Conserved Protein Domain Family
AcnX

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cd01355: AcnX 
Putative Aconitase X catalytic domain
Putative Aconitase X catalytic domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure prediction. The functions have not yet been experimentally characterized. Thus, the prediction should be treated with caution.
Statistics
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PSSM-Id: 153130
View PSSM: cd01355
Aligned: 16 rows
Threshold Bit Score: 395.583
Threshold Setting Gi: 42527709
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand bindingsubstrate
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:Based on related sequences with known structures.
  • Citation:PMID 3972791

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_127288     10 ELILSGEYGPALQKAMEIlvalgdlygadklipikSAQIAGVSYk---------nLGEAGLSFIRDLae---------mg 71   Pyrococcus aby...
NP_972807      8 EEILNGSQGEMQAKVLKTlvmyg--------eafgAERLVKVTGkyg------hlVTSFGIGVMKPVyklmde--llqse 71   Treponema dent...
XP_385227    178 QELFRGDYGEASRVAFRIvlrmahllgatrlmditQVHVDGCVY-----------TGPATLALAERLrd---------wg 237  Gibberella zea...
NP_355982    164 RAMLVGRDGIAVRQAMRIivamaaqqgasalvdvtQGHIDGCIY-----------ASPANLTFAEKMad---------mg 223  Agrobacterium ...
ZP_00217445    9 SAMLRGDFGDGVARAMRIvartaqvmsaphliditSAHIDGCLY-----------HGQTSLDFVEYFvd---------tg 68   Burkholderia c...
NP_103255     10 QSMLDGEQGPSAAAAMKIlvafsnavgarglldisGAHIDGCLY-----------HGKAGLDFVERLve---------ga 69   Mesorhizobium ...
40741473     163 KAILNGCYSPAASRAMEIllqya--------hlqdARQLIPVSRahid---aciyTGPASILIAHRFls---------qg 222 
NP_891317     19 LAMLRGDKGAAVQEAIEFqiqvg--------nffgAERFVPITHahvmg--dievMGDGGLQHLRHMtd---------qh 79   Bordetella bro...
NP_881236      8 QAMLDGRRGPTLQWALQLqkqvge-----yfgaedMVEVSSVHVsgd-----veeLGVVGTEFLEHIar---------qg 68   Bordetella per...
NP_885872      8 QGLLNGDAGDVVAKYFTWlvewgrlmgaqrlvkvdSVHTSGITAqgrvagavspeARKKTLEQVIEFtsvrmraptathv 87   Bordetella par...
Feature 1                                                                                        
NP_127288     72 AKVSVYTTLNPpg---------igDEEFMEKqre---------vieIYRKMGv--DVTSTCTPYYGan--lPKFGDHLAW 129  Pyrococcus aby...
NP_972807     72 AVSGIPFTVDPrpld------dvvPKSFLERlvfhfmyskqeeyekQLKAMGllsDDAYTCTCYFDevgntPKKGEILSW 145  Treponema dent...
XP_385227    238 GKVRVPTTLNSisvdqkrwralgvDTAFGEAada---------lgkAYVDMGa--KPTYTCAPYQLes--aPKLGEQVAW 304  Gibberella zea...
NP_355982    224 GKVRAPSTMNAisvdkanwraqgvPEDFGDPaar---------ladAYVRMGc--KPTFTCSPYLLds--aPSAGESIAW 290  Agrobacterium ...
ZP_00217445   69 AKVAVPTTLNVgsldli-hpelyhGDRTIQRdaqr--------lmdAHLQLGc--ESSFTCAPYQLkn--rPAKGEQIAW 135  Burkholderia c...
NP_103255     70 GRVQVPTTLNVgsf--------dlIHPGMVKmpaaeev-parrlmkAHLELGc--QATFTCAPYQTrf--rPSFGQQIAW 136  Mesorhizobium ...
40741473     223 AHVAIPTTLNSisvdqrrwrevgvDKNLASEanr---------lanAYVAMGa--ESTFTCAPYLLds--pPGAGDTIGW 289 
NP_891317     80 ASCAVPASSNAqcmhfhadprmaqDAEEEEKekd---------ilsRYKTMRi--AATDSCIPYQHvy--qPKIGEHVAW 146  Bordetella bro...
NP_881236     69 GSCATHTITDPrgvefh-garlrqDPGAIEIetr---------tvaAFGEMGf--KQCNNCIIYQThm--qPGLGEHLGW 134  Bordetella per...
NP_885872     88 ARVCVEDDKGGgls--------aeDQAFQKLvi------------dRARDAGi--QLTWTCAPYIAgi--lPSKNQICAW 143  Bordetella par...
Feature 1           #                                                                            
NP_127288    130 SESSAVsFANSVLGART--NREGGPSSLaaAIVGKTPNYGLHLEENRkathivtv----kaelkdetDYSLLGYKVGEiv 203  Pyrococcus aby...
NP_972807    146 AESSAVnYANSVLGAMC--NRNSGIIEMfgLIAGWVPEFGLLTDEGRkadlive------vetetlpEAQLLGSAIGIka 217  Treponema dent...
XP_385227    305 AESNAVvYSNSVLGARTmkYPDFLDISI--ALTGRAPKGGPHIYANRlasvrvnvsgienitdlddsFPPLLGYYVGTls 382  Gibberella zea...
NP_355982    291 AESNAViFANTVLGART--AKHPDFLDLciAMTGRAPLSGVYIEENRrpqrivdva---lpagiddaFWPLVGYLAGKaa 365  Agrobacterium ...
ZP_00217445  136 AESNAIvFANSVLGART--SRYGDFLDLaaAITGRAPYAGLHVEANRaarivfnapd-fsrlpsrdiYFAALGLLIGRia 212  Burkholderia c...
NP_103255    137 GESNAIvFANSVIGART--NRYGDFIDLccAMTGRAPAWGLHLSENRrgrilfeld--iaeaepsdsLFVGVGLIVGQas 212  Mesorhizobium ...
40741473     290 AESNAVvFANSVLGART--QKYPDLIDVciALTGRAPLAGVQITEERaprlcidvtv-qkhealedvFYPLLGYAVGTvv 366 
NP_891317    147 GDTGTViYANSVLGART--NFEAGKSSFaaALTGRTPEYGFHLDAARrgtlhvrl----qaqmrdfaDWGALGKIIGHpn 220  Bordetella bro...
NP_881236    135 GDTGSViYANSVYGARS--NFEAGPSALaaSMTGRVPRYGFHLDEPRkanvivrv----haaprelaEWGALGCLVGKtm 208  Bordetella per...
NP_885872    144 TESSAVvYINAMVGARS--TRNGTESAIaaAMSGWFPEFGVLLEENRqadliveve---aapseelcDWGFLGYFAGEvs 218  Bordetella par...
Feature 1                                                                                        
NP_127288    204 --enGIPYFKNl-----sPSTDELKALGASMaas----ggVALYHVEEHTPEWrts---------ivDKVEKVEIe---- 259  Pyrococcus aby...
NP_972807    218 --veNVPYIKGldrflgrELNDEVKAYFKDMgaamasngaVGLYHVENLTPEAkesgaslirkdaevYTITESELlr--- 292  Treponema dent...
XP_385227    383 --tsRIPVLTGles--ygLSTDDLKAFGAAFatv----ssAPMFHIVGVTPEAtt-----------lEAVVASELttfev 443  Gibberella zea...
NP_355982    366 --pdCIPLLRGlga--akPSRDDLKALCAAFgtt----saSPMLHIEGATPEAgla---------plETAETVTIs---- 424  Agrobacterium ...
ZP_00217445  213 --gaVVPAIVGlp---adTTEDELKALGAAAass----gaVALFHAVGVTPEAptlda----alhgqAAQRTVDVa---- 275  Burkholderia c...
NP_103255    213 --gdRIPVIAGll---ppRDEDQMKALGAAAatt----gaVALFHAVGITPEAntldq----afhghAPEETIRIt---- 275  Mesorhizobium ...
40741473     367 --agNIPLITGles--tnPTRSDLKAFSAAFatt----asAPMFHISGITPEA--------------KQFDLAGL----- 419 
NP_891317    221 qdyfAVPVIDGyg---ktPMSDELKHLGASLasy----gsMAMFHMVGATPEAptlea----afggaAPAAAMTVt---- 285  Bordetella bro...
NP_881236    209 ngywDVPVFTGld---vrPDSDALKHLGAALasf----gsIAMFHIVGVTPEAp-------------DLASTLSAe---- 264  Bordetella per...
NP_885872    219 --glRTPVLDQlr----aPSLEEAKQLSAAVatg----ggCTMFHIAGVTPEApt-----------lDAVARRPLsrihy 277  Bordetella par...
Feature 1                                            #                                           
NP_127288    260 -dKDIKEVQENf----------NAEWSEvd-fILLGCPHASLKEVKKI---------ADVIRMRETpl-----kvPLYVT 313  Pyrococcus aby...
NP_972807    293 irSSYPDIRKNk----------NAPPGL----CFIGCPHLSKEQLIKW---------TGIIEQKLKqnkkskisiPTVMT 349  Treponema dent...
XP_385227    444 kpSDLVNSWDKl---------nSAPINQpldlVSLGNPHFSLPEMRKL---------AELCQGRRKaa-----nvAVVVT 500  Gibberella zea...
NP_355982    425 -lQDMAAAWSLl----------NDGPEEvq-lVAIGSPHASLEECRAL---------AAVFAGRKRra-----dvAVIVT 478  Agrobacterium ...
ZP_00217445  276 -mADLDEIRRTln--------hGAAGDAlv-aVALGTPHFSLAEFRTLda------lLDAFDGKPAc--------DFYVN 331  Burkholderia c...
NP_103255    276 -qADIDHALSRls--------gVADGAPla-aVSLGTPHFSHEEWMRL---------LPMLREAAPgr-----giPIYVN 331  Mesorhizobium ...
40741473     420 --KRIPLADDNllsal-nglitAADDSVg--lVSLGNPHFSLEEFARFselctgrrkADSVQVIITtn------rQIYAQ 488 
NP_891317    286 -dADLQAVFDAy---------qYKDGGAn--iVVFSGPQLSLYEMQSL---------SERFAGRRVap-----gmTAVVT 339  Bordetella bro...
NP_881236    265 --RNIRILDVEadalervfqayDADFAHpd-iVVFSAPQLSAQELTLI---------ADAMLGKNVaa-----gvRMFVT 327  Bordetella per...
NP_885872    278 raADRTRIAAKl----------NTLTSEridyVVLGCPHATLHEIQVI---------ASQLEGRRVcp-----svRLEVW 333  Bordetella par...
Feature 1                                        #  ##              #                            
NP_127288    314 VSrgvkalsdfLGYTEIIERYNGRLIP---DACLVVSP------IKKWYSGVATNSGKAAfyf----rsfGLKVKLDKLE 380  Pyrococcus aby...
NP_972807    350 SPrgv---lkeFSKTEEYKKLKSFGLLf-sETCPLMYMn----nPLCAKKSVITNSNKLRty------ttAVYYKDDEIA 415  Treponema dent...
XP_385227    501 CGrsiyklaeqAGYISKLEEFGVQVLTd-tCWCMITEPv-----IPRTAKTIMTNSSKYAhy------gpGLTGKVMYFG 568  Gibberella zea...
NP_355982    479 AGqqvidaagkDGTLQSLKDSGVQVLPd-lCWCSISEPv-----FPTKTRALMTNSGKYAhygp---glsGRAVRFGSLA 549  Agrobacterium ...
ZP_00217445  332 TSrfi---lweLDEAGLAEKFAARGIQivvDTCTYITPv-----MKQLSGLVMTNSGKWAsyap---aniGVTVAYGSMR 400  Burkholderia c...
NP_103255    332 TGratl--trlQEEGALAGMEAFGLIPv-aDTCTYVTSi-----LERLDGVVMTNSGKWAhyap---gniGVTVAFAEMA 400  Mesorhizobium ...
40741473     489 ACa--------AGHVGAIETFGAQILT---DTCWCMMSes---vMDSSVVNLMTNSAKYAhyap---givRRGVHFGTLK 551 
NP_891317    340 TNhmiysdakrLGYVDVLEAAGVTILQ---GVCFYILQrlskirEENGWTNLISNSGKLVntitahrfntVLRRTADCVD 416  Bordetella bro...
NP_881236    328 APesv---vaeIEASGVKNRLTAAGVEiltGVCFYLLTpri-laSLNRFSRLTTNSAKLAnim----gghGYQIQLCRLE 399  Bordetella per...
NP_885872    334 TAwavravaqrMGLVDVIERAGGKVLT---DSCPSITRsg---hGRRMVTNAVKQGNYLQgm-------tGHEVAVGKLT 400  Bordetella par...
Feature 1              
NP_127288    381 NLILGA 386  Pyrococcus abyssi GE5
NP_972807    416 DLITGG 421  Treponema denticola ATCC 35405
XP_385227    569 SLAACV 574  Gibberella zeae PH-1
NP_355982    550 DCVESA 555  Agrobacterium tumefaciens str. C58
ZP_00217445  401 ECVRSA 406  Burkholderia cepacia R18194
NP_103255    401 DCIRSA 406  Mesorhizobium loti MAFF303099
40741473     552 DCIAAA 557 
NP_891317    417 IACTGE 422  Bordetella bronchiseptica RB50
NP_881236    400 DCIRAA 405  Bordetella pertussis Tohama I
NP_885872    401 DLVSAA 406  Bordetella parapertussis 12822

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