Conserved Protein Domain Family
MYSc_Myo9
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cd01385: MYSc_Myo9 
class IX myosin, motor domain
Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Links
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Statistics
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PSSM-Id: 276836
Aligned: 18 rows
Threshold Bit Score: 1132.86
Created: 1-Nov-2000
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #########                                            
AAC50402   160 GNLLKNLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQlg-kLEPHVFALADVAYYTMLRKRVNQCIVYP 238  human
NP_490755  181 QTLLDNLRERFANGHIYTYIGPILVAVNPFCFFPIYNPKYARLYFQSKrlgsLPPHIFAIADVCYHNMLRIKENQCVVIS 260  roundworm
EAT44232    68 ATLLENLRQRFEAGHIYTYVGSILIAVNPFKFHPIYNPKYVRLYQNQRigpiLPPHIFAIADNAYYNMLKEKRNQCIVIS 147  yellow fever mos...
EEZ98803   148 QTLLDNLRARFVAGHIYTYVGSILIALNPFKFYPIYNPKYVKLYQNRKlgpnLPPHIFAVADTAYYCMLKDRKNQCIVIS 227  red flour beetle
B2RTY4     160 KTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQlg-kLEPHIYAVADVAYHAMLQRKKNQCIVIS 238  human
EFX66210   122 ETLMDNLRARFQAGHIYTYVGSILIAVNPFKFYPIYNPKYVKLYQNRRlg-eLPPHIFAVADAAYNAMMRDRKPQCIVIS 200  common water flea
ADY39989   183 QTLLDNLRDRFNSGHIYTYIGPILVAVNPFNFFPIYNPKYARLYCQSRrlgaLPPHIFAIADVTYHNMLRIKENQCVVIS 262  pig roundworm
JAA61409   115 QTLLENLKARFERSHIYTYVGSILIAVNPFKFYPIYNPKYVRLYQNRRlg-dLPPHIFAVADAAYHAMLRSHSSQCVVIS 193  Rhipicephalus pu...
ESP05442   151 KTLLENLKTRFSNNYIYTYVGSILIAVNPFKFFPIYNPKCVKMYQNKRlg-eLPPHIFAIADAAYYTMLRTKKNQCIVIS 229  owl limpet
Q9Z1N3     160 KTLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQlg-kLEPHIYAVADVAYHAMLQRKKNQCIVIS 238  Norway rat

Feature 1      ########                                       ###########                      
AAC50402   239 GESGSGKTQSTNFLIHCLTALSQKG-YASGVERTILGACPVLEAFGNAKTAHNNNSSRFGKFIQVSYLESGIVRGAVVEK 317  human
NP_490755  261 GESGSGKTESTNHLMSHLISLSQKGsTGCSTEQTLLSAGPVLEAFGNAVTLTNNNSSRFGKFIKINYRENGMVSGANVEI 340  roundworm
EAT44232   148 GESGSGKTESTNFLLHHLTALSQKGaHGSGVEQTILSAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMVQGAVVQK 227  yellow fever mos...
EEZ98803   228 GESGSGKTESTNFLLHHLTALSQKGsHGSGVEQTILSAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYKENGMVHGAVVQK 307  red flour beetle
B2RTY4     239 GESGSGKTQSTNFLIHHLTALSQKG-FASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317  human
EFX66210   201 GESGSGKTESTNFLLHHLTALSQKGsQGCGVEQTILSAGPVLEAFGNAKTSHNNNSSRFGKFIQVNYRENGQVHGALVQK 280  common water flea
ADY39989   263 GESGSGKTESTNFLLHHLTSLSQKGsAGSSVEQTLLSAGPVLEAFGNAVTVQNNNSSRFGKFIKVNYRENGMVSGANVEI 342  pig roundworm
JAA61409   194 GESGSGKTESANLLLHHLTALSQKGsYGRGVEQTILSAGPVLEAFGNAKTKHNNNSSRFGKFIQVNYRENGMVHGAVVQK 273  Rhipicephalus pu...
ESP05442   230 GESGSGKTESTNLLLHHLTALSHKGlHGSGVEQTILGAGPVLEAFGNAKTVHNNNSSRFGKFIQVNYKENGMVHGAIVEK 309  owl limpet
Q9Z1N3     239 GESGSGKTQSTNFLIHHLTALSQKG-FASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317  Norway rat

Feature 1                                                                                      
AAC50402   318 YLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLkqPEDYFYLNQh----------------------------nL 369  human
NP_490755  341 YLLEKSRIIFQTKGERNYHVFYYLLEGADEEERKKYFLlkPHDYKYLNQn----------------------------eP 392  roundworm
EAT44232   228 YLLEKSRIVSQGHYERNYHVFYYLLSGATEQERVALHLlpADKYHYLNAk-----------------------------N 278  yellow fever mos...
EEZ98803   308 YLLEKSRICSQGRNERNYHVFYYLLEGATEQEKQILHLktPDQYYYLNKs-----------------------------C 358  red flour beetle
B2RTY4     318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLkqPEEYHYLNQitkkplrqsw----------ddycydsepdC 387  human
EFX66210   281 YLLEKTRICFQAKNERNYHVFYHLLVGSSAQEKQALHLlpPEAYRYLNQs----------------------------dY 332  common water flea
ADY39989   343 YLLEKSRIISQAADERNYHVFYYLLEGATEEERKRHFLlqPSDYYYLNQn----------------------------kF 394  pig roundworm
JAA61409   274 YLLEKSRIVSQAKKERNYHVFYYLLAGASKEEREELHLtrPEDYYYLNQsqcytlegtdeaqeytklmesmrxcivqsqC 353  Rhipicephalus pu...
ESP05442   310 YLLEKSRIVSQAKNERNYHVFYYLLAGADDSERHSLNLstPENYNYLSCs----------------------------dC 361  owl limpet
Q9Z1N3     318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLkqPEEYHFLNQitkkplrqsw----------ddycydsepdC 387  Norway rat

Feature 1                                                                                      
AAC50402   370 KIEDGEDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYKKRa--tGREEGLEVGPPEVLDTLSQLLKVkrE 447  human
NP_490755  393 FALEGVNERNEFDRLRHAMSSVGFCAKTQQTIFGIISAVLLLGNITYIKRhg-yHSDESGYIENEEVVDLVANLLHIktD 471  roundworm
EAT44232   279 LTLENCDEKYEFSRLKQSMEMVGFSAEKQRRLFAVLSAVLLLGNVEFFPKkstyHHDESVQVRNPEVVGLISELLRVkqE 358  yellow fever mos...
EEZ98803   359 HSLENVDESYEFSRLKQSMEMVGFTAEKQRRLFSVLSAVLLLGNVEFQPRrpayHHDESVGVKNPEVVFLISELLRVkqE 438  red flour beetle
B2RTY4     388 FTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKt---YRDDSIDICNPEVLPIVSELLEVkeE 464  human
EFX66210   333 HNLDEGDECYELSRLKQSMEFVGFCSETQRRIFSVLSAVLHIGNLEFQPKkstyNHDESVTVKNTAVVATIAQLLRVkeE 412  common water flea
ADY39989   395 YSAEGVNGKYEYERLKHAMDAVGFSVSSQQNMFSVISAVLLLGNIEYIKRpg-yHSDEKAYVANEELVGIIAELLHIkaA 473  pig roundworm
JAA61409   354 YTLEGTDEAQEYTKLMESMRMVGFNLDKRKRLIRVLSAVLHLGNIEFSKKst-yHSDEAVQVKNPEVLSLISSLLGVkeE 432  Rhipicephalus pu...
ESP05442   362 ITLDGTDEKYEFARLKQSMEMVGFSPETQKRIFSVLSAVLHLGNIEFKKKgd-qHHDESVSIKNEDDVKIISNLLKVkeK 440  owl limpet
Q9Z1N3     388 FTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKt---YRDDSIDICNPEVLPIVSELLEVkeE 464  Norway rat

Feature 1                                                                              ######  
AAC50402   448 ILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEavSCLSIGVLDIFGFEDF 527  human
NP_490755  472 TLMQALTMKRHVMKTETVVLRYSVSEATNTRDAMAKCIYNSLFHYIVLRINQALLKKDFSAG--KGYYIGILDIFGFEDV 549  roundworm
EAT44232   359 TLLSALTSKRVKASGETLIMQYKLPEAIAARDALAKCLYGALFDWIVLQVNHALLNKDQTMH--TGHSIGVLDIFGFEDF 436  yellow fever mos...
EEZ98803   439 TLLQALTAKKARASGETLVITYKLPEAIASRDAMAKCLYGALFDWIVLQVNHALLSKKDTLRehQGNSIGVLDIFGFEDF 518  red flour beetle
B2RTY4     465 MLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHntKTLSIGVLDIFGFEDY 544  human
EFX66210   413 ILHQALISKRARASGETLVINYRMPEAIAARDAMAKCLYGSLFDWIVMQLNHALLAKKDVDKmqRAYSIGVLDIFGFEDF 492  common water flea
ADY39989   474 NLTQAMTMKRTVMKNDTVITRYNVNEATSTRDAMAKCLYNALFHWIVLRMNQALLKKEVFSGk-KGYYIGILDIFGFEDV 552  pig roundworm
JAA61409   433 TLNSALTTKRAKAPGETLVISYKMPEAVATRDAMAKCLYGALFDWIVMQVNHALLSAKDLREh-KGNSISVLDIFGFEDF 511  Rhipicephalus pu...
ESP05442   441 TVIEALTTKKTVAGDETVVINFKMEDAIATRNAMAKCIYGALFDWIVLKVNQALLAKKHNSDh-QGNSIGVLDIFGFEDF 519  owl limpet
Q9Z1N3     465 MLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEKdtKTLSIGVLDIFGFEDY 544  Norway rat

Feature 1                                                                                      
AAC50402   528 ER--NSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLIS--------KKPTGLFYLLDEES 597  human
NP_490755  550 GSqcNSFEQLCINYANEKLQSYFNQHIFQFEQEEYLKEGISWTNIEYTDNTECVQLFQvspispfwSKPYGILRLVDEES 629  roundworm
EAT44232   437 GLq-NSFEQLCINYANEHLQYYFNLHVFKYEQKEYKREGIKWTDIEFLDNSGCLQLFE--------SKPSGLLCILDDLC 507  yellow fever mos...
EEZ98803   519 GLn-NSFEQLCINYANEHLQYYFNQHVFKYEQEEYRKEGIRWNNIDFMDNTGCLQLIE--------GKPNGLLCLLDDQC 589  red flour beetle
B2RTY4     545 EN--NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLIS--------KKPTGLLHLLDEES 614  human
EFX66210   493 GHm-NSFEQFCINYANEHLQYYFNQHVFKYEQEEYKREGIHWVNIQFVDNTGCLQLYE--------SKPNGLLCILDDQC 563  common water flea
ADY39989   553 GAqwNSFEQLCINYANEHLQAYFNQHIFQFEQEEYFKEGISWTNIEYTDNTECVQLFQ--------SKPYGILRLIDEES 624  pig roundworm
JAA61409   512 GDh-NNFEQFCINFANEHLQYYFNQHVFKYEQEEYQKEGIQWKNIEFTDNTGCLNLIE--------GKPHGLLCLLNDQC 582  Rhipicephalus pu...
ESP05442   520 GN--NSYEQFCINYANEHLQYYFNQHIFKFEQEEYTREGIQWKNIEFIDNTRCLELFS--------SKPKGLFCLLDEEC 589  owl limpet
Q9Z1N3     545 EN--NSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLIS--------KKPTGLLHLLDEES 614  Norway rat

Feature 1                                                                                      
AAC50402   598 NFPhaTSQTLLAKFKQQHEDNKYFLgTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGM 677  human
NP_490755  630 NINngTDDSMLAKLNQFLKNNEYYEtPQKKEPAFIVAHYAGKVKYQITGFREKNKDLMRQDVLNALKSSTSSVMKTLLGI 709  roundworm
EAT44232   508 NFPgaTNETLLQKFNSVHKDSTFYEkPQRKENAFIIKHYAGKVKYQVAEMREKNLDLMRQDIVSVLKNSSMAFVRELVGA 587  yellow fever mos...
EEZ98803   590 NFPgaTNETLLQKFNTVHKDNKFYNkPQKKEGAFIVVHYAGKVKYQVTDMREKNLDLMRQDIVGVLKNSSMAFVRELVGA 669  red flour beetle
B2RTY4     615 NFPqaTNQTLLDKFKHQHEDNSYIEfPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGI 694  human
EFX66210   564 NFPgaTNETLLQKFNSVNKDNDYYEvPQKREAAFIVRHYAGKVKYQSNEFREKNLDLMKADIVAVLKSSQYAFVRELVGG 643  common water flea
ADY39989   625 NINngTDESMLEKLNHFLKNNEYYEiPQKRELAFIVAHYAGKVKYQITGFREKNKDLMRQDVLMVLKNSRSAFVRDLVGD 704  pig roundworm
JAA61409   583 NFSgaTNAMLLQKFVNHHKKNPFYDmPQKRENAFLVHHYAGKVKYQIKDFKEKNLDLMRPDVVMVLKSSSVALVRELVGA 662  Rhipicephalus pu...
ESP05442   590 NFPgaTNDTLLSKFNHLHKDNLYYEvPVLREQAFVIVHYAGKVKYQIKDFREKNSDHIRTEIVSVLKKSSLSFVRELMGI 669  owl limpet
Q9Z1N3     615 NFPqaTNQTLLDKFKHQHEENSYIEfPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGI 694  Norway rat

Feature 1                                                                                      
AAC50402   678 DPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAagmsspgaqshpeelprgastpseklyrdlhnqmiksikglpwqg 757  human
NP_490755  710 DPVAVHRWNVLRSVFRAMNAFKQSTRKLQKKSAGHlrvmdsivtsprrgsdsalsaflrgelrce--------------- 774  roundworm
EAT44232   588 DPTAIKTRKQPLTVTAQFQISLIALMETLNQANPFfirciksnpnkisnqfdeatvtrqlrytgmletvrirragynvr- 666  yellow fever mos...
EEZ98803   670 DPVAVFRWAIVRAFFRAYFAFHEAGRKHRQGRVDGnknniqqryqrnhtpneniiskqrnilsinrlgrnnennevpsnn 749  red flour beetle
B2RTY4     695 DPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHddtapcailksmdsfsflqhpvhqrsleilqrckeekysitrknp 774  human
EFX66210   644 DPVAVFRWAILRAFIRAYFAFIESGKRHRARSRPSknwrnletvrtlagrlghsssslnssa------------------ 705  common water flea
ADY39989   705 DPVAVFRWNVVRATFRAMSAFRQAGSAIKRCESTShlsadtakrvvlrrssdthlsaflrgdlspe-------------- 770  pig roundworm
JAA61409   663 DPVALFRWAILRAFFRSYHALRRTTSHSQGRTNHGskrpssmyrgrhsgdsysnsnqvssrrsslgtgacpgnfaatsc- 741  Rhipicephalus pu...
ESP05442   670 DPVAVLRWAIVRAFFRCFFAFLDSGKRWRKHGGNKrlsdsqllqdpnyndnllnachqvntssdedifykghetscdddl 749  owl limpet
Q9Z1N3     695 DPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKSGHddttpctilksmdsfsflqhpvhqrsleilqrckeekysitrknp 774  Norway rat

Feature 1                                                                                      
AAC50402   758 e-----------------------------------------------dprsllqslsrlqkprafilkskgikqkqiip 790  human
NP_490755  775 ---------------------------------------------------------------vpdfcdtsmfntirnqa 791  roundworm
EAT44232   667 --------------------------------------------------ltyeefiqlyrillpkglvssqkdvrdfmn 696  yellow fever mos...
EEZ98803   750 nynrlswpqfyqrnravggias-----nktldderrrkdstgnnpnsalervlcpdearaiqranqivmknksfrprers 824  red flour beetle
B2RTY4     775 rtplsdlqgmnalneknqhdtfdi-awngrtgirqsrlssgtslldkdgifanstsskllerahgiltrnknfkskpalp 853  human
EFX66210   706 ------------------------------------------------------------------apsnvssshekltv 719  common water flea
ADY39989   771 --------------------------------------------------------------vvpdfcdtsffqtivtqa 788  pig roundworm
JAA61409   742 --------------------------------------------------pvhrgnthlcaseasvleranqimmknknt 771  Rhipicephalus pu...
ESP05442   750 -------------------------------------------------svienhlpkskarimrrasklilknksfkpk 780  owl limpet
Q9Z1N3     775 rtplsdlqgmntlneknqhdtfdiawnvrtgirqsrlptnntslldkdgifansasskllerahgiltrnknfrskpvlp 854  Norway rat

Feature 1                                                                                      
AAC50402   791 knlldskslkliiSMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVL 870  human
NP_490755  792 rrtpagksddkmsLLKSLQILKEAIGGRRLAKKPSSVSKQFEYSLTRLMSTLANATPYFIRCIKSNNDKIANHFDDNIIL 871  roundworm
EAT44232   697 tmdlnkqhyqlglTKIYMRESQKMRLDICLHTKIIDSIITIQRWFRSILQRKKYCQYRSAACTIQTYWRLYVKEKQAKFL 776  yellow fever mos...
EEZ98803   825 kkglknlqsvktlAGRTGITATNQGQLGKARKQPMTVTAQFQQSLHSLMDTLNQANPFFIRCIKSNSNKIPNQFDDETVQ 904  red flour beetle
B2RTY4     854 khllevnslkhltRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVL 933  human
EFX66210   720 sasgtttvtitsaGSHQSIRSESLLVVHKNVKKAQTVGAQFQHSLQSLMVALNTANPFFVRCIKSNRLKGPNQFDEEIVL 799  common water flea
ADY39989   789 rkqpmkpkqerqnALKSLQAVKALTGKKRITGKPSSVSKQFEHSLSRLMKTLAQATPYFIRCIKSNNEKIPNYFDDNIIL 868  pig roundworm
JAA61409   772 rsrnrvdkglknlQSVKTVVGKTHPHPQRTGRKPPTVTAQFQVSLSHLMEALNQANPFFVRCIKSNAGKVPCSFDEGVIL 851  Rhipicephalus pu...
ESP05442   781 prppslsfrdirtLKAISVNTIYGGSVRQSSKKPPSVSAQFQWSLSRLMTTLNQANPFFIRCIKSNSEKLPCTFDEEIVL 860  owl limpet
Q9Z1N3     855 khllevnslkhltRLTLQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLDQAEPYFVKCIRSNAEKLPLRFSDALVL 934  Norway rat

Feature 1                                                                               
AAC50402   871 QQLRYtGMLETVRIRR-SGYSAKYTFQDFTEQFQVLLPKDAQPCREVis-tLLEKMKIDKRNYQIGKTKVFLK 941  human
NP_490755  872 RQLRYtGMLETVRIRR-AGYSVRIEYPSFVQQYRILLRNGRDSTVDDvkeyIHSHASIDNDNIQYGTNKIFMR 943  roundworm
EAT44232   777 RKLRT-DAATIIQSAW-RGYSVRKWYTKLKTGVQVIQARIRGNQARDrf-kVALSKKLQRERAKLRSTQSLPA 846  yellow fever mosquito
EEZ98803   905 RQLRYtGMLETVRIRQ-AGFNVRLTYDEFIQLYRILLPKGLLSSQNDvr-hFLATLNLDRDNYQLGGSKVFLR 975  red flour beetle
B2RTY4     934 RQLRYtGMLETVRIRQ-SGYSSKYSFQDFVSHFHVLLPRNIIPSKFNiq-dFFRKINLNPDNYQVGKTMVFLK 1004 human
EFX66210   800 RQLRYtGMLETVRIRQ-AGFNVRLTFEEFIHHYRILLPRGLLSSQSDvh-dFLCRMNLNAEHYQIGHQKIFLR 870  common water flea
ADY39989   869 RQLRYtGMLETVRIRR-AGYSFRIECNAFVKQYRILLPNGRDSTVEDvkffFAHHPLIGEDKVQFGVTKIFMR 940  pig roundworm
JAA61409   852 QQLRYtGMLETVRIRQ-SGYSVRLPFEEFIQRYRVLLPRGLISSRSDir-dFLLRINLDRNNYQMGKTKVFLR 922  Rhipicephalus pulchellus
ESP05442   861 RQSIItFSMILLNITGySFDILISVFQEFIQLYKILLPRGLLSSKEDvk-iFLEHMTFSLEHYQIGKDKVFLR 932  owl limpet
Q9Z1N3     935 RQLRYtGMLETVRIRQ-SGYSSKYSFQDFVSHFHVLLPQHIIPSKFNiq-dFFRKININPDNYQVGKTMVFLK 1005 Norway rat

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