1IB6,1MLD,1SEV,2DFD,1SMK,1EMD


Conserved Protein Domain Family
MDH_glyoxysomal_mitochondrial

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cd01337: MDH_glyoxysomal_mitochondrial 
Click on image for an interactive view with Cn3D
Glyoxysomal and mitochondrial malate dehydrogenases
MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. Members of this subfamily are localized to the glycosome and mitochondria. MDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133422
View PSSM: cd01337
Aligned: 57 rows
Threshold Bit Score: 401.097
Threshold Setting Gi: 45187709
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ####                     #                                              
1IB6_A         1 MKVAVLGAAGGIGQALALLLKTQLPSgSELSLYDIApVTPGVAVDLSHIPTAVKIKGFSGED------ATPALEGADVVL 74  Escherichia coli
NP_587816     29 FKVAVLGAGGGIGQPLSMLLKLNDKV-SELALFDIR-GAPGVAADIGHINTTSNVVGYAPDDk----gLEKALNGADVVI 102 Schizosaccharom...
P17505        18 YKVTVLGAGGGIGQPLSLLLKLNHKV-TDLRLYDLK-GAKGVATDLSHIPTNSVVKGFTPEEpd---gLNNALKDTDMVL 92  baker's yeast
CAP80102       2 VKAVVLGAAGGIGQPLSLLLKACPLV-DDLALYDVV-NTPGVAADLSHISSVAKITGYLPKDd----gLKLALTGADVVV 75  Penicillium chr...
XP_001879719   2 VKAVVLGAAGGIGQPLALLLKANPLI-TELGLYDIV-NTPGVAADLSHISTPAKVEGYLPADd----gLKKTLTGADIVV 75  Laccaria bicolo...
XP_001729021   1 MKATVIGAAGGIGQPLSLLLKQSPYV-SDLSLYDVV-NAPGVAADLSHINTASPVQGFLPENd----gLAKAVQGSDLVI 74  Malassezia glob...
XP_503933      2 VKAVVAGAAGGIGQPLSLLLKLSPYV-TELALYDVV-NSPGVAADLSHISTKAKVTGYLPKDd----gLKNALTGANIVV 75  Yarrowia lipoly...
NP_984348      2 ARVTVLGAAGGIGQPLSLLLKTCSLV-SELNLYDLR-NAPGVAADVSHVNTDCRVAGFEGPAe-----LGRALRGADLVV 74  Ashbya gossypii...
CAP97106       2 VKIALLGAAGQIGTPLSLLCKASDLF-DEISLYDIV-HVPGIATDLNHIDTRARVSGHLPDDs----gLKKALTGADIVV 75  Penicillium chr...
EDK37405       2 VKVTVCGAAGGIGQPLSLLLKLNPQV-SHLSLFDIV-NAHGVAADLSHICTPAVVTGHQPANkedssaITEALAGTDVVI 79  Pichia guillier...
Feature 1         # ##          #   #  #                   # #                          #  #     
1IB6_A        75 ISAGVARKPGMDRSDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKAGvYDKNKLFGVTTLDIICS 154 Escherichia coli
NP_587816    103 IPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKYLVVTNPVNSTVPIFKKALERVGvHQPKHLFGVTTLDSVRA 182 Schizosaccharom...
P17505        93 IPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPVNSTVPIVAQVLKNKGvYNPKKLFGVTTLDSIRA 172 baker's yeast
CAP80102      76 IPAGIPRKPGMTRDDLFKVNAGIVKGLVESIAEFAPKAFILVISNPVNSTVPIAAEVLKAAGvFDPKRLFGVTTLDVVRA 155 Penicillium chr...
XP_001879719  76 IPAGVPRKPGMTRDDLFKINAGIVRDLATGIAATAPKAFVLVISNPVNSTVPIVAEVFKKAGvYDPKRLFGVTTLDVVRS 155 Laccaria bicolo...
XP_001729021  75 IPAGMPRKPGQTRDDLFNANASIVYGIAEGIAKAAPKAFILVISNPVNSMVPIFAEVLKAHNvYDPKRLFGVTSLDLVRA 154 Malassezia glob...
XP_503933     76 IPAGIPRKPGMTRDDLFKINAGIVRDLVTGVAQYAPDAFVLIISNPVNSTVPIAAEVLKKHNvFNPKKLFGVTTLDVVRA 155 Yarrowia lipoly...
NP_984348     75 IPAGVPRKPGMTRDDLFGINAGIVQSLVTAVAKHCPAARLLIISNPVNSTVPIAVETLKRLGkLNAARVFGVTTLDLVRA 154 Ashbya gossypii...
CAP97106      76 VTAGIARKPGMTRDDLFKTNAGIIRDIFTEIAATCPQAMCCVVTNPVNSTLPVATEALKKGGvFDPTRVFGVTTLDTVRA 155 Penicillium chr...
EDK37405      80 IPAGVPRKPGMTRADLFNINASIVRDLVANVGKTAPNAAILIISNPVNATVAIAAEVLKKLGvFNPRKLFGVTTLDSVRA 159 Pichia guillier...
Feature 1                                   #                                                  # 
1IB6_A       155 NTFVAELKGKQPGEVE-----VPVIGGHSGVTILPLLSQVPGVSf-----tEQEVADLTKRIQNAGTEVVEAKAGGGSAT 224 Escherichia coli
NP_587816    183 SRFTSQVTNGKAELLH-----IPVVGGHSGATIVPLLSQGGVELt------GEKRDALIHRIQFGGDEVVKAKAGAGSAT 251 Schizosaccharom...
P17505       173 ARFISEVENTDPTQER-----VNVIGGHSGITIIPLISQTNHKLm-----sDDKRHELIHRIQFGGDEVVKAKNGAGSAT 242 baker's yeast
CAP80102     156 ETFTQEFSGVKNAADAt----VPVIGGHSGETIVPLFSKVSPSFqi----pADRYDALVNRVQFGGDEVVKAKDGAGSAT 227 Penicillium chr...
XP_001879719 156 STFVAEKIGDLSLSKDv---vVPVVGGHSGVTIVPLLSQSSHPLpas--vdTASLDALVNRIQFGGDEVVKAKGGAGSAT 230 Laccaria bicolo...
XP_001729021 155 STFVSEAAGAKKDAANy---hVPVIGGHSGVTIVPLLSQAKPSFqa----dQQKIEELTNRIQFGGDEVVKAKNNAGSAT 227 Malassezia glob...
XP_503933    156 QTFTAAVVGESDPTKLn----IPVVGGHSGDTIVPLLSLTKPKVei----pADKLDDLVKRIQFGGDEVVQAKDGLGSAT 227 Yarrowia lipoly...
NP_984348    155 QSFLADALGRDAHRVAdlashVTVVGGHAGRTIVPLLADAQLRElq----rRGLYDSYVHRVQFGGDEVVKAKAGAGSAT 230 Ashbya gossypii...
CAP97106     156 STFVAHALGDNANPKDf---kVPVIGGHSGATILPLYSQAQPPVsl----dGQTLAGVINRVQFGGDEIVKSKQGAGSAT 228 Penicillium chr...
EDK37405     160 ETFLGELTGQSPSAIRg---hLSVIGGHSGDTIVPLINVDSTISsavsqwsPSQYQAYVKRVQFGGDEVVKAKNGAGSAT 236 Pichia guillier...
Feature 1          #                                                                             
1IB6_A       225 LSMGQAAARFGLSLVRALQGe-------qGVVECAYVEGDG--------------QYARFFSQPLLLGKNGVEe--RKSI 281 Escherichia coli
NP_587816    252 LSMAYAGARMASSVLRALAGe-------sGVEECTFVESPLyk-----------dQGIDFFASRVTLGKDGVDt--IHPV 311 Schizosaccharom...
P17505       243 LSMAHAGAKFANAVLSGFKGe-------rDVIEPSFVDSPLfk-----------sEGIEFFASPVTLGPDGIEk--IHPI 302 baker's yeast
CAP80102     228 LSMAFAGFRFAEAVIKASKGe-------kGIVEPTFVYLPGvaggd----eiakaTGLDFFSTPVELGVNGAEk-aINIL 295 Penicillium chr...
XP_001879719 231 LSMAYAGAEFASKILRAVKGe-------eGIVAPSYVSLEAdpvgaaa-ltkelgAELAYFSSNIELGPQGVVk--INPL 300 Laccaria bicolo...
XP_001729021 228 LSMAFAGARFANAVLAAAQGkk------aELPEFSYVDLAAdeaggka-vkdvigNDIAFFSVPLTLGPNGVEk--IQSL 298 Malassezia glob...
XP_503933    228 LSMAQAGFRFAEAVLKGAAGe-------kGIIEPAYIYLDGidgts----dikreVGVAFFSVPVEFGPEGAAk-aYNIL 295 Yarrowia lipoly...
NP_984348    231 LSMALAGFHFAELLLRSLAGe-------aVAPEPAFVYLPGlpggadlaralaatEPVDYFAAPVRLAAGDAAvvdTAFV 303 Ashbya gossypii...
CAP97106     229 TCMAYAGFRFIKALLVGMDGe--------AITEEAYVYLPGipggk----eiaaeLGVDYFAVKIELGKTGATk--ALPI 294 Penicillium chr...
EDK37405     237 LSMAYAGYRFAETVLNSLSDpskpvadstPVPDSSYVYLPGlpggee--fskkyvNGVTFFSVPVLLQNGEISs-fINPF 313 Pichia guillier...
Feature 1                                       
1IB6_A       282 GTLSA--FEQNALEGMLDTLKKDIALGQEFV 310 Escherichia coli
NP_587816    312 GKIND--YEESLLKVALGELKKSITKGEQFV 340 Schizosaccharomyces pombe
P17505       303 GELSS--EEEEMLQKCKETLKKNIEKGVNFV 331 baker's yeast
CAP80102     296 EGVTE--QEKKLLEACIKGLQGNIEKGVEFA 324 Penicillium chrysogenum Wisconsin 54-1255
XP_001879719 301 GKITE--AEQTLIKAAIPELQKNITTGVTFI 329 Laccaria bicolor S238N-H82
XP_001729021 299 GDISS--FESELIKKSIESLKGNIEKGVSFK 327 Malassezia globosa CBS 7966
XP_503933    296 PEAND--YEKKLLKVSIDGLYGNIAKGEEFI 324 Yarrowia lipolytica CLIB122
NP_984348    304 ADLAP--EQRALVDAALPELAASIRKGVDFV 332 Ashbya gossypii ATCC 10895
CAP97106     295 GKISE--HETRLLEVALKELKTNIATGLSFM 323 Penicillium chrysogenum Wisconsin 54-1255
EDK37405     314 EKYKItsEEANLTEVALDGLQKSIDQGTTFV 344 Pichia guilliermondii ATCC 6260

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