1BG2,1CZ7,1I5S,1II6,3KAR,2MYS,1LKX,4DB1,1B7T,1MMN,1JWY,1OE9,1D1C,1BR1,1QVI,4DBQ


Conserved Protein Domain Family
Motor_domain

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cd01363: Motor_domain 
Click on image for an interactive view with Cn3D
Myosin and Kinesin motor domain.
Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.
Statistics
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PSSM-Id: 276814
Aligned: 16 rows
Threshold Bit Score: 143.254
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:the residues of the P-loop wrap around the triphosphate region of the nucleotide and the N-terminal region forms the binding pocket for the nucleotide
  • Structure:1D1C: Dictyostelium discoideum myosin S1DC (motor domain fragment) complexed with MgADP-BeFx, contacts at 4A
  • Structure:1MMN: Dictyostelium discoideum myosin II binds AMPPNP, contacts at 4A
  • Citation:PMID 9305951
  • Structure:1JWY: Dictyostelium discoideum myosin II binds ADP, contacts at 4A
  • Structure:1QVI: Argopecten irradians myosin S1 binds MgADP.VO4, contacts at 4A
  • Structure:1B7T: Argopecten irradians myosin S1 binds MgADP contacts at 4A
  • Structure:1BR1: Gallus gallus smooth muscle myosin binds MgADP.Alf4, contacts at 4A
  • Citation:PMID 9741621
  • Structure:4DB1: Human Myosin S1DC (beta isoform) binds Mn-AMP-PNP, contacts at 4A
  • Structure:1LKX: Dictyostelium discoideum class I myosin, MyoE, binds to MgADP.VO4,contacts at 4A
  • Structure:1OE9; Gallus gallus myosin V binds a sulfate ion
  • Structure:3KAR: Saccharomyces cerevisiae Kinesin-Like Protein Kar3 motor domain bound to Mg.ADP
  • Citation:PMID 9485302
  • Structure:1II6: Human Mitotic Kinesin Eg5 bound to Mg-ADP
  • Structure:1I5S: Mouse KIF1A Motor domain bound to Mg-ADP
  • Structure:1CZ7: Drosophila melanogaster Ncd Minus-End Directed Microtubule Motor Protein bound to Mg.ADP
  • Structure:1BG2: Human ubiquitous kinesin motor domain with bound Mg-ADP
  • Citation:PMID 8606779

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ##                                                                         
1BG2_A     11 VMCRFRPlnesevnrgdkyiakfqgedtv---------------viaskpyafdrvfqsstsqeqVYNDcakkIVKDVLe 75  human
1CZ7_D     57 VFCRIRPpleseenrmcctwtyhdestvelqsid-----aqakskmgqqifsfdqvfhplssqsdIFEMvs-pLIQSALd 130 fruit fly
1I5S_A      8 VAVRVRPfnsremsrdskciiqmsgstttivnpkqpketpksfsfdysywshtspedinyasqkqVYRDigeeMLQHAFe 87  house mouse
1II6_A     21 VVVRCRPfnlaerkasahsivecdpvrkevsvrt-----ggladkssrktytfdmvfgastkqidVYRSvvcpILDEVIm 95  human
1B7T_A    119 FCIAVNPyrrlpiytdsvia--------------------------------kyrgkrkteipphLFSVad-nAYQNMVt 165 bay scallop
1MMN_A    122 FLVAVNPfkripiytqemvd--------------------------------ifkgrrrnevaphIFAIsd-vAYRSMLd 168 Dictyostelium disc...
1JWY_A    133 FLVAVNPfkripiytqemvd--------------------------------ifkgrrrnevaphIFAIsd-vAYRSMLd 179 Dictyostelium disc...
1D1C_A    122 FLVAVNPfkripiytqemvd--------------------------------ifkgrrrnevaphIFAIsd-vAYRSMLd 168 Dictyostelium disc...
1BR1_A    119 FCVVINPykqlpiysekiid--------------------------------mykgkkrhempphIYAIad-tAYRSMLq 165 chicken
1QVI_A    119 FCIAVNPyrrlpiytdsvia--------------------------------kyrgkrkteipphLFSVad-nAYQNMVt 165 bay scallop
Feature 1               ########                                                              
1BG2_A     76 gyng-tifayGQTSSGKTHTMegklh--------dpegmGIIPRIVQDifnyiysmdenlefhikvsyfeiyldkirdll 146 human
1CZ7_D    131 gyni-cifayGQTGSGKTYTMdgvp-----------esvGVIPRTVDLlfdsirgyrnlgweyeikatfleiynevlydl 198 fruit fly
1I5S_A     88 gynv-cifayGQTGAGKSYTMmgkqe---------kdqqGIIPQLCEDlfsrindttndnmsysvevsymeiycervrdl 157 house mouse
1II6_A     96 gync-tifayGQTGTGKTFTMegerspneeytweedplaGIIPRTLHQifekltdngtefsvkvslleiyneelfdllnp 174 human
1B7T_A    166 drenqsclitGESGAGKTENTk-----------------KVIMYLAKVacavkkkdeeasd------------------- 209 bay scallop
1MMN_A    169 drqnqsllitGESGAGKTENTk-----------------KVIQYLASVagrnqangs----------------------- 208 Dictyostelium disc...
1JWY_A    180 drqnqsllitGESGAGKTENTk-----------------KVIQYLASVagrnqangs----------------------- 219 Dictyostelium disc...
1D1C_A    169 drqnqsllitGESGAGKTENTk-----------------KVIQYLASVagrnqangs----------------------- 208 Dictyostelium disc...
1BR1_A    166 dredqsilctGESGAGKTENTk-----------------KVIQYLAVVasshkgkkdtsitqg----------------- 211 chicken
1QVI_A    166 drenqsclitGESGAGKTENTk-----------------KVIMYLAKVacavkkkdeeasd------------------- 209 bay scallop
Feature 1                                                      ##                             
1BG2_A    147 dv---sktnlsvhedknrvpyvkgcterfvcspdevmdTIDEGKSNrhvAVtnmnehssrSHsIFLInvkqentqt---- 219 human
1CZ7_D    199 lsneqkdmeirmaknnkndiyvsniteetvldpnhlrhLMHTAKMNratAStagnerssrSHaVTKLeligrhaek---- 274 fruit fly
1I5S_A    158 lnp-knkgnlrvrehpllgpyvedlsklavtsyndiqdLMDSGNKArtvAAtnmnetssrSHaVFNIiftqkrhdaet-- 234 house mouse
1II6_A    175 ssdvserlqmfddprnkrgviikgleeitvhnkdevyqILEKGAAKrttAAtlmnayssrSHsVFSVtihmkettidg-- 252 human
1B7T_A    210 --------------------------kkegsledqiiqANPVLEAYg-nAKttrnnnssrFGkFIRIhfgptgkiagadi 262 bay scallop
1MMN_A    209 -----------------------------gvleqqilqANPILEAFg-nAKttrnnnssrFGkFIEIqfnnagfisgasi 258 Dictyostelium disc...
1JWY_A    220 -----------------------------gvleqqilqANPILEAFg-nAKttrnnnssrFGkFIEIqfnsagfisgasi 269 Dictyostelium disc...
1D1C_A    209 -----------------------------gvleqqilqANPILEAFg-nAKttrnnnssrFGkFIEIqfnnagfisgasi 258 Dictyostelium disc...
1BR1_A    212 ------------------------psfsygelekqllqANPILEAFg-nAKtvkndnssrFGkFIRInfdvtgyivgani 266 chicken
1QVI_A    210 --------------------------kkegsledqiiqANPVLEAYg-nAKttrnnnssrFGkFIRIhfgptgkiagadi 262 bay scallop
Feature 1                                                                                     
1BG2_A        --------------------------------------------------------------------------------     human
1CZ7_D        --------------------------------------------------------------------------------     fruit fly
1I5S_A        --------------------------------------------------------------------------------     house mouse
1II6_A        --------------------------------------------------------------------------------     human
1B7T_A    263 etylleksrvtyqqsaernyhifyqicsnaipelndvmlvtpdsglysfinqgcltvdniddveefklcdeafdilgftk 342 bay scallop
1MMN_A    259 qsylleksrvvfqstternyhifyqllagataeekkalhlagpesfnylnqsgcvdikgvsdeeefkitrqamdivgfsq 338 Dictyostelium disc...
1JWY_A    270 qsylleksrvvfqseternyhifyqllagataeekkalhlagpesfnylnqsgcvdikgvsdseefkitrqamdivgfsq 349 Dictyostelium disc...
1D1C_A    259 qsylleksrvvfqseternyhifyqllagataeekkalhlagpesfnylnqsgcvdikgvsdseefkitrqamdivgfsq 338 Dictyostelium disc...
1BR1_A    267 etylleksrairqakdertfhifyyliagaseqmrndlllegfnnytflsnghvpipaqqddemfqetleamtimgftee 346 chicken
1QVI_A    263 etylleksrvtyqqsaernyhifyqicsnaipelndvmlvtpdsglysfinqgcltvdniddveefklcdeafdilgftk 342 bay scallop
Feature 1                                                                                     
1BG2_A        --------------------------------------------------------------------------------     human
1CZ7_D        --------------------------------------------------------------------------------     fruit fly
1I5S_A        --------------------------------------------------------------------------------     house mouse
1II6_A        --------------------------------------------------------------------------------     human
1B7T_A    343 eekqsmfkctasilhmgemkfkqrpreeqaesdgtaeaekvaflcginagdllkallkpkvkvgtemvtkgqnmnqvvns 422 bay scallop
1MMN_A    339 eeqmsifkii--agilhlgnikfekgagegavlkdktalnaastvfgvnpsvlekalmeprilagrdlvaqhlnveksss 416 Dictyostelium disc...
1JWY_A    350 eeqmsifkii--agilhlgnikfekgagegavlkdktalnaastvfgvnpsvlekalmeprilagrdlvaqhlnveksss 427 Dictyostelium disc...
1D1C_A    339 eeqmsifkii--agilhlgnikfekgagegavlkdktalnaastvfgvnpsvlekalmeprilagrdlvaqhlnveksss 416 Dictyostelium disc...
1BR1_A    347 eqtsilrvvssvlqlgnivfkkerntdqasmpdntaaqkvchlmginvtdftrsiltprikvgrdvvqkaqtkeqadfai 426 chicken
1QVI_A    343 eekqsmfkctasilhmgemkfkqrpreeqaesdgtaeaekvaflcginagdllkallkpkvkvgtemvtkgqnmnqvvns 422 bay scallop
Feature 1                                          ######                                     
1BG2_A    220 --------------------------eqklsgklyLVDLAGSEKvsktgaeg---------------------------- 245 human
1CZ7_D    275 --------------------------qeisvgsinLVDLAGSESpktstr------------------------------ 298 fruit fly
1I5S_A    235 ------------------------nittekvskisLVDLAGSERadstgakg---------------------------- 262 house mouse
1II6_A    253 -------------------------eelvkigklnLVDLAGSENigrsgavd---------------------------- 279 human
1B7T_A    423 vgalakslydrmfnwlvrrvnktldtkakrnyyigVLDIAGFEIfdfnsfeqlcinytnerlqqffnhhmfileqeeykk 502 bay scallop
1MMN_A    417 srdalvkalygrlflwlvkkinnvlcserkayfigVLDISGFEIfkvnsfeqlcinytneklqqffnhhmfkveqeeylk 496 Dictyostelium disc...
1JWY_A    428 srdalvkalygrlflwlvkkinnvlcqerkayfigVLDISGFEIfkvnsfeqlcinytneklqqffnhhmfkleqeeylk 507 Dictyostelium disc...
1D1C_A    417 srdalvkalygrlflwlvkkinnvlcqerkayfigVLDISGFEIfkvnsfeqlcinytneklqqffnhhmfkleqeeylk 496 Dictyostelium disc...
1BR1_A    427 ealakakferlfrwiltrvnkaldktkrqgasflgILDIAGFEIfeinsfeqlcinytneklqqlfnhtmfileqeeyqr 506 chicken
1QVI_A    423 vgalakslydrmfnwlvrrvnktldtkakrnyyigVLDIAGFEIfdfnsfeqlcinytnerlqqffnhhmfileqeeykk 502 bay scallop
Feature 1                                                                                     
1BG2_A        --------------------------------------------------------------------------------     human
1CZ7_D        --------------------------------------------------------------------------------     fruit fly
1I5S_A        --------------------------------------------------------------------------------     house mouse
1II6_A        --------------------------------------------------------------------------------     human
1B7T_A    503 egiawefidfgmdlqmcidliekpmgilsileeecmfpkaddksfqdklyqnhmg---------knrmftkpgkptrpnq 573 bay scallop
1MMN_A    497 ekinwtfidfgldsqatidlidgrqppgilalldeqsvfpnatdntlitkl------------------hshfskknaky 558 Dictyostelium disc...
1JWY_A    508 ekinwtfidfgldsqatidlidgrqppgilalldeqsvfpnatdntlitkl------------------hshfskknaky 569 Dictyostelium disc...
1D1C_A    497 ekinwtfidfgldsqatidlidgrqppgilalldeqsvfpnatdntlitkl------------------hshfskknaky 558 Dictyostelium disc...
1BR1_A    507 egiewnfidfgldlqpcielierptnppgvlalldeecwfpkatdtsfvekliqeqgnhakfqkskqlkdktefcilhya 586 chicken
1QVI_A    503 egiawefidfgmdlqmcidliekpmgilsileeecmfpkaddksfqdklyqnhmg---------knrmftkpgkptrpnq 573 bay scallop
Feature 1                                                                                     
1BG2_A    246 -------------------------------------------------------------------avldeaknINKSL 258 human
1CZ7_D    299 ---------------------------------------------------------------------mtetknINRSL 309 fruit fly
1I5S_A    263 -------------------------------------------------------------------trlkeganINKSL 275 house mouse
1II6_A    280 -------------------------------------------------------------------krareagnINQSL 292 human
1B7T_A    574 gpahfelhhyagnvpysitgwleknkdpinenvvallgaskeplvaelfkapeepagggkkkkgkssafqtisavHRESL 653 bay scallop
1MMN_A    559 eeprfsktefgvthyagqvmyeiqdwleknkdplqqdlelcfkdssdnvvtklfndpniasrakkganfitvaaqYKEQL 638 Dictyostelium disc...
1JWY_A    570 eeprfsktefgvthyagqvmyeiqdwleknkdplqqdlelcfkdssdnvvtklfndpniasrakkganfitvaaqYKEQL 649 Dictyostelium disc...
1D1C_A    559 eeprfsktefgvthyagqvmyeiqdwleknkdplqqdlelcfkdssdnvvtklfndpniasrakkganfitvaaqYKEQL 638 Dictyostelium disc...
1BR1_A    587 gkvtynasawltknmdplndnvtsllnqssdkfvadlwkdvdrivgldqmakmtesslpsasktkkgmfrtvgqlYKEQL 666 chicken
1QVI_A    574 gpahfelhhyagnvpysitgwleknkdpinenvvallgaskeplvaelfkapeepagggkkkkgkssafqtisavHRESL 653 bay scallop
Feature 1                                                               
1BG2_A    259 SALGNVIsalaegstyvpyrds------------kmtrilqdslggncRTTIVICCSP 304 human
1CZ7_D    310 SELTNVIlallqkqdhipyrns------------klthllmpslggnsKTLMFINVSP 355 fruit fly
1I5S_A    276 TTLGKVIsalaemdsgpnknkkkkktdfipyrdsvltwllrenlggnsRTAMVAALSP 333 house mouse
1II6_A    293 LTLGRVItalvertphvpyres------------kltrilqdslggrtRTSIIATISP 338 human
1B7T_A    654 NKLMKNLys--------------------------------------tHPHFVRCIIP 673 bay scallop
1MMN_A    639 ASLMATLet--------------------------------------tNPHFVRCIIP 658 Dictyostelium discoideum
1JWY_A    650 ASLMATLet--------------------------------------tNPHFVRCIIP 669 Dictyostelium discoideum
1D1C_A    639 ASLMATLet--------------------------------------tNPHFVRCIIP 658 Dictyostelium discoideum
1BR1_A    667 TKLMTTLrn--------------------------------------tNPNFVRCIIP 686 chicken
1QVI_A    654 NKLMKNLys--------------------------------------tHPHFVRCIIP 673 bay scallop

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