Conserved Protein Domain Family
MYSc_Myo18
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cd01386: MYSc_Myo18 
class XVIII myosin, motor domain
Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276837
Aligned: 21 rows
Threshold Bit Score: 806.533
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                  #       #                                           
Q92614     419 SSVLHTLRQRYGASLlHTYAGPSLLVLGPrga-pavYSEKVMHMFkg-crREDMAPHIYAVAQTAYRAMLMSRQDQSIIL 496  human
EDV22061    21 SSILHLLRQRYGNNLiHTFAGPELIVINPlht-lpiYSDKVAKFFyg-cqLGDMPPHIYATVQAAYRNMLSTLANQAIVL 98   Trichoplax adhae...
EEB20247    96 SSVLYILRQRFGNNLiHTYAAGNLLVINPqct-lsiYNEKVAALFrg-ckSEDMPPHIYAMAQSSYRSMLSSRKDQSIVL 173  human body louse
EFN74075   386 SSVLHTLRQRYASNLiHTYAGDSMIVINPvap-laiYSEKVAHMFrg-ckSEDMPPHIYAIAQSAYRGMLATRRDHSLVF 463  Camponotus flori...
EFR23843   618 SSALHVLRQRYANNLiHTRAGPVLLIINPmap-lalYSEKVASMFrgckaEDDMPPHIFSQAQTAYRAALETRRDQSIIF 696  Anopheles darlingi
EFX67125    86 ASLLHTLRCRYAASLpHTYAGQSLVVINPvtp-lavYSERMIQLFrg-ckAEDMPPHIYSSAQSAYRSMLATRCDQSLIF 163  common water flea
ADY40035   237 TSAVHVLRHRYGSGLlYTNAGALSIICMAneq-eplLCNKLVALFkg-crRQQMPPHIYASAQQAYRKMQMSGRSQCLIL 314  pig roundworm
EHJ79042   403 CGALHVLRSRYAAALpHARAGHALLVLGPprrstpvYTEKVAAMFrs-crTDDMPPHVFAAAQSAHRAMLAARRDRAIVF 481  monarch butterfly
EFO23663    91 TSVLHVLRQRYGSNLfYTYVGPRNMICLAte---spKTTTTVSLFkg-crRQQIPPHIYSSAQQAYRALQMSGRNQCIIL 166  Loa loa
EKC35139   394 SSTLHTLRQRFGANLiHTYAGSNMVVVNPmhq-msiYSEKVIHVFkg-ckQEDMPPHIYASGQIAYRDMLNSRRDQSLIM 471  Pacific oyster

Feature 1       ########                                            ###########                
Q92614     497 LGSSGSGKTTSCQHLVQYLATIAGISgn-----kvFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVA 571  human
EDV22061    99 MGPSGSGKTTNARLIMSYLTSIKYQIi--------SILEKLKAANILLDAFGTAKTSINDKASRYINLTSLDFDNAGNFV 170  Trichoplax adhae...
EEB20247   174 LGRSGSGKTHNFRHILNYLLHSAGSVnk------vLNVEKLNALHTILEAFGNARTCLSINATRCTNLITLDFDQTGQIA 247  human body louse
EFN74075   464 LGRSGAGKTTNFKHALHYLVLAAGTVnk------iLTIEKLNALFTVLEAFGNSRTHMNSNATRFTQLFSLDFDQSGQIA 537  Camponotus flori...
EFR23843   697 MGRSGAGKTTNFKHALYYLTLATAAGsgssstarpLTVEKVSAIGTILDAFGNERTALCGNATKFTQIFALDFDHAGQLV 776  Anopheles darlingi
EFX67125   164 VGRSGSGKSHNFRNSLHYLCLAAGCPsk------iITVEKLNSICLLLEAFGNCRTALNTNATRFTNIFSLDFDQSGQIA 237  common water flea
ADY40035   315 TGVTGSGKSTQLRNVCHYLCEIAGWTk-------sLSYGKISAALGVVEAFGNCATRLSKNATRFAQMFSLSFDAAASLR 387  pig roundworm
EHJ79042   482 LGRSGSGKTSAMRHCVWYLATAYPAQgs------kLTPERLEAALDVLHIFGSSRSASNLHASRFVSLTSLDFDGAGALV 555  monarch butterfly
EFO23663   167 SGTSGSGKTMQLRNICRYFCEVAGWTk-------aLSYDTISSALFVLESFGNCRTKSSGNSTRFLTMFSLSFDTAASLR 239  Loa loa
EKC35139   472 MGRSGSGKSVCAKHILSYLTLAAGSVnn------vLTGDKLNAISTLMDAFGNSRSILNTNASRYGQLTTLDFDHSGQIV 545  Pacific oyster

Feature 1                                                                                      
Q92614     572 SASIQTMLLEKLRvarrpaSEATFNVFYYLLACGD-GTLRTELHLNhlaennv-----fgivplaKPEEKQKAAQQFSKL 645  human
EDV22061   171 GASIQAHLLERSRiirkpdFEGTFSIFHQLLHGSD-AALRTDLQLNlknsgnn-----rfinssdSITDKQNDISNWAKV 244  Trichoplax adhae...
EEB20247   248 SVCVQMLMLEKQRvakrpnGEGIFNVFYWLLAGAE-SSLAKKLLLDtnasqnsn----lfmtsiyKNEDRQRAVMELNKL 322  human body louse
EFN74075   538 SASLQVLLLEKSRigrrvnGDPTFHAVYRLLAGAE-GALRKELHLTnlvaenn-----pfvtplqKHEDKQRAMVEFNRI 611  Camponotus flori...
EFR23843   777 AGSIQVLPIDRMRpsgvasGTAGSAPRWSFLAGVDvGALRKELLLEpaltggsa----vggvgsaSGAMVQQETADYQRL 852  Anopheles darlingi
EFX67125   238 AASIQVLMPERERvtrrpdGQPSFNVFYELVAGAT-GELRRYLQLDsvsgggpnaepcaymtplqSAEDRQKAAVSYARL 316  common water flea
ADY40035   388 FASIRTFLLDSSHvvkqanGEANFHVFYYLLEGAE-PELVQSLRLDsitkpf--------rspliREEDKNAALLGWSRL 458  pig roundworm
EHJ79042   556 SASVQALLPDLRP------DQSPLRALHTLFHGCD-ARLRRELLLDqapvna--------pnpyiNSSDKTDAPTEFVAL 620  monarch butterfly
EFO23663   240 NASIQTFLLEKTRinrcitNGSVFHVIRYFLQGAD-SELVAAFKQK-------------------NDNSFADSQKDWLKL 299  Loa loa
EKC35139   546 SASIQVMLFEKTRvvrrpeGEPSFHVFYQMLAGLD-SSLRNELQLNalgdpnl------fmtplqRNEDRQRAAASWSKI 618  Pacific oyster

Feature 1                                                                                      
Q92614     646 QAAMKVLGISPDEQKACWFILAAIYHLGAAGATKea-aeAGRKQFARHEWAQKAAYLLGC-SLEELSSAIFKHQHKGgtl 723  human
EDV22061   245 QNAFQLLGISKENAKGIWFILAGIYHLGFINVVTae--nSNKIHYEDPMAAQRAANILGI-TQEELSRIIFNVKPSSqvt 321  Trichoplax adhae...
EEB20247   323 TLAMNTLGINEKECFVIWSVLAAIYHLGNAGAVRv---gTNKWQFADPTHSSRACRLLGT-TSEELCQVLWNNPLSPara 398  human body louse
EFN74075   612 VAALRILGISEADEKVIWLVLAGIYHLSCAGAVKagtssQSRWQFARVECAEKAANLLGT-TVEELSRVVFSANGGGagt 690  Camponotus flori...
EFR23843   853 CQAFRTLNVDPAAVRGVWFVLAAIYHLTQSGAVMv----AGRVQFVNPRAAQKAASLLGV-PIDELLGYIWPEVANGgnn 927  Anopheles darlingi
EFX67125   317 VAALESLGVAETDSRCIWSILAAIYHLGVAGAMRgs-vsNNKIVFARPAAAQRAAILLGIgSLEELAQLAFYATPVQgam 395  common water flea
ADY40035   459 KEALSTLGISAAHARAIFSLLAAIGHLCCAGATQs---pAQKAQFVRASSAQHAAALLSV-GTDQLASAVFRGKMSSggq 534  pig roundworm
EHJ79042   621 KEALQLLSVTEQEQLAVWKIIAAICHLGWAGVARansgsGVRYQFASTGCAGRAGRLLGV-TAEELAKACFAPASPPspq 699  monarch butterfly
EFO23663   300 LDSFTELGFTEKEKAAIISVLTAILHLICAEATQn---dAPKSQFIHMQHAQQAASLLGL-EMEQLTSAVFRKNLSQtvs 375  Loa loa
EKC35139   619 FNAMEVIGMSDEERRSICYILAAIYHLGVAGAVKg---qNNKPQFARPAAALKASQLIGI-TQEELARQIFASGGSStls 694  Pacific oyster

Feature 1                                                                               ###### 
Q92614     724 qrstsfrqg------peesglgdgtgpKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSq--HSLCSMMIVDTPGFQN 795  human
EDV22061   322 gsntlstsssisslhsesppmspmgstIESYVRNVDGLAMALYDELFSIILSIINGSLMSQt-vHSKHSITILDVPGLQN 400  Trichoplax adhae...
EEB20247   399 pss------------------psdkdkLIAGVDALEGFVIGLYSEIVSVVNTLINRSLTTNi--HSTMSLIVVDSPGFQN 458  human body louse
EFN74075   691 pstprpal---------rtpspteqgkDVTGLDALEGLLVGLYSEIFHCVAALINKSISSAv--HTVSSVLLCDSPGFQN 759  Camponotus flori...
EFR23843   928 gtsasggqsg-----vsgggqskagatSAAAAEALNAFCEALYTELFYTIVGLINKSIMAAtphQTIGSVLLVDVPGFQN 1002 Anopheles darlingi
EFX67125   396 mngrssfrtgsp-vhnadgaklsmadkHLDPSEALEGFAQGLYVEAFSALVALINRSISSTa--RTISSIVAVDTPGFQN 472  common water flea
ADY40035   535 sgpgnv------------mnrfslsnrGQNGQEALEAFVAHLYNELFYAVVALLNRGLGATn-lATTTSITIIDFPGGNF 601  pig roundworm
EHJ79042   700 pptglr-------------tpspsnekEAPGSDALDAFATGLYSEVFNVIVGFVNRSTSTSs--RTSSSLLLLDSPGADN 764  monarch butterfly
EFO23663   376 snpvs---------------rfslltrNQTGQEALNRFTACLYNELFDAVVRLLNRRLGEGg-sTASSTITIVDYPGSQF 439  Loa loa
EKC35139   695 rstsmrg----------spadkgqgdfNTNAMEALEGFVIGLYSAVFNAIVSLINRSMSSNi--RTSTSLTVVDLPGFQN 762  Pacific oyster

Feature 1                                                                                      
Q92614     796 PEqgg---sarGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLep-------------pTDDSVAAVD 859  human
EDV22061   401 YDgs------rPSGFDDMIFNYAQERVQAYYHNKTISGVLDRYDQEYIDISYSSDsa------------isPNELVSLFD 462  Trichoplax adhae...
EEB20247   459 PGscg---qqsGATFSDLCHNYVQERLHLLYHNFNIIAPRDRYVQEHIDVNTDEIyse----------vnsPSQLISMLD 525  human body louse
EFN74075   760 PAscg---rqtGATFEDLCHNYLQERLQLLFHHTTLIAPKDRYVQEGIDVDYEDDyded--------gigsPQGLVSLLD 828  Camponotus flori...
EFR23843  1003 VAsvgsgigtgISTLSDLRFNYLHERLQLLFHNAMLVQPRHRYAQEMVTVDESLGlteagggtgsgsagggPSPMVALLD 1082 Anopheles darlingi
EFX67125   473 PAttttstsstSATFQDLCHNYTQERLQLLFHDTHITAQLNRYAQEHIDITLEGGtgee--------empsPEPLVDLLD 544  common water flea
ADY40035   602 NAawse-esqrTSGLADLTYNYLNERIAELFYDTSFTEPIDLYDREQVEVDIEKPtl-------------cPHQITRLID 667  pig roundworm
EHJ79042   765 PMcsg---qqsGAGLTKLLSNYMQERLQAVFHEAMLVAPRERYAQEGVTIDDGNDedwls-------esvnPGPMVDLLD 834  monarch butterfly
EFO23663   440 GSfspd--avhPRGLNDLLYNYVSERFAELYYDVCFNEPLEMYKREQVEADVEQTqn-------------sSHEICRLID 504  Loa loa
EKC35139   763 PAtcg---rnsGATFEDLCYNYAQEKIQMLYHDLTFTLQQDRYSQENVDCDFEFVts-------------sPAAMVSLID 826  Pacific oyster

Feature 1                                                                                      
Q92614     860 QAshqslvr--------slartdEARGLLWLLEEEALV----------------------------PGASEDTLLERLFS 903  human
EDV22061   463 KApsqgsrr--------hstvrgDQKGLLRHLDEESGY----------------------------SGSTEAGFIERLHF 506  Trichoplax adhae...
EEB20247   526 KSsptgvlkt-----sqtdlrevDRRGLLWLLEEESLY----------------------------PNSTDETFLERLFM 572  human body louse
EFN74075   829 RGssqsatmlrtsqsdlsgsrqmERKGLLWLLDEETVC----------------------------PGGSDETFLDRLFS 880  Camponotus flori...
EFR23843  1083 KIpqn----------------hePRKGLLWMLDEEQLLgntaalhsvsktnnnnnnnvpdeldddpANDRDARFMERLFA 1146 Anopheles darlingi
EFX67125   545 RApqsavaraq----satnlrdvERRGFLWLLDDEALV----------------------------STTSEDQLLDKLSA 592  common water flea
ADY40035   668 QKqqllncv-------didlrseERRGLLHILDEEALF----------------------------PGATDDSFFERIFV 712  pig roundworm
EHJ79042   835 KSpqntivrs-----sqadlrdcDRRGLLWLLDEESMY----------------------------PGSSDDTFLERVMS 881  monarch butterfly
EFO23663   505 QRqqlsnca-------dielrstEKRGLMCILDEEALF----------------------------PAATDDSFLERIFV 549  Loa loa
EKC35139   827 KPaqqllvrt-----ssqeikesDKKGLLWILDEEAIF----------------------------PGATEDSFMDRLFT 873  Pacific oyster

Feature 1                                                                                      
Q92614     904 YYGpqegdkkgqspLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKiisnlflgragsatv 983  human
EDV22061   507 YNSdsgk----shsLKFSDNRESFIISHCQNSFDIEYNASKWLRYAKDFLLQRQATSILSSSSRSmiglayqgftrsqsl 582  Trichoplax adhae...
EEB20247   573 HHGekd-----hqlLLRKSGPGHFVIHHLQGTNPVTYNVNGFVKAAKENPLTRSANGFLQESTKEdisevfvkgknglls 647  human body louse
EFN74075   881 HYGdrdh----qmfLRKAPGNNQFVLQHLLGTNPVLYTATGWLKATRENPVSKSAITILQESTREhvsklfvsargagvs 956  Camponotus flori...
EFR23843  1147 AYGdresretlllrASVPTGSCDVVLQHLLGTNPVLYSVSSWLKEAAAQALYLPQRALNCLRDSGkpevsglfvgtlgga 1226 Anopheles darlingi
EFX67125   593 MYNdrvfeklftrpEGTAGSRKHLMIHHGQGTNSVLYDLDGWLKSAREMPTTRNAALALTESTKEemaslfrscrgplpt 672  common water flea
ADY40035   713 HLGes-------rlIRRGCRPREFVLGHCLGGSPTVYSVNGWVKAAQPNVSEGSVLTLLHSSRDAainelfspfgmtrse 785  pig roundworm
EHJ79042   882 QYGaphh---thylIKKAPHNRQFILQHLQGTNPVLYDVSGWVKASRENPAMKRAHTLLQESQNPllsscerttdagtl- 957  monarch butterfly
EFO23663   550 HLAds-------hlIRRGTNPLTFVLRHGLDSSSVTYNVQGWVKAAQSDYADSSLTSLLCTSNNLtiasmfspvtspvtd 622  Loa loa
EKC35139   874 HHGeqkvk-kdsllRKASSIGNTFILNHFQGTNPVQYNASGWLKGCRENPLIKTAIQVLQDSKRQninelfntvkapvag 952  Pacific oyster

Feature 1                                                                                      
Q92614     984 lsgsiag---leggsqlalrratsmrktfttgMAAVKKKSLCIQMKLQVDALIDTIKK-SKLHFVHCFLPVAEGWagepr 1059 human
EDV22061   583 hlkp----------tspsrlrgsvsslhkvniRGGVKKTAPCFRPIFEMDGVLDSLRR-TTVRFIHCLVSKHHQTsdsgk 651  Trichoplax adhae...
EEB20247   648 sg-------------vegsqslrrmssirrtcSVAVKRKSISLQVKFTADGLIETLRR-TRPRFVFCLLPQHNAGnteii 713  human body louse
EFN74075   957 galcs-------smpglegsqslrrassirrtFTAVKRKNICLQVKFTVDGLVETLRR-TRVKFVHCLLPQHNAGctdnk 1028 Camponotus flori...
EFR23843  1227 messyawggssqqlqqqslrrmssirrttytgSGFPKRNGVVVQVKYTVDCLIDTLRR-TGMHFVYCYLPQHNGGtafas 1305 Anopheles darlingi
EFX67125   673 tvsgsva----giegsqslrrassirrtftsgTAGIKRKSLALQLKFQVDGLIETLRR-TKPRFVYCFIPNHRAGlvdls 747  common water flea
ADY40035   786 s---------------atlnirratqaakldaTGLPTACGFFSNISMQTECIISFARHaGGVQFVHCMQPQPPSEddgrs 850  pig roundworm
EHJ79042   958 -------------------rraasvrralasgTAGMKRRSTALQAKFIADGVVDTLRR-CGSGGIQFVCCLLTNQpnet- 1016 monarch butterfly
EFO23663   623 n---------------tplkmrkatqtikldaAGMRVISGFFAAFCFQLNYITSCIKRtTGLHFVHCIRPLSAVDvhvr- 686  Loa loa
EKC35139   953 mvsgsiv----gmegttslkrvgsmrrtfmsgTAGLKKRSMCLQVKFQVDSIIETIRK-TKCHFIHCLLPQHNAGlwelk 1027 Pacific oyster

Feature 1                                                                                      
Q92614    1060 sassrrvssss----------------------------------eldlpsgdhceagllqLDVPLLRTQLRGSRLLDAM 1105 human
EDV22061   652 k-------------------------------------------------------tsdelFNIPLMRKQLSASELIESV 676  Trichoplax adhae...
EEB20247   714 pgs---------------------------------------------------astgeniLNVPLLRSQIRGCEILPVV 742  human body louse
EFN74075  1029 sllsv-----------------------------------------------ksnqsedsvINVPLLRSQIRGSQIIDAI 1061 Camponotus flori...
EFR23843  1306 gidpvptsglnsgaslgtgnelikaeediinipllrsqvrwrgasrssgcliveahrsnrmINVCLLPTQFRGSQMLDFA 1385 Anopheles darlingi
EFX67125   748 sst---------------------------------------------------fsanddsLQVPLLRSQLRGSELLPAI 776  common water flea
ADY40035   851 t-------------------------------------------------------gsemlLDVPFVRSQLRSLLIIDAT 875  pig roundworm
EHJ79042  1017 ----------------------------------------------------------pddVNVPLLRSQFRGFQLLDAA 1038 monarch butterfly
EFO23663   687 ---------------------------------------------------------pdelLNIQYVRNQLRYLSLVNSA 709  Loa loa
EKC35139  1028 qgssp-----------------------------------------------qdkpsdenlMNVPLIRSQIRGAELLEGV 1060 Pacific oyster

Feature 1                                                                               
Q92614    1106 RMYRQGYPDHMVFSEFRRRFDVLAPhltkkh-----grnyivVDERRAVEELLECLDLEKSSCCMGLSRVFFR 1173 human
EDV22061   677 RIFRVGYPENVPYGEFRFRFGVLASadkrt--------kgpiIDEKTAAKELVEELELDRSTYRFGLTQIFFR 741  Trichoplax adhaerens
EEB20247   743 RIFKLGFPEYFPHGEFKRRFRLLAPgc--------------gGSSGHAVEEMLMLMDVDVTSYRIGVTQVFFR 801  human body louse
EFN74075  1062 RLHKVGFPKHMALGEFRRRFGLLSSdvnar-------pgspvTDERRAVEDMLLTVDVDPASYRVGQSQVEAI 1127 Camponotus floridanus
EFR23843  1386 RLYRLGFPISVPLGEFVIRFGLLAEgatgsgstgetagngggAAEAATVDSILSNCEVDSSVYRIGTSLGEVG 1458 Anopheles darlingi
EFX67125   777 RLYRQGYPDYMPLGEFVRRFNVLVPpdalpasl-ltglnsstASEKQAAEILLLHIDMERSSYRLGLSQVRES 848  common water flea
ADY40035   876 RASSRGYPERLSFKDFRRRFQCLVKssss---------lddvLDDRAAAGRILEDTGVFPHTYRLGLSQVLLR 939  pig roundworm
EHJ79042  1039 RLYKQGFPEHMPLSEFARRYRLLATsekeese---tsqqsttLSDRQIVDEMLLVLDLDVTSYRLGPTQAVPE 1108 monarch butterfly
EFO23663   710 RAASQGFPEQVPYKYFRCRFQCLLKeqnt---------sseyMDDRAISGKILEEMGAFPHRYRLGLSQVLLR 773  Loa loa
EKC35139  1061 RIYRQGFPDNMVFGEFRQRFQGLLPpsnq---------pskdADMKQAVLTILDHLDIDKLNYRVGLSQVFFR 1124 Pacific oyster

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