggegKCLYIDTEGtfrpvrlvsiaq--------------rfgldpdda 164 baker's yeast
CAD66573     111 GSLTEITGPpGCGKTQFCIMMSILatlptnmgglegAVVYIDTESafsaerlveiaesrf-------pryfnteeklllt 183 human
AAC39719      61 GEVTEIVGGpGSGKTQVCLCMAANvahg-----lqqNVLYVDSNGgltasrllqllqa-----------ktqdeeeqaea 124 human
2REC_A        60 GRIVEIYGPeSSGKTTLTLQVIAAaqr------egkTCAFIDAEHaldpiyar----------------------klgvd 111 Escherichia coli
CAA70065      41 GDILEFHGPeGTGKTEMLYHLTARcilpksegglevEVLFIDTDYhfdmlrlvtilehr---------lsqsseeiikyc 111 human
XP_788113    141 CKITEICGApGVGKTQTCIQLCVDvqipaslggvegEAVYIDTEGsfipqrawgiaqaatehchtmgdqaelkdftteki 220
EGX51637      60 GKLVEICGPpGSGKTTIAVQLVVDavs------kgeQVCWIDTLSqcptsrlegil----------------merdlask 117 Arthrobotrys ol...
XP_003344418  71 AQVIEIWGPpGVGKTAFGVQLATNclg------egkGVVWVDGFHrvpierlrsvlgskv-------krdkqgeqedatv 137 Sordaria macros...

Feature 1                                                     #                                  
1G18_A       112 tdSLLVSQPdt-----gEQALEIADMLIRSga-------lDIVVIDSVAALvpraelegemg------------dshvgl 167 Mycobacterium t...
2CVF_A        77 lsRFILFTPsd-----fKEQRRVIGSLKKTvds-----nfALVVVDSITAHyraeenr--------------------sg 126 Thermococcus ko...
1SZP_A       165 lnNVAYARAyn-----aDHQLRLLDAAAQMmse----srfSLIVVDSVMALyrtdfsgrg----------------elsa 219 baker's yeast
CAD66573     184 ssKVHLYRElt-----cDEVLQRIESLEEEiis----kgiKLVILDSVASVvrkefdaqlq--------------gnlke 240 human
AAC39719     125 lrRIQVVHAfdifqmldVLQELRGTVAQQVtgss---gtvKVVVVDSVTAVvspllggq------------------qre 183 human
2REC_A       112 idNLLCSQPdt-----gEQALEICDALARSga-------vDVIVVDSVAALtpkaeiegeig------------dshmgl 167 Escherichia coli
CAA70065     112 lgRFFLVYCs------sSTHLLLTLYSLESmfcs--hpslCLLILDSLSAFywidrvngg---------------esvnl 168 human
XP_788113    221 lsGIHYFRChn-----hVELLALVNLLPEFlskn---pkvKLIIVDSIAFHfrhdfdd-------------------msl 273
EGX51637     118 asSILRYQIt------sLAHFFAIISHLTKisl-----eiSLVIIDGISLLftkefppaasdapqfqnlpnrghekqidk 186 Arthrobotrys ol...
XP_003344418 138 deRLDALTHy------tCPSLPHLIALLCRptpscvpqntSLIVVDSLSALvnhafprtpeqkkvvd-skgnkvpslstr 210 Sordaria macros...

Feature 1                                   #                                                    
1G18_A       168 qarlMSQALRKMTGALNnsgTTAIFINQLrdkigvmf---------------------gspetttGGKALKFYASVRMDV 226 Mycobacterium t...
2CVF_A       127 liaeLSRQLQVLLWIARkhnIPVIVINQVhfdsrt------------------------emtkpvAEQTLGYRCKDILRL 182 Thermococcus ko...
1SZP_A       220 rqmhLAKFMRALQRLADqfgVAVVVTNQVvaqvdggma------------------fnpdpkkptGGNIMAHSSTTRLGF 281 baker's yeast
CAD66573     241 rnkfLAREASSLKYLAEefsIPVILTNQItthlsgalasqadlvspaddlslsegtsgsscviaaLGNTWSHSVNTRLIL 320 human
AAC39719     184 glalMMQLARELKTLARdlgMAVVVTNHItrdrds------------------------grlkpaLGRSWSFVPSTRILL 239 human
2REC_A       168 aarmMSQAMRKLAGNLKqsnTLLIFINQIrmkigvmf---------------------gnpetttGGNALKFYASVRLDI 226 Escherichia coli
CAA70065     169 qestLRKCSQCLEKLVNdyrLVLFATTQTimqkasssseepsha-------srrlcdvdidyrpyLCKAWQQLVKHRMFF 241 human
XP_788113    274 rtrlLNGLAQNFIRIATqynLAVVLTNQMttkigeg----------------------tshlipaLGESWGHACTIRVIL 331
EGX51637     187 rgrlVADIANQLQRFSAsrmAAVVVLNQLatkaargggp-----------------lelapsvhsATHSWAHAFHHRILL 249 Arthrobotrys ol...
XP_003344418 211 rlqvLQYIIGALQKLAAtrdVAIVVLTQCatkmmqaer-------------------gatlvpaiNASVWEQGISTKLVL 271 Sordaria macros...

Feature 1         #
1G18_A       227 RR 228 Mycobacterium tuberculosis
2CVF_A       183 DK 184 Thermococcus kodakarensis
1SZP_A       282 KK 283 baker's yeast
CAD66573     321 QY 322 human
AAC39719     240 DT 241 human
2REC_A       227 RR 228 Escherichia coli
CAA70065     242 SK 243 human
XP_788113    332 YW 333
EGX51637     250 LR 251 Arthrobotrys oligospora ATCC 24927
XP_003344418 272 YR 273 Sordaria macrospora k-hell

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